Life medicine最新文献_第7页

Sugt1 loss in skeletal muscle stem cells impairs muscle regeneration and causes premature muscle aging 骨骼肌干细胞中的Sugt1缺失会损害肌肉再生并导致肌肉过早老化

Life medicine Pub Date : 2023-11-02 DOI: 10.1093/lifemedi/lnad039

Zhiming He, Xiaona Chen, Gexin Liu, Yuying Li, Feng Yang, Hao Sun, Huating Wang

{"title":"Sugt1 loss in skeletal muscle stem cells impairs muscle regeneration and causes premature muscle aging","authors":"Zhiming He, Xiaona Chen, Gexin Liu, Yuying Li, Feng Yang, Hao Sun, Huating Wang","doi":"10.1093/lifemedi/lnad039","DOIUrl":"https://doi.org/10.1093/lifemedi/lnad039","url":null,"abstract":"Abstract Adult skeletal muscle stem cells (MuSCs) are essential for muscle homeostasis and regeneration. During aging, the number of MuSC and their regenerative capacity gradually decline but the underlying mechanisms remain elusive. Here we identify Sugt1 (suppressor of G2 allele of SKP1 homolog), which is a chaperone for kinetochore function during mitosis and is essential for muscle regeneration by regulating MuSCs proliferation. Sugt1 expression level is low in quiescent MuSCs but highly induced when the cells become activated and expand as proliferating myoblasts. Inducible inactivation of Sugt1 in MuSCs causes impaired muscle regeneration upon acute injury by impairing MuSC proliferation. Furthermore, loss of Sugt1 leads to cell cycle arrest in the G2/M phase and cellular senescence. Moreover, long-term loss of Sugt1 in MuSCs results in precocious muscle aging by inhibiting MuSC cell proliferation and promoting cellular senescence. Mechanistically, we identify a cytosolic E3 ubiquitin-ligase, Trim21 as a protein interacting partner for Sugt1 in myoblast cells. We further demonstrate that Sugt1 promotes the ubiquitination of p21 via Trim21; and Sugt1 loss causes p21 accumulation to inhibit cell cycle progression and stimulates cellular senescence. Collectively, our findings uncover that Sugt1 is an essential regulator for MuSC regenerative function during muscle regeneration and aging.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"57 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135975152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Clone to Synthetic Embryos 从克隆到合成胚胎

Life medicine Pub Date : 2023-10-24 DOI: 10.1093/lifemedi/lnad038

Carlos A Pinzón-Arteaga, Leqian Yu

引用次数: 0

A CRISPR/Cas9-based kinome screen identifies ErbB signaling as a new regulator of human naïve pluripotency and totipotency 基于CRISPR/ cas9的kinome筛选鉴定出ErbB信号作为人类naïve多能性和全能性的新调节剂

Life medicine Pub Date : 2023-10-20 DOI: 10.1093/lifemedi/lnad037

Jiayu Li, Xiwen Lin, Liangfu Xie, Jingru Zhao, Chunsheng Han, Hongkui Deng, Jun Xu

引用次数: 0

In situ neuronal regeneration: the potential of astrocytes 原位神经元再生:星形胶质细胞的潜能

Life medicine Pub Date : 2023-10-03 DOI: 10.1093/lifemedi/lnad036

Rongbang Tan, Reiner F Haseloff, Yuqian Mo, Jingjing Zhang

引用次数: 0

A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement 心脏老化的生物标志物框架:老化生物标志物联盟共识声明

Life medicine Pub Date : 2023-09-27 DOI: 10.1093/lifemedi/lnad035

Weiwei Zhang, Yang Che, Xiaoqiang Tang, Siqi Chen, Moshi Song, Li Wang, Ai-Jun Sun, Hou-Zao Chen, Ming Xu, Miao Wang, Jun Pu, Zijian Li, Junjie Xiao, Chun-Mei Cao, Yan Zhang, Yao Lu, Yingxin Zhao, Yan-Jiang Wang, Cuntai Zhang, Tao Shen, Weiqi Zhang, Ling Tao, Jing Qu, Yi-Da Tang, Guang-Hui Liu, Gang Pei, Jian Li, Feng Cao

