Life medicine最新文献

Correction to 8 papers to correct the volume number. 更正至8篇论文，更正卷号。

IF 7.7

Life medicine Pub Date : 2026-09-30 eCollection Date: 2026-10-01 DOI: 10.1093/lifemedi/lnag031

引用次数: 0

Conserved NCoR1 decline underlies small intestinal aging.

IF 7.7

Life medicine Pub Date : 2026-09-22 eCollection Date: 2026-10-01 DOI: 10.1093/lifemedi/lnag035

Yunuo Mao, Huili Hu

引用次数: 0

Combined organ xenotransplantation: from graft function to cross-species homeostasis. 异种联合器官移植：从移植物功能到跨物种体内平衡。

IF 7.7

Life medicine Pub Date : 2026-09-21 eCollection Date: 2026-10-01 DOI: 10.1093/lifemedi/lnag034

Kai Xing, Yuqi An, Yicheng Ling, Xiao Chen, Jiangping Song

引用次数: 0

Brain region-specific lesions in the early AIDS monkey model.

IF 7.7

Life medicine Pub Date : 2026-09-16 eCollection Date: 2026-10-01 DOI: 10.1093/lifemedi/lnag033

Tian-Zhang Song, Yan Hu, Shi-Zhe Wang, Huan-Zhi Chen, Bei-Bei Tang, Jin-Nan Li, Qing Li, Rong-Yao Huang, Li-Rong Zhang, Lin Xu, Yong-Tang Zheng

{"title":"Brain region-specific lesions in the early AIDS monkey model.","authors":"Tian-Zhang Song, Yan Hu, Shi-Zhe Wang, Huan-Zhi Chen, Bei-Bei Tang, Jin-Nan Li, Qing Li, Rong-Yao Huang, Li-Rong Zhang, Lin Xu, Yong-Tang Zheng","doi":"10.1093/lifemedi/lnag033","DOIUrl":"https://doi.org/10.1093/lifemedi/lnag033","url":null,"abstract":"Brain lesions show pronounced regional heterogeneity during chronic or advanced human immunodeficiency virus (HIV) infection; however, the regional neuropathogenesis during the acute phase remains unclear. By establishing an acute simian immunodeficiency virus (SIV)-infection model in rhesus macaques, we found acute infection-induced robust neuroinflammation and neuronal damage. Compared with the cerebral cortex, subcortical nuclei displayed earlier and more severe neuronal degeneration and loss of Nissl bodies, accompanied by greater upregulation of immune-related genes. Although SIV RNA loads in cerebrospinal fluid (CSF) and plasma were strongly correlated and peaked during acute infection, brain tissues showed no evidence of early viral reservoir establishment. The viral transactivator Tat persisted in CSF and was broadly distributed throughout the brain via passive diffusion along perivascular spaces. Similar transcriptional and inflammatory profiles were observed between macaques with acute infection and mice receiving intracisternal Tat infusions identified Tat as a principal mediator of early SIV-induced neurotoxicity. Microglia in a primed immune-vigilant state exhibited considerable enrichment in subcortical nuclei, driving exaggerated responses to Tat exposure and resulting in region-specific neuropathological outcomes. Collectively, these findings delineate the spatiotemporal landscape of acute HIV/SIV-induced brain injury and establish viral Tat as a mechanistic driver of acute neuropathogenesis.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"5 5","pages":"lnag033"},"PeriodicalIF":7.7,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13694104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149278209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bile acids as a "new hormone" in aging-related liver disease. 胆汁酸作为老年性肝病的“新激素”。

IF 7.7

Life medicine Pub Date : 2026-08-07 eCollection Date: 2026-10-01 DOI: 10.1093/lifemedi/lnag030

Buyu Deng, Xingjian Li, Yue Li, Longchuan Han, Zhihui Zou, Yingting Zhang, Jing Luo, Xinxin Tang, Hui Kong, Chenxi Shi, Ying Huang, Hanzhi Luo, Yinkun Fu, Ming He

