Alcohol and alcoholism最新文献_第9页

Harm reduction treatment for substance use, Susan E. Collins and Seema L. Clifasefi. Hogrefe Publishing, Newburyport, MA; 2023. ISBN: 9780889375079; 127 pp.; £19.90 药物使用的减低伤害治疗》，Susan E. Collins 和 Seema L. Clifasefi。Hogrefe Publishing, Newburyport, MA; 2023.ISBN: 9780889375079; 127 pp.

IF 2.8 4区医学

Alcohol and alcoholism Pub Date : 2024-01-17 DOI: 10.1093/alcalc/agad085

Joe Schofield

引用次数: 0

A machine learning model for the prediction of unhealthy alcohol use among women of childbearing age in Alabama. 预测阿拉巴马州育龄妇女不健康饮酒的机器学习模型。

IF 2.8 4区医学

Alcohol and alcoholism Pub Date : 2024-01-17 DOI: 10.1093/alcalc/agad075

Karen A Johnson, Justin T McDaniel, Joana Okine, Heather K Graham, Ellen T Robertson, Shanna McIntosh, Juliane Wallace, David L Albright

{"title":"A machine learning model for the prediction of unhealthy alcohol use among women of childbearing age in Alabama.","authors":"Karen A Johnson, Justin T McDaniel, Joana Okine, Heather K Graham, Ellen T Robertson, Shanna McIntosh, Juliane Wallace, David L Albright","doi":"10.1093/alcalc/agad075","DOIUrl":"10.1093/alcalc/agad075","url":null,"abstract":"Introduction: This study utilizes a machine learning model to predict unhealthy alcohol use treatment levels among women of childbearing age.Methods: In this cross-sectional study, women of childbearing age (n = 2397) were screened for alcohol use over a 2-year period as part of the AL-SBIRT (screening, brief intervention, and referral to treatment in Alabama) program in three healthcare settings across Alabama for unhealthy alcohol use severity and depression. A support vector machine learning model was estimated to predict unhealthy alcohol use scores based on depression score and age.Results: The machine learning model was effective in predicting no intervention among patients with lower Patient Health Questionnaire (PHQ)-2 scores of any age, but a brief intervention among younger patients (aged 18-27 years) with PHQ-2 scores >3 and a referral to treatment for unhealthy alcohol use among older patients (between the ages of 25 and 50) with PHQ-2 scores >4.Conclusions: The machine learning model can be an effective tool in predicting unhealthy alcohol use treatment levels and approaches.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134648161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baclofen in the treatment of alcohol use disorder: tailored doses matter. 巴氯芬治疗酒精使用障碍：量身定制的剂量很重要。

IF 2.1 4区医学

Alcohol and alcoholism Pub Date : 2024-01-17 DOI: 10.1093/alcalc/agad090

Renaud de Beaurepaire, Philippe Jaury

{"title":"Baclofen in the treatment of alcohol use disorder: tailored doses matter.","authors":"Renaud de Beaurepaire, Philippe Jaury","doi":"10.1093/alcalc/agad090","DOIUrl":"10.1093/alcalc/agad090","url":null,"abstract":"Aims: To address the question of tailored baclofen prescribing in alcohol use disorder (AUD) in relation to dose-dependent efficacy and the potential danger of high doses and to provide suggestions for the use of high doses of baclofen in the treatment of AUD. The context is the approvement in France of baclofen in the treatment of AUD without dose limitation, making French physicians, who usually prescribe baclofen in a tailored manner, often use high or very high doses.Methods: A narrative review of the results of randomized controlled trials (RCTs) and observational studies that used tailored baclofen prescribing and of the severe adverse effects of baclofen that have been reported in the literature.Results: The results show that RCTs using tailored doses of baclofen in AUD are not completely demonstrative, though they are encouraging according to certain meta-analyses, while observational studies that used tailored doses constantly show a good effectiveness of baclofen treatment. The results suggest that many severe adverse effects of baclofen could be related to a nonrespect by physicians of prescription rules and appropriate treatment monitoring.Conclusions: The use of tailored doses shows that the dose required to suppress cravings is highly variable, low or high, depending on each case. Analysis of the circumstances in which severe adverse effects occur suggest that a careful monitoring of baclofen prescribing might prevent a large majority of severe adverse effects. We propose that the education of the patients and the prescription skills, seriousness, and availability of the prescribing physicians are of major importance in the managing of tailored baclofen treatment of AUD.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10807704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

'Reputation, reputation, reputation! Oh, I have lost my reputation!'; A literature review on alcohol addiction in the British Sikh and/or Punjabi community and the barriers to accessing support. “名誉，名誉，名誉!”啊，我的名誉丢了!”关于英国锡克教徒和/或旁遮普社区酒精成瘾以及获得支持的障碍的文献综述。

