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A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium. 脂肪组织老化的生物标志物框架：老化生物标志物联盟的共识声明。
IF 6
Life medicine Pub Date : 2025-07-19 eCollection Date: 2025-10-01 DOI: 10.1093/lifemedi/lnaf027
Jian Yu, Yankang Zhang, Ting Zhang, Yan Bi, Yan Chen, Zheng Chen, Zhe Dai, Feifan Guo, Lixin Guo, Cheng Hu, Xiangqing Kong, Jian Li, Pingsheng Liu, Yong Liu, Jing Qu, Qiqun Tang, Congyi Wang, Liheng Wang, Jiqiu Wang, Jianping Weng, Aimin Xu, Lingyan Xu, Huijie Zhang, Jiajun Zhao, Jingjing Zhang, Weiqi Zhang, Tongjin Zhao, Weiping Zhang, Zhiming Zhu, Guang-Hui Liu, Guang Ning, Gang Pei, Li Qiang, Feng Liu, Xinran Ma
{"title":"A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium.","authors":"Jian Yu, Yankang Zhang, Ting Zhang, Yan Bi, Yan Chen, Zheng Chen, Zhe Dai, Feifan Guo, Lixin Guo, Cheng Hu, Xiangqing Kong, Jian Li, Pingsheng Liu, Yong Liu, Jing Qu, Qiqun Tang, Congyi Wang, Liheng Wang, Jiqiu Wang, Jianping Weng, Aimin Xu, Lingyan Xu, Huijie Zhang, Jiajun Zhao, Jingjing Zhang, Weiqi Zhang, Tongjin Zhao, Weiping Zhang, Zhiming Zhu, Guang-Hui Liu, Guang Ning, Gang Pei, Li Qiang, Feng Liu, Xinran Ma","doi":"10.1093/lifemedi/lnaf027","DOIUrl":"https://doi.org/10.1093/lifemedi/lnaf027","url":null,"abstract":"<p><p>Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue aging represents one of the pivotal initiating events for multi-organ senescence. To address these challenges, the Aging China Biomarkers Consortium (ABC) has established an expert consensus on biomarkers of adipose tissue aging by digesting literature and collecting insights from scientists and clinicians. This consensus provides a comprehensive evaluation of the key changes and characteristics, as well as biomarkers related to adipose tissue aging and proposes a systematic framework categorizing these biomarkers into functional, structural and humoral dimensions. Within each dimension, the ABC recommends clinically and empirically validated biomarkers and parameters for assessing both physiological and pathological changes in adipose tissue during aging, which aims to establish a foundation for future prediction, diagnosis, early warning and treatment for adipose tissue aging and its related diseases, with the ultimate goal of improving adipose tissue health and promoting healthy aging in elderly populations both in China and worldwide.</p>","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 5","pages":"lnaf027"},"PeriodicalIF":6.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fat talks first: how adipose tissue sets the pace of aging? 脂肪先说话：脂肪组织如何决定衰老的速度？
IF 6
Life medicine Pub Date : 2025-07-19 eCollection Date: 2025-10-01 DOI: 10.1093/lifemedi/lnaf028
Juanhong Liu, Qinlei Huang, Feng Liu
{"title":"Fat talks first: how adipose tissue sets the pace of aging?","authors":"Juanhong Liu, Qinlei Huang, Feng Liu","doi":"10.1093/lifemedi/lnaf028","DOIUrl":"https://doi.org/10.1093/lifemedi/lnaf028","url":null,"abstract":"<p><p>Once viewed primarily as an energy reservoir, adipose tissue (AT) is now recognized as a key endocrinal organ in regulating systemic aging. With age, AT undergoes significant remodeling, marked by altered fat distribution, visceral fat expansion, impaired thermogenesis, and chronic low-grade inflammation, which disrupts metabolic and immune homeostasis. Emerging insights from single-cell and spatial transcriptomics highlight the critical roles of adipose progenitors, immune cells, and senescent cells in driving local dysfunction and systemic decline. Through inflammatory and metabolic signaling, dysfunctional AT actively contributes to age-related pathologies. This review explores how AT functions as both an early sensor and driver of aging and discusses therapeutic opportunities targeting adipose dysfunction to promote healthy aging.</p>","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 5","pages":"lnaf028"},"PeriodicalIF":6.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Life lies in movement. 生命在于运动。
IF 6
Life medicine Pub Date : 2025-07-02 eCollection Date: 2025-10-01 DOI: 10.1093/lifemedi/lnaf024
