Life medicine最新文献_第2页

DDIT3 deficiency ameliorates systemic lupus erythematosus by regulating B cell activation and differentiation. dddit3缺乏通过调节B细胞活化和分化改善系统性红斑狼疮。

Life medicine Pub Date : 2025-03-03 eCollection Date: 2025-02-01 DOI: 10.1093/lifemedi/lnaf009

Xin Dai, Jiali Yu, Yunfei Zhang, Zhiming Wang, Yunyan Dai, Ying Hu, Xiaocui Wang, Binbin Tian, Minhui Wu, Hao Chen, Ruigao Song, Dan Ma, Cong-Yi Wang, Dawei Ye, Ziliang Zheng, Liyun Zhang, Jing Luo, Yukai Jing

{"title":"DDIT3 deficiency ameliorates systemic lupus erythematosus by regulating B cell activation and differentiation.","authors":"Xin Dai, Jiali Yu, Yunfei Zhang, Zhiming Wang, Yunyan Dai, Ying Hu, Xiaocui Wang, Binbin Tian, Minhui Wu, Hao Chen, Ruigao Song, Dan Ma, Cong-Yi Wang, Dawei Ye, Ziliang Zheng, Liyun Zhang, Jing Luo, Yukai Jing","doi":"10.1093/lifemedi/lnaf009","DOIUrl":"10.1093/lifemedi/lnaf009","url":null,"abstract":"Systemic lupus erythematosus (SLE) is characterized by the overproduction of autoantibodies, and B cells are considered to be the primary cells involved in the development of SLE. Studies have shown that DNA damage responses play a role in B cell activity in SLE. However, the exact role of DNA damage-induced transcript 3 (DDIT3) in humoral immune response and SLE pathogenesis remains unknown. We observed increased expression of DDIT3 in B cells of SLE patients and this expression was positively correlated with disease activity. In DDIT3-knockout mice, we observed disturbances in B cell development and differentiation, inhibition of B cell activation, and BCR signaling. In addition, DDIT3 deficiency leads to a reduction in T-cell-dependent humoral immune responses. Mechanistically, we found that DDIT3 promotes the transcription and expression of Itgad, which enhances PI3K signaling and B cell activation. Finally, we found that DDIT3 deficiency attenuated lupus autoimmunity and reduced germinal center responses. In conclusion, our study reveals for the first time the role of DDIT3 in adaptive immune responses, especially in B cell homeostasis, B cell activation, BCR signaling, and B cell function. These findings provide a new potential target for therapeutic intervention in SLE.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 1","pages":"lnaf009"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Many are called but few are chosen-from multiple clonal origins to one winner. 许多被召唤，但很少被选中——从多个克隆起源到一个赢家。

Life medicine Pub Date : 2025-02-24 eCollection Date: 2025-02-01 DOI: 10.1093/lifemedi/lnaf008

Qihang Chen, Zihan Liu, Bingjie Chen

引用次数: 0

Linoleic acid improves rosacea through repairing mitochondrial damage in keratinocytes. 亚油酸通过修复角质形成细胞的线粒体损伤改善酒渣鼻。

Life medicine Pub Date : 2025-02-23 eCollection Date: 2025-04-01 DOI: 10.1093/lifemedi/lnaf005

Mei Wang, Wenqin Xiao, Tangxiele Liu, Yan Zhu, Mengting Chen, Zixin Tan, San Xu, Zhixiang Zhao, Fangfen Liu, Hongfu Xie, Xiang He, Zhili Deng, Ji Li

{"title":"Linoleic acid improves rosacea through repairing mitochondrial damage in keratinocytes.","authors":"Mei Wang, Wenqin Xiao, Tangxiele Liu, Yan Zhu, Mengting Chen, Zixin Tan, San Xu, Zhixiang Zhao, Fangfen Liu, Hongfu Xie, Xiang He, Zhili Deng, Ji Li","doi":"10.1093/lifemedi/lnaf005","DOIUrl":"10.1093/lifemedi/lnaf005","url":null,"abstract":"Rosacea, as a progressive and chronic inflammatory skin disease, lacks safe and effective treatment options. Our previous study reported metabolic disturbance in rosacea patients, containing abnormal lipid metabolism. Building on this, we characterized significant alterations in fatty acid metabolism among rosacea patients, with a notable increase in linoleic acid (LNA) levels. We further demonstrated that LNA prevents rosacea-like dermatitis in LL37-induced rosacea-like mouse model. Our evidence indicated that LNA hyperactivates PPARγ signaling in the epidermis, a phenomenon observed in both rosacea patients and mouse model. Inhibiting PPARγ rescued the effect of LNA in LL37-induced mice. Additionally, our in vivo and in vitro evidence strongly supported the presence of mitochondrial damage in the keratinocytes of rosacea. LNA stimulated PPARγ to reduce the reactive oxygen species production, increasing the generation of ATP and recovering mitochondrial membrane potential. Finally, through a prospective cohort study utilizing UK Biobank data and linkage disequilibrium score regression (LDSC) regression analysis, we further confirmed LNA levels are negatively related to the risk of rosacea, highlighting LNA as a promising therapeutic strategy for rosacea treatment.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 2","pages":"lnaf005"},"PeriodicalIF":0.0,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspectives on the essence and drivers of aging. 关于老龄化的本质和驱动因素的观点。

