Alcohol and alcoholism最新文献

{"title":"Trends in economic indicators, alcohol use, and alcohol-attributable health indicators in India.","authors":"Jürgen Rehm, Ahmed S Hassan, Ari Franklin, Jayadeep Patra, Ashley Wettlaufer, Huan Jiang, Kevin D Shield","doi":"10.1093/alcalc/agaf024","DOIUrl":"10.1093/alcalc/agaf024","url":null,"abstract":"<p><strong>Aims: </strong>Economic development leading a country from a low- to middle-income status is usually associated with increases in alcohol consumption and decreases in all-cause mortality, despite increases in alcohol-attributable mortality. We analyzed this tradition for India during the years 2000-19, with attention to alcohol policy.</p><p><strong>Methods: </strong>Joinpoint analysis identified points of trend change and associated slopes for alcohol-attributable mortality and burden (disability-adjusted life years) between 2000 and 2019. Structural equation modeling assessed the relationship among adult alcohol per capita consumption, gross domestic product per capita at purchasing power parity (GDP-PPP per capita), alcohol-attributable mortality, and all-cause mortality, where mortality rates were log-transformed in the models. Pearson correlation was evaluated among study variables. Literature review examined alcohol policies in India.</p><p><strong>Results: </strong>During the first decade between 2000 and 2019, a rapidly and steadily increasing GDP-PPP per capita was associated with marked increases in alcohol consumption and decreases in all-cause mortality, despite increasing alcohol-attributable mortality. After 2010, the economic growth still increased, but the increase in alcohol consumption halted, likely due to strong alcohol control policies in availability restrictions (dry states, dry periods, high legal purchasing age and restrictions in density, and purchasing hours), as well as a high tax share on final price.</p><p><strong>Conclusion: </strong>Alcohol policies seem to have prevented further increases in alcohol consumption and attributable harm and thus should be upheld. Otherwise, increases in these harms will prevent India from fully reaping the health benefits of economic development.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of participant subgroups in a temporary alcohol abstinence challenge: compliance with abstinence and changes in drinking behaviour.","authors":"Nathalie Kools, Andrea D Rozema, Dike van de Mheen, Rob H L M Bovens, Jolanda J P Mathijssen","doi":"10.1093/alcalc/agaf026","DOIUrl":"10.1093/alcalc/agaf026","url":null,"abstract":"<p><strong>Introduction: </strong>Dividing participants of Temporary alcohol Abstinence Challenges (TACs) into subgroups can improve intervention effectiveness by identifying individuals who require extra support. In a previous study, participant subgroups were identified based on determinants of behaviour change, including drinking refusal self-efficacy, craving, and behavioural automaticity. However, the predictive value of these subgroups for TAC success remains unknown. This study examined their predictive value for (i) abstinence during a TAC and (ii) changes in drinking behaviour.</p><p><strong>Methods: </strong>Data were analysed from 1800 Dutch TAC participants who completed baseline and eight-month follow-up questionnaires. Binary logistic regression assessed the effect of subgroup on abstinence. Ordinal and binary logistic regressions within Generalized Estimating Equation models examined subgroup effects on drinking behaviour changes, including drinking frequency, glasses per drinking day, and excessive volumes.</p><p><strong>Results: </strong>TAC subgroups differed in abstinence and in changes in drinking frequency and glasses per drinking day on weekdays. 'Habitual drinkers with perceived control to refuse' and 'drinkers in control' were more likely to abstain during the challenge than 'ordinary drinkers', whereas 'drinkers not in control' were less likely to abstain. 'Drinkers in control' showed smaller reductions in drinking frequency and glasses per drinking day on weekdays compared with 'ordinary drinkers'. No significant differences were found in changes in excessive drinking volumes and glasses per drinking day on weekends.