Life medicine最新文献_第3页

The metabolic change trajectory of skeletal muscle during the life cycle: arteriovenous metabolomics. 骨骼肌在生命周期中的代谢变化轨迹：动静脉代谢组学。

IF 7.7

Life medicine Pub Date : 2026-04-27 eCollection Date: 2026-06-01 DOI: 10.1093/lifemedi/lnag014

Siyuan Huang, Yuanping Gu, Guogang Xu, Jing Han, Hao Jia, Yifan Wang, Xiao Chen, Ningning Zhang, Xiumeng Hua, Han Mo, Zhe Sun, Fei Dong, Yuan Chang, Hao Cui, Jiangping Song

引用次数: 0

Shared genetic architecture between obesity and psychiatric disorders reveals comorbid etiology and therapeutic targets. 肥胖和精神疾病之间共享的遗传结构揭示了共病的病因和治疗目标。

IF 7.7

Life medicine Pub Date : 2026-04-22 eCollection Date: 2026-06-01 DOI: 10.1093/lifemedi/lnag015

Dong Liu, Chun Dou, Chaojie Ye, Mingling Chen, Lijie Kong, Zheng Zhu, Jie Zheng, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Zhongshang Yuan, Guang Ning, Weiqing Wang, Yufang Bi, Tiange Wang

{"title":"Shared genetic architecture between obesity and psychiatric disorders reveals comorbid etiology and therapeutic targets.","authors":"Dong Liu, Chun Dou, Chaojie Ye, Mingling Chen, Lijie Kong, Zheng Zhu, Jie Zheng, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Zhongshang Yuan, Guang Ning, Weiqing Wang, Yufang Bi, Tiange Wang","doi":"10.1093/lifemedi/lnag015","DOIUrl":"10.1093/lifemedi/lnag015","url":null,"abstract":"Integrated genomic evidence on shared genetic architecture between obesity and psychiatric disorders remains limited. This work utilized multi-level genomic analytic approaches to identify pleiotropic loci, variants, and genes between 14 adiposity traits and 7 psychiatric disorders, including genetic correlation and bidirectional causality as well as gene expression, functional pathway, and druggability, using genome-wide association study data from up to 806,834 individuals of European descent. Based on 67 genetically correlated trait pairs established between the two groups, we identified 17 causal shared genes across 26 tissues, which were enriched in neurodevelopment, neuronal function, cellular transport, and developmental biology. Of these, NEGR1, CTNNB1, TAOK2, and RTN4RL1 were located in the druggable genome, and CTNNB1 and NT5C2 were clinically actionable. Mendelian randomization further supported extensive bidirectional causal associations. These findings provide robust evidence for a shared genetic etiology between adiposity and psychiatric disorders, underscoring mechanistic links and prioritizing actionable targets for comorbidity intervention.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"5 3","pages":"lnag015"},"PeriodicalIF":7.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell analysis reveals essential lncRNAs regulating human trophoblast lineage differentiation. 单细胞分析揭示了调节人类滋养细胞谱系分化的重要lncrna。

IF 7.7

Life medicine Pub Date : 2026-04-17 eCollection Date: 2026-04-01 DOI: 10.1093/lifemedi/lnag010

Weiyi Zhang, Chunyan Le, Shanru Yi, Wenqiang Liu, Xiaoyu Liu, Zhen Yin, Hong Wang, Rui Gao, Shaorong Gao, Jiayu Chen

{"title":"Single-cell analysis reveals essential lncRNAs regulating human trophoblast lineage differentiation.","authors":"Weiyi Zhang, Chunyan Le, Shanru Yi, Wenqiang Liu, Xiaoyu Liu, Zhen Yin, Hong Wang, Rui Gao, Shaorong Gao, Jiayu Chen","doi":"10.1093/lifemedi/lnag010","DOIUrl":"10.1093/lifemedi/lnag010","url":null,"abstract":"The human placenta sustains pregnancy through intricate trophoblast lineage dynamics that are critical for fetal development and pregnancy success. While studies on protein-coding genes (PCGs) have advanced our understanding of placental biology, the regulatory roles of noncoding RNAs, particularly long noncoding RNAs (lncRNAs), in trophoblast lineage specification and function remain poorly understood. Here, we profile single-cell lncRNA dynamics across human placental development, revealing distinct cell-type- and gestational stage-specific expression profiles. Integrated analysis revealed that lncRNAs modulate histone modification levels at the regulatory regions of target genes via cis-action, thereby regulating the expression of key genes essential for trophoblast differentiation. Functional studies by using in vivo and in vitro models fully identify ECEL1P2-ALPP, SEMA3B-AS1-SEMA3B, and MYCNUT/MYCNOS-MYCN as pivotal regulatory axes driving cytotrophoblast self-renewal, syncytiotrophoblast fusion, and epithelial-mesenchymal transition, respectively, which are essential for trophoblast identity and function. Notably, dysregulation of lncRNA-PCG pairs in pathological pregnancies underscores the clinical relevance of these noncoding networks. Together, our findings uncover an unappreciated layer of lineage-specific noncoding regulation, providing mechanistic insight and potential biomarkers for placental development and associated disorders.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"5 2","pages":"lnag010"},"PeriodicalIF":7.7,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HDAC8-selective inhibitor PCI-34051 protects against aortic dissection by attenuating ferroptosis of vascular smooth muscle cells. hdac8选择性抑制剂PCI-34051通过减轻血管平滑肌细胞的铁下垂来防止主动脉夹层。

