Alcohol and alcoholism最新文献

{"title":"Changes in US drinking and alcohol use disorders associated with social, health, and economic impacts of COVID-19.","authors":"William C Kerr, Yu Ye, Priscilla Martinez, Katherine J Karriker-Jaffe, Deidre Patterson, Thomas K Greenfield, Nina Mulia","doi":"10.1093/alcalc/agae082","DOIUrl":"10.1093/alcalc/agae082","url":null,"abstract":"<p><strong>Aims: </strong>The COVID-19 pandemic increased alcohol consumption in the USA as a result of widespread individual changes in drinking patterns. Few studies have utilized longitudinal data allowing the prediction of increased or decreased drinking from COVID-19 economic, social, and health impacts.</p><p><strong>Methods: </strong>Data are from 1819 respondents in the 2019-20 National Alcohol Survey and a one-year follow-up in early 2021. Changes in past-year alcohol volume, drinking days, days with 5+ drinks, and Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) alcohol use disorder (AUD) severity were measured as outcomes. Measures of COVID-19 economic, health, and social impacts were assessed for the individual and household. Economic impacts were combined into Self and Household scores. Analyses utilized multinomial logistic regression models to estimate meaningful increases or decreases in outcomes, while generalized estimating equation models estimated overall effects.</p><p><strong>Results: </strong>Increases in alcohol use and AUD severity were larger and more prevalent than decreases, and differences between sociodemographic groups in the prevalence of meaningful increases and decreases were found. Models of meaningful changes found that higher self-economic impact scores predicted increases in 5+ days and AUD severity. Generalized estimating equation models also found that the self-economic impact score predicted increased AUD severity and additionally that being an essential worker was associated with reductions in alcohol volume and 5+ days.</p><p><strong>Conclusions: </strong>Substantial changes in drinking and AUD severity were observed, with increases in these outcomes being more prevalent and larger than decreases. Results highlight the importance of the pandemic's economic impacts in predicting changes in drinking and AUD severity.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11630734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric validation of the Diagnostic Assessment Research Tool: Alcohol use disorder module.","authors":"Molly L Garber, Kyla Belisario, Emily E Levitt, Randi E McCabe, John Kelly, James MacKillop","doi":"10.1093/alcalc/agae088","DOIUrl":"10.1093/alcalc/agae088","url":null,"abstract":"<p><strong>Aims: </strong>Structured clinical interviewing is considered the gold standard in psychiatric diagnosis. The Diagnostic Assessment Research Tool (DART) is a novel modularized, non-copywritten, semi-structured interview; however, no studies have examined the psychometric properties of its alcohol use disorder (AUD) module. The primary aims of this study were to: (i) validate the factor structure of the DART AUD module and (ii) examine measurement invariance across several key demographic and subgroup factors.</p><p><strong>Methods: </strong>Participants were community members in Hamilton, Canada and Boston, USA who self-identified as making a significant AUD recovery attempt (N = 499). Internal reliability was examined via the Kuder-Richardson 20 statistic, and correlations between symptom count and drinking quantity/frequency were examined. Then, symptom-level data were included in a confirmatory factor analysis to examine model fit of a single hypothesized factor structure. Finally, measurement invariance analyses were conducted for sex, age, ethnicity (White vs. racialized), and study site.</p><p><strong>Results: </strong>This study found evidence for adequate internal reliability (rKR20 = 0.75), and symptom scores correlated with drinking quantity and frequency (r = 0.16-0.43). Confirmatory factor analysis results suggested excellent fit for the unidimensional one-factor AUD model (χ2 = 0.09, confirmatory factor index = 0.99, Tucker Lewis index = 0.99, standardized root mean square residual = 0.06, root mean square error of approximation = 0.02). Measurement invariance analyses revealed that the factor structure was equivalent between sex, age, ethnicity, and study site.</p><p><strong>Conclusions: </strong>Findings provide strong evidence for the psychometric validity of the DART AUD module and support its use in research and clinical practice. The DART represents a credible alternative to other diagnostic interviewing tools for AUD.