Junzhu Yi, Yuanyuan Du
{"title":"Life lies in movement.","authors":"Junzhu Yi, Yuanyuan Du","doi":"10.1093/lifemedi/lnaf024","DOIUrl":"https://doi.org/10.1093/lifemedi/lnaf024","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 5","pages":"lnaf024"},"PeriodicalIF":6.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium. 视觉系统老化的生物标志物框架：老化生物标志物联盟的共识声明。
IF 6
Life medicine Pub Date : 2025-06-28 eCollection Date: 2025-08-01 DOI: 10.1093/lifemedi/lnaf023
Chao Ma, Boxin Geng, Yangqing Zhang, Shan Li, Ruiyang Li, Wenben Chen, Si Wang, Weiqi Zhang, Jing Qu, Yun Feng, Qingfeng Liang, Kangxin Jin, Yonghao Gu, Wenru Su, Xuxiang Zhang, Wenjuan Zhuang, Jihong Wu, Zhaoyang Wang, Shengping Hou, Jiaxu Hong, Honghua Yu, Biao Yan, Mingguang He, Fan Lv, Guang-Hui Liu, Gang Pei, Qingjiong Zhang, Tian Xue, Zi-Bing Jin
{"title":"A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium.","authors":"Chao Ma, Boxin Geng, Yangqing Zhang, Shan Li, Ruiyang Li, Wenben Chen, Si Wang, Weiqi Zhang, Jing Qu, Yun Feng, Qingfeng Liang, Kangxin Jin, Yonghao Gu, Wenru Su, Xuxiang Zhang, Wenjuan Zhuang, Jihong Wu, Zhaoyang Wang, Shengping Hou, Jiaxu Hong, Honghua Yu, Biao Yan, Mingguang He, Fan Lv, Guang-Hui Liu, Gang Pei, Qingjiong Zhang, Tian Xue, Zi-Bing Jin","doi":"10.1093/lifemedi/lnaf023","DOIUrl":"10.1093/lifemedi/lnaf023","url":null,"abstract":"<p><p>The visual system is essential for human perception, converting light signals into electrical impulses and transmitting them to the brain to process environmental information. As individuals age, their physiological functions gradually decline, leading to age-related vision impairment that significantly impacts the quality of life in elderly individuals. China is home to the world's largest aging population and faces significant challenges in combating visual system aging through effective treatments and interventions. In response to this challenge, the Aging Biomarker Consortium (ABC) of China has developed a consensus statement on biomarkers of visual system aging by integrating cutting-edge global research and synthesizing evidence-based medicine with clinical expertise. This consensus provides a multi-dimensional evaluation framework encompassing functional, morphological, and molecular biomarkers. Validated biomarkers for each domain are recommended not only to facilitate the early detection of vision changes but also to provide insights into the progression of age-related ocular diseases. By advancing this initiative, ABC aims to revolutionize visual health management in aging societies, ultimately improving outcomes for elderly populations in China and globally.</p>","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 4","pages":"lnaf023"},"PeriodicalIF":6.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Whole-process 3D ECM-encapsulated organoid-based automated high-throughput screening platform accelerates drug discovery for rare diseases. 全流程3D ecm封装类器官自动化高通量筛选平台加速罕见疾病药物的发现。
IF 6
Life medicine Pub Date : 2025-06-14 eCollection Date: 2025-10-01 DOI: 10.1093/lifemedi/lnaf021
Zhaoting Xu, Hui Yang, Yuru Zhou, Emmanuel Enoch Dzakah, Bing Zhao
{"title":"Whole-process 3D ECM-encapsulated organoid-based automated high-throughput screening platform accelerates drug discovery for rare diseases.","authors":"Zhaoting Xu, Hui Yang, Yuru Zhou, Emmanuel Enoch Dzakah, Bing Zhao","doi":"10.1093/lifemedi/lnaf021","DOIUrl":"https://doi.org/10.1093/lifemedi/lnaf021","url":null,"abstract":"<p><p>Organoid-based high-throughput screening (HTS) is revolutionizing pharmaceutical development. However, the complexity of handling extracellular matrix (ECM) components with traditional HTS devices leads to the use of suspension cultures for organoids during HTS, which alters their transcriptomic landscape and drug responses. Although automated generation techniques for 3D ECM-encapsulated organoids have been established, limitations in operational simplicity and time efficiency remain barriers to achieving high throughput. Here, we develop a whole-process 3D ECM-encapsulated organoid-based automated