IF 7.7

Life medicine Pub Date : 2026-04-17 eCollection Date: 2026-06-01 DOI: 10.1093/lifemedi/lnag013

Jiannan Ye, Juan Shi, Xin Yi, Jingjie Chen, Yi He, Bo Huo, Hanshen Luo, Shibin Chen, Xiang Wei, Ding-Sheng Jiang, Ze-Min Fang

{"title":"HDAC8-selective inhibitor PCI-34051 protects against aortic dissection by attenuating ferroptosis of vascular smooth muscle cells.","authors":"Jiannan Ye, Juan Shi, Xin Yi, Jingjie Chen, Yi He, Bo Huo, Hanshen Luo, Shibin Chen, Xiang Wei, Ding-Sheng Jiang, Ze-Min Fang","doi":"10.1093/lifemedi/lnag013","DOIUrl":"10.1093/lifemedi/lnag013","url":null,"abstract":"Aortic dissection (AD) is a fatal emergency which lacks effective drug therapies. Previous studies demonstrated that histone deacetylase 8 (HDAC8) inhibition provides protective benefits in several cardiovascular diseases, including heart failure, fibrosis, and cardiac hypertrophy. However, the role of HDAC8 in AD remains unclear. In the present study, we investigated the function of PCI-34051, a highly selective inhibitor of HDAC8, in human aortic smooth muscle cell (HASMC) ferroptosis and β-aminopropionitrile (BAPN)-induced AD in mice. The results showed that PCI-34051 and HDAC8 knockdown significantly inhibited cystine deprivation (CD)- and imidazole ketone erastin (IKE)-induced HASMC ferroptosis, as evidenced by an increase in cell viability, reduction in cell injury/death, and lipid peroxidation levels in HASMCs. Transcriptome sequencing analysis revealed that the anti-ferroptosis effect of PCI-34051 was associated with the regulation of activator protein-1 (AP-1). Additionally, co-immunoprecipitation results showed that HDAC8 interacts with c-JUN, a component of AP-1. Overexpression of AP-1 (c-FOS and c-JUN) largely abolished the inhibitory effects of PCI-34051 on HASMC ferroptosis. More importantly, PCI-34051 reduced BAPN-induced AD incidence and aortic rupture mortality in mice by inhibiting HASMC ferroptosis and inflammatory response. Taken together, inhibition of HDAC8 by PCI-34051 may provide a preventive or therapeutic strategy for AD by attenuating HASMC ferroptosis.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"5 3","pages":"lnag013"},"PeriodicalIF":7.7,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural compounds of medicinal plants as a source for novel anti-orthopoxvirus medications. 药用植物天然化合物作为新型抗正痘病毒药物的来源。

IF 7.7

Life medicine Pub Date : 2026-04-09 eCollection Date: 2026-04-01 DOI: 10.1093/lifemedi/lnag009

Eman A Makhlouf, Riham A El-Shiekh, Mona M Okba, Hossam M Ashour

引用次数: 0

The immune effects of mesenchymal stem cell-based therapy in kidney diseases. 间充质干细胞治疗肾脏疾病的免疫效果。

IF 7.7

Life medicine Pub Date : 2026-04-07 eCollection Date: 2026-04-01 DOI: 10.1093/lifemedi/lnag008

Yachao Li, Kuai Ma, Junyi Ren, Haoyu Peng, Moussa Ide Nasser, Chi Liu

引用次数: 0

Macrophage-directed T cell recruitment augments IFN-Mediated suppression of cardiac reprogramming in vivo. 巨噬细胞定向T细胞募集增强体内ifn介导的心脏重编程抑制。

IF 7.7

Life medicine Pub Date : 2026-04-07 eCollection Date: 2026-02-01 DOI: 10.1093/lifemedi/lnag005

Yihong Cai, Hao Wang, Junbo Yang, Qianhe Li, Yuxiang Dai, Yang Zhao

引用次数: 0

Salivary volatilome profiling in pediatric eosinophilic esophagitis: a pilot study on a non-invasive approach in clinical practice. 儿童嗜酸性粒细胞性食管炎的唾液挥发物分析：一项临床实践中非侵入性方法的初步研究。

IF 7.7

Life medicine Pub Date : 2026-04-07 eCollection Date: 2026-04-01 DOI: 10.1093/lifemedi/lnag012

Rosamaria Capuano, Carla Petrella, Christian Barbato, Giulia D'Arcangelo, Giusy Russo, Alexandro Catini, Antonio Minni, Corrado Di Natale, Salvatore Oliva

