Alcohol and alcoholism最新文献

{"title":"Pre-drinking is Associated with Possible Alcohol Dependence in UK Trans and Non-Binary Communities.","authors":"Dean J Connolly, Ivan Ezquerra-Romano, Stewart O'Callaghan, Jacob Bayliss, Beth Thayne, Zhi Holloway, Emma Davies","doi":"10.1093/alcalc/agae084","DOIUrl":"https://doi.org/10.1093/alcalc/agae084","url":null,"abstract":"<p><p>In an analytical sample of 462 UK-based trans and non-binary respondents to a co-produced survey, 23.2% reported drinking with a higher risk of dependence (AUDIT scores ≥16), and 26.2% reported that they mostly drank at home alone. Pre-drinking and drinking mostly at home alone were associated with high-risk drinking and may be appropriate behaviours to address in harm reduction interventions.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring links-exposure to alcohol adverts on social media in relation to alcohol use among university students in Uganda.","authors":"Edwinah Atusingwize, Maria Nilsson, Annika Egan Sjölander, Nazarius Mbona Tumwesigye, David Musoke, Evelina Landstedt","doi":"10.1093/alcalc/agae081","DOIUrl":"10.1093/alcalc/agae081","url":null,"abstract":"<p><strong>Aim: </strong>This study assessed the association between exposure to alcohol adverts on social media and alcohol use among university students in Uganda since alcohol consumption has severe effects, especially in countries with weak regulations for alcohol marketing.</p><p><strong>Methods: </strong>In total, 996 undergraduate students at Makerere University responded to a questionnaire assessing exposure to alcohol advertising on social media (independent variable) and alcohol use (dependent variable). Adjusted multinomial logistic regression was used to analyse data.</p><p><strong>Results: </strong>One in ten students reported hazardous drinking, while three in ten students were low-risk drinkers. Most students (70.1%) reported low exposure to alcohol adverts on social media, followed by high exposure (12.1%), and 17.8% reported no exposure. A key finding was that exposure to alcohol adverts on social media was significantly associated with alcohol use, especially the high exposure and hazardous drinking (odds ratio = 12.62, 95% confidence interval: 4.43-35.96). Students reporting high exposure to alcohol adverts on social media also had higher odds of low-risk drinking (odds ratio = 3.70, 95% confidence interval: 1.88-7.27) than those with low exposure (odds ratio = 1.77, 95% confidence interval: 1.09-2.87), in reference to no exposure.</p><p><strong>Conclusion: </strong>Among Ugandan university students, exposure to alcohol adverts on social media is common and associated with alcohol use, in a dose-response manner. These findings suggest a need for a design and implementation of alcohol interventions for students using social media.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11630078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Method of accessing alcohol and binge drinking status in youth and young adults.","authors":"Jonathan K Noel, Steve Jacob, Samantha K Borden, Kelsey A Gately, Samantha R Rosenthal","doi":"10.1093/alcalc/agae087","DOIUrl":"https://doi.org/10.1093/alcalc/agae087","url":null,"abstract":"<p><strong>Aims: </strong>The study investigated relationships between how youth and young adults access alcohol and their binge drinking behaviors.</p><p><strong>Methods: </strong>Data from the Rhode Island Student Survey (11- to 18-year-olds) and the Mobile Screen Time project (18- to 24-year-old) were included. Participants were asked whether they access alcohol through several different methods (e.g. gifts, purchase, theft), and a latent class analysis was conducted to identify patterns of behavior. Logistic regression models were used to determine if class assignment was associated with binge drinking, after adjusting for age, sexual/gender status, and identification as a Black, Indigenous, and other Person of Color.</p><p><strong>Results: </strong>Among youth, participants who primarily accessed alcohol through friends had 6 times the odds of binge drinking (OR[95%CI] = 6.22 [4.08,9.49]), and those who accessed alcohol through all available sources had 23 times the odds (OR[95%CI] = 23.1 [9.08,58.6]). In young adults, participants who actively purchased alcohol had 3.7 times the odds of binge drinking (OR [95%CI] = 3.69 [1.62,8.37]).</p><p><strong>Conclusions: </strong>Distinct means of accessing alcohol in youth and young adult populations can be identified, and different methods of access may be associated with increased binge drinking. Strong availability and ID checking policies are needed for on- and off-premise locations, and the implementation of parent-centered programs should be considered.