Life medicine最新文献_第3页

A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement 肝脏衰老生物标志物框架：衰老生物标志物联盟共识声明

Life medicine Pub Date : 2024-01-30 DOI: 10.1093/lifemedi/lnae004

Mengmeng Jiang, Zhuozhao Zheng, Xuan Wang, Yanhao Chen, Jing Qu, Qiurong Ding, Weiqi Zhang, You-Shuo Liu, Jichun Yang, Weiqing Tang, Yunlong Hou, Jinhan He, Lin Wang, Pengyu Huang, Lin-Chen Li, Zhiying He, Qiang Gao, Qian Lu, Lai Wei, Yan-Jiang Wang, Zhenyu Ju, Jian-Gao Fan, Xiong-zhong Ruan, Youfei Guan, Guanghui Liu, Gang Pei, Jian Li, Yunfang Wang

{"title":"A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement","authors":"Mengmeng Jiang, Zhuozhao Zheng, Xuan Wang, Yanhao Chen, Jing Qu, Qiurong Ding, Weiqi Zhang, You-Shuo Liu, Jichun Yang, Weiqing Tang, Yunlong Hou, Jinhan He, Lin Wang, Pengyu Huang, Lin-Chen Li, Zhiying He, Qiang Gao, Qian Lu, Lai Wei, Yan-Jiang Wang, Zhenyu Ju, Jian-Gao Fan, Xiong-zhong Ruan, Youfei Guan, Guanghui Liu, Gang Pei, Jian Li, Yunfang Wang","doi":"10.1093/lifemedi/lnae004","DOIUrl":"https://doi.org/10.1093/lifemedi/lnae004","url":null,"abstract":"\u0000 In human aging, liver aging per se increases susceptibility to liver diseases but also increases vulnerability of other organs given its central role in regulating metabolism. Total liver function tends to be well maintained in the healthy elderly, so liver aging generally difficult to identify early. In response to this critical challenge, the Aging Biomarker Consortium (ABC) of China has formulated an expert consensus on biomarkers of liver aging by synthesizing the latest scientific literature, comprising insights from both scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with liver aging and presents a systematic framework to characterize these into three dimensions: functional, structural, and humoral. For the functional domain, we highlight biomarkers associated with cholesterol metabolism and liver-related coagulation function. For the structural domain, we note that hepatic steatosis and liver blood flow can serve as measurable biomarkers for liver aging. Finally, in the humoral domain, we pinpoint hepatokines and enzymatic alterations worthy of attention. The aim of this expert consensus is to establish a foundation for assessing the extent of liver aging and identify early signs of liver aging-related diseases, thereby improving liver health and the healthy life expectancy of the elderly population.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140484030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling antiviral response in the liver using human pluripotent stem cell- derived macrophages 利用人体多能干细胞衍生的巨噬细胞模拟肝脏的抗病毒反应

Life medicine Pub Date : 2024-01-12 DOI: 10.1093/lifemedi/lnae001

Yaxuan Zhang, Xingwu Zhang, Fuyu Duan, Huimin Qiao, M. Gong, Hui Qiu, Xia Chen, Peiliang Wang, Yuan He, Qiang Ding, Jie Na

引用次数: 0

Migrasomes trigger innate immune activation and mediate transmission of senescence signals across human cells 移行体触发先天性免疫激活并介导衰老信号在人体细胞间的传递

Life medicine Pub Date : 2023-12-08 DOI: 10.1093/lifemedi/lnad050

Xiaoqian Liu, Haifeng Jiao, Baohu Zhang, Sheng Zhang, K. Yan, J. Qu, Weiqi Zhang, Li Yu, Guanghui Liu

{"title":"Migrasomes trigger innate immune activation and mediate transmission of senescence signals across human cells","authors":"Xiaoqian Liu, Haifeng Jiao, Baohu Zhang, Sheng Zhang, K. Yan, J. Qu, Weiqi Zhang, Li Yu, Guanghui Liu","doi":"10.1093/lifemedi/lnad050","DOIUrl":"https://doi.org/10.1093/lifemedi/lnad050","url":null,"abstract":"\u0000 Aging is a complex and heterogeneous process, raising important questions about how aging is differently impacted by underlying genetics and external factors. Recently, migrasomes, newly discovered organelles, have been discovered to play important roles in various physiological and pathological processes by facilitating cell-to-cell communication. Thus far, their involvement in cellular senescence and aging remains largely unexplored. In this study, we aimed to investigate how migrasomes impacts on cellular aging by leveraging multiple cellular senescence models, including replicatively senescent (RS), pathologically senescent and stress-induced senescent human mesenchymal stem cells (hMSCs), as well as RS human primary fibroblasts. In all cellular aging models, we detected an enhanced formation of migrasomes. Notably, migrasomes in senescent cells exhibited an accumulation of numerous aging hallmarks, such as dysfunctional mitochondria, endogenous retroviruses, and senescence-associated pro-inflammatory cytokines. Furthermore, we discovered that migrasomes derived from senescent cells can be taken up by young cells, thereby transferring aging signals and subsequently causing premature senescence phenotypes in recipient cells. Mechanistically, we found that treatment with migrasomes derived from senescent cells activated the innate immune response. Thus, our study sheds light on a pivotal role of migrasomes in mediating the contagiousness of aging.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"33 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138589115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive Bayesian analysis assessing the effectiveness of lymphocyte immunotherapy for recurrent spontaneous abortion 评估淋巴细胞免疫疗法对复发性自然流产疗效的贝叶斯综合分析

