Life medicine最新文献_第8页

Brain assembloid: a human model for neural circuits research. 脑装配体：用于神经回路研究的人体模型

Life medicine Pub Date : 2023-08-16 eCollection Date: 2023-10-01 DOI: 10.1093/lifemedi/lnad031

Shanshan Wu, Da Wang, Yan Liu

引用次数: 0

Novel single-cell mtDNA sequencing technology reveals hidden mutations in oocytes, blastoids, and stem cells. 新的单细胞mtDNA测序技术揭示卵母细胞、母细胞和干细胞中隐藏的突变

Life medicine Pub Date : 2023-07-25 eCollection Date: 2023-08-01 DOI: 10.1093/lifemedi/lnad028

Ismail M Shakir, Mo Li

引用次数: 0

Engineered biomaterials in stem cell-based regenerative medicine. 干细胞再生医学中的工程生物材料

Life medicine Pub Date : 2023-07-20 eCollection Date: 2023-08-01 DOI: 10.1093/lifemedi/lnad027

Fei Zhu, Guangjun Nie, Changsheng Liu

{"title":"Engineered biomaterials in stem cell-based regenerative medicine.","authors":"Fei Zhu, Guangjun Nie, Changsheng Liu","doi":"10.1093/lifemedi/lnad027","DOIUrl":"10.1093/lifemedi/lnad027","url":null,"abstract":"Stem cell-based regenerative therapies, which harness the self-renewal and differentiation properties of stem cells, have been in the spotlight due to their widespread applications in treating degenerative, aging, and other, generally intractable diseases. Therapeutically effective hematopoietic stem cells, mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells have been used in numerous basic and translational studies with exciting results. However, pre-/post-transplantation issues of poor cell survival and retention, uncontrolled differentiation, and insufficient numbers of cells engrafted into host tissues are the major challenges in stem cell-based regenerative therapies. Engineered biomaterials have adjustable biochemical and biophysical properties that significantly affect cell behaviors, such as cell engraftment, survival, migration, and differentiation outcomes, thereby enhancing the engraftment of implanted stem cells and guiding tissue regeneration. Therefore, the combination of stem cell biology with bioengineered materials is a promising strategy to improve the therapeutic outcomes of stem cell-based regenerative therapy. In this review, we summarize the advances in the modulation of behaviors of stem cells via engineered biomaterials. We then present different approaches to harnessing bioengineered materials to enhance the transplantation of stem cells. Finally, we will provide future directions in regenerative therapy using stem cells.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad027"},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48720200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncovering the mystery of genetic heterogeneity in inherited peripheral neuropathies. 揭开遗传性周围神经病遗传异质性之谜

Life medicine Pub Date : 2023-07-07 eCollection Date: 2023-08-01 DOI: 10.1093/lifemedi/lnad026

Chanjuan Huo, Qinqin Cui, Ge Bai

引用次数: 0

Bone morphogenetic protein 7 derived from DPP4⁺ cells in beige fat ameliorates age-associated metabolic dysfunction. 来源于米色脂肪中DPP4 +细胞的BMP7可改善与年龄相关的代谢功能障碍

Life medicine Pub Date : 2023-07-04 eCollection Date: 2023-08-01 DOI: 10.1093/lifemedi/lnad025

Mingwei Guo, Jun Zhang, Ying Ma, Xia Wu, Jing Yao, Dongmei Wang, Jin Qiu, Peng Lu, Banru Chen, Jiqiu Wang, Lingyan Xu, Xinran Ma

引用次数: 0

Commensal bacteria and cancer immunotherapy: strategy and opportunity. 共生菌与癌症免疫治疗：策略与机遇

Life medicine Pub Date : 2023-06-23 eCollection Date: 2023-06-01 DOI: 10.1093/lifemedi/lnad024

Xusheng Zhang, Xiwen Qin, Shuo Wang

引用次数: 0

Proteomics approaches to long COVID: status and outlooks. 蛋白质组学方法治疗长冠状病毒:现状和展望

Life medicine Pub Date : 2023-06-19 eCollection Date: 2023-06-01 DOI: 10.1093/lifemedi/lnad023

Xiao Liang, Yingrui Wang, Tiannan Guo

引用次数: 0

Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy. 靶向具有细胞类型特异性功能的细胞内蛋白用于癌症免疫治疗

Life medicine Pub Date : 2023-06-17 eCollection Date: 2023-06-01 DOI: 10.1093/lifemedi/lnad019

