发布求助
文献互助 智能选刊 最新文献

Life medicine最新文献

筛选
英文 中文
Truncated DAZL mutation reduces NANOS3 expression in primordial germ cells and leads to premature ovarian insufficiency 截短的 DAZL 突变会降低原始生殖细胞中 NANOS3 的表达，导致卵巢早衰
Life medicine Pub Date : 2024-02-09 DOI: 10.1093/lifemedi/lnae007
Qingyuan Liu, Ting Guo, An Yan, Kehkooi Kee
{"title":"Truncated DAZL mutation reduces NANOS3 expression in primordial germ cells and leads to premature ovarian insufficiency","authors":"Qingyuan Liu, Ting Guo, An Yan, Kehkooi Kee","doi":"10.1093/lifemedi/lnae007","DOIUrl":"https://doi.org/10.1093/lifemedi/lnae007","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139789455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuning mitochondrial dynamics for aging intervention 调整线粒体动力学以干预衰老
Life medicine Pub Date : 2024-02-08 DOI: 10.1093/lifemedi/lnae008
Xudong Yao, Xiaojun Xia, David C Hay, Mike Shipston, H. Ouyang
{"title":"Tuning mitochondrial dynamics for aging intervention","authors":"Xudong Yao, Xiaojun Xia, David C Hay, Mike Shipston, H. Ouyang","doi":"10.1093/lifemedi/lnae008","DOIUrl":"https://doi.org/10.1093/lifemedi/lnae008","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139851524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuning mitochondrial dynamics for aging intervention 调整线粒体动力学以干预衰老
Life medicine Pub Date : 2024-02-08 DOI: 10.1093/lifemedi/lnae008
Xudong Yao, Xiaojun Xia, David C Hay, Mike Shipston, H. Ouyang
{"title":"Tuning mitochondrial dynamics for aging intervention","authors":"Xudong Yao, Xiaojun Xia, David C Hay, Mike Shipston, H. Ouyang","doi":"10.1093/lifemedi/lnae008","DOIUrl":"https://doi.org/10.1093/lifemedi/lnae008","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139791645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering microbiota-host interplay: bacterial metabolites and protein post-translational modifications 解密微生物与宿主的相互作用：细菌代谢物与蛋白质翻译后修饰
Life medicine Pub Date : 2024-02-06 DOI: 10.1093/lifemedi/lnae003
Mingya Zhang, Sangkyu Lee, Min Huang, Minjia Tan
{"title":"Deciphering microbiota-host interplay: bacterial metabolites and protein post-translational modifications","authors":"Mingya Zhang, Sangkyu Lee, Min Huang, Minjia Tan","doi":"10.1093/lifemedi/lnae003","DOIUrl":"https://doi.org/10.1093/lifemedi/lnae003","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"82 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139801326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering microbiota-host interplay: bacterial metabolites and protein post-translational modifications 解密微生物与宿主的相互作用：细菌代谢物与蛋白质翻译后修饰
Life medicine Pub Date : 2024-02-06 DOI: 10.1093/lifemedi/lnae003
Mingya Zhang, Sangkyu Lee, Min Huang, Minjia Tan
{"title":"Deciphering microbiota-host interplay: bacterial metabolites and protein post-translational modifications","authors":"Mingya Zhang, Sangkyu Lee, Min Huang, Minjia Tan","doi":"10.1093/lifemedi/lnae003","DOIUrl":"https://doi.org/10.1093/lifemedi/lnae003","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"51 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139861369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence 昼夜节律因子 CLOCK 和 BMAL1 促进非同源末端连接并拮抗细胞衰老
Life medicine Pub Date : 2024-02-04 DOI: 10.1093/lifemedi/lnae006
Yu Chen, Xiaoyu Xu, Zhixi Chen, Lingjiang Chen, Ying Jiang, Zhiyong Mao
{"title":"Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence","authors":"Yu Chen, Xiaoyu Xu, Zhixi Chen, Lingjiang Chen, Ying Jiang, Zhiyong Mao","doi":"10.1093/lifemedi/lnae006","DOIUrl":"https://doi.org/10.1093/lifemedi/lnae006","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139866712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence 昼夜节律因子 CLOCK 和 BMAL1 促进非同源末端连接并拮抗细胞衰老
Life medicine Pub Date : 2024-02-04 DOI: 10.1093/lifemedi/lnae006
Yu Chen, Xiaoyu Xu, Zhixi Chen, Lingjiang Chen, Ying Jiang, Zhiyong Mao
{"title":"Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence","authors":"Yu Chen, Xiaoyu Xu, Zhixi Chen, Lingjiang Chen, Ying Jiang, Zhiyong Mao","doi":"10.1093/lifemedi/lnae006","DOIUrl":"https://doi.org/10.1093/lifemedi/lnae006","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"47 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139806834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement 肝脏衰老生物标志物框架：衰老生物标志物联盟共识声明
Life medicine Pub Date : 2024-01-30 DOI: 10.1093/lifemedi/lnae004
Mengmeng Jiang, Zhuozhao Zheng, Xuan Wang, Yanhao Chen, Jing Qu, Qiurong Ding, Weiqi Zhang, You-Shuo Liu, Jichun Yang, Weiqing Tang, Yunlong Hou, Jinhan He, Lin Wang, Pengyu Huang, Lin-Chen Li, Zhiying He, Qiang Gao, Qian Lu, Lai Wei, Yan-Jiang Wang, Zhenyu Ju, Jian-Gao Fan, Xiong-zhong Ruan, Youfei Guan, Guanghui Liu, Gang Pei, Jian Li, Yunfang Wang