IF 2.8 4区医学

Alcohol and alcoholism Pub Date : 2024-01-17 DOI: 10.1093/alcalc/agad080

Karamdeep Kaur

{"title":"'Reputation, reputation, reputation! Oh, I have lost my reputation!'; A literature review on alcohol addiction in the British Sikh and/or Punjabi community and the barriers to accessing support.","authors":"Karamdeep Kaur","doi":"10.1093/alcalc/agad080","DOIUrl":"10.1093/alcalc/agad080","url":null,"abstract":"Aims: The literature review aimed to identify the barriers the Punjabi and/or Sikh community have in accessing support for alcohol addiction.Method: A systematic review of the literature was undertaken of four scholarly databases, Google Scholar and grey literature on UK-based research conducted after 1980 into alcohol addiction in the Punjabi and/or Sikh community. Fourteen papers met the inclusion criteria outlined in the paper and were included in the review.Results: Ten main barriers to accessing support were found; stigma, religion, lack of understanding of addiction, over reliance on a medical model of treatment and disregard of therapy, cultural implications of being a member of the Punjabi and/or Sikh community and the addiction community, gender and generational differences and a lack of government commitment to alcohol support for BME communities with a lack of culturally specific services.Conclusion: Despite the many barriers explored, the role of stigma remained a powerful theme throughout often underpinning other barriers. A key recommendation across many papers was the need for culturally sensitive support services. Several areas for future research were identified.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138450709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editors regarding 'Efficacy of psychosocial interventions to reduce alcohol use in comorbid alcohol use disorder and alcohol-related liver disease: a systematic review of randomized controlled trials'. 致编辑的信，内容涉及 "心理干预对减少合并酒精使用障碍和酒精相关肝病患者酒精使用的疗效：随机对照试验的系统回顾"。

IF 2.8 4区医学

Alcohol and alcoholism Pub Date : 2024-01-17 DOI: 10.1093/alcalc/agae001

Lien-Chung Wei

引用次数: 0

Response to Letter to the Editors regarding 'Efficacy of psychosocial interventions to reduce alcohol use in comorbid alcohol use disorder and alcohol-related liver disease: a systematic review of randomized controlled trials'. 对 "心理干预对减少合并酒精使用障碍和酒精相关肝病患者酒精使用的疗效：随机对照试验的系统回顾 "致编辑的信的回复。

IF 2.8 4区医学

Alcohol and alcoholism Pub Date : 2024-01-17 DOI: 10.1093/alcalc/agae004

Sofia Hemrage, Eileen Brobbin, Paolo Deluca, Colin Drummond

引用次数: 0

Reduction of alcohol use and increase in psychological flexibility after a naturalistic psychedelic experience: a retrospective survey. 自然迷幻体验后减少酒精使用和增加心理灵活性:一项回顾性调查。

IF 2.8 4区医学

Alcohol and alcoholism Pub Date : 2024-01-17 DOI: 10.1093/alcalc/agad078

Ewen Kervadec, Baptiste Fauvel, Lana Strika-Bruneau, Ammar Amirouche, Vincent Verroust, Pascale Piolino, Bruno Romeo, Amine Benyamina

{"title":"Reduction of alcohol use and increase in psychological flexibility after a naturalistic psychedelic experience: a retrospective survey.","authors":"Ewen Kervadec, Baptiste Fauvel, Lana Strika-Bruneau, Ammar Amirouche, Vincent Verroust, Pascale Piolino, Bruno Romeo, Amine Benyamina","doi":"10.1093/alcalc/agad078","DOIUrl":"10.1093/alcalc/agad078","url":null,"abstract":"Introduction: Alcohol use can be significantly associated with negative social, professional, and health outcomes. Even more so, alcohol use disorder (AUD) is a critical public health issue and major avoidable risk factor. This study aimed to examine the effect of a naturalistic psychedelic experience on alcohol use and related measures.Methods: A retrospective online survey was conducted on 160 individuals who reported a psychedelic experience and a concomitant drinking habit but did not necessarily have an AUD. Demographic data, characteristics of the psychedelic experience, and changes in alcohol consumption and psychological flexibility were surveyed. Results: The mean number of drinking days per week and AUDIT scores significantly decreased after the psychedelic experience (P < .001). Subjects who quit or reduced drinking had a more severe AUD (P < .01) and lower psychological flexibility (P = .003) before the psychedelic session. Alcohol use reduction was significantly associated with the intensity of the mystical experience (P = .03). Psychological flexibility increased more in participants who reduced their alcohol use (P < .001), and the change in psychological flexibility was one of the predictors of alcohol use improvement (P = .003). Conclusion: Our findings suggest that a naturalistic psychedelic experience could be associated with a reduction in alcohol use and dependency. Such positive health outcomes can be associated with the intensity of the mystical experience as well as an increase in psychological flexibility.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138045981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of over the counter "hangover remedy" use with alcohol use problems and consumption patterns among young adults. 非处方“宿醉疗法”与年轻人酒精使用问题和消费模式的关系。

