Alcohol and alcoholism最新文献

{"title":"Association of peripheral blood NLRP3, sTREM2, and p-tau217 levels with cognitive outcomes in patients with chronic alcohol-related brain damage.","authors":"Gaoyuan Xu, Ping Xu, Yihui Lei, Zhiwei Zhou, Yu Chen, Jian Zhan, Fei Feng, Zhilong Cai, Fang Chen","doi":"10.1093/alcalc/agag036","DOIUrl":"10.1093/alcalc/agag036","url":null,"abstract":"<p><strong>Objectives: </strong>Although NLRP3, sTREM2, and p-tau217 are important in Alzheimer's disease (AD), their relevance in alcohol-related brain damage (ARBD) is unclear. This study aimed to compare these biomarkers in patients with ARBD, non-alcoholic AD, and alcohol dependence without encephalopathy, and to examine their links to cognitive function.</p><p><strong>Methods: </strong>This cross-sectional study included 45 ARBD patients, 41 non-alcoholic AD patients, and 39 alcohol-dependent patients without encephalopathy. We measured peripheral serum levels of NLRP3, sTREM2, and p-tau217 by enzyme-linked immunosorbent assay and assessed cognitive function using the Montreal Cognitive Assessment and Mini-Mental State Examination. Statistical analyses were performed to evaluate group differences and associations with ARBD. ARBD patients exhibited higher levels of inflammatory markers and more severe anxiety and depression than other groups.</p><p><strong>Results: </strong>Serum sTREM2 was significantly highest in the ARBD group compared to both non-alcoholic AD and alcohol-dependent groups (P < .05). NLRP3 was also elevated in ARBD patients compared to the alcohol-dependent group (P = .005). No significant group differences were found for p-tau217. After adjusting for confounders, sTREM2 was significantly associated with cognitive, alcohol use, and mood scores, whereas NLRP3 was associated only with alcohol use and cognitive scores. Both sTREM2 and NLRP3 were independent predictors of ARBD. ROC analysis demonstrated that sTREM2 had the highest diagnostic accuracy for ARBD (AUC = 0.814), significantly outperforming NLRP3 (AUC = 0.671) and p-tau217 (AUC = 0.590).</p><p><strong>Conclusions: </strong>Serum sTREM2 and NLRP3 are promising peripheral biomarkers for ARBD. sTREM2, in particular, shows a strong association with clinical severity and demonstrates robust diagnostic potential, supporting its utility in the diagnosis and pathophysiological understanding of ARBD.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indexing reasons for heavy drinking using the Alcohol Consumption Questionnaire in a sample of American Indian adults.","authors":"Cindy L Ehlers, Libo Li, David A Gilder, Katherine J Karriker-Jaffe","doi":"10.1093/alcalc/agag028","DOIUrl":"10.1093/alcalc/agag028","url":null,"abstract":"<p><strong>Background: </strong>To better quantify reasons for high levels of drinking observed among American Indians (AIs) who drink, we measured drinking behaviors in a sample of AI adults using the Alcohol Consumption Questionnaire (ACQ).</p><p><strong>Methods: </strong>The sample consisted of 549 AI adults (54.8% female; average age = 31.7 years [standard deviation = 13.7]) living on reservations. Logistic regression models assessed associations of mean scale scores with lifetime alcohol use disorders (AUDs), adjusting for key demographics.</p><p><strong>Results: </strong>Respondents were stratified by the amount of alcohol needed to feel they had \"enough\" (level of alcohol satiety). Approximately one quarter (23.3%) of respondents reported satiety at less than binge drinking (<4 drinks for women, <5 drinks for men), 30.9% by heavy binge drinking (4-7 women, 5-9 men), 30.9% by high-intensity binge drinking (8-15 women, 10-19 men), and 14.9% were only satiated by extreme binge drinking (16+ women, 20+ men). Respondents satiated by extreme binge drinking also reported that their satisfying level of alcohol use was associated with losing their ability to walk and talk and with experiencing blackouts. The overall ACQ score and the subscale indexing consumption were significantly associated with AUD, with odds ratios ranging from 5.53 for mild AUD to 33.37 for severe AUD (each versus no AUD; all P-values < .001).</p><p><strong>Conclusion: </strong>Extreme levels of binge drinking may be associated with extreme expectations about an individual's \"satisfying\" level of alcohol exposure. The ACQ measure effectively indexes consumptive behaviors and provides an additional diagnostic tool that may help target prevention and/or treatments for AUD.