Madison E Carelock, Rohan P Master, Myung-Chul Kim, Zeng Jin, Lei Wang, Chandra K Maharjan, Nan Hua, Umasankar De, Ryan Kolb, Yufeng Xiao, Daiqing Liao, Guangrong Zheng, Weizhou Zhang

{"title":"Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy.","authors":"Madison E Carelock, Rohan P Master, Myung-Chul Kim, Zeng Jin, Lei Wang, Chandra K Maharjan, Nan Hua, Umasankar De, Ryan Kolb, Yufeng Xiao, Daiqing Liao, Guangrong Zheng, Weizhou Zhang","doi":"10.1093/lifemedi/lnad019","DOIUrl":"10.1093/lifemedi/lnad019","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) use antibodies that block cell surface immune checkpoint proteins with great efficacy in treating immunogenic or \"immune hot\" tumors such as melanoma, kidney, and lung adenocarcinoma. ICIs have limited response rates to other non-immunogenic cancers. The tumor microenvironment (TME) consists of many cell types that collectively promote tumor progression. Cancer therapeutics are commonly designed to target one molecule in one defined cell type. There is growing evidence that long-term therapeutic responses require the targeting of cancer cells and tumor-promoting populations within the TME. The question remains whether we can identify targetable molecules/pathways that are critical for multiple cell types. Here, we will discuss several molecular targets that may fit a \"two or multiple birds, one stone\" model, including the B-cell lymphoma-2 (BCL-2) family pro-survival factors, transcriptional factors including signal transducer and activator of transcription 3, the nuclear receptor 4A family (NR4A1, NR4A2, and NR4A3), as well as epigenetic regulators such as bromodomain and extra-terminal (BET) family proteins, histone deacetylase family, SET domain bifurcated histone lysine methyltransferase 1 (SETDB1), and lysine-specific demethylase 1 (LSD1/KDM1A). We will focus on the rationale of these targets in immune modulation, as well as the strategies for targeting these important proteins for cancer therapy.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad019"},"PeriodicalIF":0.0,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42671554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytoplasmic DNA sensing boosts CD4⁺ T cell metabolism for inflammatory induction. 细胞质DNA感应促进CD4+ T细胞代谢诱导炎症

Life medicine Pub Date : 2023-06-13 eCollection Date: 2023-06-01 DOI: 10.1093/lifemedi/lnad021

Jialin Ye, Jiemeng Fu, Hui Hou, Yan Wang, Wei Deng, Shumeng Hao, Yifei Pei, Jing Xu, Mingyue Zheng, Yichuan Xiao

{"title":"Cytoplasmic DNA sensing boosts CD4+ T cell metabolism for inflammatory induction.","authors":"Jialin Ye, Jiemeng Fu, Hui Hou, Yan Wang, Wei Deng, Shumeng Hao, Yifei Pei, Jing Xu, Mingyue Zheng, Yichuan Xiao","doi":"10.1093/lifemedi/lnad021","DOIUrl":"10.1093/lifemedi/lnad021","url":null,"abstract":"DNA accumulation is associated with the development of autoimmune inflammatory diseases. However, the pathological role and underlying mechanism of cytoplasmic DNA accumulation in CD4+ T cells have not been well established. Here, we show that Trex1 deficiency-induced endogenous DNA accumulation in CD4+ T cells greatly promoted their induction of autoimmune inflammation in a lupus-like mouse model. Mechanistically, the accumulated DNA in CD4+ T cells was sensed by the KU complex, then triggered the activation of DNA-PKcs and ZAK and further facilitated the activation of AKT, which exacerbated glycolysis, thereby promoting the inflammatory responses. Accordingly, blocking the DNA sensing pathway in CD4+ T cells by genetic knockout of Zak or using our newly developed ZAK inhibitor iZAK2 attenuated all pathogenic characteristics in a lupus-like inflammation mouse model induced with Trex1-deficient CD4+ T cells. Overall, our study demonstrated a causal link between DNA-sensing and metabolic reprogramming in CD4+ T cells for inflammatory induction and suggested inhibition of the DNA sensing pathway may be a potential therapy for the treatment of inflammatory diseases.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad021"},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43307524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SenoIndex: S100A8/S100A9 as a novel aging biomarker. SenoIndex: S100A8/S100A9作为一种新的衰老生物标志物

Life medicine Pub Date : 2023-06-13 eCollection Date: 2023-08-01 DOI: 10.1093/lifemedi/lnad022

Baohu Zhang, Haoteng Yan, Xiaoqian Liu, Liang Sun, Shuai Ma, Si Wang, Jing Qu, Guang-Hui Liu, Weiqi Zhang

引用次数: 0