Alcohol and alcoholism最新文献

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Drinking contexts, coping motive, simultaneous cannabis use, and high-intensity drinking among adults in the United States. 美国成年人的饮酒环境、应对动机、同时吸食大麻和高强度饮酒。
IF 2.8 4区 医学
Alcohol and alcoholism Pub Date : 2024-05-14 DOI: 10.1093/alcalc/agae038
Won Kim Cook, Camillia K Lui, Thomas K Greenfield, Meenakshi Subbaraman, Libo Li, William C Kerr
{"title":"Drinking contexts, coping motive, simultaneous cannabis use, and high-intensity drinking among adults in the United States.","authors":"Won Kim Cook, Camillia K Lui, Thomas K Greenfield, Meenakshi Subbaraman, Libo Li, William C Kerr","doi":"10.1093/alcalc/agae038","DOIUrl":"https://doi.org/10.1093/alcalc/agae038","url":null,"abstract":"<p><strong>Aims: </strong>High-intensity drinking (HID), extreme drinking considerably above the level of heavy episodic drinking (HED), is associated with long-term health and social consequences. There is limited understanding of HID beyond young adulthood. This study aims to identify concurrent risk factors for HID, comparing age differences among all adults.</p><p><strong>Methods: </strong>Multinomial logistic and linear regression modeling was performed using a nationally-representative sample of adults (analytic n = 7956) from the 2015 and 2020 National Alcohol Surveys. The outcomes were any HID of 8-11 drinks and 12+ drinks for men, and 8+ drinks for women, and corresponding frequencies. Concurrent risk factors included coping motive, sensation seeking, simultaneous use of alcohol and cannabis (SAC), and drinking at a bar or party. Analyses were stratified by age (18-29 vs. older) and sex.</p><p><strong>Results: </strong>For younger men, sensation-seeking was significantly associated with HID (vs. no HED) at both levels and frequency of HID 8-11 drinks, while drinking to cope was only significant for 12+ drinks. For older men, drinking to cope was a consistent predictor for both HID level and its frequency, but sensation-seeking was not significant. Both coping and sensation-seeking were significantly associated with any HID for all women, while coping was significant for HID frequency for younger women. Frequent drinking at bars and parties were associated with greater odds of HID for all adults. With HED as referent, similar patterns of (though fewer significant) associations were observed.</p><p><strong>Conclusions: </strong>Younger and older adults share similar risk factors for HID, with coping more consistent for older men.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141293005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rapid literature review of the effect of alcohol marketing on people with, or at increased risk of, an alcohol problem. 关于酒类营销对酗酒者或酗酒风险增加者的影响的快速文献综述。
IF 2.1 4区 医学
Alcohol and alcoholism Pub Date : 2024-05-14 DOI: 10.1093/alcalc/agae045
Rachael L Murray, Jo Leonardi-Bee, Alexander Barker, Olivia Brown, Tessa Langley
{"title":"A rapid literature review of the effect of alcohol marketing on people with, or at increased risk of, an alcohol problem.","authors":"Rachael L Murray, Jo Leonardi-Bee, Alexander Barker, Olivia Brown, Tessa Langley","doi":"10.1093/alcalc/agae045","DOIUrl":"10.1093/alcalc/agae045","url":null,"abstract":"<p><strong>Aims: </strong>To explore the effect or potential effect of alcohol marketing in people with an alcohol use disorder, in recovery from an alcohol use disorder, and hazardous and harmful drinkers.</p><p><strong>Methods: </strong>Relevant literature was identified by searching Medline (OVID), EMBASE (OVID), and PsycINFO (OVID) and relevant websites. Both quantitative and qualitative studies were eligible for inclusion. A narrative approach was used to synthesize the findings.</p><p><strong>Results: </strong>The review included 10 studies. Two quantitative and three qualitative studies focused on participants recovering from an alcohol use disorder and five quantitative studies on those with hazardous or harmful consumption levels of alcohol. The effect of alcohol advertising on alcohol use was only assessed in one study, a small experimental study of young adult heavy drinkers, which found no significant association. Studies looking at other outcomes found that people with or at risk of alcohol problems were likely to notice alcohol advertisements and find them appealing, and that advertisements may have an effect on positive alcohol-related emotions and cognitions. Among people in recovery from an alcohol use disorder, findings suggested that there could be an effect on craving, and that alcohol marketing may be perceived to trigger a desire to drink.</p><p><strong>Conclusions: </strong>Alcohol marketing is likely to have an effect on alcohol consumption in people with, or at increased risk of, an alcohol problem. Studies have also found that alcohol marketing is perceived to act as a trigger by people in recovery from alcohol problems.</p><p><strong>Summary: </strong>A rapid review explored the effect of alcohol marketing in people with an alcohol use disorder, in recovery from an alcohol use disorder, and hazardous and harmful drinkers. The findings of the 10 included studies suggest that an effect of alcohol marketing in these populations is likely.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Profiles and the impact of affective temperaments on alcohol use disorder: a cross-sectional study. 更正为:情感气质的特征及其对酒精使用障碍的影响:一项横断面研究。
