Alcohol and alcoholism最新文献

{"title":"Polygenic risk scores as predictors of topiramate's effect in treating alcohol use disorder.","authors":"Albert J Arias, Carole Siegel, Eugene Laska, Joseph Wanderling, Brendan Ho, Richard Feinn, Rachel L Kember, Hang Zhou, Ziqiang Lin, Heng Xu, Andrew Snyder, Olivia R Nicastro, Nidhi Desai, Ismene L Petrakis, Jonathan M Covault, Joel Gelernter, Joanna Biernacka, Yuna Kim, Viktor Karpyak, Charles R Marmar, Henry R Kranzler","doi":"10.1093/alcalc/agag064","DOIUrl":"https://doi.org/10.1093/alcalc/agag064","url":null,"abstract":"<p><strong>Introduction: </strong>Topiramate is efficacious for treating alcohol use disorder (AUD), but treatment response varies considerably. To advance precision treatment, we used machine-learning methods integrating clinical trial and genetic data to estimate expected response to topiramate.</p><p><strong>Methods: </strong>Random forest (RF) regression models were used to estimate expected topiramate response using randomized clinical trial data from 278 participants and 23 pre-treatment features: four alcohol polygenic risk scores (PRS), nine alcohol drinking measures, and 10 clinical and sociodemographic variables. RF importance scores quantified each feature's contribution to predictive performance. Likely Responders (LRs) were identified using quintiles of predicted treatment response and counterfactual placebo response, with LRs defined as quintiles in which randomized trial data demonstrated topiramate superiority over placebo. Variable Selection Using Random Forests (VSURF) was used to eliminate less informative and redundant predictors.</p><p><strong>Results: </strong>Two pre-treatment drinking measures consistently had the highest importance scores across all VSURF levels. The final parsimonious model retained three predictors: average drinks per day, percent heavy drinking days, and the PRS for \"Time Until Relapse,\" with bias-corrected R2 = 0.30. LRs comprised the top four predicted response quintiles (80% of the sample) across models. Compared with unlikely responders, LRs had lower baseline drinking severity and higher \"Time Until Relapse\" PRS.</p><p><strong>Conclusions: </strong>The \"Time Until Relapse\" PRS contributed meaningfully to estimating expected response, LR stratification, and observed topiramate treatment effects, although pre-treatment drinking measures remained the strongest predictors. These findings support incorporation of pharmacogenomic markers into machine-learning models to advance precision prescribing for AUD.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity reduces but does not fully counteract the detrimental associations between alcohol use and metabolic syndrome.","authors":"Jimikaye B Courtney, Ishrat Z Alam, Kelly R Evenson","doi":"10.1093/alcalc/agag066","DOIUrl":"https://doi.org/10.1093/alcalc/agag066","url":null,"abstract":"<p><strong>Background: </strong>This cross-sectional study investigated the main and interacting associations of physical activity (PA) and alcohol use with the number of metabolic syndrome (MetS) risk factors and odds of MetS.</p><p><strong>Methods: </strong>We used 2011-2014 (N = 3227) and 2015-2020 (N = 5586) National Health and Nutrition Examination Survey data for adults (20-80 years). We categorized participants into quartiles for device-based PA (2011-2014) and meeting or not meeting recommendations (≥150 vs <150 min of PA/week) for self-reported PA (2015-2020). We calculated average self-reported drinks/day. MetS risk factors were: (1) waist circumference ≥88/≥102 cm for females/males; (2) triglycerides ≥150 mg/dl; (3) blood pressure ≥130 mm Hg/≥85 mm Hg; (4) fasting glucose ≥100 mg/dl; and (5) high-density lipoprotein cholesterol (HDL-C) <50/<40 mg/dl for females/males. We categorized participants with MetS if they had ≥3 risk factors. We examined the direct and moderating associations of PA and alcohol use with number of MetS risk factors and odds of MetS.</p><p><strong>Results: </strong>Compared to Q1, adults in Q2-Q4 had fewer MetS risk factors (Q2: incidence rate ratio [IRR] = 0.90, 95% confidence interval [CI]: 0.84, 0.97; Q3: IRR = 0.80, 95% CI: 0.74, 0.87; Q4: IRR = 0.73, 95% CI: 0.67, 0.80). Compared to Q1, adults in Q3 and Q4 had lower odds of MetS when consuming ≤0.50 drinks/day (odds ratio [OR] = 0.44, 95%CI: 0.30, 0.64) or ≤0.75 drinks/day (OR = 0.43, 95%CI: 0.30, 0.60), respectively. Meeting PA recommendations was associated with fewer risk factors (IRR = 0.90, 95%CI: 0.84, 0.96). CIs were wide for some estimates due to sparsity of data at higher alcohol levels.</p><p><strong>Conclusions: </strong>Adults should consider engaging in more PA and limiting their alcohol use to reduce risk factors and overall MetS risk.