Alcohol and alcoholism最新文献

{"title":"In healthy adults with low-level alcohol intake greater age and lifetime alcohol consumption are associated with poorer manual dexterity and higher lifetime consumption is related to worse postural stability.","authors":"Timothy C Durazzo, Nicole D Evangelista, M Windy McNerney, Ansgar J Furst, Maheen M Adamson, Keith Humphreys, Dieter J Meyerhoff","doi":"10.1093/alcalc/agag055","DOIUrl":"10.1093/alcalc/agag055","url":null,"abstract":"<p><strong>Background: </strong>Low-level alcohol consumption at or below current guidelines (≤1 standard drink equivalent/day for females, ≤2 standard drink equivalents/day for males) has been indicated to carry minimal systemic health risks. This study assessed the relationships between alcohol consumption over 1- and 3-years prior to study and over lifetime and measures of manual dexterity and postural stability in healthy adults with low-level alcohol consumption.</p><p><strong>Method: </strong>Healthy, non-smoking adults (n = 83; 21-69 years old) completed measures of dominant and non-dominant hand dexterity, complex motor coordination and motor speed (Lafayette Grooved Peg Board), and static postural stability (Sharpened Romberg Test; eyes open and eyes closed conditions). Alcohol consumption over 1- and 3-years prior to study, and over lifetime, was acquired via the Lifetime Drinking History.</p><p><strong>Results: </strong>The greater multiplicative product of age and total lifetime drinks was related to poorer dexterity, complex motor coordination and motor speed for the dominant hand, and for the summed performance across the dominant and non-dominant hands. Greater lifetime average drinks/month was related to poorer static postural stability, with eyes closed. Males and females showed equivalent performance across dependent measures.</p><p><strong>Conclusions: </strong>Findings indicated higher lifetime alcohol consumption, at a level that has been historically regarded as low risk for adverse functional consequences, was associated with poorer performance on established clinical and research measures of manual dexterity, complex motor coordination and motor speed, and static postural stability. These results may have implications for current alcohol consumption public health guidelines and associated policies.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148583315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking five-factor personality model to alcohol consumption in adolescence: a systematic review and meta-analysis.","authors":"Singal Aakriti, Priscilla Adasi, Ellen Gustafsson, Sofia Therén-Waern, Johan Melander Hagborg, Ann-Sophie Lindqvist Bagge","doi":"10.1093/alcalc/agag048","DOIUrl":"10.1093/alcalc/agag048","url":null,"abstract":"<p><strong>Aims: </strong>This meta-analysis synthesizes empirical research on the association between alcohol consumption, operationalized as both volume and frequency, and Five Factor Model of Personality Traits.</p><p><strong>Methods: </strong>A systematic literature search was conducted on June 18, 2025, in PsycINFO and PubMed. The search strategy employed the following terms: tiab(\"big 5\" OR \"big five\" OR \"5 factor\" OR \"five factor\") AND tiab(alcohol). Studies meeting predefined inclusion criteria were included in both a narrative synthesis and a quantitative meta-analysis.</p><p><strong>Results: </strong>Six studies met the inclusion criteria and were included. The results showed that the FFM trait extraversion demonstrated a small but positive association with alcohol consumption, and the trait conscientiousness showed a stable inverse relationship with alcohol consumption. In contrast, findings for the FFM traits agreeableness, openness to experience, and neuroticism were heterogeneous and did not reveal consistent patterns of association. Overall, the associations between FFM traits and alcohol consumption in adolescence were modest and generally weaker than those reported in adult populations and underscore the importance of adopting a developmental perspective when interpreting the results.</p><p><strong>Conclusion: </strong>This meta-analysis highlights contradictory findings regarding the associations between adolescent alcohol consumption and the FFM of personality traits. While extraversion and conscientiousness appear to be modestly related to alcohol use, evidence concerning agreeableness, openness, and neuroticism remains inconclusive. Accordingly, future research should investigate potential moderating factors, including peer influence and family environment, to further clarify how personality traits interact with contextual influences in the development of alcohol consumption during adolescence.