HTS (wp3D-OAHTS) platform, which achieves superior throughput compared to existing reported systems for 3D organoid drug screening. Utilizing this automated platform, we generated more than 10,000 homogeneous 3D organoid domes of neuroendocrine cervical cancer (NECC) and evaluated their drug responses to 2802 compounds in 13 days. This highly efficient and reproducible approach finally enabled the identification of 5 top hits that significantly inhibited NECC organoids <i>in vitro</i> with half-maximal inhibitory concentration (IC<sub>50</sub>) of lower than 10 nM. The representative candidate, Quisinostat 2HCl, demonstrated significantly stronger anti-tumor efficacy than clinically used agents <i>in vivo</i>. This platform significantly improves the rapidity and efficiency of 3D ECM-encapsulated organoid drug screening and facilitates new drug discovery for rare diseases.</p>","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 5","pages":"lnaf021"},"PeriodicalIF":6.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lysozyme alleviates DSS-induced colitis by modulating pro-inflammatory factors and NF-κB activation. 溶菌酶通过调节促炎因子和NF-κB活化减轻dss诱导的结肠炎。
IF 6
Life medicine Pub Date : 2025-06-14 eCollection Date: 2025-10-01 DOI: 10.1093/lifemedi/lnaf020
Kai Wang, Lan Guo, Ting Wang, Fengmin Shi, Meihong Fu, Guojun Li, Songli Pan, Xianying Cao, Huanxiong Chen
{"title":"Lysozyme alleviates DSS-induced colitis by modulating pro-inflammatory factors and NF-κB activation.","authors":"Kai Wang, Lan Guo, Ting Wang, Fengmin Shi, Meihong Fu, Guojun Li, Songli Pan, Xianying Cao, Huanxiong Chen","doi":"10.1093/lifemedi/lnaf020","DOIUrl":"10.1093/lifemedi/lnaf020","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 5","pages":"lnaf020"},"PeriodicalIF":6.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial sirtuins, key regulators of aging. 线粒体sirtuins，衰老的关键调节器。
IF 6
Life medicine Pub Date : 2025-06-09 eCollection Date: 2025-08-01 DOI: 10.1093/lifemedi/lnaf019
Zhejun Ji, Guang-Hui Liu, Jing Qu
{"title":"Mitochondrial sirtuins, key regulators of aging.","authors":"Zhejun Ji, Guang-Hui Liu, Jing Qu","doi":"10.1093/lifemedi/lnaf019","DOIUrl":"10.1093/lifemedi/lnaf019","url":null,"abstract":"<p><p>Mitochondrial dysfunction is a hallmark of aging, characterized by a decline in mitochondrial biogenesis and quality control, compromised membrane integrity, elevated ROS production, damaged mitochondrial DNA (mtDNA), impaired mitochondrial-nuclear crosstalk, and deregulated metabolic balance. Among the key longevity regulators, sirtuin family members SIRT3, SIRT4, and SIRT5 are predominantly localized to mitochondria and play crucial roles in maintaining mitochondrial function and homeostasis. This review explores how mitochondrial sirtuins mitigate aging-related mitochondrial dysfunctions and their broader implications in aging-related diseases. By elucidating the intricate interplay between mitochondrial dysfunction and mitochondrial sirtuins, we aim to provide insights into therapeutic strategies for promoting healthy aging and combating age-related pathologies.</p>","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 4","pages":"lnaf019"},"PeriodicalIF":6.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of deferasirox as a human xanthine oxidase inhibitor. 去铁苷作为人黄嘌呤氧化酶抑制剂的鉴定。
Life medicine Pub Date : 2025-03-31 eCollection Date: 2025-04-01 DOI: 10.1093/lifemedi/lnaf014
Yunfei Qi, Xinheng He, Xiaoshan Wu, Tingting Zhou, Ningning Liang, Jiazheng Jiao, Yanhao Chen, Yue Yuan, Yuwei Zhang, Yucheng Wang, Yan Liu, Qiurong Ding
{"title":"Identification of deferasirox as a human xanthine oxidase inhibitor.","authors":"Yunfei Qi, Xinheng He, Xiaoshan Wu, Tingting Zhou, Ningning Liang, Jiazheng Jiao, Yanhao Chen, Yue Yuan, Yuwei Zhang, Yucheng Wang, Yan Liu, Qiurong Ding","doi":"10.1093/lifemedi/lnaf014","DOIUrl":"https://doi.org/10.1093/lifemedi/lnaf014","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 2","pages":"lnaf014"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement. 听觉系统老化的生物标志物框架：老化生物标志物联盟共识声明。