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148012984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical mental health diagnoses among anabolic-androgenic steroid consumers classified as low-risk or hazardous drinkers: a brief report.","authors":"Benjamin Bonenti, Cheneal Puljévic, Jason Ferris, Emma Davies, Adam Winstock, Gillian W Shorter, Kyle Ganson, Anthony Barnett, Jason M Nagata, Timothy Piatkowski","doi":"10.1093/alcalc/agag047","DOIUrl":"https://doi.org/10.1093/alcalc/agag047","url":null,"abstract":"<p><p>Alcohol is commonly used alongside anabolic-androgenic steroids (AAS), yet its relationship with mental health in this population remains poorly understood. Among people reporting recent AAS use, hazardous drinkers reported higher prevalence of multiple psychiatric diagnoses than low-risk drinkers, particularly mood, anxiety, trauma-related, and psychotic conditions. These associations remained after adjustment for past 12-month use of other drugs beyond alcohol and AAS. Alcohol-risk level may therefore help identify AAS consumers who require more comprehensive mental health assessment.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced ethanol consumption by mice treated orally with arachidonic acid alone or in combination with the benign yeast Saccharomyces cerevisiae.","authors":"Andrew W Day, Katrina Blandino, Emma Hayes, Jamie Maguire, Carol A Kumamoto","doi":"10.1093/alcalc/agag046","DOIUrl":"10.1093/alcalc/agag046","url":null,"abstract":"<p><strong>Aims: </strong>The goal of this study was to determine the effect of administering arachidonic acid (ARA) with or without the yeast Saccharomyces cerevisiae, on voluntary ethanol consumption by mice.</p><p><strong>Methods: </strong>Ethanol consumption was measured using a continuous access two-bottle choice experiment with water and 15% ethanol (vol/vol). Ethanol naïve C57BL/6J mice were orally inoculated with ARA (or acidic PBS as the control), S. cerevisiae, or both each evening for three evenings. Ethanol consumption and preference were measured on the following days. In additional experiments, male and female mice underwent chronic intermittent exposure to ethanol vapor. After a 2-week exposure protocol, these mice were given access to 15% ethanol (vol/vol) via a two-bottle choice and inoculated nightly with ARA and S. cerevisiae (or acidic PBS and mock as the control).</p><p><strong>Results and conclusions: </strong>Administration of ARA initially reduced ethanol preference and consumption by ethanol naïve female mice but the effects waned. In contrast, administration of ARA together with a fungus had a sustained effect that reduced preference and consumption. The effects of ARA and fungi were statistically significantly different from ARA alone on Day 3 of ethanol access. Chronically exposed mice that showed low initial consumption of ethanol in the two-bottle choice maintained low consumption when administered ARA and S. cerevisiae. These findings support the future development of a therapeutic regimen utilizing ARA and yeast, or targeting eicosanoids, that could be developed as a supplement to current approaches to reduce ethanol consumption.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13293251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional magnetic response imaging predictors of alcohol use disorder treatment outcome: a systematic review.","authors":"Mahmoud Elsayed, Ryan Siroosi, Peter Najdzionek, Carly McIntyre-Wood, Tegan Hargreaves, Ashley Blakely, Emily Mote, James MacKillop","doi":"10.1093/alcalc/agag035","DOIUrl":"10.1093/alcalc/agag035","url":null,"abstract":"<p><strong>Background: </strong>Despite evidence-based pharmacological and behavioural interventions, alcohol use disorder (AUD) is associated with highly variable treatment outcomes. Functional magnetic resonance imaging (fMRI) may identify neural markers that predict treatment response, ultimately supporting a precision medicine approach to AUD.</p><p><strong>Objectives: </strong>This systematic review synthesized evidence on fMRI predictors of treatment outcomes in individuals with AUD, evaluated methodological consistency, and identified gaps to guide biomarker development.