Life medicine Pub Date : 2023-12-08 DOI: 10.1093/lifemedi/lnad049

Rongzhou Chen, Haohan Xu, Yujia Hou, Hanghang Liu, Zheng Zheng, Shaohua Ma

{"title":"A comprehensive Bayesian analysis assessing the effectiveness of lymphocyte immunotherapy for recurrent spontaneous abortion","authors":"Rongzhou Chen, Haohan Xu, Yujia Hou, Hanghang Liu, Zheng Zheng, Shaohua Ma","doi":"10.1093/lifemedi/lnad049","DOIUrl":"https://doi.org/10.1093/lifemedi/lnad049","url":null,"abstract":"\u0000 Recurrent spontaneous abortion (RSA) affects 2%–5% of couples worldwide and remains a subject of debate regarding the effectiveness of lymphocyte immunotherapy (LIT) due to limited retrospective studies. We conducted a comprehensive Bayesian analysis to assess the impact of LIT on RSA. Using data from the Shenzhen Maternity and Child Healthcare Hospital (2001–2020, n = 2,316), a Bayesian generalized linear model with predictive projection feature selection was employed. Our analysis revealed a significant improvement in live birth rates for RSA patients undergoing LIT. Notably, LIT had a greater impact compared to the other 85 factors considered. To mitigate research bias, we conducted a Bayesian meta-analysis combining our dataset with 19 previously reported studies (1985–2021, n = 4,246). Additionally, we developed an empirical model highlighting the four key factors, they are LIT result, age, paternal blood type and anticardiolipin antibody. Younger age (19–27), paternal blood type B, and a positive anticardiolipin antibody (IgM) were associated with better therapeutic outcomes in LIT for RSA. These findings aid clinicians in identifying suitable candidates for LIT and improving treatment outcomes.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"44 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138588407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoxia-induced one-carbon metabolic reprogramming in glioma stem-like cells 缺氧诱导胶质瘤干样细胞的一碳代谢重编程

Life medicine Pub Date : 2023-11-23 DOI: 10.1093/lifemedi/lnad048

Xuan-Cheng He, Jian Wang, Min-Yang Shi, Chang-Mei Li, Zhao-Qian Teng

引用次数: 0

Generation of renal tubular organoids from adult SOX9+ kidney progenitor cells 利用成体 SOX9+肾脏祖细胞生成肾小管器质性组织

Life medicine Pub Date : 2023-11-23 DOI: 10.1093/lifemedi/lnad047

Dewei Zhou, Dandan Li, Hao Nie, Jun Duan, Sarah Liu, Yujia Wang, Wei Zuo

{"title":"Generation of renal tubular organoids from adult SOX9+ kidney progenitor cells","authors":"Dewei Zhou, Dandan Li, Hao Nie, Jun Duan, Sarah Liu, Yujia Wang, Wei Zuo","doi":"10.1093/lifemedi/lnad047","DOIUrl":"https://doi.org/10.1093/lifemedi/lnad047","url":null,"abstract":"The pathogenesis of several kidney diseases results in the eventual destruction of the renal tubular system, which can progress to end-stage renal disease. Previous studies have demonstrated the involvement of a population of SOX9-positive cells in kidney regeneration and repair process following kidney injury. However, the ability of these cells to autonomously generate kidney organoids has never been investigated. Here, we isolated SOX9+ kidney progenitor cells (KPCs) from both mice and humans, and tested their differentiation potential in vitro. The data showed that the human SOX9+ KPC could self-assembly into organoids with kidney-like morphology. We also used single-cell RNA sequencing to characterize the organoid cell populations, and identified four distinct types of renal tubular cells. Comparing to the induced pluripotent stem cell (iPSC)-derived kidney organoids, KPC demonstrated more tubular differentiation potential but failed to differentiate into glomerular cells. KPC-derived organoid formation involved expression of genes related to metanephric development and followed a similar mechanism to renal injury repair in acute kidney injury (AKI) patients. Altogether, our study provided a potentially useful approach to generate kidney tubular organoids for future application.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"45 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139245369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A framework of biomarkers for skeletal aging: a consensus statement by the Aging Biomarker Consortium 骨骼老化生物标志物框架：老化生物标志物联合会共识声明

Life medicine Pub Date : 2023-11-22 DOI: 10.1093/lifemedi/lnad045

Jinlong Suo, Yibo Gan, Yangli Xie, Shuqin Xu, Jianfang Wang, Di Chen, Lin Chen, Lianfu Deng, Shiqing Feng, Jingdong Jackie Han, Qing Jiang, Guanghua Lei, Peng Liu, Xianghang Luo, Xin Ma, Jing Qu, Chunli Song, P. Tang, Tingting Tang, Sijia Wang, Xiaochun Wei, Chengtie Wu, Guozhi Xiao, Liu Yang, Licheng Zhang, Weiqi Zhang, Zhenlin Zhang, Guanghui Liu, Changqing Zhang, Gang Pei, Jian Luo, Rui Yue, Weiguo Zou