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing alcohol consumption across phosphatidylethanol levels using HDL-cholesterol as a predictor.","authors":"Alexander Årving, Thor Hilberg, Elisabeth Wiik Vigerust, Benedicte Jørgenrud, Stig Tore Bogstrand, Jørg Mørland, Gudrun Høiseth","doi":"10.1093/alcalc/agae085","DOIUrl":"10.1093/alcalc/agae085","url":null,"abstract":"<p><strong>Aims: </strong>Prior research has established a correlation between increases of High-Density Lipoprotein Cholesterol (HDL-C) levels and alcohol consumption. This study aimed to explore the association between phosphatidylethanol (PEth) levels and the amount of consumed ethanol, utilizing HDL-C as a surrogate marker on a population level. This endeavor offers an adjunct to other studies.</p><p><strong>Methods: </strong>PEth and HDL-C levels in 50 751 samples from 29 899 patients in Norway were measured simultaneously in whole blood and serum, respectively. Linear mixed model analyses were employed to assess HDL-C levels within different PEth intervals. Drawing on previous research indicating an increase of .0035 mmol/L in HDL-C per gram of pure ethanol consumed per day, and assuming no alcohol intake in the zero PEth group, we estimated mean daily ethanol intake at the group level for males in each PEth interval.</p><p><strong>Results: </strong>Results revealed a significant correlation between PEth and HDL-C levels (Spearman's rho = .385 for women, .420 for men, P < .001). Estimated mean HDL-C levels indicated higher alcohol consumption with increasing PEth. Specifically, men with PEth values in the .031-0.100 μmol/L (22-70 ng/ml) interval were estimated to consume approximately mean 20 grams of ethanol daily, while those in the .301-0.500 μmol/L (212-351 ng/ml) PEth interval had an estimated mean daily ethanol intake of 51 grams.</p><p><strong>Conclusions: </strong>The results from this study suggest an approximate estimation of mean daily amounts of consumed ethanol at group levels in different PEth intervals, based on previously shown correlation of ethanol consumption and HDL-C increase.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11642604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of topiramate and naltrexone on neural activity during anticipatory anxiety in individuals with alcohol use disorder.","authors":"Gezelle Dali, Warren Logge, Henry R Kranzler, Tristan Hurzeler, Hugh Gallagher, Paul S Haber, Kirsten C Morley","doi":"10.1093/alcalc/agae078","DOIUrl":"10.1093/alcalc/agae078","url":null,"abstract":"<p><p>Topiramate has been found to be effective in reducing alcohol use and may also attenuate anxiety severity in patients with alcohol use disorder (AUD). This study compared the neural response of treatment-seeking patients with AUD on either topiramate or naltrexone during an anticipatory anxiety task. Participants were 42 patients with AUD who were randomized to receive either topiramate (n = 23; titrated dose up to 200 mg/day) or naltrexone (n = 19; 50 mg/day) for 12-weeks as part of a larger randomized controlled trial. Following 6 weeks of treatment, participants completed an anticipatory anxiety task during a functional magnetic resonance imaging (fMRI) session. The task presented a series of high-threat and low-threat stimuli followed by an unpleasant or pleasant image, respectively. Primary whole-brain analyses revealed no significant differences in neural activation between the topiramate and naltrexone groups. Deactivation for safe cues relative to threat cues was observed within the precuneus, inferior parietal lobule and the cingulate gyrus. In the precentral and middle frontal gyri, threat cues elicited greater activation. Exploratory analyses revealed an effect of change in anxiety from baseline to week 6, with a greater reduction associated with a reduced response to threat cues relative to safe cues in the cuneus and lingual gyrus. The current study is the first to examine and compare neural activation during anticipatory anxiety in treatment-seeking individuals on topiramate and naltrexone. This preliminary research contributes to our understanding of the therapeutic mechanisms of these alcohol pharmacotherapies.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11573881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of binge alcohol use with functional outcomes among individuals with COVID-19 infection.","authors":"Sebastian T Tong, Michael Gottlieb, Imtiaz Ebna Mannan, Zihan Zheng, Manisha Sinha, Michelle Santangelo, Kristyn Gatling, Efrat Kean, Phillip Watts, Ralph Wang, Juan Carlos Montoy, Ahamed Idris, Samuel MacDonald, Ryan Huebinger, Mandy Hill, Kelli N O'Laughlin, Nicole L Gentile, Jocelyn Dorney, Caitlin Malicki, Joann G Elmore, Kate Diaz Roldan, Gary Chan, Zhenqiu Lin, Robert A Weinstein, Kari A Stephens","doi":"10.1093/alcalc/agae086","DOIUrl":"10.1093/alcalc/agae086","url":null,"abstract":"<p><strong>Aims: </strong>Alcohol consumption along with negative sequelae from excess alcohol intake increased during the COVID-19 pandemic. We evaluated the association between binge alcohol use and long-term functional outcomes among COVID-19-positive individuals.