Life medicine最新文献_第6页

Heterochronic parabiosis alters the transcriptomic landscape to combat aging and aging-related diseases in aging-accelerated mice. 异慢性异种共生改变了衰老加速小鼠的转录组学景观，以对抗衰老和衰老相关疾病。

IF 7.7

Life medicine Pub Date : 2025-07-01 eCollection Date: 2025-12-01 DOI: 10.1093/lifemedi/lnaf025

Haochen Wang, Wencong Lyu, Yuzhe Sun, Xinyi Jia, Jinlong Bi, Ran Wei, Zhehao Du, Fanju Meng, Jianuo He, Shiyi Wang, Lijun Zhang, Chao Nie, Wei Tao

{"title":"Heterochronic parabiosis alters the transcriptomic landscape to combat aging and aging-related diseases in aging-accelerated mice.","authors":"Haochen Wang, Wencong Lyu, Yuzhe Sun, Xinyi Jia, Jinlong Bi, Ran Wei, Zhehao Du, Fanju Meng, Jianuo He, Shiyi Wang, Lijun Zhang, Chao Nie, Wei Tao","doi":"10.1093/lifemedi/lnaf025","DOIUrl":"10.1093/lifemedi/lnaf025","url":null,"abstract":"Aging is a multifactorial process involving a gradual decline in cellular and tissue functions, making it a major risk factor for aging-related degenerative diseases. In this study, we utilized the senescence-accelerated mouse prone 8 mice model, which mimics pathological characteristics of Alzheimer's disease, fatty liver disease, and cardiac fibrosis, to construct a heterochronic parabiosis model and systematically investigate the rejuvenating effects of heterochronic parabiosis on the brain, liver, and heart. Our findings revealed that heterochronic parabiosis promotes synaptic plasticity and neuronal communication, restores hepatocyte metabolic functions, and reduces chronic inflammation and fibrosis in the heart. Notably, heterochronic parabiosis significantly downregulates the expression of age-related disease risk genes. In addition, endothelial cells, as cell types directly exposed to the circulatory environment, demonstrated the highest sensitivity to heterochronic parabiosis across three organs, and exhibited significantly reduced inflammation after intervention, suggesting that they may play an early and central role in the rejuvenation process. Overall, our study increases the understanding of the molecular and cellular mechanisms of aging and its related diseases, highlights the multiorgan and multitarget potential of heterochronic parabiosis in delaying aging and mitigating aging-related diseases, and provides new therapeutic targets for achieving healthy aging.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 6","pages":"lnaf025"},"PeriodicalIF":7.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12732672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium. 视觉系统老化的生物标志物框架：老化生物标志物联盟的共识声明。

IF 6

Life medicine Pub Date : 2025-06-28 eCollection Date: 2025-08-01 DOI: 10.1093/lifemedi/lnaf023

Chao Ma, Boxin Geng, Yangqing Zhang, Shan Li, Ruiyang Li, Wenben Chen, Si Wang, Weiqi Zhang, Jing Qu, Yun Feng, Qingfeng Liang, Kangxin Jin, Yonghao Gu, Wenru Su, Xuxiang Zhang, Wenjuan Zhuang, Jihong Wu, Zhaoyang Wang, Shengping Hou, Jiaxu Hong, Honghua Yu, Biao Yan, Mingguang He, Fan Lv, Guang-Hui Liu, Gang Pei, Qingjiong Zhang, Tian Xue, Zi-Bing Jin

{"title":"A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium.","authors":"Chao Ma, Boxin Geng, Yangqing Zhang, Shan Li, Ruiyang Li, Wenben Chen, Si Wang, Weiqi Zhang, Jing Qu, Yun Feng, Qingfeng Liang, Kangxin Jin, Yonghao Gu, Wenru Su, Xuxiang Zhang, Wenjuan Zhuang, Jihong Wu, Zhaoyang Wang, Shengping Hou, Jiaxu Hong, Honghua Yu, Biao Yan, Mingguang He, Fan Lv, Guang-Hui Liu, Gang Pei, Qingjiong Zhang, Tian Xue, Zi-Bing Jin","doi":"10.1093/lifemedi/lnaf023","DOIUrl":"10.1093/lifemedi/lnaf023","url":null,"abstract":"The visual system is essential for human perception, converting light signals into electrical impulses and transmitting them to the brain to process environmental information. As individuals age, their physiological functions gradually decline, leading to age-related vision impairment that significantly impacts the quality of life in elderly individuals. China is home to the world's largest aging population and faces significant challenges in combating visual system aging through effective treatments and interventions. In response to this challenge, the Aging Biomarker Consortium (ABC) of China has developed a consensus statement on biomarkers of visual system aging by integrating cutting-edge global research and synthesizing evidence-based medicine with clinical expertise. This consensus provides a multi-dimensional evaluation framework encompassing functional, morphological, and molecular biomarkers. Validated biomarkers for each domain are recommended not only to facilitate the early detection of vision changes but also to provide insights into the progression of age-related ocular diseases. By advancing this initiative, ABC aims to revolutionize visual health management in aging societies, ultimately improving outcomes for elderly populations in China and globally.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 4","pages":"lnaf023"},"PeriodicalIF":6.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole-process 3D ECM-encapsulated organoid-based automated high-throughput screening platform accelerates drug discovery for rare diseases. 全流程3D ecm封装类器官自动化高通量筛选平台加速罕见疾病药物的发现。

