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Restoring carboxypeptidase E rescues BDNF maturation and neurogenesis in aged brains. 恢复羧肽酶E可挽救老年脑BDNF成熟和神经发生
Life medicine Pub Date : 2023-04-11 eCollection Date: 2023-04-01 DOI: 10.1093/lifemedi/lnad015
Hongmei Liu, Dongfang Jiang, Fuwen Yao, Tingting Li, Bo Zhou, Song Zhao, Keyan Yang, Haiping Feng, Jiaqi Shen, Jinglan Tang, Sijia Wang, Yu-Xin Zhang, Yun Wang, Qian Li, Yongliang Zhao, Caixia Guo, Tie-Shan Tang
{"title":"Restoring carboxypeptidase E rescues BDNF maturation and neurogenesis in aged brains.","authors":"Hongmei Liu, Dongfang Jiang, Fuwen Yao, Tingting Li, Bo Zhou, Song Zhao, Keyan Yang, Haiping Feng, Jiaqi Shen, Jinglan Tang, Sijia Wang, Yu-Xin Zhang, Yun Wang, Qian Li, Yongliang Zhao, Caixia Guo, Tie-Shan Tang","doi":"10.1093/lifemedi/lnad015","DOIUrl":"10.1093/lifemedi/lnad015","url":null,"abstract":"<p><p>Adult neurogenesis declines with age due to the less functional neural stem cells (NSCs) and niches, but the underlying molecular bases for this impaired condition remain unclear. Here we analyzed >55,000 single-cell transcriptomes from two discrete neurogenic niches across the mouse lifespan, and identified new features and populations in NSCs, new markers, and neurogenic regional-specific alternations during aging. Intercellular communication analysis revealed defects in brain-derived neurotrophic factor (BDNF)-TrkB signaling cascade in old NSCs. Carboxypeptidase E (CPE) was found to be highly enriched in NSCs, and played a crucial role in mature/proBDNF balance and adult neurogenesis. Diminishment of CPE with aging resulted in impaired generation of BDNF, thus limiting the neurogenesis in old neurogenic niches. Restoring CPE expression markedly rescued the adult neurogenesis by increasing the production of mature BDNF, offering an attractive therapeutic strategy for the treatment of certain disorders in regions associated with constitutive neurogenesis.</p>","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad015"},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47018071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
m6A modification: a new avenue for anti-cancer therapy. m 6A修饰：抗癌治疗的新途径
Life medicine Pub Date : 2023-04-08 eCollection Date: 2023-02-01 DOI: 10.1093/lifemedi/lnad008
Yongtai Bai, Kai Li, Jinying Peng, Chengqi Yi
{"title":"m<sup>6</sup>A modification: a new avenue for anti-cancer therapy.","authors":"Yongtai Bai, Kai Li, Jinying Peng, Chengqi Yi","doi":"10.1093/lifemedi/lnad008","DOIUrl":"10.1093/lifemedi/lnad008","url":null,"abstract":"<p><p>To date, over 170 different kinds of chemical modifications on RNAs have been identified, some of which are involved in multiple aspects of RNA fate, ranging from RNA processing, nuclear export, translation, and RNA decay. m<sup>6</sup>A, also known as <i>N</i> <sup>6</sup>-methyladenosine, is a prominent internal RNA modification that is catalyzed primarily by the METTL3-METTL14-WTAP methyltransferase complex in higher eukaryotic mRNA and long noncoding RNA (lncRNA). In recent years, abnormal m<sup>6</sup>A modification has been linked to the occurrence, development, progression, and prognosis of the majority of cancers. In this review, we provide an update on the most recent m<sup>6</sup>A modification discoveries as well as the critical roles of m<sup>6</sup>A modification in cancer development and progression. We summarize the mechanisms of m<sup>6</sup>A involvement in cancer and list potential cancer therapy inhibitors that target m<sup>6</sup>A regulators such as \"writer\" METTL3 and \"eraser\" FTO.</p>","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad008"},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48762151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 3D genome and its impacts on human health and disease. 三维基因组及其对人类健康和疾病的影响
Life medicine Pub Date : 2023-03-23 eCollection Date: 2023-04-01 DOI: 10.1093/lifemedi/lnad012
Siqi Wang, Zhengyu Luo, Weiguang Liu, Tengfei Hu, Zhongying Zhao, Michael G Rosenfeld, Xiaoyuan Song