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of fathers' alcohol consumption in Australia.","authors":"Megan Cook, Cassandra Hopkins, Amy Pennay, Liana Leach, Amanda Cooklin, Sarah Callinan","doi":"10.1093/alcalc/agag062","DOIUrl":"https://doi.org/10.1093/alcalc/agag062","url":null,"abstract":"<p><p>This study aims to provide population-based descriptive information about the prevalence of fathers' drinking in Australia and compare their drinking practices to non-fathers. Findings show that fatherhood is not protective when it comes to alcohol consumption, and fathers are more likely to drink at a level that places them at increased risk of short-term harm.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weekend discharge, alcohol relapse, and graft survival post-transplant in alcohol-associated liver disease: cohort study.","authors":"Ayato Obana, Garren Montgomery, Miho Akabane, Tony Boualoy, Dhiaeddine Djabri, Austin D Schenk, Sylvester Black, Kenneth Washburn, Timothy M Pawlik, Khalid Mumtaz","doi":"10.1093/alcalc/agag060","DOIUrl":"https://doi.org/10.1093/alcalc/agag060","url":null,"abstract":"<p><strong>Aim: </strong>To examine the association between weekend discharge and post-transplant alcohol relapse, graft survival, and acute rejection in liver transplant recipients with alcohol-associated liver disease (ALD).</p><p><strong>Methods: </strong>Single-center retrospective cohort study of 362 adult ALD liver transplant recipients (2016-2023). Weekend discharge was compared with weekday discharge. The primary outcome was alcohol relapse, analyzed using competing-risks methods with death as a competing event; secondary outcomes were graft survival and acute cellular rejection (ACR).</p><p><strong>Results: </strong>Sixty one (16.9%) had weekend discharge. Weekend recipients were older (median 59 vs. 53 years; P = .01); other baseline characteristics were comparable. Three-year cumulative relapse incidence was 13.7% vs. 21.1% (P = .36). Weekend discharge was not independently associated with relapse (adjusted HR 0.89, 95% CI 0.46-1.71; P = .72); shorter pre-transplant abstinence was the only independent predictor (adjusted HR 0.99/month; P = .03). Although unadjusted 3-year graft survival was lower in the weekend group (76.6% vs. 89.6%; P = .03), this difference was not retained after adjustment (adjusted HR 1.50, 95% CI 0.80-2.83; P = .21). Unadjusted ACR incidence was comparable across all horizons (P ≥ .25).</p><p><strong>Conclusions: </strong>Among ALD liver transplant recipients managed with standardized discharge education and protocolized relapse surveillance, weekend discharge was not independently associated with alcohol relapse or graft survival after adjustment, and unadjusted ACR incidence did not differ between discharge groups. However, both adjusted estimates remain compatible with clinically meaningful benefit or harm, and these findings therefore represent a failure to detect an association rather than evidence of equivalence. Protocolized discharge care may mitigate the impact of reduced weekend staffing, although discharge timing itself may simply exert little influence on these outcomes. Multicenter studies are needed to assess generalizability.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Drs. Stockley and Hendricks' letter: caution in interpreting alcohol-inflammation associations.","authors":"Jimikaye B Courtney, Kailyn Lowder","doi":"10.1093/alcalc/agag054","DOIUrl":"10.1093/alcalc/agag054","url":null,"abstract":"","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences and expectations of people with alcohol use disorder and their families in general medical settings in Japan: a qualitative study.","authors":"Kazumi Inokuchi, Ayako Kohno, Megumi Yoshigai, Yoko Nishishita, Amy O'Donnell, Yuichi Imanaka","doi":"10.1093/alcalc/agag057","DOIUrl":"https://doi.org/10.1093/alcalc/agag057","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to explore the factors influencing the transition from non-psychiatric medical institutions (NPMIs) (e.g. internal medicine or emergency departments) to specialized treatment from the perspectives of people with alcohol use disorder (AUD) and their families.</p><p><strong>Method: </strong>A qualitative study using semi-structured in-depth interviews with people with AUD and their families who had visited NPMIs. Participants were recruited through purposive sampling from self-help groups. Interviews were audio-recorded, transcribed verbatim, and thematically analyzed.</p><p><strong>Results: </strong>Interviews were conducted from July to October 2024 with 13 people with AUD and eight family members. Four themes were identified: (1) Lack of knowledge and stigma among people with AUD and families affects early AUD support; (2) Situations where interactions with non-specialists do not lead to AUD support; (3) Collaboration between families and healthcare providers helped enable access to specialized treatment; and (4) Expectations for AUD support in NPMIs based on an empathetic approach.