IF 7.7

Life medicine Pub Date : 2025-06-14 eCollection Date: 2025-10-01 DOI: 10.1093/lifemedi/lnaf021

Zhaoting Xu, Hui Yang, Yuru Zhou, Emmanuel Enoch Dzakah, Bing Zhao

{"title":"Whole-process 3D ECM-encapsulated organoid-based automated high-throughput screening platform accelerates drug discovery for rare diseases.","authors":"Zhaoting Xu, Hui Yang, Yuru Zhou, Emmanuel Enoch Dzakah, Bing Zhao","doi":"10.1093/lifemedi/lnaf021","DOIUrl":"10.1093/lifemedi/lnaf021","url":null,"abstract":"Organoid-based high-throughput screening (HTS) is revolutionizing pharmaceutical development. However, the complexity of handling extracellular matrix (ECM) components with traditional HTS devices leads to the use of suspension cultures for organoids during HTS, which alters their transcriptomic landscape and drug responses. Although automated generation techniques for 3D ECM-encapsulated organoids have been established, limitations in operational simplicity and time efficiency remain barriers to achieving high throughput. Here, we develop a whole-process 3D ECM-encapsulated organoid-based automated HTS (wp3D-OAHTS) platform, which achieves superior throughput compared to existing reported systems for 3D organoid drug screening. Utilizing this automated platform, we generated more than 10,000 homogeneous 3D organoid domes of neuroendocrine cervical cancer (NECC) and evaluated their drug responses to 2802 compounds in 13 days. This highly efficient and reproducible approach finally enabled the identification of 5 top hits that significantly inhibited NECC organoids in vitro with half-maximal inhibitory concentration (IC50) of lower than 10 nM. The representative candidate, Quisinostat 2HCl, demonstrated significantly stronger anti-tumor efficacy than clinically used agents in vivo. This platform significantly improves the rapidity and efficiency of 3D ECM-encapsulated organoid drug screening and facilitates new drug discovery for rare diseases.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 5","pages":"lnaf021"},"PeriodicalIF":7.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lysozyme alleviates DSS-induced colitis by modulating pro-inflammatory factors and NF-κB activation. 溶菌酶通过调节促炎因子和NF-κB活化减轻dss诱导的结肠炎。

IF 7.7

Life medicine Pub Date : 2025-06-14 eCollection Date: 2025-10-01 DOI: 10.1093/lifemedi/lnaf020

Kai Wang, Lan Guo, Ting Wang, Fengmin Shi, Meihong Fu, Guojun Li, Songli Pan, Xianying Cao, Huanxiong Chen

引用次数: 0

Mitochondrial sirtuins, key regulators of aging. 线粒体sirtuins，衰老的关键调节器。

IF 6

Life medicine Pub Date : 2025-06-09 eCollection Date: 2025-08-01 DOI: 10.1093/lifemedi/lnaf019

Zhejun Ji, Guang-Hui Liu, Jing Qu

引用次数: 0

Identification of deferasirox as a human xanthine oxidase inhibitor. 去铁苷作为人黄嘌呤氧化酶抑制剂的鉴定。

Life medicine Pub Date : 2025-03-31 eCollection Date: 2025-04-01 DOI: 10.1093/lifemedi/lnaf014

Yunfei Qi, Xinheng He, Xiaoshan Wu, Tingting Zhou, Ningning Liang, Jiazheng Jiao, Yanhao Chen, Yue Yuan, Yuwei Zhang, Yucheng Wang, Yan Liu, Qiurong Ding

引用次数: 0

A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement. 听觉系统老化的生物标志物框架：老化生物标志物联盟共识声明。

Life medicine Pub Date : 2025-03-07 eCollection Date: 2025-02-01 DOI: 10.1093/lifemedi/lnaf011

Xiaolong Fu, Si Wang, Yunhao Wu, Yu Sun, Wenwen Liu, Xin Xi, Geng-Lin Li, Ke Liu, Wei Yuan, Fangyi Chen, Hongyang Wang, Tao Yang, Yuhe Liu, Jialin Zheng, Haibo Shi, Jing Qu, Xiaowei Chen, Limin Suo, Yideng Huang, Xinbo Xu, Xuxia Tang, Xiaojun Li, Lei Xu, Xia Gao, Lisheng Yu, Yilai Shu, Weiqi Zhang, Jinpeng Sun, Huijun Yuan, Shusheng Gong, Wenyan Li, Xiulan Ma, Dingjun Zha, Jiangang Gao, Huawei Li, Zuhong He, Guang-Hui Liu, Gang Pei, Weijia Kong, Haibo Wang, Renjie Chai