{"title":"A framework of biomarkers for skeletal aging: a consensus statement by the Aging Biomarker Consortium","authors":"Jinlong Suo, Yibo Gan, Yangli Xie, Shuqin Xu, Jianfang Wang, Di Chen, Lin Chen, Lianfu Deng, Shiqing Feng, Jingdong Jackie Han, Qing Jiang, Guanghua Lei, Peng Liu, Xianghang Luo, Xin Ma, Jing Qu, Chunli Song, P. Tang, Tingting Tang, Sijia Wang, Xiaochun Wei, Chengtie Wu, Guozhi Xiao, Liu Yang, Licheng Zhang, Weiqi Zhang, Zhenlin Zhang, Guanghui Liu, Changqing Zhang, Gang Pei, Jian Luo, Rui Yue, Weiguo Zou","doi":"10.1093/lifemedi/lnad045","DOIUrl":"https://doi.org/10.1093/lifemedi/lnad045","url":null,"abstract":"The skeleton is an important structural and metabolic organ in human body, while aging is the physiological basis for degenerative skeletal diseases. China has the largest aging population in the world and faces great challenges in preventing and managing diseases related to skeletal aging. To address these challenges, the Aging China Biomarkers Consortium (ABC) has reached an expert consensus on biomarkers of skeletal aging by synthesizing the literature and insights from scientists and clinicians. The consensus provides a comprehensive assessment of biomarkers associated with skeletal aging and proposes a systematic framework that categorizes biomarkers into three dimensions, namely, functional, structural, and humoral dimensions. Within each dimension, the ABC recommended clinical and evidential research-based biomarkers for physiological aging and degenerative pathologies of the skeleton. This expert consensus aims to lay the foundation for future studies to assess the prediction, diagnosis, early warning and treatment of diseases associated with skeletal aging, with the ultimate goal of improving the skeletal health of elderly populations in China and around the world.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139247679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in robotic arm-based 3D bioprinting for biomedical applications 基于机械臂的三维生物打印技术在生物医学应用方面的进展

Life medicine Pub Date : 2023-11-21 DOI: 10.1093/lifemedi/lnad046

Kai Li, Wen Hui Huang, Hai Tao Guo, Yan Yan Liu, Shuxian Chen, Heng Liu, Qi Gu

引用次数: 0

Tmem88 plays an essential role in pharyngeal pouch progenitor specification by inhibiting Wnt/β-catenin signaling Tmem88通过抑制Wnt/β-catenin信号在咽袋祖细胞规格化过程中发挥重要作用

Life medicine Pub Date : 2023-11-17 DOI: 10.1093/lifemedi/lnad044

Jingwen Liu, Liping Yang, Zidong Lu, Qiang Wan

{"title":"Tmem88 plays an essential role in pharyngeal pouch progenitor specification by inhibiting Wnt/β-catenin signaling","authors":"Jingwen Liu, Liping Yang, Zidong Lu, Qiang Wan","doi":"10.1093/lifemedi/lnad044","DOIUrl":"https://doi.org/10.1093/lifemedi/lnad044","url":null,"abstract":"Pharyngeal pouches, which are endodermal outpockets that segment the pharyngeal arches, play a crucial role in the development of craniofacial skeletons in vertebrate embryos. Our previous study successfully identified pharyngeal pouch progenitors (PPPs) in zebrafish embryos and emphasized the significance of BMP2b signaling in their specification. However, the specific mechanism by which these progenitors originate from endodermal cells remains largely unknown. Here we found that the pharmacological activation of Wnt signaling pathway disrupts the emergence of PPPs and subsequently hinders the formation of pharyngeal pouches. Moreover, we have identified the expression of tmem88a and tmem88b (collectively known as tmem88a/b) in PPPs during the early-somite stages. Furthermore, the deficiency of tmem88a/b leads to an excessive accumulation of β-catenin in both the cytoplasm and nucleus of endodermal cells that are intended to differentiate into PPPs. Importantly, suppressing the hyperactivation of Wnt/β-catenin signaling through pharmacological treatment, the defects in PPP specification in tmem88a/b−/− mutants are successfully rescued. In summary, our findings establish a clear connection between the specification of PPPs and the regulation of Wnt signaling mediated by Tmem88. These results underscore the pivotal role of Tmem88 in the development of pharyngeal pouches.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"24 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139264028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secretagogin regulates asynchronous and spontaneous glutamate release in hippocampal neurons through interaction with Doc2α 分泌素通过与Doc2α的相互作用调节海马神经元的异步和自发谷氨酸释放

Life medicine Pub Date : 2023-11-14 DOI: 10.1093/lifemedi/lnad041

Yingfeng Tu, Jiao Qin, Qiao-Ming Zhang, Tie-Shan Tang, Lifang Wang, Jun Yao

引用次数: 0