IF 2.1 4区 医学
Alcohol and alcoholism Pub Date : 2024-05-14 DOI: 10.1093/alcalc/agae046
{"title":"Correction to: Profiles and the impact of affective temperaments on alcohol use disorder: a cross-sectional study.","authors":"","doi":"10.1093/alcalc/agae046","DOIUrl":"https://doi.org/10.1093/alcalc/agae046","url":null,"abstract":"","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing causal relationship between drinking behavior and metabolic syndrome: one-sample Mendelian randomization analysis. 解决饮酒行为与代谢综合征之间的因果关系:单样本孟德尔随机分析。
IF 2.8 4区 医学
Alcohol and alcoholism Pub Date : 2024-05-14 DOI: 10.1093/alcalc/agae039
Chuan-Wei Yang, Yu-Syuan Wei, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Cheng-Chieh Lin, Tsai-Chung Li
{"title":"Addressing causal relationship between drinking behavior and metabolic syndrome: one-sample Mendelian randomization analysis.","authors":"Chuan-Wei Yang, Yu-Syuan Wei, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Cheng-Chieh Lin, Tsai-Chung Li","doi":"10.1093/alcalc/agae039","DOIUrl":"https://doi.org/10.1093/alcalc/agae039","url":null,"abstract":"<p><strong>Aims: </strong>Alcohol drinking is associated with central obesity, hypertension, and hyperlipidemia, which further causes metabolic syndrome (MetS). However, prior epidemiological studies on such associations lack experimental evidence for a causal relationship. This study aims to explore the causal relationship between drinking behavior and MetS in Taiwan population by using Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>A cross-sectional study was conducted using the Taiwan Biobank database, which comprised 50 640 Han Chinese who were 30-70 years old without cancer from 2008 to 2020. In MR analysis, we constructed weighted and unweighted genetic risk scores by calculating SNP alleles significantly associated with alcohol drinking. We calculated odds ratios and 95% confidence interval (CI) by using a two-stage regression model.</p><p><strong>Results: </strong>A total of 50 640 participants were included with a mean age of 49.5 years (SD: 1.67 years), 36.6% were men. The adjusted odds ratio (aOR) of MetS per 5% increase in the likelihood of genetic predisposition to drink based on weighted genetic risk score with adjustment was 1.11 (95% CI: 1.10, 1.12, P < .001). Analysis was also conducted by grouping the likelihood of genetic predisposition to drink based on quartiles with multivariate adjustment. Using Q1 as the reference group, the aORs of MetS for Q2, Q3, and Q4 were 1.19 (1.12, 1.27, p < .001), 1.31 (1.23, 1.40, p < .001), and 1.87 (1.75, 2.00, p < .001), respectively, for the weighted genetic risk score.</p><p><strong>Conclusions: </strong>This study shows a modest relationship between drinking behavior and MetS by using MR analysis.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing reward and relief/habit drinking profiles in a study of naltrexone, varenicline, and placebo. 纳曲酮、伐伦克林和安慰剂研究中的奖励和缓解/习惯性饮酒特征。
IF 2.1 4区 医学
Alcohol and alcoholism Pub Date : 2024-05-14 DOI: 10.1093/alcalc/agae044
Annabel Kady, Erica N Grodin, Lara A Ray
{"title":"Characterizing reward and relief/habit drinking profiles in a study of naltrexone, varenicline, and placebo.","authors":"Annabel Kady, Erica N Grodin, Lara A Ray","doi":"10.1093/alcalc/agae044","DOIUrl":"10.1093/alcalc/agae044","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to clarify differences in mood, craving, and treatment response between reward and relief/habit individuals in a study of naltrexone, varenicline, and placebo. We hypothesized that relief/habit individuals would have a poorer mood during early abstinence and higher levels of alcohol craving than reward individuals. We hypothesized that reward individuals would demonstrate better drinking outcomes on naltrexone versus placebo.