Life medicine Pub Date : 2025-02-22 eCollection Date: 2025-04-01 DOI: 10.1093/lifemedi/lnaf006

Haim Y Cohen, Vera Gorbunova, Steve Horvath, Brian K Kennedy, Wei Li, João Pedro de Magalhães, Andrei Seluanov, Moshi Song, Keiichiro Suzuki

引用次数: 0

A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium. 骨骼肌衰老的生物标志物框架：衰老生物标志物联盟的共识声明。

Life medicine Pub Date : 2025-01-26 eCollection Date: 2024-12-01 DOI: 10.1093/lifemedi/lnaf001

Ning Huang, Meiling Ge, Xiaolei Liu, Xu Tian, Pengbin Yin, Zhijun Bao, Feng Cao, Ng Shyh-Chang, Biao Dong, Lunzhi Dai, Zhenji Gan, Ping Hu, Jing Qu, Si Wang, Huating Wang, Qian Xiao, Rui Yue, Jirong Yue, Licheng Zhang, Yong Zhang, Hongbo Zhang, Weiqi Zhang, Guang-Hui Liu, Gang Pei, Yong Liu, Dahai Zhu, Birong Dong

{"title":"A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium.","authors":"Ning Huang, Meiling Ge, Xiaolei Liu, Xu Tian, Pengbin Yin, Zhijun Bao, Feng Cao, Ng Shyh-Chang, Biao Dong, Lunzhi Dai, Zhenji Gan, Ping Hu, Jing Qu, Si Wang, Huating Wang, Qian Xiao, Rui Yue, Jirong Yue, Licheng Zhang, Yong Zhang, Hongbo Zhang, Weiqi Zhang, Guang-Hui Liu, Gang Pei, Yong Liu, Dahai Zhu, Birong Dong","doi":"10.1093/lifemedi/lnaf001","DOIUrl":"10.1093/lifemedi/lnaf001","url":null,"abstract":"The skeletal muscle is an important organ for movement and metabolism in human body, and its physiological aging underlies the occurrence of muscle atrophy and sarcopenia. China has the largest aging population in the world and is facing a grand challenge with how to prevent and treat skeletal muscle aging-related diseases. To address this difficult problem, the Aging Biomarker Consortium (ABC) of China has reached an expert consensus on biomarkers of skeletal muscle aging by synthesizing literatures and insights from scientists and clinicians. This consensus attempts to provide a comprehensive assessment of biomarkers associated with skeletal muscle aging, and proposes a systematic framework to classify them into three dimensions: functional, structural, and humoral. Within each dimension, the experts recommend clinically relevant biomarkers for skeletal muscle aging. This consensus aims to lay the foundation for future research on skeletal muscle aging, facilitating precise prediction, diagnosis, and treatment of skeletal muscle aging and sarcopenia. It is anticipated to make significant contributions to healthy aging of skeletal muscle in the elderly population in China and around the world as well.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"3 6","pages":"lnaf001"},"PeriodicalIF":0.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11851484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence. 以细胞衰老为靶点，探讨卵巢衰老机制及治疗方法。

Life medicine Pub Date : 2025-01-23 eCollection Date: 2025-02-01 DOI: 10.1093/lifemedi/lnaf004

Weicheng Tang, Kaichen Wang, Yourong Feng, Kuan-Hao Tsui, Keshav K Singh, Michael B Stout, Shixuan Wang, Meng Wu

{"title":"Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence.","authors":"Weicheng Tang, Kaichen Wang, Yourong Feng, Kuan-Hao Tsui, Keshav K Singh, Michael B Stout, Shixuan Wang, Meng Wu","doi":"10.1093/lifemedi/lnaf004","DOIUrl":"10.1093/lifemedi/lnaf004","url":null,"abstract":"The ovary is a crucial gonadal organ that supports female reproductive and endocrine functions. Ovarian aging can result in decreased fertility and dysfunction across multiple organs. Research has demonstrated that cellular senescence in various cell types within the ovary can trigger a decline in ovarian function through distinct stress responses, resulting in ovarian aging. This review explores how cellular senescence may contribute to ovarian aging and reproductive failure. Additionally, we discuss the factors that cause ovarian cellular senescence, including the accumulation of advanced glycation end products, oxidative stress, mitochondrial dysfunction, DNA damage, telomere shortening, and exposure to chemotherapy. Furthermore, we discuss senescence in six distinct cell types, including oocytes, granulosa cells, ovarian theca cells, immune cells, ovarian surface epithelium, and ovarian endothelial cells, inside the ovary and explore their contribution to the accelerated ovarian aging. Lastly, we describe potential senotherapeutics for the treatment of ovarian aging and offer novel strategies for ovarian longevity.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 1","pages":"lnaf004"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the metabolic heterogeneity and commonality in senescent cells using systems modeling. 利用系统建模揭示衰老细胞的代谢异质性和共性。

