Alcohol and alcoholism最新文献

{"title":"A scoping review of Dry January: evidence and future directions.","authors":"Megan Strowger, Matthew K Meisel, Sarah Uriarte, Suzanne M Colby","doi":"10.1093/alcalc/agaf057","DOIUrl":"10.1093/alcalc/agaf057","url":null,"abstract":"<p><p>Dry January is a temporary alcohol abstinence challenge where participants commit to abstaining from drinking alcohol for one month. It has grown in popularity since its inception >10 years ago. The current scoping review sought to broadly characterize the peer-reviewed literature on Dry January, summarize its main findings, strengths and limitations, and delineate future research directions. In total, 90 publications were screened and 16 were reviewed. Findings revealed that compared to drinkers in the general population who did not participate, Dry January participants tended to report having higher incomes, completed university education, reported being female, younger, and engaging in heavy drinking at baseline. Those who consumed light to moderate amounts of alcohol were more likely to report successfully abstaining than heavier drinkers. Among successful abstainers, short- and mid-term sustained reductions in self-reported alcohol use and improved biological outcomes, well-being, and drink refusal self-efficacy were observed. Benefits were also reported among those who did not fully abstain. Most Dry January participants would participate in the program again. Overall, Dry January demonstrates significant promise and warrants more rigorous research. As nearly all extant research derives from the United Kingdom, future research should investigate applications and effects beyond that population.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective effects of oxytocin on alcohol drinking in subpopulations of male and female mice following intermittent predator stress.","authors":"Melinda L Helms, Michelle A Nipper, Deborah A Finn, Andrey E Ryabinin","doi":"10.1093/alcalc/agaf042","DOIUrl":"10.1093/alcalc/agaf042","url":null,"abstract":"<p><strong>Aims: </strong>Excessive alcohol use is often triggered by traumatic experiences, when subjects consume alcohol-containing beverages as a passive coping mechanism to relieve negative affect. There are no FDA-approved medications that are specifically recommended for patients with alcohol use disorder who use alcohol to decrease the consequences of trauma. The current study used a mouse model of predator stress-enhanced drinking to test whether administration of oxytocin (OXT) could selectively target subjects with increased sensitivity to psychological trauma.</p><p><strong>Methods: </strong>Male and female C57BL/6J mice established consumption of 10% ethanol in a 2-bottle choice procedure and then were exposed to predator odor (soiled rat bedding) during four intermittent 30-minute sessions. Mice were designated as Sensitive, increasing ethanol intake, or Resilient, showing no increases in intake, following the predator odor exposures. Effects of OXT (1 mg/kg) on ethanol intake were examined at two and at four hours following treatment using an automated lickometer system.</p><p><strong>Results: </strong>OXT non-selectively decreased ethanol and water intake in male and female mice during the first two hours after administration, suggesting sedative effects. Importantly, when analyzed at four hours post-injection, OXT selectively decreased ethanol, but not water intake, in male mice and in the Sensitive subgroup of female mice and had no significant effects on ethanol intake in the Resilient female mice.</p><p><strong>Conclusions: </strong>These results indicate that the predator odor model can help screen for pharmacotherapies to treat patients consuming alcohol to passively cope with trauma-induced negative affect. Further studies need to test whether OXT is preferentially effective in such subjects.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 5","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreases in serum α-Klotho levels in association with levels of regular alcohol drinking and binge drinking among US adults.","authors":"Dylan Fromm, Jianmin Zhu, Wonjun Billy Kim, Yudan Wei","doi":"10.1093/alcalc/agaf054","DOIUrl":"https://doi.org/10.1093/alcalc/agaf054","url":null,"abstract":"<p><strong>Aims: </strong>Alcohol consumption is associated with numerous detrimental health outcomes and aging-related disorders. This study aims to investigate the impact of alcohol drinking levels and drinking behavior on serum levels of Klotho protein, an anti-aging biomarker for health and longevity, in middle-aged and older adults.