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of alcohol use disorder on cognition in correlation with aging: a community-based retrospective cohort study.","authors":"Hesham Essa, Hossam M Ali, Paul H Min, Dina N Ali, Val Lowe, Ronald C Petersen, David S Knopman, Emily S Lundt, Carly T Mester, Nicholas L Bormann, Doo-Sup Choi","doi":"10.1093/alcalc/agae080","DOIUrl":"10.1093/alcalc/agae080","url":null,"abstract":"<p><strong>Aims: </strong>Excessive alcohol use is associated with an increased risk of cognitive impairment. Since increased amyloid plaque burden exacerbates cognitive decline, we sought to assess the potential impact of alcohol use disorder (AUD) on cognition, memory, and amyloid burden corresponding with age.</p><p><strong>Methods: </strong>We conducted the retrospective analysis with 6036 subjects, including 269 AUD+ subjects. A four-item CAGE (C-Cutting Down, A-Annoyance by Criticism, G-Guilty Feeling, E-Eye-openers) alcohol questionnaire was given during the recruitment to determine AUD in each participant. We assessed cognitive function, focusing on memory using neuropsychological testing. For 1038 participants, including 57 AUD+ subjects, we measured amyloid burden using the 11C Pittsburgh Compound B tracer-based positron emission tomography imaging.</p><p><strong>Results: </strong>AUD+ was significantly associated with lower scores of cognition and memory function relative to AUD- individuals. No significant association was found with AUD and elevated brain amyloid under the age of 65. However, further analysis showed that those aged ≥65 showed greater odds for abnormal amyloid in AUD+ compared to AUD- participants.</p><p><strong>Conclusions: </strong>Our results underscore AUD as a risk factor for cognitive decline and diminished memory, particularly in aging populations. The role of AUD in brain amyloid accumulation requires further study.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-drinking is Associated with Possible Alcohol Dependence in UK Trans and Non-Binary Communities.","authors":"Dean J Connolly, Ivan Ezquerra-Romano, Stewart O'Callaghan, Jacob Bayliss, Beth Thayne, Zhi Holloway, Emma Davies","doi":"10.1093/alcalc/agae084","DOIUrl":"https://doi.org/10.1093/alcalc/agae084","url":null,"abstract":"<p><p>In an analytical sample of 462 UK-based trans and non-binary respondents to a co-produced survey, 23.2% reported drinking with a higher risk of dependence (AUDIT scores ≥16), and 26.2% reported that they mostly drank at home alone. Pre-drinking and drinking mostly at home alone were associated with high-risk drinking and may be appropriate behaviours to address in harm reduction interventions.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing alcohol consumption across phosphatidylethanol levels using HDL-cholesterol as a predictor.","authors":"Alexander Årving, Thor Hilberg, Elisabeth Wiik Vigerust, Benedicte Jørgenrud, Stig Tore Bogstrand, Jørg Mørland, Gudrun Høiseth","doi":"10.1093/alcalc/agae085","DOIUrl":"10.1093/alcalc/agae085","url":null,"abstract":"<p><strong>Aims: </strong>Prior research has established a correlation between increases of High-Density Lipoprotein Cholesterol (HDL-C) levels and alcohol consumption. This study aimed to explore the association between phosphatidylethanol (PEth) levels and the amount of consumed ethanol, utilizing HDL-C as a surrogate marker on a population level. This endeavor offers an adjunct to other studies.</p><p><strong>Methods: </strong>PEth and HDL-C levels in 50 751 samples from 29 899 patients in Norway were measured simultaneously in whole blood and serum, respectively. Linear mixed model analyses were employed to assess HDL-C levels within different PEth intervals. Drawing on previous research indicating an increase of .0035 mmol/L in HDL-C per gram of pure ethanol consumed per day, and assuming no alcohol intake in the zero PEth group, we estimated mean daily ethanol intake at the group level for males in each PEth interval.</p><p><strong>Results: </strong>Results revealed a significant correlation between PEth and HDL-C levels (Spearman's rho = .385 for women, .420 for men, P < .001). Estimated mean HDL-C levels indicated higher alcohol consumption with increasing PEth. Specifically, men with PEth values in the .031-0.100 μmol/L (22-70 ng/ml) interval were estimated to consume approximately mean 20 grams of ethanol daily, while those in the .301-0.500 μmol/L (212-351 ng/ml) PEth interval had an estimated mean daily ethanol intake of 51 grams.</p><p><strong>Conclusions: </strong>The results from this study suggest an approximate estimation of mean daily amounts of consumed ethanol at group levels in different PEth intervals, based on previously shown correlation of ethanol consumption and HDL-C increase.