</p><p><strong>Conclusions: </strong>This study demonstrated the predictive value of subgroups for abstinence but found limited predictive value for changes in drinking behaviour after the challenge. Future research could explore personalized support to optimize behaviour change.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality outcomes in alcohol related cognitive impairment in an acute hospital setting.","authors":"Helen White, Lynn Owens, Edward Britton, David Byrne, Omar Elshaarawy, Ian Gilmore, Andrea Jorgensen, Cecil Kullu, Munir Pirmohamed, Christopher Probert, Gillian O'Hare, Paul Richardson","doi":"10.1093/alcalc/agaf033","DOIUrl":"https://doi.org/10.1093/alcalc/agaf033","url":null,"abstract":"<p><strong>Aims: </strong>Alcohol related cognitive impairment (ARCI) impacts an individual's ability to engage in treatment thus may result in poorer outcomes. We aimed to describe outcomes in a legacy cohort of patients with ARCI, identified in an acute hospital setting.</p><p><strong>Method: </strong>We conducted a retrospective review of a cohort of patients who underwent screening for ARCI between 1 April 2017 and 31 March 2018. Those identified with alternative causes of cognitive impairment were excluded. The Montreal Cognitive Assessment Tool (MoCA©) was utilized to determine presence, and severity, of cognitive impairment. These patients were referred to a multi-disciplinary meeting (MDT) and an out-patient clinic. Mortality was recorded at 3 years. Cox-regression analysis was undertaken and, Kaplan Meier (KM) plots were prepared to visualize the data.</p><p><strong>Results: </strong>A total of 210 patients met criteria for ARCI screening. Multi-variate analysis found an association between ARCI and mortality at 3 years, Hazard Ratio (HR) 1.732 (p = .019). Co-existent Chronic Liver disease (CLD) increased this association, HR 1.722 (p = .020) but CLD in isolation did not increase mortality risk, HR 1.223 (p = .401). Severe ARCI had the strongest mortality association (p = <.001). Subsequent engagement with the ARCI care pathway improved outcomes, HR .324; (p = .008).</p><p><strong>Conclusion: </strong>ARCI, identified by a simple, bed-side test is significantly associated with early mortality. This relationship is more marked in the presence of liver disease. The more severe the ARCI, the stronger relationship with death by 3 years. The cohort mean age was 52, a decade younger than the expected age at diagnosis of cognitive impairment in the general population.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"You've got mail: comparing individuals who do and do not provide DNA saliva samples by mail in a study of severe alcohol use disorder.","authors":"Michelle Eglovitch, Alexis Edwards, Kathryn Polak, Steven J Ondersma, Kenneth Kendler, Dace Svikis","doi":"10.1093/alcalc/agaf028","DOIUrl":"10.1093/alcalc/agaf028","url":null,"abstract":"<p><strong>Objective: </strong>Many genetic studies of psychiatric disorders rely on participants to mail in DNA samples. Differences in who returns a sample may affect the generalizability of these studies, but little attention has focused on possible differences between participants who do and do not provide samples. The present study compared participants with severe lifetime alcohol use disorder (AUD) who did and did not return saliva DNA samples.</p><p><strong>Methods: </strong>N = 3927 individuals were recruited through Facebook for a genome-wide association study of severe AUD. Participants completed an online survey and agreed to provide a saliva DNA sample by mail. Survey measures included: demographics, quantity and frequency of recent alcohol and tobacco use, impulsivity, and personality. Participants who returned the saliva kit (n = 2412) were compared to those who did not provide DNA samples (n = 1515) were compared using univariate Chi-square and t-tests.</p><p><strong>Results: </strong>The sample was predominantly White (88.3%) and female (64.0%). DNA providers were more likely than non-providers to report graduate-level education. DNA providers were also less likely to report recent cigarette smoking and scored higher on measures of conscientiousness, perseverance, and premeditation. Using multivariate regression, the most parsimonious model found that being male, a non-smoker, and endorsing perseverance was associated with providing DNA.