{"title":"Bile acids as a \"new hormone\" in aging-related liver disease.","authors":"Buyu Deng, Xingjian Li, Yue Li, Longchuan Han, Zhihui Zou, Yingting Zhang, Jing Luo, Xinxin Tang, Hui Kong, Chenxi Shi, Ying Huang, Hanzhi Luo, Yinkun Fu, Ming He","doi":"10.1093/lifemedi/lnag030","DOIUrl":"10.1093/lifemedi/lnag030","url":null,"abstract":"Bile acids (BAs) have evolved from their classical definition as digestive surfactants to be recognized as potent endocrine signaling molecules that orchestrate systemic metabolism. Through activation of nuclear receptors, such as farnesoid X receptor (FXR), and membrane receptors, such as G protein-coupled BA receptor 1 (GPBAR1/TGR5), BAs regulate glucose, lipid, immune, and energy homeostasis. Aging reshapes BA synthesis, enterohepatic circulation, hydrophobicity, microbial biotransformation, and receptor responsiveness, thereby linking BA metabolism to hepatic senescence, inflammaging, and age-associated liver vulnerability. In turn, dysregulated BA signaling can amplify mitochondrial stress, endoplasmic reticulum stress, impaired autophagy, immune dysfunction, and senescence-associated secretory phenotypes, suggesting a bidirectional relationship between BA remodeling and aging progression. This review critically examines the role of BAs as hormone-like mediators within the aging liver microenvironment, summarizes major BA species and receptor preferences, integrates gut microbiota-BA crosstalk, and evaluates the therapeutic potential and caveats of targeting the BA-FXR-TGR5 axis in aging-related liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-associated liver disease (ALD), autoimmune liver diseases (AILD), chronic hepatitis B (CHB), and hepatocellular carcinoma (HCC).","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"5 5","pages":"lnag030"},"PeriodicalIF":7.7,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic disorders and osteoarthritis: novel insights into pathological mechanisms and therapeutic strategies. 代谢紊乱和骨关节炎：病理机制和治疗策略的新见解。

IF 7.7

Life medicine Pub Date : 2026-07-15 eCollection Date: 2026-08-01 DOI: 10.1093/lifemedi/lnag029

Chunchun Xue, Wenyun Kui, Xiaofeng Li, Lingxing Li, Lilong Song, Dong Mao, John R Speakman, Ling Qin, Liping Tong, Di Chen

引用次数: 0

A framework of biomarkers for renal aging: a consensus statement by the Aging Biomarker Consortium. 肾脏衰老的生物标志物框架：衰老生物标志物联盟的共识声明。

IF 7.7

Life medicine Pub Date : 2026-07-13 eCollection Date: 2026-08-01 DOI: 10.1093/lifemedi/lnag026

Aging Biomarker Consortium, Xiaoyan Zhang, Anqun Chen, Linli Lv, Liang Ma, Yan Zheng, Beibei Ma, Ziying Zhong, Yaobin Jing, Aiming Qiu, Yunxia Shao, Weiqi Zhang, Jun Cen, Lili Zhou, Wei Chen, Chun Zhang, Jian Li, Jing Chen, Baoxue Yang, Youhua Liu, Jing Qu, Fan Yi, Jinghong Zhao, Bi-Cheng Liu, Xiong Zhong Ruan, Limin Lu, Feng Zheng, Guang-Hui Liu, Gang Pei, Jing Nie, Youfei Guan