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11642604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of topiramate and naltrexone on neural activity during anticipatory anxiety in individuals with alcohol use disorder.","authors":"Gezelle Dali, Warren Logge, Henry R Kranzler, Tristan Hurzeler, Hugh Gallagher, Paul S Haber, Kirsten C Morley","doi":"10.1093/alcalc/agae078","DOIUrl":"10.1093/alcalc/agae078","url":null,"abstract":"<p><p>Topiramate has been found to be effective in reducing alcohol use and may also attenuate anxiety severity in patients with alcohol use disorder (AUD). This study compared the neural response of treatment-seeking patients with AUD on either topiramate or naltrexone during an anticipatory anxiety task. Participants were 42 patients with AUD who were randomized to receive either topiramate (n = 23; titrated dose up to 200 mg/day) or naltrexone (n = 19; 50 mg/day) for 12-weeks as part of a larger randomized controlled trial. Following 6 weeks of treatment, participants completed an anticipatory anxiety task during a functional magnetic resonance imaging (fMRI) session. The task presented a series of high-threat and low-threat stimuli followed by an unpleasant or pleasant image, respectively. Primary whole-brain analyses revealed no significant differences in neural activation between the topiramate and naltrexone groups. Deactivation for safe cues relative to threat cues was observed within the precuneus, inferior parietal lobule and the cingulate gyrus. In the precentral and middle frontal gyri, threat cues elicited greater activation. Exploratory analyses revealed an effect of change in anxiety from baseline to week 6, with a greater reduction associated with a reduced response to threat cues relative to safe cues in the cuneus and lingual gyrus. The current study is the first to examine and compare neural activation during anticipatory anxiety in treatment-seeking individuals on topiramate and naltrexone. This preliminary research contributes to our understanding of the therapeutic mechanisms of these alcohol pharmacotherapies.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11573881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Method of accessing alcohol and binge drinking status in youth and young adults.","authors":"Jonathan K Noel, Steve Jacob, Samantha K Borden, Kelsey A Gately, Samantha R Rosenthal","doi":"10.1093/alcalc/agae087","DOIUrl":"https://doi.org/10.1093/alcalc/agae087","url":null,"abstract":"<p><strong>Aims: </strong>The study investigated relationships between how youth and young adults access alcohol and their binge drinking behaviors.</p><p><strong>Methods: </strong>Data from the Rhode Island Student Survey (11- to 18-year-olds) and the Mobile Screen Time project (18- to 24-year-old) were included. Participants were asked whether they access alcohol through several different methods (e.g. gifts, purchase, theft), and a latent class analysis was conducted to identify patterns of behavior. Logistic regression models were used to determine if class assignment was associated with binge drinking, after adjusting for age, sexual/gender status, and identification as a Black, Indigenous, and other Person of Color.</p><p><strong>Results: </strong>Among youth, participants who primarily accessed alcohol through friends had 6 times the odds of binge drinking (OR[95%CI] = 6.22 [4.08,9.49]), and those who accessed alcohol through all available sources had 23 times the odds (OR[95%CI] = 23.1 [9.08,58.6]). In young adults, participants who actively purchased alcohol had 3.7 times the odds of binge drinking (OR [95%CI] = 3.69 [1.62,8.37]).</p><p><strong>Conclusions: </strong>Distinct means of accessing alcohol in youth and young adult populations can be identified, and different methods of access may be associated with increased binge drinking. Strong availability and ID checking policies are needed for on- and off-premise locations, and the implementation of parent-centered programs should be considered.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring links-exposure to alcohol adverts on social media in relation to alcohol use among university students in Uganda.","authors":"Edwinah Atusingwize, Maria Nilsson, Annika Egan Sjölander, Nazarius Mbona Tumwesigye, David Musoke, Evelina Landstedt","doi":"10.1093/alcalc/agae081","DOIUrl":"10.1093/alcalc/agae081","url":null,"abstract":"<p><strong>Aim: </strong>This study assessed the association between exposure to alcohol adverts on social media and alcohol use among university students in Uganda since alcohol consumption has severe effects, especially in countries with weak regulations for alcohol marketing.