Alcohol and alcoholism最新文献_第10页

Association of over the counter "hangover remedy" use with alcohol use problems and consumption patterns among young adults. 非处方“宿醉疗法”与年轻人酒精使用问题和消费模式的关系。

IF 2.1 4区医学

Alcohol and alcoholism Pub Date : 2024-01-17 DOI: 10.1093/alcalc/agad081

Dae-Hee Han, Jordan P Davis, Daryl L Davies, John D Clapp, Eric R Pedersen, Adam M Leventhal

引用次数: 0

Alcohol metabolism in alcohol use disorder: a potential therapeutic target. 酒精使用障碍中的酒精代谢:一个潜在的治疗靶点。

IF 2.1 4区医学

Alcohol and alcoholism Pub Date : 2024-01-11 DOI: 10.1093/alcalc/agad077

Taylor Lehner, Bin Gao, Bryan Mackowiak

{"title":"Alcohol metabolism in alcohol use disorder: a potential therapeutic target.","authors":"Taylor Lehner, Bin Gao, Bryan Mackowiak","doi":"10.1093/alcalc/agad077","DOIUrl":"10.1093/alcalc/agad077","url":null,"abstract":"Ethanol metabolism plays an essential role in how the body perceives and experiences alcohol consumption, and evidence suggests that modulation of ethanol metabolism can alter the risk for alcohol use disorder (AUD). In this review, we explore how ethanol metabolism, mainly via alcohol dehydrogenase and aldehyde dehydrogenase 2 (ALDH2), contributes to drinking behaviors by integrating preclinical and clinical findings. We discuss how alcohol dehydrogenase and ALDH2 polymorphisms change the risk for AUD, and whether we can harness that knowledge to design interventions for AUD that alter ethanol metabolism. We detail the use of disulfiram, RNAi strategies, and kudzu/isoflavones to inhibit ALDH2 and increase acetaldehyde, ideally leading to decreases in drinking behavior. In addition, we cover recent preclinical evidence suggesting that strategies other than increasing acetaldehyde-mediated aversion can decrease ethanol consumption, providing other potential metabolism-centric therapeutic targets. However, modulating ethanol metabolism has inherent risks, and we point out some of the key areas in which more data are needed to mitigate these potential adverse effects. Finally, we present our opinions on the future of treating AUD by the modulation of ethanol metabolism.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10783952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89716547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The adolescent and young adult microbiome and its association with substance use: a scoping review. 青少年和年轻人的微生物组及其与物质使用的关系：范围界定综述。

IF 2.1 4区医学

Alcohol and alcoholism Pub Date : 2024-01-11 DOI: 10.1093/alcalc/agad055

Brittney D Browning, Anna E Kirkland, Rejoyce Green, Melinda Engevik, Alexander V Alekseyenko, Lorenzo Leggio, Rachel L Tomko, Lindsay M Squeglia

{"title":"The adolescent and young adult microbiome and its association with substance use: a scoping review.","authors":"Brittney D Browning, Anna E Kirkland, Rejoyce Green, Melinda Engevik, Alexander V Alekseyenko, Lorenzo Leggio, Rachel L Tomko, Lindsay M Squeglia","doi":"10.1093/alcalc/agad055","DOIUrl":"10.1093/alcalc/agad055","url":null,"abstract":"Aims: The microbiome is a critical factor in health throughout human development. The aims of this scoping review are to (i) elucidate the differences between the youth (post-natal day 21-65 for rodents, 2-7 years for non-human primates, and 10-25 years for humans) microbiome with other life stages and (ii) identify youth-specific microbial changes associated with substance use.Methods: Peer-reviewed studies published up to May 2023 were identified in PubMed and SCOPUS and included gut and oral microbiome studies from rodents, non-human primates, and humans (N = 1733). Twenty-six articles were determined eligible based on inclusion criteria (aim 1: n = 19, aim 2: n = 7).Results: The adolescent and young adult oral and gut microbiomes are distinct compared to other life stages, within both non-human and human models. While there is limited research in this area, the microbiome appears to be vulnerable to substance use exposure earlier in life, including substances commonly initiated and escalated during adolescence and young adulthood (i.e. alcohol, cannabis, and tobacco).Conclusions: Studies across the lifespan indicate that adolescence and young adulthood are distinct periods of development, where the microbiome is sensitive to exposures, including substance use. There is a need for more studies focused on the adolescent and young adult microbiome and substance use, as well as focused on the oral microbiome during this developmental period. Understanding the gut and oral microbiome during adolescence and young adulthood may provide insight into the pathophysiology of substance use disorders.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10979412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10144530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discrimination, gender dysphoria, drinking to cope, and alcohol harms in the UK trans and non-binary community. 英国跨性别和非二元群体中的歧视、性别焦虑、饮酒应对以及酒精危害。