</p><p><strong>Methods: </strong>Using a prospective, longitudinal, multisite cohort study design, we evaluated the association between binge alcohol use and mental and physical functional outcomes using Patient-Reported Outcomes Measurement Information System (PROMIS)-29 scores three and six months postinfection. Eligible patients were those who presented with COVID-19-like symptoms, tested positive for COVID-19, and completed a three-month survey. Binge drinking was identified at the time of infection using the Tobacco, Alcohol, Prescription medication and other Substance use screener. Generalized estimating equation models, adjusted for demographic characteristics, social determinants of health, substance use, comorbidities, and COVID-19 vaccine status, were used to assess the association between binge alcohol use and mental and physical functional outcomes.</p><p><strong>Results: </strong>Of 3529 individuals, 23.7% screened positive for binge drinking. At three months, prior self-reported binge drinking was associated with differences in physical function [estimate: 1.08; 95% confidence interval (CI) 0.44, 1.71], pain interference (estimate: -0.86; 95% CI -1.57, -0.15), and physical health (estimate: 1.09; 95% CI 0.43, 1.75). At six months, no associations were found between binge drinking and outcomes.</p><p><strong>Conclusions: </strong>Binge alcohol use before COVID-19 infection was associated with statistically significant but clinically irrelevant improvements in function at three months, which were not sustained at six months. Postinfectious and postpandemic stressors may have played a larger impact on functional outcomes than binge alcohol use. A higher frequency of binge drinking and its association with functional outcomes, particularly among individuals with COVID-19 warrants further study.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142919067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: IQ in high school as a predictor of midlife alcohol drinking patterns.","authors":"","doi":"10.1093/alcalc/agae079","DOIUrl":"https://doi.org/10.1093/alcalc/agae079","url":null,"abstract":"","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of previous detoxifications on intelligence, speed, attention, and executive functioning in patients with moderate to severe alcohol use disorder.","authors":"Jeroen Staudt, Hein De Haan, Serge Walvoort, Yvonne Rensen, Jos Egger, Boukje Dijkstra","doi":"10.1093/alcalc/agae083","DOIUrl":"https://doi.org/10.1093/alcalc/agae083","url":null,"abstract":"<p><strong>Introduction and aims: </strong>Repeatedly undergoing supervised, medical, detoxification from chronic alcohol use may contribute to impairments in neurocognitive functioning of patients with an alcohol use disorder (AUD). Unsupervised, non-medical, detoxification, however, may also contribute to neurocognitive impairments, given the absence of first choice prescription medication to counteract severe withdrawal effects. So far, findings from previous studies are inconclusive and specifically effects of non-medical detoxifications are not investigated yet. Using an association modeling approach, this study investigates whether intelligence, speed, attention, and executive functioning are influenced by previous medical and/or non-medical detoxifications.</p><p><strong>Methods: </strong>A total of 106 participants with AUD underwent a clinical medical supervised detoxification. Basic characteristics of the patient were recorded including the number of previous medical and non-medical detoxifications. Neuropsychological assessment was conducted after 6 weeks of abstinence.</p><p><strong>Results: </strong>The amount of previous medical detoxifications (F (1, 87) = 4.108, P = .046) and the group of medical detoxifications (F(1, 87) = 4734, P = .032), predicted performance on one out of 14 dependent variables, i.e. the \"d2 Number of Signs\" task. Though \"Age of onset of daily alcohol use\" contributed significantly to this relationship, the change of the regression coefficient of the model was ˂10%. The number of non-medical or total amount of previous detoxifications did not predict any of the dependent variables.</p><p><strong>Conclusion: </strong>The results indicate limited evidence of a linear association between either medical, non-medical, or total amount of previous detoxifications and measures of intelligence, speed, attention, or executive functioning, while controlling for relevant confounders.