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol-involved suicide mortality prevalence estimates and identification of co-occurring substance use from the National Violent Death Reporting System, 2022-2023.","authors":"Madeline B Benz, Siqi Li, Brandon A Gaudiano, Ted R Miller","doi":"10.1093/alcalc/agag065","DOIUrl":"https://doi.org/10.1093/alcalc/agag065","url":null,"abstract":"<p><p>Using National Violent Death Reporting System data (2022-2023), 14 909 suicide decedents (34%) tested positive for alcohol. The most common substances co-occurring with alcohol were marijuana, antidepressants, opioids, and benzodiazepines; polysubstance use was high, with 52% testing positive for alcohol and ≥1 other substance. Findings suggest an overall alcohol-involved suicide mortality rate of 24%, appearing higher than prior estimates.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological interventions for alcohol use disorder on quality of life: a meta-analysis of randomized controlled trials.","authors":"Dimy Fluyau, Neelambika Revadigar, Paul Kim","doi":"10.1093/alcalc/agag067","DOIUrl":"10.1093/alcalc/agag067","url":null,"abstract":"<p><strong>Aims: </strong>Quality of life (QoL), a critical factor for sustaining recovery from alcohol use disorder (AUD), has been examined as an AUD-related outcome in randomized controlled trials (RCTs) that evaluated pharmacotherapy for AUD. This review evaluates the efficacy of this therapy in improving mental and physical health-related QoL.</p><p><strong>Methods: </strong>RCTs were identified across seven databases. Study quality was evaluated using the Cochrane risk-of-bias tool for randomized trials version 2. A systematic review with meta-analysis was conducted. The review adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines and was registered with PROSPERO (CRD420261277890).</p><p><strong>Results: </strong>Eighteen RCTs with 4376 participants were evaluated. Naltrexone was linked to improvements in both mental QoL (d = 0.30, 95% CI: 0.08-0.52) and physical QoL (d = 0.16, 95% CI: 0.01-0.31). Nalmefene improved physical QoL (d = 0.13, 95% CI: 0.02-0.25) but not mental QoL (d = 0.18, 95% CI: -0.004 to 0.354). Topiramate showed no improvement in either domain. However, further analysis indicated that topiramate was associated with a small improvement in physical QoL, which could correlate with a reduced percentage of heavy drinking days. Interpret these findings with caution. Acamprosate, sertraline, and psilocybin were associated with improved mental or physical QoL, whereas ketamine, varenicline, levetiracetam XR, and quetiapine were not. Interpretation is limited to single trials-no eligible RCTs reporting the specified QoL outcomes for disulfiram.</p><p><strong>Conclusions: </strong>Certain medications for AUD are linked with improved mental and physical QoL, but evidence remains limited. Future RCTs should assess QoL and establish whether improvements are clinically meaningful.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of cannabidiol on risky decision-making and autonomic function in alcohol use disorder.","authors":"Ellen McGuire, Tristan Hurzeler, Warren Logge, Joshua Watt, Iain S McGregor, Anastasia Suraev, Paul S Haber, Kirsten C Morley","doi":"10.1093/alcalc/agag068","DOIUrl":"10.1093/alcalc/agag068","url":null,"abstract":"<p><strong>Aims: </strong>To examine the effects of cannabidiol (CBD) on psychophysiological responding and risky decision-making in individuals with alcohol use disorder (AUD).</p><p><strong>Methods: </strong>In a double-blind, placebo-controlled crossover trial, 18 participants with AUD completed the Columbia Card Task (CCT) following administration of CBD and placebo. Skin conductance responses (SCR) and high-frequency heart rate variability (HF-HRV) were assessed as indices of autonomic responding during task performance. Risk-taking was indexed by the number of cards selected on the CCT.</p><p><strong>Results: </strong>CBD did not significantly affect SCR (P = .16, pBH = .326) or risky decision-making on the CCT (P > .63, pBH = 0.67). However, CBD significantly increased HF-HRV (β = 0.53, SE = 0.19, P = .005; pBH = 0.020). There was no evidence that the relationships between HF-HRV or SCR and risky decision-making differed between CBD and placebo conditions (drug × HF-HRV: P = .92; drug × SCR: P = .958; both pBH = .958).</p><p><strong>Discussion: </strong>CBD increased HF-HRV but did not significantly alter SCR, risky decision-making, or the relationship between autonomic responses and risky decision-making. These findings suggest that CBD influences autonomic responding during task performance, although the functional significance of this effect remains uncertain. The modest sample size and relatively healthy, non-treatment-seeking sample may have limited the ability to detect broader physiological and behavioural effects.