Life medicine最新文献

DDIT3 deficiency ameliorates systemic lupus erythematosus by regulating B cell activation and differentiation.

Life medicine Pub Date : 2025-03-03 eCollection Date: 2025-02-01 DOI: 10.1093/lifemedi/lnaf009

Xin Dai, Jiali Yu, Yunfei Zhang, Zhiming Wang, Yunyan Dai, Ying Hu, Xiaocui Wang, Binbin Tian, Minhui Wu, Hao Chen, Ruigao Song, Dan Ma, Cong-Yi Wang, Dawei Ye, Ziliang Zheng, Liyun Zhang, Jing Luo, Yukai Jing

{"title":"DDIT3 deficiency ameliorates systemic lupus erythematosus by regulating B cell activation and differentiation.","authors":"Xin Dai, Jiali Yu, Yunfei Zhang, Zhiming Wang, Yunyan Dai, Ying Hu, Xiaocui Wang, Binbin Tian, Minhui Wu, Hao Chen, Ruigao Song, Dan Ma, Cong-Yi Wang, Dawei Ye, Ziliang Zheng, Liyun Zhang, Jing Luo, Yukai Jing","doi":"10.1093/lifemedi/lnaf009","DOIUrl":"10.1093/lifemedi/lnaf009","url":null,"abstract":"Systemic lupus erythematosus (SLE) is characterized by the overproduction of autoantibodies, and B cells are considered to be the primary cells involved in the development of SLE. Studies have shown that DNA damage responses play a role in B cell activity in SLE. However, the exact role of DNA damage-induced transcript 3 (DDIT3) in humoral immune response and SLE pathogenesis remains unknown. We observed increased expression of DDIT3 in B cells of SLE patients and this expression was positively correlated with disease activity. In DDIT3-knockout mice, we observed disturbances in B cell development and differentiation, inhibition of B cell activation, and BCR signaling. In addition, DDIT3 deficiency leads to a reduction in T-cell-dependent humoral immune responses. Mechanistically, we found that DDIT3 promotes the transcription and expression of Itgad, which enhances PI3K signaling and B cell activation. Finally, we found that DDIT3 deficiency attenuated lupus autoimmunity and reduced germinal center responses. In conclusion, our study reveals for the first time the role of DDIT3 in adaptive immune responses, especially in B cell homeostasis, B cell activation, BCR signaling, and B cell function. These findings provide a new potential target for therapeutic intervention in SLE.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 1","pages":"lnaf009"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium.

Life medicine Pub Date : 2025-01-26 eCollection Date: 2024-12-01 DOI: 10.1093/lifemedi/lnaf001

Ning Huang, Meiling Ge, Xiaolei Liu, Xu Tian, Pengbin Yin, Zhijun Bao, Feng Cao, Ng Shyh-Chang, Biao Dong, Lunzhi Dai, Zhenji Gan, Ping Hu, Jing Qu, Si Wang, Huating Wang, Qian Xiao, Rui Yue, Jirong Yue, Licheng Zhang, Yong Zhang, Hongbo Zhang, Weiqi Zhang, Guang-Hui Liu, Gang Pei, Yong Liu, Dahai Zhu, Birong Dong

{"title":"A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium.","authors":"Ning Huang, Meiling Ge, Xiaolei Liu, Xu Tian, Pengbin Yin, Zhijun Bao, Feng Cao, Ng Shyh-Chang, Biao Dong, Lunzhi Dai, Zhenji Gan, Ping Hu, Jing Qu, Si Wang, Huating Wang, Qian Xiao, Rui Yue, Jirong Yue, Licheng Zhang, Yong Zhang, Hongbo Zhang, Weiqi Zhang, Guang-Hui Liu, Gang Pei, Yong Liu, Dahai Zhu, Birong Dong","doi":"10.1093/lifemedi/lnaf001","DOIUrl":"10.1093/lifemedi/lnaf001","url":null,"abstract":"The skeletal muscle is an important organ for movement and metabolism in human body, and its physiological aging underlies the occurrence of muscle atrophy and sarcopenia. China has the largest aging population in the world and is facing a grand challenge with how to prevent and treat skeletal muscle aging-related diseases. To address this difficult problem, the Aging Biomarker Consortium (ABC) of China has reached an expert consensus on biomarkers of skeletal muscle aging by synthesizing literatures and insights from scientists and clinicians. This consensus attempts to provide a comprehensive assessment of biomarkers associated with skeletal muscle aging, and proposes a systematic framework to classify them into three dimensions: functional, structural, and humoral. Within each dimension, the experts recommend clinically relevant biomarkers for skeletal muscle aging. This consensus aims to lay the foundation for future research on skeletal muscle aging, facilitating precise prediction, diagnosis, and treatment of skeletal muscle aging and sarcopenia. It is anticipated to make significant contributions to healthy aging of skeletal muscle in the elderly population in China and around the world as well.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"3 6","pages":"lnaf001"},"PeriodicalIF":0.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11851484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence.

