Life medicine最新文献_第5页

Integrating GLP-1 receptor agonists with anti-amyloid immunotherapy for Alzheimer's disease: a phased clinical roadmap. GLP-1受体激动剂联合抗淀粉样蛋白免疫疗法治疗阿尔茨海默病：分阶段临床路线图

IF 7.7

Life medicine Pub Date : 2025-11-14 eCollection Date: 2025-10-01 DOI: 10.1093/lifemedi/lnaf036

Junzhe Huang, Shengya Wang, Vincent C T Mok, Weihong Song, Ho Ko, Yun Zhang

引用次数: 0

Centenarians: a model of immune resilience against multimorbidity. 百岁老人：对抗多种疾病的免疫弹性模型。

IF 6

Life medicine Pub Date : 2025-10-13 eCollection Date: 2025-12-01 DOI: 10.1093/lifemedi/lnaf033

引用次数: 0

Explore sirtuin family: SIRT5 as a ticket for the entrance of the TBK1-RelA axis to skeletal muscle rejuvenation. 探索sirtuin家族：SIRT5作为TBK1-RelA轴进入骨骼肌年轻化的入场券。

IF 7.7

Life medicine Pub Date : 2025-10-13 eCollection Date: 2025-10-01 DOI: 10.1093/lifemedi/lnaf034

引用次数: 0

From seq-ing to modeling: towards a molecular understanding of special properties of immature neurons in the human hippocampus. 从测序到建模：对人类海马体中未成熟神经元特性的分子理解。

IF 7.7

Life medicine Pub Date : 2025-09-30 eCollection Date: 2025-12-01 DOI: 10.1093/lifemedi/lnaf031

引用次数: 0

Iron metabolism disorder promotes postovulatory oocyte aging by inducing oxidative stress damage. 铁代谢紊乱通过诱导氧化应激损伤促进排卵后卵母细胞衰老。

IF 6

Life medicine Pub Date : 2025-09-30 eCollection Date: 2025-12-01 DOI: 10.1093/lifemedi/lnaf032

Ziqi Huang, Bicheng Wang, Ying Tian, Xiangning Xu, Jiaqi Zhang, Shuo Lou, Jingyi Kang, Ningning Zhang, Ke Song, Jingyu Li, Jing Weng, Yuanjing Liang, Xiaokui Yang, Wei Ma

{"title":"Iron metabolism disorder promotes postovulatory oocyte aging by inducing oxidative stress damage.","authors":"Ziqi Huang, Bicheng Wang, Ying Tian, Xiangning Xu, Jiaqi Zhang, Shuo Lou, Jingyi Kang, Ningning Zhang, Ke Song, Jingyu Li, Jing Weng, Yuanjing Liang, Xiaokui Yang, Wei Ma","doi":"10.1093/lifemedi/lnaf032","DOIUrl":"10.1093/lifemedi/lnaf032","url":null,"abstract":"Reactive oxygen species (ROS) involve in oocyte postovulatory aging, yet the mechanism of ROS accumulation is not fully understood. We explored iron metabolic status and its relationship with ROS in mouse oocytes during postovulatory aging in vivo. We found that heme oxygenase 1 (HO-1) expression was increased in oviduct and iron metabolism was disordered in oocytes with time post-ovulation. The aging oocytes were manifested with high iron content and disturbed expressions of iron metabolic proteins, including ferritin heavy chain (FHC), mitochondrial ferritin (FtMT), divalent metal transporter 1 (DMT1), ferroportin1 (FPN1), iron regulatory protein 2 (IRP2) and transferrin receptor 1 (TFR1), along with increased cytosolic free Fe2+, lipid peroxidation, DNA damage, mitochondrial and lysosomal abnormality, and defects in spindle and chromosome alignment. These in vivo aging cells contained stable glutathione peroxidase 4 (GPX4) and 4-hydroxynonenal (4-HNE), unexpectedly, but had more iron and degenerative changes than their in vitro counterparts. The intraperitoneal deferoxamine (DFO) could alleviate all these changes and improve the fertilization competence and preimplantation development. Similarly, the HO-1 inhibitor Zinc Protoporphyrin (ZnPP) also could do this. Together, the iron homeostasis disturbance participates in ROS accumulation and degenerative changes in postovulatory aging oocytes, which can be alleviated by iron chelating.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 6","pages":"lnaf032"},"PeriodicalIF":6.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12732666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral organ crosstalk in the regulation of ovarian endocrine function and reproductive homeostasis. 外周器官串扰在调节卵巢内分泌功能和生殖稳态中的作用。

IF 7.7

Life medicine Pub Date : 2025-08-28 eCollection Date: 2025-12-01 DOI: 10.1093/lifemedi/lnaf029

Lixuan Huang, Lei Xu, Chuyu Yun, Jie Qiao, Xinyu Qi

引用次数: 0

A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium. 脂肪组织老化的生物标志物框架：老化生物标志物联盟的共识声明。

IF 7.7

Life medicine Pub Date : 2025-07-19 eCollection Date: 2025-10-01 DOI: 10.1093/lifemedi/lnaf027