{"title":"Salivary volatilome profiling in pediatric eosinophilic esophagitis: a pilot study on a non-invasive approach in clinical practice.","authors":"Rosamaria Capuano, Carla Petrella, Christian Barbato, Giulia D'Arcangelo, Giusy Russo, Alexandro Catini, Antonio Minni, Corrado Di Natale, Salvatore Oliva","doi":"10.1093/lifemedi/lnag012","DOIUrl":"10.1093/lifemedi/lnag012","url":null,"abstract":"Eosinophilic esophagitis (EoE) is a chronic immune disease requiring repeated endoscopies for diagnosis and monitoring in children. Saliva represents a promising non-invasive biofluid, and volatile organic compounds (VOCs) may indicate disease presence and activity. This study aimed to examine the VOCs profile in saliva samples from children with EoE and to compare it with other gastrointestinal (GI) conditions and healthy controls. Thirty-five samples from children with EoE (including 13 active and 22 non-active cases), 19 from children with other GI conditions, and 46 from healthy controls were analyzed. Gas chromatography-ion mobility spectrometry (GC-IMS) identified 63 distinct VOC signal areas. The abundance of 16 of them was found significantly different (P < 0.01) in EoE vs. controls, EoE vs. other GI conditions, and active vs. non-active EoE. Among them, cis-3-hexen-1-ol and 2-phenylethanol show a ubiquitous capability to discriminate EoE against different populations. Linear discriminant analysis (LDA) of the panel of 16 VOCs achieved 83.3% accuracy in classifying EoE vs. healthy controls, 81.2% accuracy in distinguishing EoE from GI controls, and 80.0% accuracy in classifying active vs. non-active EoE. Salivary VOC profiling enables accurate discrimination of pediatric EoE from controls and stratification by disease activity. This non-invasive approach holds promise as a diagnostic and monitoring tool in clinical practice, especially in children.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"5 2","pages":"lnag012"},"PeriodicalIF":7.7,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The multistep progression of areca nut-induced oral cancer: a mechanistic roadmap from pathogenesis to precision therapy. 槟榔诱发口腔癌的多步骤进展：从发病机制到精准治疗的机制路线图。

IF 7.7

Life medicine Pub Date : 2026-03-27 eCollection Date: 2026-04-01 DOI: 10.1093/lifemedi/lnag011

Na Yu, Wenqiu Cai, Congyi Zhang, Qiyue Cai, Zisong Zhang, Yuqing Hu, Yan Sun, Kaiyao Yin, Feng Ren, KangXin Chang, MeiLing Jin, Dongxia Li, Liwen Zhang, Heming Wu, Mengwei Li

{"title":"The multistep progression of areca nut-induced oral cancer: a mechanistic roadmap from pathogenesis to precision therapy.","authors":"Na Yu, Wenqiu Cai, Congyi Zhang, Qiyue Cai, Zisong Zhang, Yuqing Hu, Yan Sun, Kaiyao Yin, Feng Ren, KangXin Chang, MeiLing Jin, Dongxia Li, Liwen Zhang, Heming Wu, Mengwei Li","doi":"10.1093/lifemedi/lnag011","DOIUrl":"10.1093/lifemedi/lnag011","url":null,"abstract":"Areca nut is classified as a Group 1 carcinogen by the International Agency for Research on Cancer. It is a widely consumed psychoactive substance with profound cultural roots in regions including Hunan, Hainan, and Taiwan of China. Its key bioactive components include alkaloids (e.g. arecoline and arecaidine) and areca nut-specific nitrosamines, that induce DNA damage, reactive oxygen species bursts, and chronic inflammation in oral tissues. Coupled with mechanical trauma from chewing, these insults drive the malignant progression of oral submucous fibrosis to oral cavity carcinomas. This review systematically outlines the pathological progression from normal oral mucosa to invasive oral cavity carcinomas, highlighting two core mediators of oral submucous fibrosis carcinogenesis: immune microenvironment reprogramming and oncogenic signaling activation. Furthermore, this review elaborates the molecular mechanisms of areca nut-induced oral cancer, providing a theoretical foundation for biomarker discovery and the development of novel therapeutic strategies. It also provides actionable guidance for reducing the incidence of areca nut-related oral cavity carcinomas and improving patient prognosis.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"5 2","pages":"lnag011"},"PeriodicalIF":7.7,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histidine phosphorylation of NME1 regulates the Hippo pathway via the ARHGAP17-CDC42-cytoskeleton axis. NME1组氨酸磷酸化通过arhgap17 - cdc42 -细胞骨架轴调控Hippo通路。

IF 7.7

Life medicine Pub Date : 2026-03-12 eCollection Date: 2026-02-01 DOI: 10.1093/lifemedi/lnag002

Xian Liu, Zhongnan Chen, Jianxi Zhu, Shengcheng Deng, Zhifen Zhou, Wenbin Ma, Zhou Songyang

引用次数: 0