{"title":"The 3D genome and its impacts on human health and disease.","authors":"Siqi Wang, Zhengyu Luo, Weiguang Liu, Tengfei Hu, Zhongying Zhao, Michael G Rosenfeld, Xiaoyuan Song","doi":"10.1093/lifemedi/lnad012","DOIUrl":"10.1093/lifemedi/lnad012","url":null,"abstract":"<p><p>Eukaryotic genomes are highly compacted in the cell nucleus. Two loci separated by a long linear distance can be brought into proximity in space through DNA-binding proteins and RNAs, which contributes profoundly to the regulation of gene expression. Recent technology advances have enabled the development and application of the chromosome conformation capture (3C) technique and a host of 3C-based methods that enable genome-scale investigations into changes in chromatin high-order structures during diverse physiological processes and diseases. In this review, we introduce 3C-based technologies and discuss how they can be utilized to glean insights into the impacts of three-dimensional (3D) genome organization in normal physiological and disease processes.</p>","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad012"},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46870299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human platelet lysate as a substitute for serum in natural killer cell generation and expansion. 人血小板裂解液在自然杀伤细胞的产生和扩增中替代血清
Life medicine Pub Date : 2023-03-13 eCollection Date: 2023-04-01 DOI: 10.1093/lifemedi/lnad011
Chao Li, Hao Zhu, Lei Zhang, Xianwei Liu, Yibing Ji, Haihong Zhang, Zhongpeng Li, Chen Wu, Fangfang Zhu
{"title":"Human platelet lysate as a substitute for serum in natural killer cell generation and expansion.","authors":"Chao Li, Hao Zhu, Lei Zhang, Xianwei Liu, Yibing Ji, Haihong Zhang, Zhongpeng Li, Chen Wu, Fangfang Zhu","doi":"10.1093/lifemedi/lnad011","DOIUrl":"10.1093/lifemedi/lnad011","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"1 1","pages":"lnad011"},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61609295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chromatin 3D structure, phase separation and disease. 染色质三维结构，相分离和疾病
Life medicine Pub Date : 2023-03-08 eCollection Date: 2023-04-01 DOI: 10.1093/lifemedi/lnad010
Lili Fan, Xinyi Liu, Diana Guallar, Junjun Ding
{"title":"Chromatin 3D structure, phase separation and disease.","authors":"Lili Fan, Xinyi Liu, Diana Guallar, Junjun Ding","doi":"10.1093/lifemedi/lnad010","DOIUrl":"10.1093/lifemedi/lnad010","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad010"},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44222173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Waking up the silenced beauty: CRISPR/Cas9 mediated reactivation of fetal hemoglobin genes to treat severe beta-thalassemia in young patients. 唤醒沉默的美丽:CRISPR/Cas9介导的胎儿血红蛋白基因再激活治疗年轻患者严重的-地中海贫血
Life medicine Pub Date : 2023-03-06 eCollection Date: 2023-04-01 DOI: 10.1093/lifemedi/lnad009
Liren Wang, Stefan Siwko, Dali Li
{"title":"Waking up the silenced beauty: CRISPR/Cas9 mediated reactivation of fetal hemoglobin genes to treat severe beta-thalassemia in young patients.","authors":"Liren Wang, Stefan Siwko, Dali Li","doi":"10.1093/lifemedi/lnad009","DOIUrl":"10.1093/lifemedi/lnad009","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad009"},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42678269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence accelerates efficient mining of functional peptides. 人工智能加速了功能肽的高效挖掘
Life medicine Pub Date : 2023-02-23 eCollection Date: 2023-04-01 DOI: 10.1093/lifemedi/lnad005
Xudong Zhang, Cesar de la Fuente-Nunez, Jun Wang
{"title":"Artificial intelligence accelerates efficient mining of functional peptides.","authors":"Xudong Zhang, Cesar de la Fuente-Nunez, Jun Wang","doi":"10.1093/lifemedi/lnad005","DOIUrl":"10.1093/lifemedi/lnad005","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad005"},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48955364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in human organoids-on-chips in biomedical research. 人体类器官芯片在生物医学研究中的进展