IF 2.1 4区医学

Alcohol and alcoholism Pub Date : 2024-01-17 DOI: 10.1093/alcalc/agad081

Dae-Hee Han, Jordan P Davis, Daryl L Davies, John D Clapp, Eric R Pedersen, Adam M Leventhal

引用次数: 0

Alcohol metabolism in alcohol use disorder: a potential therapeutic target. 酒精使用障碍中的酒精代谢:一个潜在的治疗靶点。

IF 2.1 4区医学

Alcohol and alcoholism Pub Date : 2024-01-11 DOI: 10.1093/alcalc/agad077

Taylor Lehner, Bin Gao, Bryan Mackowiak

{"title":"Alcohol metabolism in alcohol use disorder: a potential therapeutic target.","authors":"Taylor Lehner, Bin Gao, Bryan Mackowiak","doi":"10.1093/alcalc/agad077","DOIUrl":"10.1093/alcalc/agad077","url":null,"abstract":"Ethanol metabolism plays an essential role in how the body perceives and experiences alcohol consumption, and evidence suggests that modulation of ethanol metabolism can alter the risk for alcohol use disorder (AUD). In this review, we explore how ethanol metabolism, mainly via alcohol dehydrogenase and aldehyde dehydrogenase 2 (ALDH2), contributes to drinking behaviors by integrating preclinical and clinical findings. We discuss how alcohol dehydrogenase and ALDH2 polymorphisms change the risk for AUD, and whether we can harness that knowledge to design interventions for AUD that alter ethanol metabolism. We detail the use of disulfiram, RNAi strategies, and kudzu/isoflavones to inhibit ALDH2 and increase acetaldehyde, ideally leading to decreases in drinking behavior. In addition, we cover recent preclinical evidence suggesting that strategies other than increasing acetaldehyde-mediated aversion can decrease ethanol consumption, providing other potential metabolism-centric therapeutic targets. However, modulating ethanol metabolism has inherent risks, and we point out some of the key areas in which more data are needed to mitigate these potential adverse effects. Finally, we present our opinions on the future of treating AUD by the modulation of ethanol metabolism.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10783952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89716547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discrimination, gender dysphoria, drinking to cope, and alcohol harms in the UK trans and non-binary community. 英国跨性别和非二元群体中的歧视、性别焦虑、饮酒应对以及酒精危害。

IF 2.8 4区医学

Alcohol and alcoholism Pub Date : 2024-01-11 DOI: 10.1093/alcalc/agad060

Emma L Davies, Ivan Ezquerra-Romano, Beth Thayne, Zhi Holloway, Jacob Bayliss, Stewart O'Callaghan, Dean J Connolly

{"title":"Discrimination, gender dysphoria, drinking to cope, and alcohol harms in the UK trans and non-binary community.","authors":"Emma L Davies, Ivan Ezquerra-Romano, Beth Thayne, Zhi Holloway, Jacob Bayliss, Stewart O'Callaghan, Dean J Connolly","doi":"10.1093/alcalc/agad060","DOIUrl":"10.1093/alcalc/agad060","url":null,"abstract":"Transgender (trans) and non-binary people may be at increased risk of alcohol harms, but little is known about motives for drinking in this community. This study explored the relationship between risk of alcohol dependence, experience of alcohol harms, drinking motives, dysphoria, and discrimination within a United Kingdom sample of trans and non-binary people with a lifetime history of alcohol use. A cross-sectional survey was co-produced with community stakeholders and administered to a purposive sample of trans and non-binary people from 1 February until 31 March 2022. A total of 462 respondents were included-159 identified as non-binary and/or genderqueer (identities outside the man/woman binary), 135 solely as women, 63 solely as men, 15 as another gender identity, 90 selected multiple identities. Higher levels of reported discrimination were associated with higher risk of dependence and more reported harms from drinking. Coping motives, enhancement motives, and drinking to manage dysphoria were associated with higher Alcohol Use Disorders Identification Test scores. Social, coping, and enhancement motives alongside discrimination and drinking to have sex were associated with harms. The relationship between discrimination and risk of dependence was mediated by coping motives and drinking to manage dysphoria. Further to these associations, we suggest that reducing discrimination against trans and non-binary communities might reduce alcohol harms in this population. Interventions should target enhancement motives, coping motives and gender dysphoria. Social and enhancement functions of alcohol could be replaced by alcohol free supportive social spaces.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0