Life medicine最新文献

Single-cell analysis reveals essential lncRNAs regulating human trophoblast lineage differentiation. 单细胞分析揭示了调节人类滋养细胞谱系分化的重要lncrna。

IF 6

Life medicine Pub Date : 2026-04-17 eCollection Date: 2026-04-01 DOI: 10.1093/lifemedi/lnag010

Weiyi Zhang, Chunyan Le, Shanru Yi, Wenqiang Liu, Xiaoyu Liu, Zhen Yin, Hong Wang, Rui Gao, Shaorong Gao, Jiayu Chen

{"title":"Single-cell analysis reveals essential lncRNAs regulating human trophoblast lineage differentiation.","authors":"Weiyi Zhang, Chunyan Le, Shanru Yi, Wenqiang Liu, Xiaoyu Liu, Zhen Yin, Hong Wang, Rui Gao, Shaorong Gao, Jiayu Chen","doi":"10.1093/lifemedi/lnag010","DOIUrl":"https://doi.org/10.1093/lifemedi/lnag010","url":null,"abstract":"The human placenta sustains pregnancy through intricate trophoblast lineage dynamics that are critical for fetal development and pregnancy success. While studies on protein-coding genes (PCGs) have advanced our understanding of placental biology, the regulatory roles of noncoding RNAs, particularly long noncoding RNAs (lncRNAs), in trophoblast lineage specification and function remain poorly understood. Here, we profile single-cell lncRNA dynamics across human placental development, revealing distinct cell-type- and gestational stage-specific expression profiles. Integrated analysis revealed that lncRNAs modulate histone modification levels at the regulatory regions of target genes via cis-action, thereby regulating the expression of key genes essential for trophoblast differentiation. Functional studies by using in vivo and in vitro models fully identify ECEL1P2-ALPP, SEMA3B-AS1-SEMA3B, and MYCNUT/MYCNOS-MYCN as pivotal regulatory axes driving cytotrophoblast self-renewal, syncytiotrophoblast fusion, and epithelial-mesenchymal transition, respectively, which are essential for trophoblast identity and function. Notably, dysregulation of lncRNA-PCG pairs in pathological pregnancies underscores the clinical relevance of these noncoding networks. Together, our findings uncover an unappreciated layer of lineage-specific noncoding regulation, providing mechanistic insight and potential biomarkers for placental development and associated disorders.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"5 2","pages":"lnag010"},"PeriodicalIF":6.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural compounds of medicinal plants as a source for novel anti-orthopoxvirus medications. 药用植物天然化合物作为新型抗正痘病毒药物的来源。

IF 6

Life medicine Pub Date : 2026-04-09 eCollection Date: 2026-04-01 DOI: 10.1093/lifemedi/lnag009

Eman A Makhlouf, Riham A El-Shiekh, Mona M Okba, Hossam M Ashour

引用次数: 0

The immune effects of mesenchymal stem cell-based therapy in kidney diseases. 间充质干细胞治疗肾脏疾病的免疫效果。

IF 6

Life medicine Pub Date : 2026-04-07 eCollection Date: 2026-04-01 DOI: 10.1093/lifemedi/lnag008

Yachao Li, Kuai Ma, Junyi Ren, Haoyu Peng, Moussa Ide Nasser, Chi Liu

引用次数: 0

Macrophage-directed T cell recruitment augments IFN-Mediated suppression of cardiac reprogramming in vivo. 巨噬细胞定向T细胞募集增强体内ifn介导的心脏重编程抑制。

IF 6

Life medicine Pub Date : 2026-04-07 eCollection Date: 2026-02-01 DOI: 10.1093/lifemedi/lnag005

Yihong Cai, Hao Wang, Junbo Yang, Qianhe Li, Yuxiang Dai, Yang Zhao

引用次数: 0

Salivary volatilome profiling in pediatric eosinophilic esophagitis: a pilot study on a non-invasive approach in clinical practice. 儿童嗜酸性粒细胞性食管炎的唾液挥发物分析：一项临床实践中非侵入性方法的初步研究。

IF 6

Life medicine Pub Date : 2026-04-07 eCollection Date: 2026-04-01 DOI: 10.1093/lifemedi/lnag012

Rosamaria Capuano, Carla Petrella, Christian Barbato, Giulia D'Arcangelo, Giusy Russo, Alexandro Catini, Antonio Minni, Corrado Di Natale, Salvatore Oliva