</p><p><strong>Methods: </strong>A comprehensive search of PubMed/MEDLINE, Embase, and PsycINFO combined terms related to fMRI, AUD, and treatment outcomes. Eligible studies included participants with AUD receiving pharmacological, behavioural, or neuromodulatory interventions with fMRI measures collected before or early in treatment to predict clinical outcomes. Screening and extraction were conducted in duplicate using Covidence, and study quality was assessed with the Grading of Recommendations Assessment, Development, and Evaluation framework.</p><p><strong>Results: </strong>Of 342 records, 15 studies met the inclusion criteria. Most used alcohol cue reactivity tasks (k = 11), with others using resting-state fMRI (k = 2), a monetary reward task (k = 1), or an alcohol-specific Go/No-Go task (k = 1). Pharmacological treatments were most common (k = 8), followed by behavioural therapies (k = 6) and one neuromodulation trial. Across paradigms, neural activity in the ventral striatum, orbitofrontal cortex, and anterior cingulate cortex commonly predicted outcomes. Greater prefrontal engagement predicted improvement, while heightened striatal cue reactivity predicted relapse. Resting-state findings suggested reduced reward- and stress-network connectivity corresponded with better outcomes. Across studies, however, considerable heterogeneity and inconsistency were present and sample sizes tended to be small.</p><p><strong>Conclusions: </strong>Evidence implicates frontostriatal and salience circuitry in predicting AUD treatment outcomes, but inconsistency and underpowered studies limit firm conclusions. Larger longitudinal studies are needed to robustly validate clinically useful biomarkers.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13253039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural language processing of patient in-session speech to predict brief motivational interviewing alcohol intervention response: an exploratory study.","authors":"Mahmoud Elsayed, Kyla L Belisario, Ashley Blakely, Sabrina K Syan, Emily Levitt, Molly Garber, Emily MacKillop, Iris Balodis, Lawrence H Sweet, James MacKillop","doi":"10.1093/alcalc/agag033","DOIUrl":"10.1093/alcalc/agag033","url":null,"abstract":"<p><strong>Background: </strong>Motivational interviewing (MI) is a patient-centred, goal-oriented psychotherapy for alcohol use disorder (AUD) and numerous other conditions. While some language patterns have been linked to MI response, less is known about how broader linguistic features, sentiment, and engagement relate to post-intervention drinking. This study used natural language processing to examine these associations and clarify mechanisms through which MI for AUD exerts its effects.</p><p><strong>Methods: </strong>Adults with AUD (N = 68) completed a single MI session with structured feedback and discussion of potential drinking changes. Speech transcripts were analysed for change-, emotion-, motivation-, substance-, and health-related words. Sentiment analysis assessed emotional polarity, and engagement was measured by total words spoken. Linear regression models tested associations between linguistic features and drinking outcomes, including drinks/week, percent heavy drinking days (%HDD), and percent drinking days (%DD).</p><p><strong>Results: </strong>Participants showed significant reductions in drinks per week and %DD. Consistent with recent reviews of MI predictors, linguistic analyses found that greater use of change talk and health-related language was associated with more drinks per week at follow-up, whereas greater emotional talk and positive sentiment predicted fewer drinks per week. Health- and substance-related language predicted higher %HDD, while social motivation-related language predicted lower %DD. Term-frequency and multivariate analyses supported these patterns.</p><p><strong>Conclusions: </strong>Via natural language processing of MI speech, linguistic features such as motivational content and sentiment were linked to drinking outcomes. Findings demonstrate the potential of this approach as a scalable, data-driven complement to traditional coding systems, with applications for real-time feedback, clinician training, and personalized interventions.