Triple network resting-state functional connectivity patterns of alcohol heavy drinking.

IF 2.1 4区 医学 Q3 SUBSTANCE ABUSE
Mahmoud Elsayed, Emma Marsden, Tegan Hargreaves, Sabrina K Syan, James MacKillop, Michael Amlung
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Abstract

Aims: Previous neuroimaging research in alcohol use disorder (AUD) has found altered functional connectivity in the brain's salience, default mode, and central executive (CEN) networks (i.e. the triple network model), though their specific associations with AUD severity and heavy drinking remains unclear. This study utilized resting-state fMRI to examine functional connectivity in these networks and measures of alcohol misuse.

Methods: Seventy-six adult heavy drinkers completed a 7-min resting-state functional MRI scan during visual fixation. Linear regression models tested if connectivity in the three target networks was associated with past 12-month AUD symptoms and number of heavy drinking days in the past 30 days. Exploratory analyses examined correlations between connectivity clusters and impulsivity and psychopathology measures.

Results: Functional connectivity within the CEN network (right and left lateral prefrontal cortex [LPFC] seeds co-activating with 13 and 15 clusters, respectively) was significantly associated with AUD symptoms (right LPFC: β = .337, p-FDR = .016; left LPFC: β = .291, p-FDR = .028) but not heavy drinking (p-FDR > .749). Post-hoc tests revealed six clusters co-activating with the CEN network were associated with AUD symptoms-right middle frontal gyrus, right inferior parietal gyrus, left middle temporal gyrus, and left and right cerebellum. Neither the default mode nor the salience network was significantly associated with alcohol variables. Connectivity in the left LPFC was correlated with monetary delay discounting (r = .25, p = .03).

Conclusions: These findings support previous associations between connectivity within the CEN network and AUD severity, providing additional specificity to the relevance of the triple network model to AUD.

重度饮酒的三重网络静息态功能连接模式
目的:以往的酒精使用障碍(AUD)神经影像学研究发现,大脑的显著性、默认模式和中央执行(CEN)网络(即三重网络模型)的功能连接发生了改变,但它们与AUD严重程度和大量饮酒的具体关系仍不清楚。本研究利用静息态 fMRI 检查了这些网络的功能连接性和酒精滥用的测量:76名成年重度饮酒者在视觉固定期间完成了7分钟的静息态功能磁共振成像扫描。线性回归模型检验了三个目标网络的连接性是否与过去 12 个月的 AUD 症状和过去 30 天的大量饮酒天数有关。探索性分析检验了连通性集群与冲动性和精神病理学测量之间的相关性:结果:CEN网络(右侧和左侧前额叶皮层[LPFC]种子分别与13个和15个集群共同激活)内的功能连接与AUD症状显著相关(右侧LPFC:β = .337,p-FDR = .016;左侧LPFC:β = .291,p-FDR = .028),但与大量饮酒无关(p-FDR > .749)。事后检验显示,与 CEN 网络共同激活的六个集群与 AUD 症状相关--右侧额叶中回、右侧顶叶下回、左侧颞叶中回和左右小脑。默认模式和显著性网络均与酒精变量无明显关联。左侧LPFC的连接性与货币延迟折现相关(r = .25, p = .03):这些发现支持了之前 CEN 网络内的连通性与 AUD 严重程度之间的关联,为三重网络模型与 AUD 的相关性提供了更多特异性。
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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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