Relationship between alcohol intake based on daily smartphone-reported consumption and PEth concentrations in healthy volunteers.

IF 2.1 4区医学 Q3 SUBSTANCE ABUSE

Alcohol and alcoholism Pub Date : 2024-05-14 DOI:10.1093/alcalc/agae040

Trine Finanger, Katrine Melby, Olav Spigset, Trine N Andreassen, Stian Lydersen, Ragnhild Bergene Skråstad

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引用次数: 0

Abstract

Aims: To investigate the association between alcohol consumption registered daily with a digital smartphone-based diary and concentration of phosphatidylethanol (PEth) 16:0/18:1 in a population without a known alcohol use disorder (AUD), and evaluate whether prospective registration of alcohol consumption is better than retrospective registration and if the association between alcohol intake and PEth was affected by sex or body mass index (BMI).

Methods: A total of 41 women and 21 men without AUD-diagnosis registered their alcohol consumption prospectively with a digital diary for 14 days, and retrospectively with the Timeline Followback method in the same time interval. PEth was measured before and after the registration period.

Results: The correlation between alcohol consumption and PEth varied from 0.65 to 0.87. It did not depend significantly on the reporting method, and was not influenced by sex or BMI. Based on the regression coefficient, a reduction of alcohol consumption by two alcohol units (26 g of pure ethanol) per day would lead to a reduction of the PEth concentration of about 0.1 μmol/l, and vice versa.

Conclusions: There was a good correlation between PEth concentration and alcohol consumption, both when alcohol consumption was reported prospectively and retrospectively. The preferred cut-off for PEth should be adjusted to the level of alcohol consumption considered harmful and a purposeful trade-off between sensitivity and specificity. In order to identify persons with a daily alcohol consumption of more than two or three units of alcohol with a sensitivity of 80% or 90%, we suggest a cut-off of around 0.1 μmol/l.

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根据智能手机报告的每日酒精摄入量与健康志愿者体内 PEth 浓度之间的关系。

目的：在未发现酒精使用障碍（AUD）的人群中，研究通过基于智能手机的数字日记每天记录的酒精消耗量与磷脂酰乙醇（PEth）16:0/18:1浓度之间的关系，并评估酒精消耗量的前瞻性登记是否优于回顾性登记，以及酒精摄入量与磷脂酰乙醇（PEth）之间的关系是否受性别或体重指数（BMI）的影响：方法：41名女性和21名男性在未确诊AUD的情况下通过数字日记对其饮酒量进行了为期14天的前瞻性登记，并在相同时间间隔内通过时间轴回溯法对其饮酒量进行了回顾性登记。结果显示，饮酒量与酒精浓度之间存在相关性：结果：酒精消耗量与 PEth 之间的相关性从 0.65 到 0.87 不等。它与报告方法无明显关系，也不受性别或体重指数的影响。根据回归系数，每天减少 2 个酒精单位（26 克纯乙醇）的饮酒量将导致 PEth 浓度降低约 0.1 μmol/l，反之亦然：无论是前瞻性报告还是回顾性报告饮酒量，PEth 浓度与饮酒量之间都有很好的相关性。PEth的首选临界值应根据被认为有害的饮酒水平进行调整，并在灵敏度和特异性之间进行有目的的权衡。为了以 80% 或 90% 的灵敏度识别每日饮酒量超过 2 或 3 个单位的人群，我们建议将临界值设定在 0.1 μmol/l 左右。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alcohol and alcoholism 医学-药物滥用

CiteScore

4.70

自引率

3.60%

发文量

审稿时长

4-8 weeks

期刊介绍： About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.