{"title":"A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement","authors":"Mengmeng Jiang, Zhuozhao Zheng, Xuan Wang, Yanhao Chen, Jing Qu, Qiurong Ding, Weiqi Zhang, You-Shuo Liu, Jichun Yang, Weiqing Tang, Yunlong Hou, Jinhan He, Lin Wang, Pengyu Huang, Lin-Chen Li, Zhiying He, Qiang Gao, Qian Lu, Lai Wei, Yan-Jiang Wang, Zhenyu Ju, Jian-Gao Fan, Xiong-zhong Ruan, Youfei Guan, Guanghui Liu, Gang Pei, Jian Li, Yunfang Wang","doi":"10.1093/lifemedi/lnae004","DOIUrl":"https://doi.org/10.1093/lifemedi/lnae004","url":null,"abstract":"\u0000 In human aging, liver aging per se increases susceptibility to liver diseases but also increases vulnerability of other organs given its central role in regulating metabolism. Total liver function tends to be well maintained in the healthy elderly, so liver aging generally difficult to identify early. In response to this critical challenge, the Aging Biomarker Consortium (ABC) of China has formulated an expert consensus on biomarkers of liver aging by synthesizing the latest scientific literature, comprising insights from both scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with liver aging and presents a systematic framework to characterize these into three dimensions: functional, structural, and humoral. For the functional domain, we highlight biomarkers associated with cholesterol metabolism and liver-related coagulation function. For the structural domain, we note that hepatic steatosis and liver blood flow can serve as measurable biomarkers for liver aging. Finally, in the humoral domain, we pinpoint hepatokines and enzymatic alterations worthy of attention. The aim of this expert consensus is to establish a foundation for assessing the extent of liver aging and identify early signs of liver aging-related diseases, thereby improving liver health and the healthy life expectancy of the elderly population.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140484030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling antiviral response in the liver using human pluripotent stem cell- derived macrophages 利用人体多能干细胞衍生的巨噬细胞模拟肝脏的抗病毒反应
Life medicine Pub Date : 2024-01-12 DOI: 10.1093/lifemedi/lnae001
Yaxuan Zhang, Xingwu Zhang, Fuyu Duan, Huimin Qiao, M. Gong, Hui Qiu, Xia Chen, Peiliang Wang, Yuan He, Qiang Ding, Jie Na
{"title":"Modeling antiviral response in the liver using human pluripotent stem cell- derived macrophages","authors":"Yaxuan Zhang, Xingwu Zhang, Fuyu Duan, Huimin Qiao, M. Gong, Hui Qiu, Xia Chen, Peiliang Wang, Yuan He, Qiang Ding, Jie Na","doi":"10.1093/lifemedi/lnae001","DOIUrl":"https://doi.org/10.1093/lifemedi/lnae001","url":null,"abstract":"","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"54 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139531840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Migrasomes trigger innate immune activation and mediate transmission of senescence signals across human cells 移行体触发先天性免疫激活并介导衰老信号在人体细胞间的传递
Life medicine Pub Date : 2023-12-08 DOI: 10.1093/lifemedi/lnad050
Xiaoqian Liu, Haifeng Jiao, Baohu Zhang, Sheng Zhang, K. Yan, J. Qu, Weiqi Zhang, Li Yu, Guanghui Liu
{"title":"Migrasomes trigger innate immune activation and mediate transmission of senescence signals across human cells","authors":"Xiaoqian Liu, Haifeng Jiao, Baohu Zhang, Sheng Zhang, K. Yan, J. Qu, Weiqi Zhang, Li Yu, Guanghui Liu","doi":"10.1093/lifemedi/lnad050","DOIUrl":"https://doi.org/10.1093/lifemedi/lnad050","url":null,"abstract":"\u0000 Aging is a complex and heterogeneous process, raising important questions about how aging is differently impacted by underlying genetics and external factors. Recently, migrasomes, newly discovered organelles, have been discovered to play important roles in various physiological and pathological processes by facilitating cell-to-cell communication. Thus far, their involvement in cellular senescence and aging remains largely unexplored. In this study, we aimed to investigate how migrasomes impacts on cellular aging by leveraging multiple cellular senescence models, including replicatively senescent (RS), pathologically senescent and stress-induced senescent human mesenchymal stem cells (hMSCs), as well as RS human primary fibroblasts. In all cellular aging models, we detected an enhanced formation of migrasomes. Notably, migrasomes in senescent cells exhibited an accumulation of numerous aging hallmarks, such as dysfunctional mitochondria, endogenous retroviruses, and senescence-associated pro-inflammatory cytokines. Furthermore, we discovered that migrasomes derived from senescent cells can be taken up by young cells, thereby transferring aging signals and subsequently causing premature senescence phenotypes in recipient cells. Mechanistically, we found that treatment with migrasomes derived from senescent cells activated the innate immune response. Thus, our study sheds light on a pivotal role of migrasomes in mediating the contagiousness of aging.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"33 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138589115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信