{"title":"A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement.","authors":"Xiaolong Fu, Si Wang, Yunhao Wu, Yu Sun, Wenwen Liu, Xin Xi, Geng-Lin Li, Ke Liu, Wei Yuan, Fangyi Chen, Hongyang Wang, Tao Yang, Yuhe Liu, Jialin Zheng, Haibo Shi, Jing Qu, Xiaowei Chen, Limin Suo, Yideng Huang, Xinbo Xu, Xuxia Tang, Xiaojun Li, Lei Xu, Xia Gao, Lisheng Yu, Yilai Shu, Weiqi Zhang, Jinpeng Sun, Huijun Yuan, Shusheng Gong, Wenyan Li, Xiulan Ma, Dingjun Zha, Jiangang Gao, Huawei Li, Zuhong He, Guang-Hui Liu, Gang Pei, Weijia Kong, Haibo Wang, Renjie Chai","doi":"10.1093/lifemedi/lnaf011","DOIUrl":"https://doi.org/10.1093/lifemedi/lnaf011","url":null,"abstract":"Hearing is one of the most vital sensory functions in human beings and a crucial means of perceiving and acquiring information from the natural environment. The advancement of human society is closely linked to the development of language, with hearing serving as the foundation for verbal communication. As individuals age, the deterioration of the auditory system becomes a significant factor contributing to sensory impairments in the elderly. In addition to hearing loss, the aging of the auditory system is also associated with cognitive decline and psychosocial disorders, which severely impact the quality of life for older adults. Currently, there are no effective treatments or interventions available for addressing the aging of the auditory system. Therefore, identifying biomarkers of the auditory system aging is of great significance. The Aging Biomarker Consortium of China has conducted a comprehensive evaluation of aging biomarkers in the auditory system, focusing on three dimensions: morphological, functional, and humoral biomarkers. This initiative aims to establish a foundation for assessing the degree of aging in the auditory system and to promote the management of auditory health in an aging society, ultimately enhancing the auditory health of the elderly population both in China and globally.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 1","pages":"lnaf011"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development. 肠道类器官的进展和应用：模拟肠道疾病和治疗发展。

Life medicine Pub Date : 2025-03-07 eCollection Date: 2025-04-01 DOI: 10.1093/lifemedi/lnaf012

Xiaoting Xu, Yuping Zhang, Guoxin Huang, Ansu Perekatt, Yan Wang, Lei Chen

引用次数: 0

DDIT3 deficiency ameliorates systemic lupus erythematosus by regulating B cell activation and differentiation. dddit3缺乏通过调节B细胞活化和分化改善系统性红斑狼疮。

Life medicine Pub Date : 2025-03-03 eCollection Date: 2025-02-01 DOI: 10.1093/lifemedi/lnaf009

Xin Dai, Jiali Yu, Yunfei Zhang, Zhiming Wang, Yunyan Dai, Ying Hu, Xiaocui Wang, Binbin Tian, Minhui Wu, Hao Chen, Ruigao Song, Dan Ma, Cong-Yi Wang, Dawei Ye, Ziliang Zheng, Liyun Zhang, Jing Luo, Yukai Jing

{"title":"DDIT3 deficiency ameliorates systemic lupus erythematosus by regulating B cell activation and differentiation.","authors":"Xin Dai, Jiali Yu, Yunfei Zhang, Zhiming Wang, Yunyan Dai, Ying Hu, Xiaocui Wang, Binbin Tian, Minhui Wu, Hao Chen, Ruigao Song, Dan Ma, Cong-Yi Wang, Dawei Ye, Ziliang Zheng, Liyun Zhang, Jing Luo, Yukai Jing","doi":"10.1093/lifemedi/lnaf009","DOIUrl":"10.1093/lifemedi/lnaf009","url":null,"abstract":"Systemic lupus erythematosus (SLE) is characterized by the overproduction of autoantibodies, and B cells are considered to be the primary cells involved in the development of SLE. Studies have shown that DNA damage responses play a role in B cell activity in SLE. However, the exact role of DNA damage-induced transcript 3 (DDIT3) in humoral immune response and SLE pathogenesis remains unknown. We observed increased expression of DDIT3 in B cells of SLE patients and this expression was positively correlated with disease activity. In DDIT3-knockout mice, we observed disturbances in B cell development and differentiation, inhibition of B cell activation, and BCR signaling. In addition, DDIT3 deficiency leads to a reduction in T-cell-dependent humoral immune responses. Mechanistically, we found that DDIT3 promotes the transcription and expression of Itgad, which enhances PI3K signaling and B cell activation. Finally, we found that DDIT3 deficiency attenuated lupus autoimmunity and reduced germinal center responses. In conclusion, our study reveals for the first time the role of DDIT3 in adaptive immune responses, especially in B cell homeostasis, B cell activation, BCR signaling, and B cell function. These findings provide a new potential target for therapeutic intervention in SLE.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"4 1","pages":"lnaf009"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Many are called but few are chosen-from multiple clonal origins to one winner. 许多被召唤，但很少被选中——从多个克隆起源到一个赢家。

Life medicine Pub Date : 2025-02-24 eCollection Date: 2025-02-01 DOI: 10.1093/lifemedi/lnaf008

Qihang Chen, Zihan Liu, Bingjie Chen

引用次数: 0