{"title":"A framework of biomarkers for renal aging: a consensus statement by the Aging Biomarker Consortium.","authors":"Aging Biomarker Consortium, Xiaoyan Zhang, Anqun Chen, Linli Lv, Liang Ma, Yan Zheng, Beibei Ma, Ziying Zhong, Yaobin Jing, Aiming Qiu, Yunxia Shao, Weiqi Zhang, Jun Cen, Lili Zhou, Wei Chen, Chun Zhang, Jian Li, Jing Chen, Baoxue Yang, Youhua Liu, Jing Qu, Fan Yi, Jinghong Zhao, Bi-Cheng Liu, Xiong Zhong Ruan, Limin Lu, Feng Zheng, Guang-Hui Liu, Gang Pei, Jing Nie, Youfei Guan","doi":"10.1093/lifemedi/lnag026","DOIUrl":"10.1093/lifemedi/lnag026","url":null,"abstract":"Renal aging involves structural and functional kidney decline (reduced size/nephrons, glomerulosclerosis, tubular atrophy, functional loss) and is an independent risk factor for kidney and systemic degenerative diseases. On 16 May 2025, the Aging Biomarker Consortium convened an expert consensus meeting in Shanghai, proposing a multidimensional biomarker framework: functional (estimated glomerular filtration rate, renal blood flow), structural (renal volume loss), and humoral (Klotho, N-terminal Pro-B-type natriuretic peptide, senescence-associated secretory phenotype factors). The consensus also supports machine-learning models for biological age assessment and calls for multi-center cohorts and translational collaboration to improve elderly kidney health.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"5 4","pages":"lnag026"},"PeriodicalIF":7.7,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13521335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-species metabolic profiling of follicular compartments in obesity. 肥胖患者滤泡室的跨物种代谢分析。

IF 7.7

Life medicine Pub Date : 2026-07-11 eCollection Date: 2026-08-01 DOI: 10.1093/lifemedi/lnag028

Yiqiu Wu, Shiyu Xie, Mengyuan Zhu, Yu Tian, Hengjie Wang, Shoubin Tang, Minjian Chen, Qiang Wang, Longsen Han, Shuai Zhu

{"title":"Cross-species metabolic profiling of follicular compartments in obesity.","authors":"Yiqiu Wu, Shiyu Xie, Mengyuan Zhu, Yu Tian, Hengjie Wang, Shoubin Tang, Minjian Chen, Qiang Wang, Longsen Han, Shuai Zhu","doi":"10.1093/lifemedi/lnag028","DOIUrl":"10.1093/lifemedi/lnag028","url":null,"abstract":"Impaired fertility in obese women is closely associated with disruptions in follicular microenvironment homeostasis. However, the underlying metabolic signatures remain poorly characterized. In this study, we employed a high-fat diet induced obese mouse model and conducted comparative metabolomic analyses of granulosa cells, follicular fluid, and serum from obese mice and women. Our results revealed prevalent metabolic disturbances across species, including dysregulated amino acid metabolism, suppressed steroidogenesis, and impaired fatty acid β-oxidation. Notably, ceramide accumulation in granulosa cells and follicular fluid suggested an insulin-resistant follicular microenvironment. These findings indicate obesity-induced metabolic reprogramming in the follicular niche, highlighting conserved disruptions in energy metabolism and steroidogenic capacity. Overall, our data provide a metabolic framework to elucidate obesity-associated subfertility and suggest potential metabolic targets for diagnosing and treating reproductive disorders.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"5 4","pages":"lnag028"},"PeriodicalIF":7.7,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13503033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel framework for studying human aging: trophoblast stem cell-syncytiotrophoblast platform as a physiologically relevant and accelerated model of cellular aging. 研究人类衰老的新框架：滋养细胞干细胞-合胞滋养细胞平台作为细胞衰老的生理相关和加速模型。

IF 7.7

Life medicine Pub Date : 2026-07-11 eCollection Date: 2026-08-01 DOI: 10.1093/lifemedi/lnag027

Qingqing Zhang, Elison Po Wa Lee, Baicheng Lin, Timothy Theodore Ka Ki Tam, Zhen Feng, Pentao Liu

引用次数: 0

PLIN5-mediated lipid droplet-mitochondria contacts dysregulation underlies the increased susceptibility to acute kidney injury with aging. plin5介导的脂滴-线粒体接触失调是随着年龄增长急性肾损伤易感性增加的基础。

IF 7.7

Life medicine Pub Date : 2026-07-08 eCollection Date: 2026-08-01 DOI: 10.1093/lifemedi/lnag025

Siyang Wang, Jie Gao, Zhuo Li, Yue Xu, Guangyan Cai, Xiangmei Chen

引用次数: 0