Jian Yu, Yankang Zhang, Ting Zhang, Yan Bi, Yan Chen, Zheng Chen, Zhe Dai, Feifan Guo, Lixin Guo, Cheng Hu, Xiangqing Kong, Jian Li, Pingsheng Liu, Yong Liu, Jing Qu, Qiqun Tang, Congyi Wang, Liheng Wang, Jiqiu Wang, Jianping Weng, Aimin Xu, Lingyan Xu, Huijie Zhang, Jiajun Zhao, Jingjing Zhang, Weiqi Zhang, Tongjin Zhao, Weiping Zhang, Zhiming Zhu, Guang-Hui Liu, Guang Ning, Gang Pei, Li Qiang, Feng Liu, Xinran Ma

{"title":"A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium.","authors":"Jian Yu, Yankang Zhang, Ting Zhang, Yan Bi, Yan Chen, Zheng Chen, Zhe Dai, Feifan Guo, Lixin Guo, Cheng Hu, Xiangqing Kong, Jian Li, Pingsheng Liu, Yong Liu, Jing Qu, Qiqun Tang, Congyi Wang, Liheng Wang, Jiqiu Wang, Jianping Weng, Aimin Xu, Lingyan Xu, Huijie Zhang, Jiajun Zhao, Jingjing Zhang, Weiqi Zhang, Tongjin Zhao, Weiping Zhang, Zhiming Zhu, Guang-Hui Liu, Guang Ning, Gang Pei, Li Qiang, Feng Liu, Xinran Ma","doi":"10.1093/lifemedi/lnaf027","DOIUrl":"10.1093/lifemedi/lnaf027","url":null,"abstract":"Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue aging represents one of the pivotal initiating events for multi-organ senescence. To address these challenges, the Aging China Biomarkers Consortium (ABC) has established an expert consensus on biomarkers of adipose tissue aging by digesting literature and collecting insights from scientists and clinicians. This consensus provides a comprehensive evaluation of the key changes and characteristics, as well as biomarkers related to adipose tissue aging and proposes a systematic framework categorizing these biomarkers into functional, structural and humoral dimensions. Within each dimension, the ABC recommends clinically and empirically validated biomarkers and parameters for assessing both physiological and pathological changes in adipose tissue during aging, which aims to establish a foundation for future prediction, diagnosis, early warning and treatment for adipose tissue aging and its related diseases, with the ultimate goal of improving adipose tissue health and promoting healthy aging in elderly populations both in China and worldwide.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 5","pages":"lnaf027"},"PeriodicalIF":7.7,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fat talks first: how adipose tissue sets the pace of aging? 脂肪先说话：脂肪组织如何决定衰老的速度？

IF 7.7

Life medicine Pub Date : 2025-07-19 eCollection Date: 2025-10-01 DOI: 10.1093/lifemedi/lnaf028

Juanhong Liu, Qinlei Huang, Feng Liu

引用次数: 0

deepBlastoid: a deep learning model for automated and efficient evaluation of human blastoids. deepBlastoid：一个深度学习模型，用于自动和有效地评估人类囊胚。

IF 7.7

Life medicine Pub Date : 2025-07-11 eCollection Date: 2025-12-01 DOI: 10.1093/lifemedi/lnaf026

Zejun Fan, Zhenyu Li, Yiqing Jin, Arun Pandian Chandrasekaran, Ismail M Shakir, Yingzi Zhang, Aisha Siddique, Mengge Wang, Xuan Zhou, Yeteng Tian, Peter Wonka, Mo Li

{"title":"deepBlastoid: a deep learning model for automated and efficient evaluation of human blastoids.","authors":"Zejun Fan, Zhenyu Li, Yiqing Jin, Arun Pandian Chandrasekaran, Ismail M Shakir, Yingzi Zhang, Aisha Siddique, Mengge Wang, Xuan Zhou, Yeteng Tian, Peter Wonka, Mo Li","doi":"10.1093/lifemedi/lnaf026","DOIUrl":"10.1093/lifemedi/lnaf026","url":null,"abstract":"Recent advances in human blastoids have opened new avenues for modeling early human development and implantation. Human blastoids can be generated in large numbers, making them well-suited for high-throughput screening. However, automated methods for evaluating and characterizing blastoid morphology are lacking. We developed a deep-learning model-deepBlastoid-for automated classification of live human blastoids using only brightfield images. The model processes 273.6 images per second with an average accuracy of 87%, which is further improved to 97% by integrating a Confidence Rate metric. deepBlastoid outperformed human experts in throughput while matching accuracy in blastoid classification. We demonstrated the utility of the model in two use cases: (i) systematic assessment of the effect of lysophosphatidic acid (LPA) on blastoid formation and (ii) evaluating the impact of dimethyl sulfoxide (DMSO) on blastoid formation. The evaluation results of deepBlastoid using over 10,000 images were consistent with the known drug effects and showed subtle but significant effects that might have been overlooked in manual assessments. The publicly available deepBlastoid model enables researchers to train customized models based on their imaging and protocols, providing an efficient, automated tool for blastoid classification with broad applications in research, drug screening, and in-vitro-fertilization applications.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 6","pages":"lnaf026"},"PeriodicalIF":7.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12732673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Life lies in movement. 生命在于运动。

IF 7.7

Life medicine Pub Date : 2025-07-02 eCollection Date: 2025-10-01 DOI: 10.1093/lifemedi/lnaf024

Junzhu Yi, Yuanyuan Du

引用次数: 0