</p><p><strong>Conclusions: </strong>In an online sample of individuals with severe AUD, participants who did not provide DNA samples showed multiple demographic and psychosocial differences from those who did provide samples. These findings may have implications for generalizability and suggest that further research is needed.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explaining socioeconomic inequalities in alcohol use disorder symptoms: the role of social capital and drinking motives.","authors":"Karen Schelleman-Offermans, Alessandro Sasso, Karlijn Massar, Cátia Pinto Teixeira","doi":"10.1093/alcalc/agaf012","DOIUrl":"10.1093/alcalc/agaf012","url":null,"abstract":"<p><strong>Introduction: </strong>Empirical evidence of the buffering effect of social capital and its underlying psychosocial mechanisms on socio-economic inequalities in alcohol use disorder (AUD) symptoms is limited. As socio-economic disadvantages often go together with deficits in resources and considering social capital's beneficial effects on health, we hypothesized a stronger buffering (at high scores) and a cumulative disadvantaged effect (at low scores) of social capital on AUD symptoms among people reporting higher socio-economic disadvantage compared with their more advantaged counterparts. Additionally, we investigated whether this moderation effect was associated with drinking motives.</p><p><strong>Method: </strong>Three-hundred and sixty-five young adults participated in a cross-sectional online questionnaire measuring all model variables. First, we tested a moderation model, including AUD symptoms (DV), perceived socio-economic disadvantage (IV), and social capital (moderator). Secondly, we tested a moderated mediation model, additionally including drinking motives as mediators of the moderation effect tested in the first model.</p><p><strong>Results: </strong>In the case of high social capital, young adults reporting higher socio-economic disadvantage reported fewer AUD symptoms than their advantaged counterparts, which was associated with their lower endorsement of coping, enhancement, and social motives. When social capital was low, those reporting higher socio-economic disadvantages showed higher AUD symptoms than their advantaged counterparts, which was associated with their higher endorsement of coping motives only.</p><p><strong>Conclusion: </strong>Social capital can buffer (at high levels) or aggravate (at low levels) socio-economic inequalities in AUD symptoms, and drinking for coping, enhancement, and social motives may explain why this happens.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of cytochrome P4502E1 in ethanol mediated diseases: a narrative update.","authors":"Samir Zakhari, Manuela Neuman, Helmut K Seitz","doi":"10.1093/alcalc/agaf014","DOIUrl":"10.1093/alcalc/agaf014","url":null,"abstract":"<p><p>Cytochrome P450 (CYPs) superfamily of enzymes metabolize thousands of endogenous and exogenous substrates including ethanol. Results: Cytochrome P4502E1 (CYP2E1) is involved in ethanol metabolism as part of the so-called microsomal ethanol metabolizing system, in the metabolism of fatty acids and some drugs such as acetaminophen and isoniazid, and in the activation of a variety of procarcinogens (PCs). Chronic ethanol consumption induces CYP2E1 which may result in an enhanced metabolism of these drugs to their toxic intermediates, and in the generation of carcinogens. In addition, ethanol oxidation increases and is associated with the generation of reactive oxygen species (ROS). This oxidative stress is an important driver for the development of alcohol-associated liver disease (AALD) and alcohol-mediated cancer (AMC). ROS may bind directly to proteins and to DNA. ROS may also lead to lipid peroxidation (LPO) with the generation of LPO products. These LPO products may bind to DNA forming etheno-DNA adducts. Cell culture studies as well as animal experiments have shown that CYP2E1 knock-out animals or the inhibition of CYP2E1 by chemicals results in a significant improvement of liver histology. CYP2E1 is also involved in pathogenesis of hepatic steatosis and fibrosis. More recent studies in patients with AALD have demonstrated an improvement of serum transaminase activities when CYP2E1 was inhibited by clomethiazole. In addition to its role in the generation of ROS, CYP2E1 also enhances the activation of PCs and decreases the level of retinol and retinoic acid in the liver. Conclusion: Inhibition of CYP2E1 may improve AALD and may inhibit AMC.