Life medicine Pub Date : 2025-01-23 eCollection Date: 2025-02-01 DOI: 10.1093/lifemedi/lnaf004

Weicheng Tang, Kaichen Wang, Yourong Feng, Kuan-Hao Tsui, Keshav K Singh, Michael B Stout, Shixuan Wang, Meng Wu

{"title":"Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence.","authors":"Weicheng Tang, Kaichen Wang, Yourong Feng, Kuan-Hao Tsui, Keshav K Singh, Michael B Stout, Shixuan Wang, Meng Wu","doi":"10.1093/lifemedi/lnaf004","DOIUrl":"10.1093/lifemedi/lnaf004","url":null,"abstract":"The ovary is a crucial gonadal organ that supports female reproductive and endocrine functions. Ovarian aging can result in decreased fertility and dysfunction across multiple organs. Research has demonstrated that cellular senescence in various cell types within the ovary can trigger a decline in ovarian function through distinct stress responses, resulting in ovarian aging. This review explores how cellular senescence may contribute to ovarian aging and reproductive failure. Additionally, we discuss the factors that cause ovarian cellular senescence, including the accumulation of advanced glycation end products, oxidative stress, mitochondrial dysfunction, DNA damage, telomere shortening, and exposure to chemotherapy. Furthermore, we discuss senescence in six distinct cell types, including oocytes, granulosa cells, ovarian theca cells, immune cells, ovarian surface epithelium, and ovarian endothelial cells, inside the ovary and explore their contribution to the accelerated ovarian aging. Lastly, we describe potential senotherapeutics for the treatment of ovarian aging and offer novel strategies for ovarian longevity.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 1","pages":"lnaf004"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pluripotent stem cell-based immunotherapy: advances in translational research, cell differentiation, and gene modifications.

Life medicine Pub Date : 2025-01-18 eCollection Date: 2025-02-01 DOI: 10.1093/lifemedi/lnaf002

Qi Lei, Hongkui Deng, Shicheng Sun

引用次数: 0

Single-cell RNA sequencing reveals the intercellular crosstalk and the regulatory landscape of stromal cells during the whole life of the mouse ovary.

Life medicine Pub Date : 2024-12-28 eCollection Date: 2024-12-01 DOI: 10.1093/lifemedi/lnae041

Wan Jiang, Wenya Sun, Yue Peng, Hao Xu, Haonan Fan, Xin Jin, Yue Xiao, Yuxiang Wang, Pin Yang, Wenjie Shu, Jing Li

{"title":"Single-cell RNA sequencing reveals the intercellular crosstalk and the regulatory landscape of stromal cells during the whole life of the mouse ovary.","authors":"Wan Jiang, Wenya Sun, Yue Peng, Hao Xu, Haonan Fan, Xin Jin, Yue Xiao, Yuxiang Wang, Pin Yang, Wenjie Shu, Jing Li","doi":"10.1093/lifemedi/lnae041","DOIUrl":"10.1093/lifemedi/lnae041","url":null,"abstract":"The heterogeneity of ovarian mesenchymal/stromal cells has just been revealed in both mice and humans. However, it remains unclear about the cellular development trace and the intercellular communication network in the whole life of the ovary. In the study, we integrated ours and published single-cell RNA sequencing data from E11.5 (embryonic day 11.5) until M12 (12-month-old) ovaries to show the dynamics of somatic cells along the developmental timeline. The intercellular crosstalk among somatic cell types was depicted with collagen signaling pathway as the most outgoing signals from stromal cells. We identified mesenchymal progenitor cells (CD24+) as the origin of stromal cells. Although their numbers decreased significantly in adults, the cells served as the major signal sender until ovarian senescence. Moreover, the ovarian injury could activate these stem cells and induce stroma remodeling in the aged ovary. Thus, mesenchymal progenitor cells may represent a new strategy to delay ovarian aging in the future.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"3 6","pages":"lnae041"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal stem cells in intestinal homeostasis and colorectal tumorigenesis.