</p><p><strong>Conclusions: </strong>To improve the transition of people with AUD from NPMIs to specialized treatment, healthcare providers should recognize the risks of offering inappropriate reassurance or general advice such as 'cut down' or 'have alcohol-free days,' which may reinforce existing harmful behaviours. Providers should understand how people with AUD and their families interpret medical interactions, work to enhance collaboration with families, cultivate a non-stigmatizing approach, and proactively share knowledge about alcohol-related harm and self-help group resources.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A meta-review of the evidence on addiction recovery mutual help organizations.","authors":"Morgan R Klein, Jenny B O'Connor, Samuel Acuff, John F Kelly, Emily A Hennessy","doi":"10.1093/alcalc/agag059","DOIUrl":"10.1093/alcalc/agag059","url":null,"abstract":"<p><strong>Background: </strong>Mutual help organizations (MHOs) for alcohol and substance use disorders are peer-based programs offering recovery-specific social support. A wide-ranging, diverse body of published MHO literature examines their clinical and public health utility. We conducted a meta-review (\"overview of reviews\") to synthesize this evidence and identify trends, limitations, and gaps across existing syntheses.</p><p><strong>Methods: </strong>We searched five electronic databases (August 2023) using tailored search strings to identify reviews of MHOs. We coded review characteristics and quality ratings (A Measurement Tool to Assess Systematic Reviews 2) in duplicate and quantified overlap of primary studies [corrected covered area (CCA)].</p><p><strong>Results: </strong>Twenty-five reviews (one scoping, 15 systematic, and 9 meta-analyses) were included, encompassing 163 111 participants and 645 unique primary studies, with minimal overlap (CCA = 1.76%). Overall methodological quality was mixed. Most reviews focused on 12-step MHOs/12-step facilitation (20; 80%), particularly Alcoholics Anonymous (13; 52%). Few focused on adolescents (2), individuals with co-occurring disorders (3), or Indigenous populations (1). Over half (56%) did not report race/ethnicity; those that did reported ranges from 0% to 81% White (M = 58.4%). Sex/gender was reported in 48% (M = 71.5% male). All meta-analyses examined alcohol and/or other substance use outcomes; some also assessed related outcomes, e.g. social connection, physical/mental health, education/employment, criminal justice involvement, and cost-effectiveness/healthcare utilization.</p><p><strong>Conclusions: </strong>Despite numerous reviews, the synthesis literature is limited in methodological rigor, with a narrow focus on 12-step MHOs. Reporting of outcomes and demographic data is inconsistent, but improves over time. Given variation in individuals' recovery pathways, future syntheses should examine newer, non-12-step MHOs, distinct populations, and outcomes beyond alcohol/substance use behaviors.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The limited predictive value of initial serum ethanol concentration for assessing risk of complicated alcohol withdrawal: a retrospective cohort analysis.","authors":"Michelle Thompson, Katherine Sherman, Andrew N Farkas","doi":"10.1093/alcalc/agag058","DOIUrl":"https://doi.org/10.1093/alcalc/agag058","url":null,"abstract":"<p><strong>Introduction: </strong>Alcohol intoxicated patients frequently present to emergency departments and often require assessment of withdrawal risk. While Predictor of Alcohol Withdrawal Severity Score effectively predicts severe withdrawal outcomes, its reliance on patient history can be a limitation in the emergency department. Initial serum ethanol concentrations in these patients are sometimes used to make disposition decisions despite a lack of evidence to support their association with complicated alcohol withdrawal risk.</p><p><strong>Methods: </strong>A retrospective cohort analysis was performed on 61 279 Veterans Health Administration emergency department visits from 2010 to 2019 which resulted in hospital admission after an initial serum ethanol concentration of >50 mg/dl was measured. Patients who developed withdrawal during their Emergency Department (ED) stay were excluded. Variables included serum ethanol concentration, demographics, and prior withdrawal history. Outcomes were International Classification of Diseases (ICD)-coded alcohol withdrawal and delirium tremens (DTs). Statistical analyses comprised Analysis of Variance (ANOVA), risk ratios, and logistic regression adjusting for prior withdrawal history.</p><p><strong>Results: </strong>Among the cohort, 15% experienced alcohol withdrawal, and 1% developed DTs. While initial serum ethanol levels were higher in those with withdrawal (213 vs 203 mg/dl), the correlation was modest, and weaker than serum aspartate aminotransferase/alanine aminotransferase. Prior withdrawal history was a stronger predictor (Relative Risk [RR] 3.72 for withdrawal; RR 5.52 for DTs). After logistic regression adjusting for prior withdrawal history, serum ethanol concentration ≥400 mg/dl was not a useful predictor of withdrawal or DT risk (Odds Ratio [OR] ~ 1.00).