</p><p><strong>Methods: </strong>A nationally representative sample of 4225 adults aged 40-79 years from the 2013-2016 National Health and Nutrition Examination Surveys were analyzed using multiple general linear models. Drinking levels were classified as light (consumed ≤ 2 drinks for men and ≤ 1 drink for women in a day), moderate (3-4 for men and 2-3 drinks for women), and heavy drinking (≥ 5 for men and ≥ 4 drinks for women), according to national guidelines.</p><p><strong>Results: </strong>Significantly decreased serum ɑ-Klotho levels were found in all levels of drinking in a dose-dependent manner, with weighted geometric means of 798.80 (P = .0238), 774.75 (P = .0006), 751.83 (P = .0027), and 744.33 pg/ml (P < .0001) in light, moderate, heavy, and former heavy drinkers, respectively, compared to non-drinkers (827.69 pg/ml). After adjusting for covariates, moderate drinking was associated with a 6.53% (P < .0001) decrease, heavy drinking with an 8.97% (P = .0004) decrease, and former heavy drinking with an 7.26% (P < .0001) decrease in ɑ-Klotho levels. Similarly, binge drinking ≥ 4 days in the past month was associated with a 9.17% (P = .0341) decrease in serum ɑ-Klotho.</p><p><strong>Conclusions: </strong>This study demonstrates a significantly inverse relationship between alcohol consumption and serum ɑ-Klotho levels in middle-aged and older adults. Further studies are warranted to elucidate the role of reducing Klotho levels in alcohol-induced health and aging disorders.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol produces sex differences in ataxia but not nonspatial cognition in aged rats compared to younger rats.","authors":"Emily L Kerr, Averi Garscia, Jadyn Hartwig, Sam Stumo, Audrey Crippen, Pravesh Sharma, Douglas B Matthews","doi":"10.1093/alcalc/agaf049","DOIUrl":"https://doi.org/10.1093/alcalc/agaf049","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigated if acute alcohol exposure produces sex differences in aged rats compared to adult and adolescent rats on ataxia and nonspatial cognition.</p><p><strong>Materials and methods: </strong>Sex- and age-related differences were assessed by using aged, young adult, and adolescent Sprague-Dawley rats. For acute alcohol exposure, animals were administered either 1 or 2 g/kg alcohol via intraperitoneal injection before testing. To examine the effects of acute alcohol exposure on balance and motor control and nonspatial learning, animals underwent behavioral testing in the aerial righting reflex (ARR) and Morris water maze (MWM) tests. Blood alcohol levels were determined 60 min following administration of either 1.0 or 2.0 g/kg alcohol.</p><p><strong>Results: </strong>Sex differences were found in the ARR, as aged females were significantly less sensitive to the effect of acute alcohol exposure compared to aged males. Age was also found to significantly affect ARR performance, where aged animals performed worse than younger animals in response to acute alcohol. However, these sex- and age-related differences were not found in the nonspatial MWM test or in blood alcohol concentrations.</p><p><strong>Conclusions: </strong>These results indicate that the sex- and age-dependent effects of acute alcohol exposure are task specific. In conclusion, these findings highlight the importance of studying the effects of acute alcohol on the aged population.