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148203756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol use during pregnancy and public awareness of harms: findings from the CAMH Monitor Survey, Ontario, Canada.","authors":"Danijela Dozet, Anca R Ialomiteanu, Hayley A Hamilton, Svetlana Popova","doi":"10.1093/alcalc/agag029","DOIUrl":"10.1093/alcalc/agag029","url":null,"abstract":"<p><strong>Background and aims: </strong>Alcohol use during pregnancy and breastfeeding can have adverse consequences for child development, including fetal alcohol spectrum disorder (FASD). This study investigated the prevalence of alcohol use during pregnancy and breastfeeding and its associations with current substance use behaviors and beliefs about the safety of alcohol use in pregnancy.</p><p><strong>Methods: </strong>This cross-sectional study used pooled data from the 2018-2020 CAMH Monitor Survey, a population-based survey of adults in Ontario (N = 5957). Descriptive analyses and multivariable logistic regression were conducted to examine associations between maternal alcohol use and sociodemographic characteristics, substance use, and beliefs.</p><p><strong>Results: </strong>Of parous women (n = 1512; mean age: 65 years), 14.7% reported drinking alcohol during their most recent pregnancy (30 years prior, on average) and 17.8% while breastfeeding. Alcohol use during pregnancy was associated with lifetime substance use, current tobacco and alcohol use, and misconceptions about alcohol use in pregnancy. Gender differences emerged in beliefs: while awareness of FASD was relatively high among both women (87.2%) and men (80.6%), men were more likely than women to hold inaccurate beliefs, including that small amounts or certain types of alcohol may be safe during pregnancy. Men and women who were current drinkers of alcohol were significantly more likely to endorse these misconceptions.</p><p><strong>Conclusions: </strong>Public health messaging and maternal alcohol use prevention strategies must address persistent misconceptions about alcohol use in pregnancy and engage not only women and expectant mothers, but also men, partners, and broader social networks. Interventions should integrate education, universal screening, and trauma-informed care.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Models of care for the management of alcohol use disorder in general hospital settings and transition to the community: a scoping review.","authors":"Julia M A Sinclair, Sofia Hemrage, Nicola J Kalk, Georgia Foote, Melinda King, Julia Morris, Seilin Uhm, Amy Kitajima, Paul S Haber, Thomas Phillips","doi":"10.1093/alcalc/agag037","DOIUrl":"10.1093/alcalc/agag037","url":null,"abstract":"<p><strong>Background: </strong>Early detection of alcohol use disorder (AUD) amongst people admitted to general hospitals offers an opportunity for early intervention and accesses to evidence-based care. However, current operational models for the management of AUD in these settings are poorly defined, limiting the ability to assess their impact on individual patient outcomes, treatment effectiveness, or healthcare system efficiency. This scoping review aims to identify and characterize existing models of AUD management within general hospitals.</p><p><strong>Methods: </strong>A scoping review approach was adopted, including relevant peer-reviewed publications between 1990 and 2025. Studies needed to report on ≥2 care components (systematic screening, brief interventions, medically assisted alcohol withdrawal, relapse prevention initiation, psychosocial interventions, transition to community, provision of training) to be included. Screening and data extraction were performed independently by at least reviewers.</p><p><strong>Results: </strong>Fifty-one (n = 51) records were included, and four distinct models of care were identified (consultation liaison; screening, brief intervention, and referral to treatment; protocol implementation; supported diversion). Models varied in their clinical purpose, target population, and care delivery focus. Within each model, differences in aims, context, and implementation resulted in substantial heterogeneity.</p><p><strong>Conclusion: </strong>Consultation liaison models provided the most multifaceted care, with a specialist team providing clinical leadership, access to evidence-based interventions, transition to community services, and training of the wider workforce, but rarely described any wider systematic screening for AUD. A consistent observation across all identified models was the limited interface with mental health care, representing a critical gap in current AUD management within general hospitals.