{"title":"A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement","authors":"Weiwei Zhang, Yang Che, Xiaoqiang Tang, Siqi Chen, Moshi Song, Li Wang, Ai-Jun Sun, Hou-Zao Chen, Ming Xu, Miao Wang, Jun Pu, Zijian Li, Junjie Xiao, Chun-Mei Cao, Yan Zhang, Yao Lu, Yingxin Zhao, Yan-Jiang Wang, Cuntai Zhang, Tao Shen, Weiqi Zhang, Ling Tao, Jing Qu, Yi-Da Tang, Guang-Hui Liu, Gang Pei, Jian Li, Feng Cao","doi":"10.1093/lifemedi/lnad035","DOIUrl":"https://doi.org/10.1093/lifemedi/lnad035","url":null,"abstract":"Abstract Cardiac aging constitutes a significant risk factor for cardiovascular diseases prevalent among the elderly population. Urgent attention is required to prioritize preventive and management strategies for age-related cardiovascular conditions to safeguard the well-being of elderly individuals. In response to this critical challenge, the Aging Biomarker Consortium (ABC) of China has formulated an expert consensus on cardiac aging biomarkers. This consensus draws upon the latest scientific literature and clinical expertise to provide a comprehensive assessment of biomarkers associated with cardiac aging. Furthermore, it presents a standardized methodology for characterizing biomarkers across three dimensions: functional, structural, and humoral. The functional dimension encompasses a broad spectrum of markers that reflect diastolic and systolic functions, sinus node pacing, neuroendocrine secretion, coronary microcirculation, and cardiac metabolism. The structural domain emphasizes imaging markers relevant to concentric cardiac remodeling, coronary artery calcification, and epicardial fat deposition. The humoral aspect underscores various systemic (N) and heart-specific (X) markers, including endocrine hormones, cytokines, and other plasma metabolites. The ABC’s primary objective is to establish a robust foundation for assessing cardiac aging, thereby furnishing a dependable reference for clinical applications and future research endeavors. This aims to contribute significantly to the enhancement of cardiovascular health and overall well-being among elderly individuals.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135534530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colonic stem cell from severe ulcerative colitis maintains environment-independent immune activation by altering chromatin accessibility and global m 6A loss 来自严重溃疡性结肠炎的结肠干细胞通过改变染色质可及性和全局m6a损失来维持不依赖环境的免疫激活

Life medicine Pub Date : 2023-09-13 DOI: 10.1093/lifemedi/lnad034

Chuandong Liu, Jie Li, Hua Jin, Qian Zhao, Fangle Li, Zurui Huang, Boyuan Mei, Wenxuan Gong, Xia Wang, Dali Han

{"title":"Colonic stem cell from severe ulcerative colitis maintains environment-independent immune activation by altering chromatin accessibility and global m 6A loss","authors":"Chuandong Liu, Jie Li, Hua Jin, Qian Zhao, Fangle Li, Zurui Huang, Boyuan Mei, Wenxuan Gong, Xia Wang, Dali Han","doi":"10.1093/lifemedi/lnad034","DOIUrl":"https://doi.org/10.1093/lifemedi/lnad034","url":null,"abstract":"Abstract Ulcerative colitis (UC) is a chronic inflammatory disease of colon, which is characterized by crypt architectural distortion. Alternation of colonic stem cell (CoSC) contributed to the occurrence of UC, yet the regulatory mechanisms remain unclear. To investigate the dysregulation of transcriptional and post-transcriptional regulation, we performed RNA-seq, ATAC-seq, and m 6A meRIP-seq analysis of the cultured CoSCs that isolated from UC patients. The transcriptome analysis revealed distinct expression signatures of UC patients in mild and severe stages. We observed abnormal activation of immune and extracellular matrix-related genes in patients affected by severe UC. The chromatin accessibility at the promoter regions of these genes was also specifically increased in the severe stage. In addition, we identified that a global loss of RNA m 6A modification in severe stage accompanied by higher expression of the m 6A demethylase FTO. The aberrant activation of large number immune and extracellular matrix-related genes, including IL4R, HLA-DPA1 and COL6A1, was related to both gain of chromatin accessibility and loss of m 6A in severe UC patients. Our finding revealed an environment-independent immune activation of CoSCs in UC and provided FTO as a potential therapeutic target.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134992460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paeoniflorin relieves arterial stiffness induced by a high-fat/high-sugar diet by disrupting the YAP-PPM1B interaction. 芍药苷通过破坏YAP-PPM1B相互作用来缓解高脂肪/高糖饮食引起的动脉硬化