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal drinking, stress and use of aggressive parenting over the course of the COVID-19 pandemic.","authors":"Jennifer Price Wolf, Bridget Freisthler","doi":"10.1093/alcalc/agaf020","DOIUrl":"https://doi.org/10.1093/alcalc/agaf020","url":null,"abstract":"<p><strong>Aims: </strong>The COVID-19 pandemic had a demonstrated impact on parenting but little is known about how parental drinking, stress, and use of aggressive discipline (a parenting behavior associated with abusive parenting and negative outcomes for children) have changed over time. We examine rates of alcohol use, stress, and aggressive discipline at three time points during the COVID-19 pandemic and investigate what maternal, child, and time-varying factors predict weekly use of aggressive parenting.</p><p><strong>Methods: </strong>We use longitudinal data from the Central Ohio Family Study (COFLS), including women (n = 234) with a child between the ages of 0-12 and recruited via Facebook, Craigslist.org, and word of mouth. Participants completed an on-line survey for 3 consecutive years beginning in April-May 2020 and 1 and 2 years later. Multilevel logistic regression models were used to examine use of aggressive discipline at the three time points, controlling for time-varying, and maternal and child characteristics.</p><p><strong>Results: </strong>Past week use of aggressive discipline peaked in Wave 1 (35.9%) and decreased at Wave 2 (3.8%) and Wave 3 (28.2%; OR = .463; 95% CI: .369, .580). Parental stress (OR = 1.052; 95% CI: 1.010, 1.096), social isolation (OR = 1.412; 95% CI: 1.197, 1.668), social companionship (OR = 1.113; 95% CI: 1.007, 1.229), and frequency of drinking (OR = 1.049; 95% CI: 1.014, 1.085) were significantly related to higher odds of using aggressive discipline over the three waves.</p><p><strong>Conclusions: </strong>Although rates of aggressive discipline declined, frequency of drinking and stress demonstrated a consistent pattern in relation to aggressive discipline during the COVID-19 pandemic.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of 30-day readmission among those treated with alcohol withdrawal in acute hospitals in England.","authors":"Thomas Phillips, Rachel Coleman, Simon Coulton","doi":"10.1093/alcalc/agaf022","DOIUrl":"https://doi.org/10.1093/alcalc/agaf022","url":null,"abstract":"<p><strong>Aims: </strong>To examine predictors of 30-day readmissions to acute hospitals in England for patients treated for alcohol withdrawal (AW).</p><p><strong>Methods: </strong>Retrospective cross-sectional analysis of routine hospital administrative data (i.e. Hospital Episode Statistics-Admitted Patient Care records) for adults admitted to non-specialist hospitals in England 2017-18.</p><p><strong>Results: </strong>AW admissions were associated with digestive, circulatory, respiratory, and endocrine disorders and were of short duration (median 3 days). Of the 19 588 completed AW admissions examined in 2017-18, 3957 (20.2%) resulted in readmission within 30 days. The strongest predictors of 30-day readmission were being no fixed abode (Adjusted Odds Ratio (AOR) 1.81, 95%CI 1.44-2.26), prior discharge against medical advice (AOR 1.57, 95%CI 1.40-1.77), and greater Charlson comorbidity index total score (AOR 1.02, 95%CI 1.02-1.03).</p><p><strong>Discussion: </strong>AW 30-day admissions are common and associated to complex case presentations that require high levels of community support on discharge. Hospital-based alcohol teams should prioritize strategies, which maximize medically managed AW, effective transitions to specialist community care including outreach teams and strong collaborations with physical and mental health outpatient services. Together with specialist initiatives within community mental health teams, assertive outreach, and homeless services 30-day readmissions may be minimized.