Life medicine Pub Date : 2023-02-21 eCollection Date: 2023-02-01 DOI: 10.1093/lifemedi/lnad007
Yaqing Wang, Jianhua Qin
{"title":"Advances in human organoids-on-chips in biomedical research.","authors":"Yaqing Wang, Jianhua Qin","doi":"10.1093/lifemedi/lnad007","DOIUrl":"10.1093/lifemedi/lnad007","url":null,"abstract":"<p><p>Organoids-on-chips is opening up new frontier of research in biomedical field by combining organoids and organs-on-chips technology. The integrative technology offers great opportunities to maximize the potentials of organoids with higher fidelity, thus building advanced organ model systems in a physiologically relevant manner. In this review, we highlight the key features of organoids-on-chips and how this integrative technology could be used to build organoids in higher fidelity under controlled cellular microenvironment. We then introduce the recent progress of organoids-on-chips and their applications in biomedical research. We also discuss the opportunities and challenges of the nascent field of organoids-on-chips that lie ahead to accelerate their utility in disease research, drug testing, and regenerative medicine.</p>","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad007"},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45629332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of blastoids from human parthenogenetic stem cells. 从人类孤雌生殖干细胞中产生囊胚
Life medicine Pub Date : 2023-02-18 eCollection Date: 2023-02-01 DOI: 10.1093/lifemedi/lnad006
Ke Zhong, Yu-Xin Luo, Dan Li, Zhe-Ying Min, Yong Fan, Yang Yu
{"title":"Generation of blastoids from human parthenogenetic stem cells.","authors":"Ke Zhong, Yu-Xin Luo, Dan Li, Zhe-Ying Min, Yong Fan, Yang Yu","doi":"10.1093/lifemedi/lnad006","DOIUrl":"10.1093/lifemedi/lnad006","url":null,"abstract":"<p><p>Parthenogenetic embryos derive their genomes entirely from the maternal genome and lack paternal imprint patterns. Many achievements have been made in the study of genomic imprinting using human parthenogenetic embryonic stem cells (hPg-ESCs). However, due to developmental defects and ethical limits, a comprehensive understanding of parthenogenetic embryonic development is still lacking. Here, we generated parthenogenetic blastoids (hPg-EPSCs blastoids) from hPg-ESC-derived extended pluripotent stem cells (hPg-EPSCs) using our previously published two-step induction protocol. Morphology, specific marker expression and single-cell transcriptome analysis showed that hPg-EPSCs blastoids contain crucial cell lineages similar to blastoids (hBp-EPSCs blastoids) generated from human biparental EPSCs (hBp-EPSCs). Single-cell RNA-seq compared the expression of genes related to imprinting and X chromosome inactivation in hPg-EPSCs blastoids and hBp-EPSCs blastoids. In conclusion, we generated parthenogenetic blastoids, which will potentially promote the study of genomic imprinting in embryonic development and uncover the influence of parental origin bias on human development and pathological mechanisms.</p>","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad006"},"PeriodicalIF":0.0,"publicationDate":"2023-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45854108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolutionary conservation analysis of human arachidonic acid metabolism pathway genes. 人类花生四烯酸代谢途径基因的进化保守性分析
Life medicine Pub Date : 2023-02-10 eCollection Date: 2023-04-01 DOI: 10.1093/lifemedi/lnad004
Cengfan Wei, Meng Wang, Xiu-Jie Wang
{"title":"Evolutionary conservation analysis of human arachidonic acid metabolism pathway genes.","authors":"Cengfan Wei, Meng Wang, Xiu-Jie Wang","doi":"10.1093/lifemedi/lnad004","DOIUrl":"10.1093/lifemedi/lnad004","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad004"},"PeriodicalIF":0.0,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45891603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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