Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake.

IF 2.1 4区 医学 Q3 SUBSTANCE ABUSE
Colleen McGowan, Monika Krah, Nia Fogelman, Dongju Seo, Rajita Sinha
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引用次数: 0

Abstract

Aims: Peripheral cortisol represents one biological measure of the hypothalamic-pituitary-adrenal (HPA) axis, a significant component of the stress system, which is altered by chronic alcohol consumption. However, whether heavy alcohol use affects the HPA axis differentially between the sexes and whether basal cortisol levels are a biomarker of prospective alcohol intake is unknown.

Methods: We recruited light moderate (LM) and binge-heavy (BH) drinkers of alcohol (n = 118). Repeated fasting morning cortisol levels were studied over a 2-hour period to assess basal levels while participants underwent a neuroimaging scan.

Results: Significantly higher average cortisol levels in BH compared to LM groups across four timepoints were observed (P < .018). Overall sex differences were observed with women showing higher initial cortisol levels at the first timepoint with a blunted decrease over the morning relative to men (P < .003). Average morning cortisol differentially predicted prospective future 30-day daily reports of alcohol consumption by sex and group, such that LM males had a positive significant relationship and BH males had a negative non-significant relationship between cortisol and drinking.

Conclusions: Findings indicate that morning plasma cortisol is upregulated in the BH vs. LM group. Although females had higher initial morning cortisol levels, BH males showed a dysregulated negative relationship between stress and binge drinking in contrast to the LM group. Future work should further investigate the role of cortisol and other stress hormones as biomarkers of problematic drinking behaviors in men and women.

与暴饮暴食相关的较高清晨皮质醇水平的性别差异以及与未来酒精摄入量的前瞻性关联。
目的:外周皮质醇是下丘脑-垂体-肾上腺轴(HPA)的一种生物测量指标,HPA轴是应激系统的重要组成部分,长期饮酒会改变HPA轴。然而,大量饮酒是否会对不同性别的 HPA 轴产生不同的影响,以及基础皮质醇水平是否是未来酒精摄入量的生物标志物,目前尚不清楚:我们招募了轻度中度(LM)和暴饮暴食重度(BH)饮酒者(n = 118)。在参加者接受神经影像扫描的同时,对他们在2小时内的早晨空腹皮质醇水平进行了重复研究,以评估基础水平:结果:与 LM 组相比,BH 组在四个时间点上的皮质醇平均水平明显更高(P 结论:研究结果表明,早晨血浆皮质醇水平与 LM 组相比明显更高:研究结果表明,与 LM 组相比,BH 组的晨间血浆皮质醇浓度升高。虽然女性清晨皮质醇水平较高,但与 LM 组相比,BH 组男性在压力和暴饮之间表现出失调的负相关。未来的工作应进一步研究皮质醇和其他应激激素作为问题饮酒行为生物标志物在男性和女性中的作用。
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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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