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148395388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How assessment method shapes reported reasons for quitting or reducing alcohol in a sample treated for alcohol use.","authors":"Christiana Prestigiacomo, Melissa Fry, Molly Jacobs, Timothy B Salguero, Melissa A Cyders","doi":"10.1093/alcalc/agag034","DOIUrl":"10.1093/alcalc/agag034","url":null,"abstract":"<p><strong>Aims: </strong>A recent review found that individuals who have received treatment for alcohol use disorder report several reasons for quitting or reducing alcohol use. However, the reasons varied across studies depending on the measurement method. This study aimed to qualitatively compare, within the same group of individuals in recovery, reasons for quitting or reducing alcohol use as reported on a scale versus an open-ended question.</p><p><strong>Methods: </strong>Data were collected from 203 individuals in recovery (Mean age = 42.9, 52.2% male, 77.8% White) who have had treatment for AUD. Participants reported their reasons for quitting or reducing alcohol in two ways: (1) completing the Reasons for Quitting Questionnaire and (2) responding to an open-ended question asking them to list their top three reasons. Thematic coding used a directed content analysis approach.</p><p><strong>Results: </strong>Endorsement of themes differed significantly between the two measures. While all scale-based themes also appeared in the open-ended responses, the latter yielded additional unique themes: fear of consequences, religious reasons, and hitting rock bottom. Even for overlapping themes, endorsement levels varied across measures.</p><p><strong>Conclusions: </strong>Findings highlight the need for standardization in assessing this construct, as the measurement method influenced the reasons reported. Future research should develop a standardized scale informed by open-ended responses to more accurately capture relevant themes.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147969622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing sentiment and self-reported experiences with nonalcoholic beverages in the context of efforts to quit or cut down on drinking.","authors":"Samuel F Acuff, Molly A Bowdring, John F Kelly, Alex M Russell","doi":"10.1093/alcalc/agag049","DOIUrl":"10.1093/alcalc/agag049","url":null,"abstract":"<p><strong>Background: </strong>Nonalcoholic beverages (NABs), which emulate characteristics of alcoholic counterparts but contain little or no alcohol, have become increasingly popular. Though NABs might serve as alcohol substitutes for some, lowering the overall public health burden caused by alcohol consumption, NABs may create risks for other vulnerable populations, such as those in or attempting recovery from alcohol use disorder. Little research has investigated how people attempting to quit drinking use and talk about NABs. The present study characterized how NABs are discussed and experienced in the context of efforts to quit or reduce alcohol use within an online alcohol recovery forum.</p><p><strong>Methods: </strong>We conducted a qualitative content analysis of 200 NAB-related posts from the r/stopdrinking subreddit. Two coders independently annotated posts using a structured codebook.</p><p><strong>Results: </strong>Of returned posts, 153 mentioned NABs and met criteria for inclusion. Most (86.8%) expressed either positive (35.3%) or neutral (52.2%) sentiment toward NABs, and over half (55.5%) stated abstinence as a current recovery goal. Posts mentioned: perceived benefits (46.4%), recommendations for NABs (32%), barriers to use (30%), requests for opinions about NABs (28.8%), warnings about NABs sometimes containing low amounts of alcohol (9.8%), consequences from drinking NABs (13.7%), and experiences mistakenly being served alcohol after ordering a NAB (6.5%).</p><p><strong>Conclusions: </strong>Results highlight largely positive sentiment and perceived benefits among posts in the r/stopdrinking subreddit. However, NABs may also present important risks, including mistakenly being served alcohol when ordering a NAB and as a risk pathway for returning to former levels of alcohol use.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"61 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13339844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148395390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}