IF 2.8 4区医学

Alcohol and alcoholism Pub Date : 2024-01-11 DOI: 10.1093/alcalc/agad060

Emma L Davies, Ivan Ezquerra-Romano, Beth Thayne, Zhi Holloway, Jacob Bayliss, Stewart O'Callaghan, Dean J Connolly

{"title":"Discrimination, gender dysphoria, drinking to cope, and alcohol harms in the UK trans and non-binary community.","authors":"Emma L Davies, Ivan Ezquerra-Romano, Beth Thayne, Zhi Holloway, Jacob Bayliss, Stewart O'Callaghan, Dean J Connolly","doi":"10.1093/alcalc/agad060","DOIUrl":"10.1093/alcalc/agad060","url":null,"abstract":"Transgender (trans) and non-binary people may be at increased risk of alcohol harms, but little is known about motives for drinking in this community. This study explored the relationship between risk of alcohol dependence, experience of alcohol harms, drinking motives, dysphoria, and discrimination within a United Kingdom sample of trans and non-binary people with a lifetime history of alcohol use. A cross-sectional survey was co-produced with community stakeholders and administered to a purposive sample of trans and non-binary people from 1 February until 31 March 2022. A total of 462 respondents were included-159 identified as non-binary and/or genderqueer (identities outside the man/woman binary), 135 solely as women, 63 solely as men, 15 as another gender identity, 90 selected multiple identities. Higher levels of reported discrimination were associated with higher risk of dependence and more reported harms from drinking. Coping motives, enhancement motives, and drinking to manage dysphoria were associated with higher Alcohol Use Disorders Identification Test scores. Social, coping, and enhancement motives alongside discrimination and drinking to have sex were associated with harms. The relationship between discrimination and risk of dependence was mediated by coping motives and drinking to manage dysphoria. Further to these associations, we suggest that reducing discrimination against trans and non-binary communities might reduce alcohol harms in this population. Interventions should target enhancement motives, coping motives and gender dysphoria. Social and enhancement functions of alcohol could be replaced by alcohol free supportive social spaces.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of transdermal alcohol monitoring devices in a laboratory setting. 实验室环境中透皮酒精监测装置的准确性。

IF 2.8 4区医学

Alcohol and alcoholism Pub Date : 2024-01-11 DOI: 10.1093/alcalc/agad068

Eileen Brobbin, Paolo Deluca, Simon Coulton, Colin Drummond

{"title":"Accuracy of transdermal alcohol monitoring devices in a laboratory setting.","authors":"Eileen Brobbin, Paolo Deluca, Simon Coulton, Colin Drummond","doi":"10.1093/alcalc/agad068","DOIUrl":"10.1093/alcalc/agad068","url":null,"abstract":"The development of transdermal alcohol sensors (TASs) presents a new method to monitor alcohol consumption with the ability to objectively measure data 24/7. We aimed to evaluate the accuracy of two TASs (BACtrack Skyn and Smart Start BARE) in a laboratory setting. Thirty-two adults received a dose of ethanol 0.56 g/kg body weight as a 20% solution while wearing the two TASs and provided Breath Alcohol Concentration (BrAC) measurements for 3.5 h postalcohol consumption. Pearson's correlations and repeated measures analysis of variance tests were conducted on the peak, time-to-peak, and area under the curve data. Bland-Altman plots were derived. A time series analysis and cross-correlations were conducted to adjust for time lag. Both TASs were able to detect alcohol and increase within 20 min. BrAC peaked significantly quicker than Skyn and BARE. BrAC and Skyn peaks were negatively significantly correlated (r = -0.381, P = .035, n = 31), while Skyn and BARE peaks were positively significantly correlated (r = 0.380, P = .038, n = 30). Repeated measures analysis of variance found a significant difference between BrAC, Skyn, and BARE (F(1.946, 852.301) = 459.873, P < .001)). A time series analysis found when BrAC-Skyn and BrAC-BARE were adjusted for the delay to peak, and there was still a significant difference. Failure rates: 1.7% (Skyn) and 4.8% (BARE). Some evidence was obtained for TAS validity as both consistently detected alcohol. Failure rates and time lag show improvements in older device generations. However, neither TAS presented strong equivalence to the breathalyser even when the lag time was adjusted. With further testing and technology advancements, TAS could be a potential alcohol monitoring tool. Two of the newest TAS devices were worn in laboratory conditions for one afternoon to compare their accuracy of alcohol monitoring to a breathalyser. Findings suggest that the two TASs (BACtrack Skyn and SmartStart BARE) recorded significantly similar data postalcohol consumption, but not with the breathalyser.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Satisfaction with a digital support tool targeting alcohol consumption: perspectives from participants in a randomized control trial. 对针对饮酒的数字支持工具的满意度：来自随机对照试验参与者的观点。

