Life medicine最新文献_第4页

Follicular fluid-derived exosomes rejuvenate ovarian aging through miR-320a-3p-mediated FOXQ1 inhibition 卵泡液源性外泌体通过 miR-320a-3p 介导的 FOXQ1 抑制作用使卵巢衰老恢复活力

Life medicine Pub Date : 2024-03-25 DOI: 10.1093/lifemedi/lnae013

Yu Liu, Hongbei Mu, Yu Chen, Kexin Li, Q. Mei, Lingjuan Wang, Tianyu Tang, Qiuzi Shen, Huaibiao Li, Ling Zhang, Jing Li, W. Xiang

{"title":"Follicular fluid-derived exosomes rejuvenate ovarian aging through miR-320a-3p-mediated FOXQ1 inhibition","authors":"Yu Liu, Hongbei Mu, Yu Chen, Kexin Li, Q. Mei, Lingjuan Wang, Tianyu Tang, Qiuzi Shen, Huaibiao Li, Ling Zhang, Jing Li, W. Xiang","doi":"10.1093/lifemedi/lnae013","DOIUrl":"https://doi.org/10.1093/lifemedi/lnae013","url":null,"abstract":"\u0000 Ovarian aging is mainly characterized by a progressive decline in oocyte quantity and quality, which ultimately leads to female infertility. Various therapies have been established to cope with ovarian aging, among which exosome-based therapy is considered a promising strategy that can benefit ovarian functions via multiple pathways. Here, we isolated and characterized exosomes derived from ovarian follicular fluid and profiled the differential expression patterns of noncoding exosomal RNAs in young and aged women. Treatment with young mouse-derived exosomes efficiently rescued ovarian function in aged mice. The follicular fluid exosomes from young mice and miR-320-3p can also promote the proliferation of ovarian granulosa cells and improve mitochondrial function from old mice in vitro. Exosomes can increase the number of primordial and growing follicles, and improve the developmental ability of oocytes in the old mice in vivo. The mechanism may be involve that exosomes transfer miR-320-3p to granulosa cells, and inhibit the expression of FOXQ1. And hnRNPA2B1 controls miR-320-3p entry into exosomes. This work provides insights into the antiaging potential of follicular fluid-derived exosomes and the underlying molecular mechanisms, which may facilitate prevention of ovarian aging and an improvement in female fertility.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140384410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain organoids: from unguided to regionalized to nucleus-specific 脑器质性组织：从无引导到区域化再到特异性细胞核

Life medicine Pub Date : 2024-03-22 DOI: 10.1093/lifemedi/lnae014

Yangfei Xiang, In-Hyun Park

引用次数: 0

Monkey multi-organ cell atlas exposed to estrogen.

Life medicine Pub Date : 2024-03-22 eCollection Date: 2024-04-01 DOI: 10.1093/lifemedi/lnae012

Wen Fang, Jiao Qu, Wanjun Zhao, Xinran Cao, Jinran Liu, Quan Han, Dijun Chen, Wen Lv, Yicheng Xie, Yang Sun

{"title":"Monkey multi-organ cell atlas exposed to estrogen.","authors":"Wen Fang, Jiao Qu, Wanjun Zhao, Xinran Cao, Jinran Liu, Quan Han, Dijun Chen, Wen Lv, Yicheng Xie, Yang Sun","doi":"10.1093/lifemedi/lnae012","DOIUrl":"10.1093/lifemedi/lnae012","url":null,"abstract":"Awareness of estrogen's effects on health is broadening rapidly. The effects of long-term high levels of estrogen on the body involve multiple organs. Here, we used both single-cell chromatin accessibility and RNA sequencing data to analyze the potential effect of estrogen on major organs. The integrated cell map enabled in-depth dissection and comparison of molecular dynamics, cell-type compositions, and cellular heterogeneity across multiple tissues and organs under estrogen stimulation. We also inferred pseudotime cell trajectories and cell-cell communications to uncover key molecular signatures underlying their cellular processes in major organs in response to estrogen. For example, estrogen could induce the differentiation of IFIT3 + neutrophils into S100A9 + neutrophils involved in the function of endosome-to-lysosome transport and the multivesicular body sorting pathway in liver tissues. Furthermore, through integration with human genome-wide association study data, we further identified a subset of risk genes during disease development that were induced by estrogen, such as AKT1 (related to endometrial cancer), CCND1 (related to breast cancer), HSPH1 (related to colorectal cancer), and COVID-19 and asthma-related risk genes. Our work uncovers the impact of estrogen on the major organs, constitutes a useful resource, and reveals the contribution and mechanism of estrogen to related diseases.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"3 2","pages":"lnae012"},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracing TMEM106B fibril deposition in aging and Parkinson’s disease with dementia brains 追踪衰老和帕金森病痴呆大脑中的 TMEM106B 纤维沉积情况