</p><p><strong>Methods: </strong>In total, 996 undergraduate students at Makerere University responded to a questionnaire assessing exposure to alcohol advertising on social media (independent variable) and alcohol use (dependent variable). Adjusted multinomial logistic regression was used to analyse data.</p><p><strong>Results: </strong>One in ten students reported hazardous drinking, while three in ten students were low-risk drinkers. Most students (70.1%) reported low exposure to alcohol adverts on social media, followed by high exposure (12.1%), and 17.8% reported no exposure. A key finding was that exposure to alcohol adverts on social media was significantly associated with alcohol use, especially the high exposure and hazardous drinking (odds ratio = 12.62, 95% confidence interval: 4.43-35.96). Students reporting high exposure to alcohol adverts on social media also had higher odds of low-risk drinking (odds ratio = 3.70, 95% confidence interval: 1.88-7.27) than those with low exposure (odds ratio = 1.77, 95% confidence interval: 1.09-2.87), in reference to no exposure.</p><p><strong>Conclusion: </strong>Among Ugandan university students, exposure to alcohol adverts on social media is common and associated with alcohol use, in a dose-response manner. These findings suggest a need for a design and implementation of alcohol interventions for students using social media.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11630078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of binge alcohol use with functional outcomes among individuals with COVID-19 infection.","authors":"Sebastian T Tong, Michael Gottlieb, Imtiaz Ebna Mannan, Zihan Zheng, Manisha Sinha, Michelle Santangelo, Kristyn Gatling, Efrat Kean, Phillip Watts, Ralph Wang, Juan Carlos Montoy, Ahamed Idris, Samuel MacDonald, Ryan Huebinger, Mandy Hill, Kelli N O'Laughlin, Nicole L Gentile, Jocelyn Dorney, Caitlin Malicki, Joann G Elmore, Kate Diaz Roldan, Gary Chan, Zhenqiu Lin, Robert A Weinstein, Kari A Stephens","doi":"10.1093/alcalc/agae086","DOIUrl":"10.1093/alcalc/agae086","url":null,"abstract":"<p><strong>Aims: </strong>Alcohol consumption along with negative sequelae from excess alcohol intake increased during the COVID-19 pandemic. We evaluated the association between binge alcohol use and long-term functional outcomes among COVID-19-positive individuals.</p><p><strong>Methods: </strong>Using a prospective, longitudinal, multisite cohort study design, we evaluated the association between binge alcohol use and mental and physical functional outcomes using Patient-Reported Outcomes Measurement Information System (PROMIS)-29 scores three and six months postinfection. Eligible patients were those who presented with COVID-19-like symptoms, tested positive for COVID-19, and completed a three-month survey. Binge drinking was identified at the time of infection using the Tobacco, Alcohol, Prescription medication and other Substance use screener. Generalized estimating equation models, adjusted for demographic characteristics, social determinants of health, substance use, comorbidities, and COVID-19 vaccine status, were used to assess the association between binge alcohol use and mental and physical functional outcomes.</p><p><strong>Results: </strong>Of 3529 individuals, 23.7% screened positive for binge drinking. At three months, prior self-reported binge drinking was associated with differences in physical function [estimate: 1.08; 95% confidence interval (CI) 0.44, 1.71], pain interference (estimate: -0.86; 95% CI -1.57, -0.15), and physical health (estimate: 1.09; 95% CI 0.43, 1.75). At six months, no associations were found between binge drinking and outcomes.</p><p><strong>Conclusions: </strong>Binge alcohol use before COVID-19 infection was associated with statistically significant but clinically irrelevant improvements in function at three months, which were not sustained at six months. Postinfectious and postpandemic stressors may have played a larger impact on functional outcomes than binge alcohol use. A higher frequency of binge drinking and its association with functional outcomes, particularly among individuals with COVID-19 warrants further study.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142919067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: IQ in high school as a predictor of midlife alcohol drinking patterns.","authors":"","doi":"10.1093/alcalc/agae079","DOIUrl":"https://doi.org/10.1093/alcalc/agae079","url":null,"abstract":"","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}