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13665463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training hepatologists in alcohol use disorder management: a pilot study.","authors":"Jayant Mahadevan, Udit Panda, Abhishek Kumar Sharma, Daniel Paul Ritish Kavati, Likhitha Chandra, N Kubenthiran, Prabhat Kumar Chand, Pratima Murthy, Sanjeev Arora, Ashwani K Singal","doi":"10.1093/alcalc/agag063","DOIUrl":"10.1093/alcalc/agag063","url":null,"abstract":"<p><strong>Background and aims: </strong>Alcohol use disorder (AUD) and alcohol associated liver disease (ALD) commonly co-occur, and integrated approaches to treatment are associated with better outcomes. This study aimed to develop an online module, the Program for Advanced Training of Hepatologists in Alcohol Use Disorder Management (PRATHAM), to enroll and train hepatologists, and to evaluate changes in participants' knowledge, attitudes, practices, and self-perceived competence pre- and post-training.</p><p><strong>Methods: </strong>This included identification of specific needs, establishing learning objectives, designing a curriculum, and developing didactic presentations for hepatologists. Interested participants were enrolled in the online module and were asked to submit pre-tests, clinical cases, and a post-test, which included an evaluation of knowledge, attitudes, practice, and self-perceived competence. Descriptive statistics and the Wilcoxon signed-rank test were used to analyze the data. An intention-to-treat analysis was used to address missing data.</p><p><strong>Results: </strong>An 8-week curriculum was developed for 18 hepatologists from five different countries. Of these, 17 completed the pre-test, and 11 filled out the post-test proforma. Eleven complex clinical cases were discussed. There was a significant improvement in the participants' knowledge, practice, and self-perceived competence pre- and post-training. However, no significant change in attitudes was noted.</p><p><strong>Conclusions: </strong>This study underscores the importance of tailored educational interventions in medical specialties such as hepatology, where practitioners frequently encounter patients with AUD. The significant improvements in practice, self-efficacy, and knowledge highlight the potential of targeted training programs to enhance patient care. Future studies could engage a more diverse group of hepatologists and evaluate patient outcomes.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heartbeat counting task performance in alcohol use disorder: a systematic review and meta-analysis.","authors":"Nicolás Guillermo González, Luisa Göde, Lucía Alba-Ferrara","doi":"10.1093/alcalc/agag061","DOIUrl":"10.1093/alcalc/agag061","url":null,"abstract":"<p><strong>Aims: </strong>Interoception has been proposed as a relevant process in alcohol use disorder (AUD), and studies using the heartbeat counting task (HCT) have often reported poorer performance in individuals with AUD than in healthy controls (HC). However, concerns about the construct validity of the HCT complicate interpretation of these findings. This systematic review and meta-analysis quantified the magnitude and consistency of group differences in HCT performance between adults with AUD and HC, without assuming that the task provides a process-pure measure of cardiac interoceptive accuracy.</p><p><strong>Methods: </strong>Eligible studies compared adults diagnosed with AUD with HC and reported sufficient HCT data to compute standardized mean differences. PubMed/MEDLINE, PsycINFO, Embase, and Web of Science were searched up to 4 November 2025. Study quality was assessed using an adapted Newcastle-Ottawa Scale. Hedges' g values were pooled using a random-effects model. The review received no specific external funding and was preregistered in PROSPERO [ID = CRD420251173904].</p><p><strong>Results: </strong>Six studies including 314 individuals with AUD and 324 HC were included. The pooled effect was moderate-to-large and negative, indicating lower HCT performance in AUD than HC, g = -0.79, 95% CI [-0.96, -0.63]. All included studies showed negative effect sizes, although the small evidence base limits certainty.</p><p><strong>Conclusions: </strong>Lower HCT performance appears to represent a preliminary but consistent task-level behavioral difference in AUD. These findings should not be interpreted as direct evidence of reduced cardiac interoceptive accuracy, but they support further investigation of whether HCT performance relates to clinically relevant AUD features.