Life medicine Pub Date : 2024-03-07 DOI: 10.1093/lifemedi/lnae011

Wanbing Zhao, Yun Fan, Qinyue Zhao, Zhen Fan, Jue Zhao, Wenbo Yu, Wensheng Li, Dan Li, Cong Liu, Jian Wang

{"title":"Tracing TMEM106B fibril deposition in aging and Parkinson’s disease with dementia brains","authors":"Wanbing Zhao, Yun Fan, Qinyue Zhao, Zhen Fan, Jue Zhao, Wenbo Yu, Wensheng Li, Dan Li, Cong Liu, Jian Wang","doi":"10.1093/lifemedi/lnae011","DOIUrl":"https://doi.org/10.1093/lifemedi/lnae011","url":null,"abstract":"\u0000 Transmembrane protein 106B (TMEM106B), previously identified as a risk factor in frontotemporal lobar degeneration, has recently been detected to form fibrillar aggregates in the brains of patients with various neurodegenerative diseases (NDs) and normal elders. While, the specifics of when and where TMEM106B fibrils accumulate in human brains, as well as their connection to aging and disease progression, remain poorly understood. Here, we identified an antibody (NBP1-91311) that directly binds to TMEM106B fibrils extracted from the brain in vitro and to Thioflavin S positive TMEM106B fibrillar aggregates in brain sections. We discovered that TMEM106B fibrils deposit in the human brain in an age-dependent manner. Notably, the TMEM106B fibril load in the brains of Parkinson’s disease with dementia patients was significantly higher than in age-matched elders. Additionally, we found that TMEM106B fibrils predominantly accumulate in astrocytes and neurons and do not co-localize with the pathological deposition formed by other amyloid proteins such as α-synuclein, Aβ, and Tau. Our work provides a comprehensive analysis of the burden and cellular distribution of TMEM106B fibrils in human brains, underscoring the impact of both aging and disease conditions on TMEM106B fibril deposition. This highlights the potential significance of TMEM106B fibrils in various age-related NDs.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteoporosis under psychological stress: mechanisms and therapeutics 心理压力下的骨质疏松症：机制与疗法

Life medicine Pub Date : 2024-03-07 DOI: 10.1093/lifemedi/lnae009

Hao-Kun Xu, Jie-Xi Liu, Ze-Kai Zhou, Chen-Xi Zheng, B. Sui, Yuan Yuan, Liang Kong, Yan Jin, Ji Chen

引用次数: 0

When synthetic biology meets medicine 当合成生物学遇上医学

Life medicine Pub Date : 2024-03-06 DOI: 10.1093/lifemedi/lnae010

Yuge Feng, Cong Su, Guobin Mao, Baoting Sun, Yizhi Cai, Junbiao Dai, Yingxin Ma

引用次数: 0

Programmable G-to-Y base editing using engineered DNA glycosylase 利用工程 DNA 糖基化酶进行可编程 G-Y 碱基编辑

Life medicine Pub Date : 2024-02-17 DOI: 10.1093/lifemedi/lnae005

Huawei Tong, Tonghuai Li, Hui Yang