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of acute alcohol consumption in a novel rodent model of decision-making.","authors":"Atanu Giri, Cory N Heaton, Serina A Batson, Andrea Y Macias, Neftali F Reyes, Alexis A Salcido, Luis D Davila, Lara I Rakocevic, Dirk W Beck, Raquel J Ibañez Alcalá, Safa B Hossain, Paulina Vara, Sabrina M Drammis, Kenichiro Negishi, Laura E O'Dell, Adrianna E Rosales, Travis M Moschak, Ki A Goosens, Alexander Friedman","doi":"10.1093/alcalc/agaf017","DOIUrl":"10.1093/alcalc/agaf017","url":null,"abstract":"<p><strong>Aims: </strong>We sought to explore how acute alcohol exposure alters decision-making in rats performing an approach-avoid decision-making task. Increasing concentrations of alcohol were mixed with decreasing concentrations of sucrose to mimic mixed/sweetened alcoholic beverages.</p><p><strong>Methods: </strong>Rats were trained on an apparatus in which different concentrations of sucrose were available in four different corners of the arena. During daily sessions, a tone signaled each trial start, followed by illumination (15 lux, blue LEDs) of a single corner port, indicating the potential availability of sucrose at that location. The rat (one rat per arena, both females and males) then chose to approach the lit corner to have the solution dispensed or avoid it, with no solution being dispensed. We examined how the decisions to pursue sucrose rewards shifted with the addition and subsequent removal of ethanol from the sucrose ports.</p><p><strong>Results: </strong>Males were greatly affected by the introduction of alcohol into the task environment, shifting their approach preference to solutions containing higher alcohol concentrations rather than maintaining the prior preference for high-sucrose-concentration solutions. In contrast, females' choice patterns and task performance remained largely unchanged. We also explore a method for identifying changes in decision-making tendencies during and after alcohol consumption within individual subjects.</p><p><strong>Conclusions: </strong>This research explores the introduction of alcohol in varying concentrations with sucrose solutions during an approach-avoid task, with male decision-making and behavioral patterns significantly impacted. We also explore a novel approach for identifying individual adaptations of decision-making behavior when alcohol becomes available, which could be expanded upon in future research.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol misuse and health-related behaviors among people with HIV during the COVID-19 stay-at-home directive: an ALIVE-Ex sub-study.","authors":"Tekeda F Ferguson, Danielle E Levitt, Liz Simon, Patricia E Molina, Stefany D Primeaux","doi":"10.1093/alcalc/agaf019","DOIUrl":"10.1093/alcalc/agaf019","url":null,"abstract":"<p><strong>Aims: </strong>Alcohol misuse may adversely impact health-promoting behaviors. Our objective was to evaluate health-related behaviors in people with HIV with alcohol misuse during the early phase of the COVID-19 pandemic, aiming to understand how alcohol misuse influences these behaviors during health-related emergencies.</p><p><strong>Methods: </strong>Eighty people with HIV (64% male, 51 ± 11 years of age), enrolled in the ALIVE-Ex Study (NCT03299205), consented to a cross-sectional phone survey during the Louisiana stay-at-home order. Alcohol use, dietary intake, physical activity (PA), and emotional well-being over the previous week were assessed. Based on their pre-pandemic Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) score, participants were categorized into having alcohol misuse (AUDIT-C ≥ 3 female (F)/4 male (M)) or having no/low use (AUDIT-C < 3F/4M). Descriptive statistics, Spearman correlations, and crude and adjusted logistic regression models were estimated.</p><p><strong>Results: </strong>Participants with alcohol misuse reported more alcohol use, more frequent meat and salty snack intake, and higher frequency of feeling tense and panicked over the previous week than people with HIV having no/low use (P < .05). Higher alcohol use was associated with more meat and salty snack intake, more frequent vigorous PA, higher PA level, and more emotional distress (P < .05).</p><p><strong>Conclusions: </strong>Overall, participants having alcohol misuse and those reporting higher alcohol use during the stay-at-home order reported less healthy dietary patterns and more emotional distress, while engaging in more PA, compared to participants with lower alcohol use. These data suggest that during health-related emergencies, consideration of patients' prior and current alcohol use is necessary when encouraging healthy behavioral patterns.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}