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six approved drugs for alcohol use disorder: algorithms for their use according to the aims of treatment.","authors":"Fabio Caputo, Teo Vignoli, Lisa Lungaro, Anna Costanzini, Alberto Casabianca, Giacomo Caio, Gianni Testino, Giovanni Addolorato, Roberto De Giorgio","doi":"10.1093/alcalc/agag052","DOIUrl":"10.1093/alcalc/agag052","url":null,"abstract":"<p><strong>Background: </strong>The pharmacological management of alcohol use disorder (AUD) currently includes six medications approved by different regulatory agencies worldwide: acamprosate (ACM), naltrexone (NTX), nalmefene (NMF), disulfiram (DF), baclofen, and sodium oxybate (SO). Their optimal use should be aligned with the main aims of treatment, namely reduction of alcohol consumption and maintenance of complete abstinence.</p><p><strong>Objectives: </strong>This brief review summarizes the role of these six approved medications in AUD treatment and proposes practical treatment algorithms according to treatment goals, mechanisms of action, and clinically relevant outcomes.</p><p><strong>Methods: </strong>A focused narrative review of the literature was conducted, prioritizing meta-analyses, systematic reviews, randomized controlled trials, and relevant regulatory documents. Evidence on efficacy, safety, tolerability, and clinical applicability was interpreted pragmatically to support first-, second-, and third-line pharmacological strategies.</p><p><strong>Results: </strong>For reducing alcohol intake, NMF or NTX are proposed as first-line pharmacotherapies, with baclofen considered as a second-line option when these agents are partially effective or ineffective. For maintaining abstinence, ACM is proposed as a first-line strategy. In selected clinical settings, including severe AUD, protracted alcohol withdrawal syndrome, high motivation for aversive treatment, or liver disease, SO, baclofen, DF, or NTX may serve as second-line options. Combined pharmacotherapy may be considered in highly adherent patients, whereas off-label drugs remain third-line options for refractory cases.</p><p><strong>Conclusions: </strong>Improved knowledge of the efficacy, safety, and tolerability of the six approved medications may support more appropriate, individualized, and goal-oriented pharmacological management of patients with AUD. The proposed algorithms are intended as pragmatic tools to aid clinical decision-making rather than as formal guidelines.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caution in interpreting alcohol-inflammation associations.","authors":"Creina S Stockley, Henk F J Hendriks","doi":"10.1093/alcalc/agag053","DOIUrl":"https://doi.org/10.1093/alcalc/agag053","url":null,"abstract":"","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Job stressors and the incidence of alcohol-related outcomes: prospective findings from the national French ESPS survey.","authors":"Isabelle Niedhammer, Maël Quatrevaux","doi":"10.1093/alcalc/agag056","DOIUrl":"https://doi.org/10.1093/alcalc/agag056","url":null,"abstract":"<p><strong>Background: </strong>Prospective studies are lacking on the associations between job stressors and alcohol-related outcomes in the working population. The objectives were to explore the prospective associations of these exposures, including changes in exposure, with three alcohol-related outcomes.</p><p><strong>Methods: </strong>The study relied on the prospective data of the national French ESPS survey (Health, health care and insurance survey) collected among a sample of 2080 workers in 2010 and 2014. Ten job stressors, derived from the job strain and effort-reward imbalance models, in 2010 (baseline) and changes in these exposures between 2010 and 2014 were studied. The incidence of three alcohol-related outcomes in 2014 (follow-up) was assessed using the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) among the study sample of workers free of these outcomes at baseline: intermediate/heavy drinking, binge drinking, and alcohol misuse. Robust Poisson regression models were performed to study the exposure-outcome associations before and after adjustment for covariates. Gender-related interactions were tested.</p><p><strong>Results: </strong>Job insecurity at baseline predicted the incidence of binge drinking at follow-up [incidence rate ratio (IRR) = 2.18; 95% confidence interval (CI): 1.33-3.58], and persistent job insecurity in both 2010 and 2014 displayed the strongest association with the incidence of binge drinking (IRR = 2.74; 95% CI: 1.36-5.54). Redundancy plan at baseline was borderline significant as a predictive factor of the incidence of binge drinking. Low freedom at work at baseline predicted the incidence of alcohol misuse among women.</p><p><strong>Conclusions: </strong>Job stressors, particularly those related to employment uncertainty, predicted the incidence of alcohol-related outcomes, especially binge drinking. Job stressors, including persistent exposures, may warrant more attention for preventing alcohol-related outcomes.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}