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory control in response to alcohol-promoting commercials in individuals with alcohol use disorder.","authors":"Takefumi Ueno, Naho Nakayama, Shou Fukushima, Kazunori Matsuguchi, Kazuhiro Tojiki, Chenyu Qian, Shisei Tei, Hidehiko Takahashi, Junya Fujino","doi":"10.1093/alcalc/agaf056","DOIUrl":"https://doi.org/10.1093/alcalc/agaf056","url":null,"abstract":"<p><p>Alcohol use disorder (AUD) is characterized by impaired inhibitory control, which plays a role in the continued consumption of alcohol and relapse despite harmful consequences. External environmental cues, such as alcohol-related advertisements, can aggravate cravings and influence drinking behavior; however, their impact on cognitive processes, including inhibitory control, remains unclear. This study investigated the effect of alcohol-related digital video commercials on inhibitory control in individuals with AUD. A total of 20 participants with AUD and 20 healthy control (HC) watched alcohol and neutral commercials while performing a cognitive task that measured inhibitory control. Consequently, drinking desire or the interference effects on inhibitory control induced by alcohol commercials showed no significant differences between the two groups. However, when the AUD group was subdivided by severity, the severe AUD subgroup exhibited significantly greater interference from alcohol-related commercials than the HC group. These results suggest that individuals with severe AUD may be particularly susceptible to alcohol-related cues presented in digital video commercials, highlighting that such advertisements potentially exacerbate their condition. Continued research using ecologically valid, real-world stimuli is essential to refine interventions aimed at reducing cue reactivity and improving treatment outcomes for individuals with AUD.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circumstances surrounding alcohol toxicity deaths and prior pharmacotherapy for alcohol use disorder in Ontario, Canada.","authors":"William Wynne, Anita Iacono, Joanna Yang, Bisola Hamzat, Pamela Leece, Gillian Kolla, Rob Boyd, Nikki Bozinoff, Mike Franklyn, Dana Shearer, Ashley Smoke, Fangyun Wu, Paul Newcombe, Tara Gomes","doi":"10.1093/alcalc/agaf055","DOIUrl":"https://doi.org/10.1093/alcalc/agaf055","url":null,"abstract":"<p><strong>Introduction: </strong>Despite a high prevalence of alcohol use disorder (AUD) in Canada, access to medication-based treatment remains poor. Therefore, our aim was to explore patterns of alcohol toxicity deaths in Ontario, Canada, circumstances surrounding death, prior healthcare interactions, and pharmacotherapy for AUD.</p><p><strong>Methods: </strong>We conducted a population-based repeated cross-sectional study of alcohol toxicity deaths occurring between 1 January 2018 and 30 June 2022 in Ontario, Canada. We reported trends in deaths over time and determined demographic characteristics of decedents, circumstances surrounding death, and prior healthcare interactions. Among a subset of the cohort with an AUD diagnosis eligible for public drug benefits, we reported receipt of medications used to treat AUD before death.</p><p><strong>Results: </strong>We identified 1346 alcohol toxicity deaths over the study period, at a median age of 42 years, with 73.8% occurring among men. The majority of alcohol toxicity deaths involved other substances, including opioids (75.2%), benzodiazepines (10.8%), and/or stimulants (45.2%). Half had an AUD (50.4%) and 62.7% had an opioid, benzodiazepine or stimulant use disorder. Among decedents who were public drug beneficiaries with an AUD (N = 361), only 3.6% were actively prescribed first-line AUD pharmacotherapies (naltrexone and/or acamprosate) at time of death.</p><p><strong>Conclusions: </strong>We found that the majority of alcohol toxicity deaths in Ontario involved other non-alcohol substances. We also detected a high prevalence of prior healthcare encounters for substance use disorders (SUDs) and low prevalence of evidence-based AUD pharmacotherapy. This suggests a need for integrated treatment across concurrent SUDs and improved access to pharmacotherapies for AUD across Ontario.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of lifetime excessive alcohol use on behavioural and psychological symptoms of dementia.","authors":"Emytis Tavakoli, Elaina Niciforos, Parmida Amid, Ari B Cuperfain, Amer M Burhan, Sarah Colman, Li Chu, Simon J C Davies, Peter Derkach, Philip Gerretsen, Ariel Graff-Guerrero, Maria Hussain, Zahinoor Ismail, Donna Kim, Linda Krisman, Benoit H Mulsant, Bruce G Pollock, Soham Rej, Aviva Rostas, Tarek K Rajji, Lisa Van Bussel, Sanjeev Kumar, Sarah Elmi","doi":"10.1093/alcalc/agaf048","DOIUrl":"https://doi.org/10.1093/alcalc/agaf048","url":null,"abstract":"<p><strong>Introduction: </strong>Excessive alcohol use (EAU) elevates the risk of dementia through various mechanisms, yet its impact on the behavioural and psychological symptoms of dementia (BPSDs) remains uncertain.