IF 2.8 4区医学

Alcohol and alcoholism Pub Date : 2024-01-11 DOI: 10.1093/alcalc/agad070

Elizabeth S Collier, Jenny Blomqvist, Marcus Bendtsen

{"title":"Satisfaction with a digital support tool targeting alcohol consumption: perspectives from participants in a randomized control trial.","authors":"Elizabeth S Collier, Jenny Blomqvist, Marcus Bendtsen","doi":"10.1093/alcalc/agad070","DOIUrl":"10.1093/alcalc/agad070","url":null,"abstract":"Aim: Intervention design may be improved through evaluating the feedback from those who have been exposed to such interventions. As such, here the perspectives of the intervention group from a recent randomized control trial investigating the effectiveness of a digital alcohol intervention, in terms of perceived suitability and usefulness of the support tool they engaged with, were investigated.Methods: Respondents (N=475; 45% of the intervention group) answered five quantitative questions addressing user experience, completed the 10-item System Useability Scale, and were offered the opportunity to write free-text feedback. Quantitative measures were analysed using ordinal and linear regression with baseline characteristics as predictors, and free-text responses were evaluated using content analysis.Results: Overall, respondents were positive towards the intervention in terms of it fitting their needs, the usefulness of the tools included, and the usefulness of text message content. The intervention was perceived as more helpful by respondents with lower total weekly alcohol consumption, higher self-reported confidence in their ability to reduce their drinking, and the perceived importance there of, at baseline. The free-text comments revealed the value of reminders as prompts to reflect on one's own drinking behaviour. Nonetheless, criticisms of the intervention were voiced, primarily highlighting the repetitive nature of the reminders and the lack of individuation in advice. Some also feltlike the intervention was impersonal and targeted only a specific drinking pattern.Conclusions: Experiences of the intervention group in this trial were generally positive, though there may be demand for more individualised, targeted intervention design.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10783947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promoting Alcohol Reduction in Non-Treatment Seeking parents (PAReNTS): a pilot feasibility cluster randomized controlled trial of brief alcohol interventions with parents in contact with child safeguarding services. 促进未寻求治疗的父母(父母)减少酒精:与儿童保护服务接触的父母进行短暂酒精干预的试点可行性集群随机对照试验。

IF 2.8 4区医学

Alcohol and alcoholism Pub Date : 2024-01-11 DOI: 10.1093/alcalc/agad076

Ruth McGovern, Deborah Smart, Hayley Alderson, Tony Fouweather, Eileen Kaner

{"title":"Promoting Alcohol Reduction in Non-Treatment Seeking parents (PAReNTS): a pilot feasibility cluster randomized controlled trial of brief alcohol interventions with parents in contact with child safeguarding services.","authors":"Ruth McGovern, Deborah Smart, Hayley Alderson, Tony Fouweather, Eileen Kaner","doi":"10.1093/alcalc/agad076","DOIUrl":"10.1093/alcalc/agad076","url":null,"abstract":"Many parents who come into contact with early help and children's social care services are risky drinkers. This study aimed to investigate the feasibility and acceptability of conducting a trial of brief alcohol interventions within this setting. We conducted a three-arm pilot feasibility cluster randomised controlled trial in the North-East of England. The additive interventions were: i) screening and a healthy lifestyle leaflet (control); ii) brief advice; iii) extended brief intervention. The trial was later reduced to two-arm due to the extended brief intervention being infeasible. Of the 1769 parents that were approached, 429 consented to be screened (24%), the majority were eligible to participate (n = 415; 97%), 147 of which (35%) scored ≥5 on the AUDIT-C screening tool. There were 108 parents (74%) who consented to participate in the trial (n = 50 control; n = 58 brief advice). Follow-up rates at 6 and 12-months were 61% and 43%. The TLFB30 was found to be a suitable tool to measure the primary outcome of heavy episodic drinking. Qualitative data showed that parents and practitioners largely found trial procedures to be acceptable, however, care should be taken when discussing alcohol risk with parents in this setting. Most of the a-priori success criteria were met in this pilot feasibility trial. The findings suggest that it may be feasible to conduct a two-arm randomised controlled trial of brief alcohol interventions to parents in contact with early help and social care. The TLFB30 was found to be a suitable tool to measure the primary outcome of heavy episodic drinking.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10783945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89716620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-beverage alcohol consumption in Russia: new evidence from Jewish Autonomous Oblast. 俄罗斯的非饮料酒消费：犹太自治州的新证据。