Life medicine Pub Date : 2025-03-07 eCollection Date: 2025-02-01 DOI: 10.1093/lifemedi/lnaf011
Xiaolong Fu, Si Wang, Yunhao Wu, Yu Sun, Wenwen Liu, Xin Xi, Geng-Lin Li, Ke Liu, Wei Yuan, Fangyi Chen, Hongyang Wang, Tao Yang, Yuhe Liu, Jialin Zheng, Haibo Shi, Jing Qu, Xiaowei Chen, Limin Suo, Yideng Huang, Xinbo Xu, Xuxia Tang, Xiaojun Li, Lei Xu, Xia Gao, Lisheng Yu, Yilai Shu, Weiqi Zhang, Jinpeng Sun, Huijun Yuan, Shusheng Gong, Wenyan Li, Xiulan Ma, Dingjun Zha, Jiangang Gao, Huawei Li, Zuhong He, Guang-Hui Liu, Gang Pei, Weijia Kong, Haibo Wang, Renjie Chai
{"title":"A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement.","authors":"Xiaolong Fu, Si Wang, Yunhao Wu, Yu Sun, Wenwen Liu, Xin Xi, Geng-Lin Li, Ke Liu, Wei Yuan, Fangyi Chen, Hongyang Wang, Tao Yang, Yuhe Liu, Jialin Zheng, Haibo Shi, Jing Qu, Xiaowei Chen, Limin Suo, Yideng Huang, Xinbo Xu, Xuxia Tang, Xiaojun Li, Lei Xu, Xia Gao, Lisheng Yu, Yilai Shu, Weiqi Zhang, Jinpeng Sun, Huijun Yuan, Shusheng Gong, Wenyan Li, Xiulan Ma, Dingjun Zha, Jiangang Gao, Huawei Li, Zuhong He, Guang-Hui Liu, Gang Pei, Weijia Kong, Haibo Wang, Renjie Chai","doi":"10.1093/lifemedi/lnaf011","DOIUrl":"https://doi.org/10.1093/lifemedi/lnaf011","url":null,"abstract":"<p><p>Hearing is one of the most vital sensory functions in human beings and a crucial means of perceiving and acquiring information from the natural environment. The advancement of human society is closely linked to the development of language, with hearing serving as the foundation for verbal communication. As individuals age, the deterioration of the auditory system becomes a significant factor contributing to sensory impairments in the elderly. In addition to hearing loss, the aging of the auditory system is also associated with cognitive decline and psychosocial disorders, which severely impact the quality of life for older adults. Currently, there are no effective treatments or interventions available for addressing the aging of the auditory system. Therefore, identifying biomarkers of the auditory system aging is of great significance. The Aging Biomarker Consortium of China has conducted a comprehensive evaluation of aging biomarkers in the auditory system, focusing on three dimensions: morphological, functional, and humoral biomarkers. This initiative aims to establish a foundation for assessing the degree of aging in the auditory system and to promote the management of auditory health in an aging society, ultimately enhancing the auditory health of the elderly population both in China and globally.</p>","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 1","pages":"lnaf011"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development. 肠道类器官的进展和应用：模拟肠道疾病和治疗发展。
Life medicine Pub Date : 2025-03-07 eCollection Date: 2025-04-01 DOI: 10.1093/lifemedi/lnaf012
Xiaoting Xu, Yuping Zhang, Guoxin Huang, Ansu Perekatt, Yan Wang, Lei Chen
{"title":"Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development.","authors":"Xiaoting Xu, Yuping Zhang, Guoxin Huang, Ansu Perekatt, Yan Wang, Lei Chen","doi":"10.1093/lifemedi/lnaf012","DOIUrl":"https://doi.org/10.1093/lifemedi/lnaf012","url":null,"abstract":"<p><p>Gut organoids are 3D cellular structures derived from adult or pluripotent stem cells, capable of closely replicating the physiological properties of the gut. These organoids serve as powerful tools for studying gut development and modeling the pathogenesis of intestinal diseases. This review provides an in-depth exploration of technological advancements and applications of gut organoids, with a focus on their construction methods. Additionally, the potential applications of gut organoids in disease modeling, microenvironmental simulation, and personalized medicine are summarized. This review aims to offer perspectives and directions for understanding the mechanisms of intestinal health and disease as well as for developing innovative therapeutic strategies.</p>","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 2","pages":"lnaf012"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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