Life medicine Pub Date : 2025-01-20 eCollection Date: 2025-04-01 DOI: 10.1093/lifemedi/lnaf003

Gong-Hua Li, Yu-Hong Li, Qin Yu, Qing-Qing Zhou, Run-Feng Zhang, Chong-Jun Weng, Ming-Xia Ge, Qing-Peng Kong

{"title":"Unraveling the metabolic heterogeneity and commonality in senescent cells using systems modeling.","authors":"Gong-Hua Li, Yu-Hong Li, Qin Yu, Qing-Qing Zhou, Run-Feng Zhang, Chong-Jun Weng, Ming-Xia Ge, Qing-Peng Kong","doi":"10.1093/lifemedi/lnaf003","DOIUrl":"https://doi.org/10.1093/lifemedi/lnaf003","url":null,"abstract":"Cellular senescence is a key contributor to aging and aging-related diseases, but its metabolic profiles are not well understood. Here, we performed a systematic analysis of the metabolic features of four types of cellular senescence (replication, irradiation, reactive oxygen species [ROS], and oncogene) in 12 cell lines using genome-wide metabolic modeling and meta-analysis. We discovered that replicative and ROS-induced senescence share a common metabolic signature, marked by decreased lipid metabolism and downregulated mevalonate pathway, while irradiation and oncogene-induced senescence exhibit more heterogeneity and divergence. Our genome-wide knockout simulations showed that enhancing the mevalonate pathway, by administrating mevalonate for instance, could reverse the metabolic alterations associated with senescence and human tissue aging, suggesting a potential anti-aging or lifespan-extending effect. Indeed, the experiment in Caenorhabditis elegans showed that administrating mevalonate significantly increased the lifespan. Our study provides a new insight into the metabolic landscape of cell senescence and identifies potential targets for anti-aging interventions.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 2","pages":"lnaf003"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pluripotent stem cell-based immunotherapy: advances in translational research, cell differentiation, and gene modifications. 基于多能干细胞的免疫治疗：在转化研究、细胞分化和基因修饰方面的进展。

Life medicine Pub Date : 2025-01-18 eCollection Date: 2025-02-01 DOI: 10.1093/lifemedi/lnaf002

Qi Lei, Hongkui Deng, Shicheng Sun

引用次数: 0

Single-cell RNA sequencing reveals the intercellular crosstalk and the regulatory landscape of stromal cells during the whole life of the mouse ovary. 单细胞RNA测序揭示了小鼠卵巢整个生命周期间质细胞的细胞间串扰和调控景观。

Life medicine Pub Date : 2024-12-28 eCollection Date: 2024-12-01 DOI: 10.1093/lifemedi/lnae041

Wan Jiang, Wenya Sun, Yue Peng, Hao Xu, Haonan Fan, Xin Jin, Yue Xiao, Yuxiang Wang, Pin Yang, Wenjie Shu, Jing Li

{"title":"Single-cell RNA sequencing reveals the intercellular crosstalk and the regulatory landscape of stromal cells during the whole life of the mouse ovary.","authors":"Wan Jiang, Wenya Sun, Yue Peng, Hao Xu, Haonan Fan, Xin Jin, Yue Xiao, Yuxiang Wang, Pin Yang, Wenjie Shu, Jing Li","doi":"10.1093/lifemedi/lnae041","DOIUrl":"10.1093/lifemedi/lnae041","url":null,"abstract":"The heterogeneity of ovarian mesenchymal/stromal cells has just been revealed in both mice and humans. However, it remains unclear about the cellular development trace and the intercellular communication network in the whole life of the ovary. In the study, we integrated ours and published single-cell RNA sequencing data from E11.5 (embryonic day 11.5) until M12 (12-month-old) ovaries to show the dynamics of somatic cells along the developmental timeline. The intercellular crosstalk among somatic cell types was depicted with collagen signaling pathway as the most outgoing signals from stromal cells. We identified mesenchymal progenitor cells (CD24+) as the origin of stromal cells. Although their numbers decreased significantly in adults, the cells served as the major signal sender until ovarian senescence. Moreover, the ovarian injury could activate these stem cells and induce stroma remodeling in the aged ovary. Thus, mesenchymal progenitor cells may represent a new strategy to delay ovarian aging in the future.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"3 6","pages":"lnae041"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal stem cells in intestinal homeostasis and colorectal tumorigenesis. 肠道干细胞在肠道稳态和结直肠肿瘤发生中的作用。

Life medicine Pub Date : 2024-12-25 eCollection Date: 2024-10-01 DOI: 10.1093/lifemedi/lnae042

Gaoli Shi, Yang Li, Haihong Shen, Qiankun He, Pingping Zhu

引用次数: 0