</p><p><strong>Methods: </strong>In this exploratory cross-sectional analysis of baseline data from the Standardizing Care for Neuropsychiatric Symptoms and Quality of Life in Dementia (StaN) study (ClinicalTrials.gov/NCT03672201), we included individuals with Alzheimer's disease and related dementias requiring BPSD treatment. We compared demographic characteristics and presentation of BPSDs (using the total and domain scores on the Neuropsychiatric Inventory-Clinician) in those with and without a lifetime history of EAU.</p><p><strong>Results: </strong>Among 193 participants [mean (SD) age: 80.6 (9.7) years, male: 48.4%], those in the EAU group (n = 17) and in the comparator group (n = 176) had severe and comparable cognitive impairment, with a median Functional Assessment Staging Tool for Dementia score of 6e. Participants with EAU were significantly younger than comparators [mean age (SD): 72.9 (7.1) years vs. 81.4 (9.5) years] (t = -3.678, df = 181, P < .001), and were more frequently male (76.5% [13 of 17] vs. 46.6% [82 of 176]; P = .036). In a sensitivity analysis, there were no differences in the Neuropsychiatric Inventory-Clinician total or individual domain scores between those with EAU and a subsample of those without EAU matched for age, sex, and recruitment site.</p><p><strong>Conclusion: </strong>This exploratory study found that among individuals with Alzheimer's disease and related dementias and BPSDs, lifetime history of EAU is more frequent in younger males. Future studies may further examine the impact of EAU in individuals with BPSDs.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testing the influence of nutrient content claims and a health warning label on consumer perceptions of ready-to-drink alcoholic beverages: an online randomized experiment.","authors":"Samantha M Forbes, Lana Vanderlee, Erin Hobin","doi":"10.1093/alcalc/agaf051","DOIUrl":"10.1093/alcalc/agaf051","url":null,"abstract":"<p><strong>Aims: </strong>To investigate the influence of health-oriented nutrient content claims (NCC; e.g. 140 calories) and a health warning label (HWL) depicting cancer risks on consumer product perceptions of ready-to-drink (RTD) alcoholic beverages, including potential differences in subgroups.</p><p><strong>Methods: </strong>An online within-participants experiment was conducted among alcohol consumers ages 18-64 in Canada (n = 4689). Participants viewed the front panel of RTD alcoholic beverage containers according to four label conditions: (1) NCC vs. no label, (2) NCC + HWL vs. no label, (3) HWL vs. no label, (4) no label vs. no label. When viewing each pair, participants were asked to select which product they: (a) are interested in trying, and (b) buy to reduce health risks. Responses were assessed using generalized estimating equation and logistic regression models within the overall sample and subgroups, including gender, age group, education, alcohol use, and body weight intentions.</p><p><strong>Results: </strong>When asked to select the product to try and to reduce health risks, participants were more likely to select the product with NCC, compared to NCC + HWL or HWL. When NCC were present, women were more interested in trying the product and those trying to lose weight had higher odds of perceiving reduced health risks. No other characteristics were associated with label effects.</p><p><strong>Conclusions: </strong>NCC on RTD alcohol products influenced product appeal and risk perceptions among consumers, particularly women and those trying to lose weight. Prohibiting NCC on alcohol packaging could be an effective policy strategy to prevent increased appeal and minimize consumer confusion about alcohol health risks.