Life medicine Pub Date : 2023-09-12 eCollection Date: 2023-10-01 DOI: 10.1093/lifemedi/lnad029

Zhipeng Chen, Yanan Liu, Mengke Li, Jiawei Song, Jianping Lin, Ding Ai

引用次数: 0

A framework of biomarkers for vascular aging: A consensus statement by the Aging Biomarker Consortium 血管老化的生物标志物框架:老化生物标志物联盟的共识声明

Life medicine Pub Date : 2023-08-30 DOI: 10.1093/lifemedi/lnad033

Le Zhang, Jun Guo, Yuehong Liu, Shimin Sun, Baohua Liu, Qi Yang, Jun Tao, Xiao-Li Tian, Jun Pu, Huashan Hong, Miao Wang, Hou-Zao Chen, Jie Ren, Xiaoming Wang, Zhen Liang, Yuan Wang, Kai Huang, Weiqi Zhang, Jing Qu, Zhenyu Ju, Guang-Hui Liu, Gang Pei, Jian Li, Cuntai Zhang

{"title":"A framework of biomarkers for vascular aging: A consensus statement by the Aging Biomarker Consortium","authors":"Le Zhang, Jun Guo, Yuehong Liu, Shimin Sun, Baohua Liu, Qi Yang, Jun Tao, Xiao-Li Tian, Jun Pu, Huashan Hong, Miao Wang, Hou-Zao Chen, Jie Ren, Xiaoming Wang, Zhen Liang, Yuan Wang, Kai Huang, Weiqi Zhang, Jing Qu, Zhenyu Ju, Guang-Hui Liu, Gang Pei, Jian Li, Cuntai Zhang","doi":"10.1093/lifemedi/lnad033","DOIUrl":"https://doi.org/10.1093/lifemedi/lnad033","url":null,"abstract":"Abstract Aging of the vasculature, which is integral to the functioning of literally all human organs, serves as a fundamental physiological basis for age-related alterations as well as a shared etiological mechanism for various chronic diseases prevalent in the elderly population. China, home to the world’s largest aging population, faces an escalating challenge in addressing the prevention and management of these age-related conditions. To meet this challenge, the Aging Biomarker Consortium (ABC) of China has developed an expert consensus on biomarkers of vascular aging (VA) by synthesizing literature and insights from scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with VA and presents a systemic framework to classify them into three dimensions: functional, structural and humoral. Within each dimension, the expert panel recommends the most clinically relevant VA biomarkers. For the functional domain, biomarkers reflecting vascular stiffness and endothelial function are highlighted. The structural dimension encompasses metrics for vascular structure, microvascular structure and distribution. Additionally, proinflammatory factors are emphasized as biomarkers with the humoral dimension. The aim of this expert consensus is to establish a foundation for assessing the extent of VA and conducting research related to VA, with the ultimate goal of improving the vascular health of the elderly in China and globally.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136080949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transglutaminase-crosslinked extracellular matrix in cirrhotic liver tissues provides pro-fibrotic mechano-microenvironment for cells 转谷氨酰胺酶交联的肝硬化肝组织细胞外基质为细胞提供促纤维化的机械微环境

Life medicine Pub Date : 2023-08-23 DOI: 10.1093/lifemedi/lnad030

Cheng Lyu, Wenyu Kong, Yan Zhang, Zhiqiang Liu, Kaini Liang, Yanan Du

引用次数: 0

Mutations in TUBA4A lead to human zygotic arrest and early developmental failure. TUBA4A突变导致人类受精卵停滞和早期发育失败

Life medicine Pub Date : 2023-08-23 eCollection Date: 2023-10-01 DOI: 10.1093/lifemedi/lnad032

Lin Li, Linfan Mao, Zhiguo Zhang, Yiying Yu, Miaohui Ding, Yongyan Zhi, Yunxia Cao, Beili Chen, Jie Na

引用次数: 0