在酒精使用障碍患者中,促动脉粥样硬化的医疗条件与广泛的区域性脑代谢物异常有关。

IF 2.1 4区 医学 Q3 SUBSTANCE ABUSE
Timothy C Durazzo, Eric P Kraybill, Lauren H Stephens, April C May, Dieter J Meyerhoff
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引用次数: 0

摘要

目的:许多研究都报道了酒精使用障碍(AUD)患者大脑代谢物普遍异常的情况,但没有考虑到高血压、2 型糖尿病、丙型肝炎血清阳性和高脂血症等易导致动脉粥样硬化的疾病对代谢物水平的影响。这些情况与无 AUD 患者的脑代谢物异常有关。我们预测,寻求治疗的 AUD 和致动脉粥样硬化原(Atherogenic+)患者与无致动脉粥样硬化原的 AUD 患者(Atherogenic-)和健康对照组(CON)相比,其神经元活力[N-乙酰天冬氨酸(NAA)]和细胞膜周转/合成[含胆碱化合物(Cho)]的区域代谢物指标较低:方法:动脉粥样硬化+(59 人)、动脉粥样硬化-(51 人)和健康对照组(49 人)完成了 1.5 T 质子磁共振光谱成像研究。比较了各组在皮层灰质(GM)、白质(WM)和部分皮层下区域的 NAA、Cho、总肌酸和肌醇含量:致动脉粥样硬化+者的额叶GM和颞叶WM NAA低于CON。致动脉粥样硬化+患者的顶叶GM、额叶、顶叶和枕叶WM以及皮层核NAA水平低于致动脉粥样硬化-患者和CON患者。与 CON 相比,Atherogenic- 显示出更低的额叶 GM 和 WM NAA 水平。在额叶 GM、顶叶 WM 和丘脑中,"致动脉粥样硬化+"的 Cho 水平低于 "致动脉粥样硬化-"和 "致动脉粥样硬化-"。致动脉粥样硬化+患者的额叶WM和小脑蚓部Cho水平低于致动脉粥样硬化-和致动脉粥样硬化患者:研究结果表明,AUD 患者的致动脉粥样硬化条件与神经元完整性和细胞膜周转/合成受到的损害增加有关。在 "致动脉粥样硬化+"患者中观察到的更大代谢物异常可能与氧化应激相关的神经元和神经胶质细胞结构受损和/或动脉血管活性/管腔活力受损有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pro-atherogenic medical conditions are associated with widespread regional brain metabolite abnormalities in those with alcohol use disorder.

Aims: Widespread brain metabolite abnormalities in those with alcohol use disorder (AUD) were reported in numerous studies, but the effects of the pro-atherogenic conditions of hypertension, type 2 diabetes mellitus, hepatitis C seropositivity, and hyperlipidemia on metabolite levels were not considered. These conditions were associated with brain metabolite abnormalities in those without AUD. We predicted treatment-seeking individuals with AUD and pro-atherogenic conditions (Atherogenic+) demonstrate lower regional metabolite markers of neuronal viability [N-acetylaspartate (NAA)] and cell membrane turnover/synthesis [choline-containing compounds (Cho)], compared with those with AUD without pro-atherogenic conditions (Atherogenic-) and healthy controls (CON).

Methods: Atherogenic+ (n = 59) and Atherogenic- (n = 51) and CON (n = 49) completed a 1.5 T proton magnetic resonance spectroscopic imaging study. Groups were compared on NAA, Cho, total creatine, and myoinositol in cortical gray matter (GM), white matter (WM), and select subcortical regions.

Results: Atherogenic+ had lower frontal GM and temporal WM NAA than CON. Atherogenic+ showed lower parietal GM, frontal, parietal and occipital WM and lenticular nuclei NAA level than Atherogenic- and CON. Atherogenic- showed lower frontal GM and WM NAA than CON. Atherogenic+ had lower Cho level than CON in the frontal GM, parietal WM, and thalamus. Atherogenic+ showed lower frontal WM and cerebellar vermis Cho than Atherogenic- and CON.

Conclusions: Findings suggest proatherogenic conditions in those with AUD were associated with increased compromise of neuronal integrity and cell membrane turnover/synthesis. The greater metabolite abnormalities observed in Atherogenic+ may relate to increased oxidative stress-related compromise of neuronal and glial cell structure and/or impaired arterial vasoreactivity/lumen viability.

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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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