IF 2.8 4区医学

Alcohol and alcoholism Pub Date : 2024-01-11 DOI: 10.1093/alcalc/agad087

Andrey Korotayev, Vadim Ustyuzhanin, Yevgeniy Ivanov, Leonid Issaev

{"title":"Non-beverage alcohol consumption in Russia: new evidence from Jewish Autonomous Oblast.","authors":"Andrey Korotayev, Vadim Ustyuzhanin, Yevgeniy Ivanov, Leonid Issaev","doi":"10.1093/alcalc/agad087","DOIUrl":"10.1093/alcalc/agad087","url":null,"abstract":"Introduction: Previous studies in Izhevsk, Novosibirsk, and Kazan have found that non-beverage alcohol is a large part of alcohol consumption in Russia. Whereas those places are relatively high-income cities, there are no studies about such a problem in low-income regions of Russia. The aim of this study is to investigate correlates and factors associated with non-beverage alcohol consumption in eastern regions of Russia, e.g. the Jewish Autonomous Oblast and to assess effectiveness of implementing Russian policies to restrict consumption of non-beverage alcohol.Materials and methods: A survey of adults in the Jewish Autonomous Oblast of Russia was performed on workdays to assess non-beverage drinking patterns in summer 2022. The questionnaire included questions about socio-demographic status and alcohol use, including non-beverage alcohol consumption and drinking patterns. We use logistic regression to identify risk factors of consuming non-beverages.Results: First, ~30% of individuals suffering from alcohol problems drink non-beverage alcohol. Second, those who regularly consume non-beverage alcohol compared with those who chronically drink legal strong alcohol are on average more likely to experience the negative effects of alcohol consumption. Third, income and marriage are the main factors negatively associated with surrogate alcohol consumption. Besides, age shows a curvilinear relationship with that.Conclusions: We suggest that a modified anti-surrogate policy to increase the minimum price of pharmacy alcohol and to enforce restrictions on the sale of non-beverage alcohol is needed in Russia. Such measures could prevent an increase in non-beverage alcohol consumption in Russia against the backdrop of declining real incomes of the population.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"59 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139428261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involuntary social isolation and alcohol consumption: an ecological momentary assessment in Germany amid the COVID-19 pandemic. 非自愿社交隔离和饮酒：新冠肺炎大流行期间德国的生态瞬时评估。

IF 2.8 4区医学

Alcohol and alcoholism Pub Date : 2024-01-11 DOI: 10.1093/alcalc/agad069

Matthias Haucke, Stephan Heinzel, Shuyan Liu

{"title":"Involuntary social isolation and alcohol consumption: an ecological momentary assessment in Germany amid the COVID-19 pandemic.","authors":"Matthias Haucke, Stephan Heinzel, Shuyan Liu","doi":"10.1093/alcalc/agad069","DOIUrl":"10.1093/alcalc/agad069","url":null,"abstract":"Aims: Alcohol consumption often occurs in a social setting, which was affected by social distancing measures amid the coronavirus disease-2019 (COVID-19) pandemic. In this study, we examine how involuntary social isolation (i.e. comparing a no-lockdown stage with a lockdown stage) affects the association between loneliness, social activities, and drinking behavior.Method: We performed an ecological momentary assessment eight times per day for 7 days amid the COVID-19 pandemic in Germany. We recruited 280 participants and assessed their trait loneliness, daily state loneliness, social activities, and drinking behaviors.Results: We found that a lockdown condition moderates the association between trait and daily state loneliness and alcohol consumption. During a lockdown stage, trait loneliness was positively associated, whereas state loneliness was negatively associated with alcohol consumption. During a no-lockdown stage, trait and state loneliness were both negatively associated with alcohol consumption. For both no-lockdown and lockdown stages, duration of social interaction, male gender, and weekends was positively associated with alcohol consumption.Conclusion: Our study suggests that an involuntary social isolation condition (i.e. a lockdown stage) changes how trait loneliness is associated with alcohol consumption.","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Between-hospital care referrals for severe alcohol-related liver disease during the COVID-19 pandemic, 2020 to 2022. 2020年至2022年新冠肺炎大流行期间因严重酒精相关肝病转诊至医院之间。

IF 2.1 4区医学

Alcohol and alcoholism Pub Date : 2024-01-11 DOI: 10.1093/alcalc/agad071

Erik Almazan, Juliette Dixon, Avi Gerstenblith, Sarah Andrews, James Flanary, Andrew M Cameron, Ahmet Gurakar, Po-Hung Chen

引用次数: 0