Neural responses to reward, threat, and emotion regulation and transition to hazardous alcohol use.

IF 2.1 4区 医学 Q3 SUBSTANCE ABUSE
Katelyn T Kirk-Provencher, Matthew E Sloan, Keinada Andereas, Cooper J Erickson, Rosa H Hakimi, Anne E Penner, Joshua L Gowin
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引用次数: 0

Abstract

Aims: Reward processing and regulation of emotions are thought to impact the development of addictive behaviors. In this study, we aimed to determine whether neural responses during reward anticipation, threat appraisal, emotion reactivity, and cognitive reappraisal predicted the transition from low-level to hazardous alcohol use over a 12-month period.

Methods: Seventy-eight individuals aged 18-22 with low-level alcohol use [i.e. Alcohol Use Disorder Identification Test (AUDIT) score <7] at baseline were enrolled. They completed reward-based and emotion regulation tasks during magnetic resonance imaging to examine reward anticipation, emotional reactivity, cognitive reappraisal, and threat anticipation (in the nucleus accumbens, amygdala, superior frontal gyrus, and insula, respectively). Participants completed self-report measures at 3-, 6-, 9-, and 12-month follow-up time points to determine if they transitioned to hazardous use (as defined by AUDIT scores ≥8).

Results: Of the 57 participants who completed follow-up, 14 (24.6%) transitioned to hazardous alcohol use. Higher baseline AUDIT scores were associated with greater odds of transitioning to hazardous use (odds ratio = 1.73, 95% confidence interval 1.13-2.66, P = .005). Brain activation to reward, threat, and emotion regulation was not associated with alcohol use. Of the neural variables, the amygdala response to negative imagery was numerically larger in young adults who transitioned to hazardous use (g = 0.31), but this effect was not significant.

Conclusions: Baseline drinking levels were significantly associated with the transition to hazardous alcohol use. Studies with larger samples and longer follow-up should test whether the amygdala response to negative emotional imagery can be used to indicate a future transition to hazardous alcohol use.

对奖赏、威胁和情绪调节的神经反应以及向危险饮酒的过渡。
目的:奖赏处理和情绪调节被认为会影响成瘾行为的发展。在这项研究中,我们旨在确定奖赏预期、威胁评估、情绪反应和认知再评估过程中的神经反应是否能预测12个月内从低度饮酒到危险饮酒的转变:78名年龄在18-22岁之间的低度酗酒者[即酒精使用障碍鉴定测试(AUDIT)得分结果]接受了研究:在完成随访的 57 名参与者中,有 14 人(24.6%)转为酗酒。基线 AUDIT 分数越高,过渡到危险饮酒的几率越大(几率比 = 1.73,95% 置信区间 1.13-2.66,P = .005)。大脑对奖赏、威胁和情绪调节的激活与饮酒无关。在神经变量中,杏仁核对负面意象的反应在数量上大于过渡到有害使用的年轻人(g = 0.31),但这种影响并不显著:结论:基线饮酒水平与过渡到危险饮酒有很大关系。对更大样本和更长时间随访的研究应检验杏仁核对负面情绪想象的反应是否可用于预示未来向危险饮酒的转变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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