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"60 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drinking motives link positive and negative life events to problematic alcohol use during the COVID-19 pandemic: a longitudinal study.","authors":"Daniel W Geda, Bethany L Stangl, Avery Arsenault, Matthew F Thompson, Melanie L Schwandt, David Goldman, Vijay A Ramchandani, Nancy Diazgranados, Jeremy W Luk","doi":"10.1093/alcalc/agae068","DOIUrl":"https://doi.org/10.1093/alcalc/agae068","url":null,"abstract":"<p><strong>Purpose: </strong>Stressful life events are associated with problematic drinking, and alcohol misuse has been exacerbated during the coronavirus disease 2019 (COVID-19) pandemic. While coping motives may account for this association, positive life events (PLEs) and enhancement motives are understudied. To address these gaps, we examined the associations of history of alcohol use disorder (AUD), negative life events (NLEs), and PLEs with problematic alcohol use and tested coping and enhancement motives as mediators.</p><p><strong>Methods: </strong>The sample included baseline and follow-up data from 241 participants enrolled in the National Institute on Alcohol Abuse and Alcoholism COVID-19 Pandemic Impact on Alcohol Study. Endorsements of past year PLEs and NLEs and their associations with problematic alcohol use were examined. Among the 202 current drinkers, path analyses tested mediational pathways via coping and enhancement motives.</p><p><strong>Results: </strong>The top two PLEs were change in work conditions (21.6%) and taking a vacation (20.3%). The top two NLEs were change in social activities (36.5%) and major change in recreation (26.6%). Individuals with a history of AUD and those who experienced more NLEs reported higher coping and enhancement motives, which were associated with higher problematic alcohol use. Individuals who experienced more PLEs reported lower coping motives, which was associated with lower problematic alcohol use.</p><p><strong>Conclusions: </strong>Besides coping motives, enhancement motives were also associated with pandemic problematic alcohol use. Alcohol interventions targeting reward- and relief-driven drinking patterns may be beneficial to individuals with a history of AUD and those who experienced more NLEs. More research is needed to study PLEs which may help inform the development of strength-based alcohol interventions.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"59 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hazardous alcohol consumption across different industries in Sweden: a pooled cross-sectional study.","authors":"Emelie Thern, Katrina J Blindow, Erica Jonsson, Emma Brulin, Jonas Landberg, Theo Bodin, Devy L Elling","doi":"10.1093/alcalc/agae077","DOIUrl":"10.1093/alcalc/agae077","url":null,"abstract":"<p><strong>Aim: </strong>The current study aims to (i) examine differences in hazardous alcohol consumption across different industries in Sweden and (ii) assess to what degree any such difference can be attributed to a differential distribution of nicotine use, health, and work environments among individuals working in these industries.</p><p><strong>Methods: </strong>A pooled cross-sectional study was conducted including all participants of the survey of Health, Work Environment, and Lifestyle Habits between 2012 and 2023 (n = 54 378), collected by an occupational health service company (Feelgood). The survey contained self-reported information on alcohol use, industry, nicotine use, health, and work environment. Crude and adjusted odds ratios with 95% confidence intervals were obtained by pooled logistic regression analyses.</p><p><strong>Results: </strong>Hazardous alcohol use was highly prevalent in the current study population (37%), especially among individuals in the accommodation/food service, arts/entertainment/recreation, and the construction industry. Compared to individuals working in education, individuals in these industries had >1.6-fold increased odds of reporting hazardous alcohol consumption. Differences in nicotine use and physical work environment between the industries explained some of the differences in hazardous alcohol consumption between industries, while differences in health and psychosocial work environment had limited effects on the estimates.</p><p><strong>Conclusion: </strong>We identified several industries in the Swedish workforce where hazardous alcohol use is highly prevalent. While differences in nicotine use, health, and work environment explained a part of these risk differences, most of the risk differences remained.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"59 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}