</p><p><strong>Conclusions: </strong>Initial serum ethanol concentration offers a measurable but limited predictive value for complicated alcohol withdrawal risk, and no utility when a reliable prior history is available.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verbal memory performance in alcohol-cocaine versus alcohol use disorder: selective impairment in delayed free recall.","authors":"Diego Remón-Gallo, Lourdes Aguilar, Llanyra García-Ullán, Armando González-Sánchez, Carlos Llanes-Álvarez, Saray Llorente-Diez, Begoña Vicente-Hernández, Jesús Pérez, Carlos Roncero","doi":"10.1093/alcalc/agag042","DOIUrl":"https://doi.org/10.1093/alcalc/agag042","url":null,"abstract":"<p><strong>Aim: </strong>To examine whether individuals with alcohol-cocaine use disorder exhibit selective impairments in self-initiated verbal retrieval compared to individuals with alcohol use disorder alone.</p><p><strong>Methods: </strong>Sixty outpatients meeting Diagnostic and Statistical Manual of Mental Disorders-Five Edition (DSM-5) criteria for Alcohol Use Disorder were classified into alcohol-only (n = 29) and alcohol-cocaine (n = 31) groups using the Structured Clinical Interview for DSM-5. Narrative delayed free recall was assessed in all participants (n = 60), while word-list learning and visual memory measures were available for 51 participants. Group differences were examined using general linear models controlling for age, estimated intellectual quotient, and benzodiazepine use. Urine toxicology screening was conducted prior to each assessment session to ensure recent abstinence from substances.</p><p><strong>Results: </strong>After adjustment, the alcohol-cocaine group demonstrated significantly lower performance in delayed free recall of narrative material compared to the alcohol-only group (P = .010, η2p = .114). A similar but non-significant trend was observed for delayed word-list recall (P = .054). No group differences were found in cued recall, recognition performance, or visual memory measures.</p><p><strong>Conclusions: </strong>Alcohol-cocaine use disorder was associated with reduced efficiency in self-initiated verbal retrieval, while externally supported recall and visual memory remained relatively preserved. These findings suggest a selective impairment in strategic retrieval processes rather than a generalized memory deficit.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual- and area-level inequalities in alcohol-related disorders and emergency hospital admissions in Catalonia.","authors":"Pol Rovira, Irene Lana, Regina Muñoz, Lidia Segura, Joan Colom, Jürgen Rehm, Sergi Trias-Llimós","doi":"10.1093/alcalc/agag039","DOIUrl":"10.1093/alcalc/agag039","url":null,"abstract":"<p><strong>Aims: </strong>This study examines socioeconomic inequalities in alcohol-related emergency room (ER) visits in Catalonia, combining individual and area-level socioeconomic factors and comparing the results with the ones for all ER visits.</p><p><strong>Methods: </strong>This population-based study retrospectively analyzed all 7 043 795 individuals aged 12 and older who received public healthcare in Catalonia in 2022 using sociodemographic, ER visits, and medical diagnoses data. Individuals were classified by individual-based and area-based socioeconomic levels (ISL and ASL, respectively). Binomial models assessed associations between ISL and ER visits, stratifying results by sex, age, and ASL. Alternative models were performed including interactions between both socioeconomic levels.</p><p><strong>Results: </strong>In 2022, 22.2% of individuals visited ERs, of which 0.45% accounted for alcohol-related ER visits. Socioeconomic disparities were evident: individuals in the lowest ISL had an alcohol-related ER visit prevalence six times higher than the highest ISL. This pattern persisted across ASL, with more pronounced effects in wealthier regions. Age and sex influenced trends, with middle-aged males from low ISL groups showing the highest prevalence ratios. Interaction analysis revealed that the combined effect of low individual socioeconomic status and living in disadvantaged areas was smaller than would be expected if the effects were multiplicative.</p><p><strong>Conclusions: </strong>Significant socioeconomic disparities in ER visits exist in Catalonia, with lower socioeconomic groups, especially at the individual level, experiencing higher rates of alcohol-related ER visits. These findings underscore the need to address socioeconomic inequalities in healthcare access, particularly concerning alcohol-related health outcomes, highlighting the need to further research ISL and ASL interactions.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13240592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148175206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}