{"title":"Salivary volatilome profiling in pediatric eosinophilic esophagitis: a pilot study on a non-invasive approach in clinical practice.","authors":"Rosamaria Capuano, Carla Petrella, Christian Barbato, Giulia D'Arcangelo, Giusy Russo, Alexandro Catini, Antonio Minni, Corrado Di Natale, Salvatore Oliva","doi":"10.1093/lifemedi/lnag012","DOIUrl":"https://doi.org/10.1093/lifemedi/lnag012","url":null,"abstract":"Eosinophilic esophagitis (EoE) is a chronic immune disease requiring repeated endoscopies for diagnosis and monitoring in children. Saliva represents a promising non-invasive biofluid, and volatile organic compounds (VOCs) may indicate disease presence and activity. This study aimed to examine the VOCs profile in saliva samples from children with EoE and to compare it with other gastrointestinal (GI) conditions and healthy controls. Thirty-five samples from children with EoE (including 13 active and 22 non-active cases), 19 from children with other GI conditions, and 46 from healthy controls were analyzed. Gas chromatography-ion mobility spectrometry (GC-IMS) identified 63 distinct VOC signal areas. The abundance of 16 of them was found significantly different (P < 0.01) in EoE vs. controls, EoE vs. other GI conditions, and active vs. non-active EoE. Among them, cis-3-hexen-1-ol and 2-phenylethanol show a ubiquitous capability to discriminate EoE against different populations. Linear discriminant analysis (LDA) of the panel of 16 VOCs achieved 83.3% accuracy in classifying EoE vs. healthy controls, 81.2% accuracy in distinguishing EoE from GI controls, and 80.0% accuracy in classifying active vs. non-active EoE. Salivary VOC profiling enables accurate discrimination of pediatric EoE from controls and stratification by disease activity. This non-invasive approach holds promise as a diagnostic and monitoring tool in clinical practice, especially in children.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"5 2","pages":"lnag012"},"PeriodicalIF":6.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The multistep progression of areca nut-induced oral cancer: a mechanistic roadmap from pathogenesis to precision therapy. 槟榔诱发口腔癌的多步骤进展：从发病机制到精准治疗的机制路线图。

IF 6

Life medicine Pub Date : 2026-03-27 eCollection Date: 2026-04-01 DOI: 10.1093/lifemedi/lnag011

Na Yu, Wenqiu Cai, Congyi Zhang, Qiyue Cai, Zisong Zhang, Yuqing Hu, Yan Sun, Kaiyao Yin, Feng Ren, KangXin Chang, MeiLing Jin, Dongxia Li, Liwen Zhang, Heming Wu, Mengwei Li

{"title":"The multistep progression of areca nut-induced oral cancer: a mechanistic roadmap from pathogenesis to precision therapy.","authors":"Na Yu, Wenqiu Cai, Congyi Zhang, Qiyue Cai, Zisong Zhang, Yuqing Hu, Yan Sun, Kaiyao Yin, Feng Ren, KangXin Chang, MeiLing Jin, Dongxia Li, Liwen Zhang, Heming Wu, Mengwei Li","doi":"10.1093/lifemedi/lnag011","DOIUrl":"https://doi.org/10.1093/lifemedi/lnag011","url":null,"abstract":"Areca nut is classified as a Group 1 carcinogen by the International Agency for Research on Cancer. It is a widely consumed psychoactive substance with profound cultural roots in regions including Hunan, Hainan, and Taiwan of China. Its key bioactive components include alkaloids (e.g. arecoline and arecaidine) and areca nut-specific nitrosamines, that induce DNA damage, reactive oxygen species bursts, and chronic inflammation in oral tissues. Coupled with mechanical trauma from chewing, these insults drive the malignant progression of oral submucous fibrosis to oral cavity carcinomas. This review systematically outlines the pathological progression from normal oral mucosa to invasive oral cavity carcinomas, highlighting two core mediators of oral submucous fibrosis carcinogenesis: immune microenvironment reprogramming and oncogenic signaling activation. Furthermore, this review elaborates the molecular mechanisms of areca nut-induced oral cancer, providing a theoretical foundation for biomarker discovery and the development of novel therapeutic strategies. It also provides actionable guidance for reducing the incidence of areca nut-related oral cavity carcinomas and improving patient prognosis.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"5 2","pages":"lnag011"},"PeriodicalIF":6.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histidine phosphorylation of NME1 regulates the Hippo pathway via the ARHGAP17-CDC42-cytoskeleton axis. NME1组氨酸磷酸化通过arhgap17 - cdc42 -细胞骨架轴调控Hippo通路。

IF 6

Life medicine Pub Date : 2026-03-12 eCollection Date: 2026-02-01 DOI: 10.1093/lifemedi/lnag002

Xian Liu, Zhongnan Chen, Jianxi Zhu, Shengcheng Deng, Zhifen Zhou, Wenbin Ma, Zhou Songyang

引用次数: 0

New paradigm for aging research: aging studies through innovative AI applications and interdisciplinary collaborations. 老龄化研究新范式：通过创新人工智能应用和跨学科合作进行老龄化研究。

IF 6

Life medicine Pub Date : 2026-02-19 eCollection Date: 2026-02-01 DOI: 10.1093/lifemedi/lnaf039

Zeyu Gao, Mei Li, Jingyi Li, Moshi Song

引用次数: 0

How PM_2.5 drives dementia: emerging mechanisms and unanswered questions. PM2.5如何导致痴呆症：新出现的机制和未解之谜。

IF 6

Life medicine Pub Date : 2026-02-02 eCollection Date: 2026-04-01 DOI: 10.1093/lifemedi/lnag007

Alexia D Defrancesco, Chenju Yi, Brian G Oliver, Hui Chen

引用次数: 0

iPSC-derived breast cancer models: advancing the study of BRCA1-driven tumorigenesis. ipsc衍生的乳腺癌模型：推进brca1驱动的肿瘤发生研究

IF 6

Life medicine Pub Date : 2026-02-02 eCollection Date: 2026-04-01 DOI: 10.1093/lifemedi/lnag006

Pengguihang Zeng, Zhuheng Zhang, Xinyi Liu, Junjun Ding

引用次数: 0