</p><p><strong>Methods: </strong>Data were culled from a randomized, double-blind, placebo-controlled human trial of 53 individuals (18F/16M) with alcohol use disorder randomized to varenicline (n = 19), naltrexone (n = 15), or matched placebo (n = 19). In this 6-day practice quit trial, participants attempted to abstain from drinking and completed daily diaries. Participants were classified into reward or relief/habit subgroups based on self-reported motivation for drinking. Multilinear models tested differences in mood and alcohol craving between reward and relief/habit individuals. General linear models tested differences between reward and relief/habit individuals' drinking outcomes on each medication versus placebo.</p><p><strong>Results: </strong>Relief/habit individuals showed decreases in positive mood and increases in negative mood over the quit attempt across medications, compared to reward individuals (P's < .05). Reward individuals' tension decreased on naltrexone, while relief/habit individuals' tension remained stable (F = 3.64, P = .03). Reward individuals in the placebo group had higher percent days abstinent than relief individuals in the placebo group (P < .001).</p><p><strong>Discussion: </strong>This study suggests relief/habit individuals' mood worsens during early abstinence. Our finding that reward individuals' tension decreased on naltrexone and increased on placebo may suggest a clinical response to the medication.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol effects on interoception shape expectancies and subjective effects: a registered report using the heart rate discrimination task. 酒精对互感形状预期和主观效果的影响:使用心率辨别任务的注册报告。
IF 2.8 4区 医学
Alcohol and alcoholism Pub Date : 2024-05-14 DOI: 10.1093/alcalc/agae025
Mateo Leganes-Fonteneau
{"title":"Alcohol effects on interoception shape expectancies and subjective effects: a registered report using the heart rate discrimination task.","authors":"Mateo Leganes-Fonteneau","doi":"10.1093/alcalc/agae025","DOIUrl":"10.1093/alcalc/agae025","url":null,"abstract":"<p><strong>Aims: </strong>Alcohol acutely impacts interoceptive processes, which in turn affect the perception of alcohol effects and the development of alcohol expectancies. However, previous research is limited by the tools used to measure cardiac interoception and subjective alcohol effects. This registered report proposes a re-examination of previous findings using a state-of-the-art measure of interoceptive capacity, the heart rate discrimination task, and measurements of subjective alcohol effects across both ascending and descending limbs.</p><p><strong>Methods: </strong>In a double-blind, placebo-controlled experiment, n = 36 participants were given 0.4 g/kg of ethanol, and a baseline measure of alcohol expectancies was obtained. Changes in interoceptive capacity after beverage administration, along with measures of light-headedness, mood, and biphasic alcohol effects, were assessed over two sessions.</p><p><strong>Hypotheses: </strong>As registered in this secondary data analysis, alcohol was expected to acutely impact different indices of interoceptive capacity, and those changes were hypothesized to correlate with subjective alcohol effects and expectancies. Analyses were conducted only following in-principle acceptance.</p><p><strong>Results: </strong>Alcohol-induced changes in interoceptive capacity predicted the development of light-headedness, stimulation, and negative mood. Changes in interoceptive capacity were also correlated with negative alcohol expectancies, as measured 2 weeks prior to the experiment. These effects were unique to the interoceptive condition, as null effects were observed in an exteroceptive control task.</p><p><strong>Discussion: </strong>This report offers a replication of key previous findings that alcohol impacts interoceptive processes to shape the detection of subjective alcohol effects. We propose that, through repeated drinking occasions, bodily responses feed into the experience of intoxication, shaping future expectancies about alcohol effects.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural responses to reward, threat, and emotion regulation and transition to hazardous alcohol use. 对奖赏、威胁和情绪调节的神经反应以及向危险饮酒的过渡。
IF 2.1 4区 医学
Alcohol and alcoholism Pub Date : 2024-05-14 DOI: 10.1093/alcalc/agae043
Katelyn T Kirk-Provencher, Matthew E Sloan, Keinada Andereas, Cooper J Erickson, Rosa H Hakimi, Anne E Penner, Joshua L Gowin