Life medicine Pub Date : 2024-12-25 eCollection Date: 2024-10-01 DOI: 10.1093/lifemedi/lnae042

Gaoli Shi, Yang Li, Haihong Shen, Qiankun He, Pingping Zhu

引用次数: 0

GlycoRNAs: more than the intersection of glycobiology and RNA biology.

Life medicine Pub Date : 2024-12-12 eCollection Date: 2024-10-01 DOI: 10.1093/lifemedi/lnae044

Haidong Li, Ruijin Zhang, Runsheng Chen, Jianjun Luo

引用次数: 0

DDO1002, an NRF2-KEAP1 inhibitor, improves hematopoietic stem cell aging and stress response.

Life medicine Pub Date : 2024-12-12 eCollection Date: 2024-12-01 DOI: 10.1093/lifemedi/lnae043

Yuwen Li, Aiwei Wu, Xinrong Jin, Haiping Shen, Chenyan Zhao, Xiao Yi, Hui Nie, Mingwei Wang, Shouchun Yin, Hongna Zuo, Zhenyu Ju, Zhenyu Jiang, Hu Wang

{"title":"DDO1002, an NRF2-KEAP1 inhibitor, improves hematopoietic stem cell aging and stress response.","authors":"Yuwen Li, Aiwei Wu, Xinrong Jin, Haiping Shen, Chenyan Zhao, Xiao Yi, Hui Nie, Mingwei Wang, Shouchun Yin, Hongna Zuo, Zhenyu Ju, Zhenyu Jiang, Hu Wang","doi":"10.1093/lifemedi/lnae043","DOIUrl":"10.1093/lifemedi/lnae043","url":null,"abstract":"Oxidative stress diminishes the functionality of hematopoietic stem cells (HSCs) as age advances, with heightened reactive oxygen species (ROS) levels exacerbating DNA damage, cellular senescence, and hematopoietic impairment. DDO1002, a potent inhibitor of the NRF2-KEAP1 pathway, modulates the expression of antioxidant genes. Yet, the extent to which it mitigates hematopoietic decline post-total body irradiation (TBI) or in the context of aging remains to be elucidated. Our study has elucidated the role of DDO1002 in modulating NRF2 activity, which, in turn, activates the NRF2-driven antioxidant response element (ARE) signaling cascade. This activation can diminish intracellular levels of ROS, thereby attenuating cellular senescence. In addition, DDO1002 has been demonstrated to ameliorate DNA damage and avert HSC apoptosis, underscoring its potential to mitigate hematopoietic injury precipitated by TBI. Competitive transplantation assay revealed that the administration of DDO1002 can improve the reconstitution and self-renewal capacity of HSCs in aged mice. Single-cell sequencing analysis elucidated that DDO1002 treatment attenuated intracellular inflammatory signaling pathways and mitigated ROS pathway in aged HSCs, suggesting its potential to restore the viability of these cells. Consequently, DDO1002 effectively activated the NRF2-ARE pathway, delaying cellular senescence and ameliorating impaired hematopoiesis, thereby demonstrating its potential as a therapeutic agent for age-related hematopoietic disorders.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"3 6","pages":"lnae043"},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic orchestration of drug-tolerant persister cells in cancer.

Life medicine Pub Date : 2024-12-07 eCollection Date: 2024-12-01 DOI: 10.1093/lifemedi/lnae040

Meng Nie, Zeping Hu

引用次数: 0

Targeted delivery of a cationic dendrimer with a plaque-homing peptide for the treatment of atherosclerosis.

Life medicine Pub Date : 2024-11-25 eCollection Date: 2024-12-01 DOI: 10.1093/lifemedi/lnae039

Tarik Zahr, Tianyu Li, Divya Bhansali, Qianfen Wan, Kam W Leong, Li Qiang

引用次数: 0