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary evidence for perceived rapid alcohol tolerance growth as a risk factor for problematic alcohol use.","authors":"Frances L Wang, Brooke S G Molina, Sarah L Pedersen, Deepa A Thomas","doi":"10.1093/alcalc/agaf053","DOIUrl":"https://doi.org/10.1093/alcalc/agaf053","url":null,"abstract":"<p><strong>Background: </strong>Preclinical research with animals suggests that a propensity to more rapidly adapt to the effects of alcohol could be an important neurobiological difference underlying alcohol use disorder (AUD). Research translating this work to humans is scarce. We tested whether adults' self-perceptions of rapidly developing alcohol tolerance following the onset of regular drinking was associated with increased risk of problematic alcohol use (using scores that excluded tolerance items), while controlling for several potentially important confounders.</p><p><strong>Methods: </strong>Adults who reported current heavy drinking completed an online survey (N = 160; M(SD) = 32.24(9.30) years old; 56.3% Black, 43.8% White; 55% Female, 45% Male). Participants reported the extent to which \"my tolerance to alcohol seemed to build up very quickly once I started drinking frequently.\" Initial subjective response was measured as the number of drinks to experience alcohol effects during the first five drinking experiences and acquired tolerance as the difference between current and initial subjective response. Participants reported on alcohol consequences and dependence symptoms using modified DSM-5 criteria (i.e. problematic alcohol use), past year alcohol consumption, and demographic characteristics.</p><p><strong>Results: </strong>Hierarchical linear regression showed that perceived rapid tolerance growth was uniquely associated with problematic alcohol use (excluding tolerance symptoms) after controlling for initial subjective response, acquired tolerance, DSM-5-related tolerance, alcohol consumption, race, sex, and age.</p><p><strong>Conclusions: </strong>Individuals who reported experiencing rapid tolerance growth when they started regularly drinking showed increased risk for problematic alcohol use. Future prospective research on this topic is warranted and could help uncover a novel risk factor for AUD.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in alcohol withdrawal management by medical toxicologists in the acute care setting: an analysis of the Toxicology Investigators Consortium (ToxIC) Core Registry, 2016-2022.","authors":"John D DelBianco, Kira J Galeano, Gillian A Beauchamp, Ryan M Surmaitis, Stephanie E Shara, Alison Sutter, Hope Kincaid, Joseph J Stirparo, Kathryn L Wheel, Alexandra M Amaducci","doi":"10.1093/alcalc/agaf047","DOIUrl":"10.1093/alcalc/agaf047","url":null,"abstract":"<p><strong>Aims: </strong>Alcohol withdrawal syndrome (AWS) requires urgent treatment to prevent morbidity and mortality. In the acute care setting, medical toxicologists play a critical role in AWS management, including the use of gamma-aminobutyric acid agonists and adjunctive medications. We aim to introduce the addiction medicine community to this role by describing clinical presentation and treatment of patients with AWS in the Toxicology Investigators Consortium Core Registry.</p><p><strong>Methods: </strong>Medical toxicologists from participating sites enter demographic, exposure, clinical presentation, and treatment data on all patients they evaluate into the Core Registry. This was a secondary analysis of registry patients evaluated for AWS from 2016 to 2022. Data were coded in a spreadsheet and analyzed using descriptive statistics.</p><p><strong>Results: </strong>We included 1093 cases. Agitation and delirium/toxic psychosis were documented in 373 (34.1%) and 227 (20.8%) patients, respectively. Benzodiazepines were the most common gamma-aminobutyric acid agonist treatment (n = 539, 49.3%). There was an overall decrease in the use of benzodiazepines alone and increases in the use of phenobarbital, ketamine, and dexmedetomidine. Intubation was performed in 115 (10.5%) patients. Naltrexone, used for alcohol use disorder, was given in 88 (8.1%) cases. The absolute number of AWS cases increased during this period.</p><p><strong>Conclusions: </strong>Use of benzodiazepines alone to manage AWS decreased while phenobarbital, ketamine, and dexmedetomidine use increased. Many patients had severe withdrawal manifestations, and some received alcohol use disorder treatment, suggesting that medical toxicologists see more severe cases in the acute care setting and have an opportunity to address the underlying use disorder.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}