{"title":"Neural responses to reward, threat, and emotion regulation and transition to hazardous alcohol use.","authors":"Katelyn T Kirk-Provencher, Matthew E Sloan, Keinada Andereas, Cooper J Erickson, Rosa H Hakimi, Anne E Penner, Joshua L Gowin","doi":"10.1093/alcalc/agae043","DOIUrl":"10.1093/alcalc/agae043","url":null,"abstract":"<p><strong>Aims: </strong>Reward processing and regulation of emotions are thought to impact the development of addictive behaviors. In this study, we aimed to determine whether neural responses during reward anticipation, threat appraisal, emotion reactivity, and cognitive reappraisal predicted the transition from low-level to hazardous alcohol use over a 12-month period.</p><p><strong>Methods: </strong>Seventy-eight individuals aged 18-22 with low-level alcohol use [i.e. Alcohol Use Disorder Identification Test (AUDIT) score <7] at baseline were enrolled. They completed reward-based and emotion regulation tasks during magnetic resonance imaging to examine reward anticipation, emotional reactivity, cognitive reappraisal, and threat anticipation (in the nucleus accumbens, amygdala, superior frontal gyrus, and insula, respectively). Participants completed self-report measures at 3-, 6-, 9-, and 12-month follow-up time points to determine if they transitioned to hazardous use (as defined by AUDIT scores ≥8).</p><p><strong>Results: </strong>Of the 57 participants who completed follow-up, 14 (24.6%) transitioned to hazardous alcohol use. Higher baseline AUDIT scores were associated with greater odds of transitioning to hazardous use (odds ratio = 1.73, 95% confidence interval 1.13-2.66, P = .005). Brain activation to reward, threat, and emotion regulation was not associated with alcohol use. Of the neural variables, the amygdala response to negative imagery was numerically larger in young adults who transitioned to hazardous use (g = 0.31), but this effect was not significant.</p><p><strong>Conclusions: </strong>Baseline drinking levels were significantly associated with the transition to hazardous alcohol use. Studies with larger samples and longer follow-up should test whether the amygdala response to negative emotional imagery can be used to indicate a future transition to hazardous alcohol use.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex differences in neuronal activation in the cortex and midbrain during quinine-adulterated alcohol intake. 摄入奎宁掺杂酒精时大脑皮层和中脑神经元激活的性别差异
IF 2.8 4区 医学
Alcohol and alcoholism Pub Date : 2024-05-14 DOI: 10.1093/alcalc/agae031
Miranda E Arnold, Jesse R Schank
{"title":"Sex differences in neuronal activation in the cortex and midbrain during quinine-adulterated alcohol intake.","authors":"Miranda E Arnold, Jesse R Schank","doi":"10.1093/alcalc/agae031","DOIUrl":"10.1093/alcalc/agae031","url":null,"abstract":"<p><strong>Aims: </strong>Continued alcohol consumption despite negative consequences is a core symptom of alcohol use disorder. This is modeled in mice by pairing negative stimuli with alcohol, such as adulterating alcohol solution with quinine. Mice consuming alcohol under these conditions are considered to be engaging in aversion-resistant intake. Previously, we have observed sex differences in this behavior, with females more readily expressing aversion-resistant consumption. We also identified three brain regions that exhibited sex differences in neuronal activation during quinine-alcohol drinking: ventromedial prefrontal cortex (vmPFC), posterior insular cortex (PIC), and ventral tegmental area (VTA). Specifically, male mice showed increased activation in vmPFC and PIC, while females exhibited increased activation in VTA. In this study, we aimed to identify what specific type of neurons are activated in these regions during quinine-alcohol drinking.</p><p><strong>Method: </strong>We assessed quinine-adulterated alcohol intake using the two-bottle choice procedure. We also utilized RNAscope in situ hybridization in the three brain regions that previously exhibited a sex difference to examine colocalization of Fos, glutamate, GABA, and dopamine.</p><p><strong>Result: </strong>Females showed increased aversion-resistant alcohol consumption compared to males. We also found that males had higher colocalization of glutamate and Fos in vmPFC and PIC, while females had greater dopamine and Fos colocalization in the VTA.</p><p><strong>Conclusions: </strong>Collectively, these experiments suggest that glutamatergic output from the vmPFC and PIC may have a role in suppressing, and dopaminergic activity in the VTA may promote, aversion-resistant alcohol consumption. Future experiments will examine neuronal circuits that contribute to sex differences in aversion resistant consumption.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From childhood trauma to alcohol use disorder severity - significance of depressive symptoms and expectations towards analgesic effects of alcohol. 从童年创伤到酒精使用障碍的严重程度--抑郁症状和对酒精镇痛效果的期望的重要性。
IF 2.8 4区 医学
Alcohol and alcoholism Pub Date : 2024-05-14 DOI: 10.1093/alcalc/agae041
Justyna Zaorska, Jakub Skrzeszewski, Paweł Kobyliński, Elisa Maria Trucco, Marcin Wojnar, Maciej Kopera, Andrzej Jakubczyk
{"title":"From childhood trauma to alcohol use disorder severity - significance of depressive symptoms and expectations towards analgesic effects of alcohol.","authors":"Justyna Zaorska, Jakub Skrzeszewski, Paweł Kobyliński, Elisa Maria Trucco, Marcin Wojnar, Maciej Kopera, Andrzej Jakubczyk","doi":"10.1093/alcalc/agae041","DOIUrl":"https://doi.org/10.1093/alcalc/agae041","url":null,"abstract":"<p><strong>Aims: </strong>The objective of the current study was to describe and analyse associations between childhood emotional abuse, severity of depressive symptoms, and analgesic expectations of drinking in individuals with alcohol use disorder (AUD).</p><p><strong>Methods: </strong>A total of 240 individuals aged 43.85 ± 11.0 with severe AUD entering an inpatient, abstinence-based, and drug-free treatment program were assessed. The data on AUD severity, depressive symptoms, expectations towards the analgesic effects of alcohol and childhood emotional trauma was collected using questionnaire measures. The PROCESS SPSS macro for serial mediation with bootstrapping was used to test whether current severity of depressive symptoms and expectations towards analgesic effects of alcohol use serially mediated the association between childhood emotional abuse on AUD symptom severity.</p><p><strong>Results: </strong>There was evidence for two simple mediated effects, whereby the severity of depressive symptoms mediated the association between childhood emotional abuse on AUD symptom severity, and expectations towards analgesic effects of alcohol mediated the association between childhood emotional abuse on AUD symptom severity. There was also evidence to support serial mediation whereby both severity of depressive symptoms and expectations towards analgesic effects of alcohol mediated the association between childhood emotional abuse on AUD symptom severity.</p><p><strong>Conclusions: </strong>It might be clinically relevant to address experiences of childhood emotional trauma, as well as individual expectations of analgesic effects of alcohol, in AUD treatment programs.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of a self-help guide during a temporary alcohol abstinence challenge: a randomized controlled trial. 临时戒酒挑战期间自助指南的有效性:随机对照试验。
IF 2.1 4区 医学
Alcohol and alcoholism Pub Date : 2024-05-14 DOI: 10.1093/alcalc/agae034
Annelien Esselink, Andrea D Rozema, Nathalie Kools, Tim Van Den Berk, Rob H L M Bovens, Jolanda J P Mathijssen
{"title":"Effectiveness of a self-help guide during a temporary alcohol abstinence challenge: a randomized controlled trial.","authors":"Annelien Esselink, Andrea D Rozema, Nathalie Kools, Tim Van Den Berk, Rob H L M Bovens, Jolanda J P Mathijssen","doi":"10.1093/alcalc/agae034","DOIUrl":"10.1093/alcalc/agae034","url":null,"abstract":"<p><strong>Background: </strong>The popularity of temporary abstinence challenges (TACs) concerning alcohol consumption is increasing. Support is found to be essential for participants to help them get through a challenge. This study aimed to evaluate the additional effect of a self-help guide, based on health behaviour theories and behaviour change techniques, on (i) successful completion of a TAC and (ii) changes in drinking refusal self-efficacy (DRSE), behavioural automaticity, craving, and alcohol consumption.</p><p><strong>Methods: </strong>A randomized controlled trial was performed (OSF registries: OSF.IO/B95VU). NoThanks participants received a questionnaire before the TAC (T0) and 8 months after the TAC (T1). Out of a subgroup of 1308 respondents who were interested in additional support, 652 were randomly assigned to receive the guide (experimental group), and 656 did not receive any additional support (control group). Logistic regressions and (generalized) linear mixed model analyses were used.</p><p><strong>Results: </strong>After 8 months, all participants showed a significant decrease in behavioural automaticity, craving, and alcohol consumption, irrespective of group assignment. No significant changes were observed in the DRSE. This degree of change over time in behavioural automaticity, craving, and alcohol consumption did not differ between the experimental and control group. Sensitivity analyses with participants in the experimental group, who differed in exposure to the guide, did not show differences either.</p><p><strong>Conclusion: </strong>The self-help guide, and how it was designed, added no value to the TAC. Future research should focus on more bottom-up, customized support and explore what (different subgroups of) participants think they need as extra support during a TAC.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11128764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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