Life medicine最新文献_第8页

A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement 心脏老化的生物标志物框架:老化生物标志物联盟共识声明

Life medicine Pub Date : 2023-09-27 DOI: 10.1093/lifemedi/lnad035

Weiwei Zhang, Yang Che, Xiaoqiang Tang, Siqi Chen, Moshi Song, Li Wang, Ai-Jun Sun, Hou-Zao Chen, Ming Xu, Miao Wang, Jun Pu, Zijian Li, Junjie Xiao, Chun-Mei Cao, Yan Zhang, Yao Lu, Yingxin Zhao, Yan-Jiang Wang, Cuntai Zhang, Tao Shen, Weiqi Zhang, Ling Tao, Jing Qu, Yi-Da Tang, Guang-Hui Liu, Gang Pei, Jian Li, Feng Cao

{"title":"A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement","authors":"Weiwei Zhang, Yang Che, Xiaoqiang Tang, Siqi Chen, Moshi Song, Li Wang, Ai-Jun Sun, Hou-Zao Chen, Ming Xu, Miao Wang, Jun Pu, Zijian Li, Junjie Xiao, Chun-Mei Cao, Yan Zhang, Yao Lu, Yingxin Zhao, Yan-Jiang Wang, Cuntai Zhang, Tao Shen, Weiqi Zhang, Ling Tao, Jing Qu, Yi-Da Tang, Guang-Hui Liu, Gang Pei, Jian Li, Feng Cao","doi":"10.1093/lifemedi/lnad035","DOIUrl":"https://doi.org/10.1093/lifemedi/lnad035","url":null,"abstract":"Abstract Cardiac aging constitutes a significant risk factor for cardiovascular diseases prevalent among the elderly population. Urgent attention is required to prioritize preventive and management strategies for age-related cardiovascular conditions to safeguard the well-being of elderly individuals. In response to this critical challenge, the Aging Biomarker Consortium (ABC) of China has formulated an expert consensus on cardiac aging biomarkers. This consensus draws upon the latest scientific literature and clinical expertise to provide a comprehensive assessment of biomarkers associated with cardiac aging. Furthermore, it presents a standardized methodology for characterizing biomarkers across three dimensions: functional, structural, and humoral. The functional dimension encompasses a broad spectrum of markers that reflect diastolic and systolic functions, sinus node pacing, neuroendocrine secretion, coronary microcirculation, and cardiac metabolism. The structural domain emphasizes imaging markers relevant to concentric cardiac remodeling, coronary artery calcification, and epicardial fat deposition. The humoral aspect underscores various systemic (N) and heart-specific (X) markers, including endocrine hormones, cytokines, and other plasma metabolites. The ABC’s primary objective is to establish a robust foundation for assessing cardiac aging, thereby furnishing a dependable reference for clinical applications and future research endeavors. This aims to contribute significantly to the enhancement of cardiovascular health and overall well-being among elderly individuals.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135534530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colonic stem cell from severe ulcerative colitis maintains environment-independent immune activation by altering chromatin accessibility and global m 6A loss 来自严重溃疡性结肠炎的结肠干细胞通过改变染色质可及性和全局m6a损失来维持不依赖环境的免疫激活

Life medicine Pub Date : 2023-09-13 DOI: 10.1093/lifemedi/lnad034

Chuandong Liu, Jie Li, Hua Jin, Qian Zhao, Fangle Li, Zurui Huang, Boyuan Mei, Wenxuan Gong, Xia Wang, Dali Han

{"title":"Colonic stem cell from severe ulcerative colitis maintains environment-independent immune activation by altering chromatin accessibility and global m 6A loss","authors":"Chuandong Liu, Jie Li, Hua Jin, Qian Zhao, Fangle Li, Zurui Huang, Boyuan Mei, Wenxuan Gong, Xia Wang, Dali Han","doi":"10.1093/lifemedi/lnad034","DOIUrl":"https://doi.org/10.1093/lifemedi/lnad034","url":null,"abstract":"Abstract Ulcerative colitis (UC) is a chronic inflammatory disease of colon, which is characterized by crypt architectural distortion. Alternation of colonic stem cell (CoSC) contributed to the occurrence of UC, yet the regulatory mechanisms remain unclear. To investigate the dysregulation of transcriptional and post-transcriptional regulation, we performed RNA-seq, ATAC-seq, and m 6A meRIP-seq analysis of the cultured CoSCs that isolated from UC patients. The transcriptome analysis revealed distinct expression signatures of UC patients in mild and severe stages. We observed abnormal activation of immune and extracellular matrix-related genes in patients affected by severe UC. The chromatin accessibility at the promoter regions of these genes was also specifically increased in the severe stage. In addition, we identified that a global loss of RNA m 6A modification in severe stage accompanied by higher expression of the m 6A demethylase FTO. The aberrant activation of large number immune and extracellular matrix-related genes, including IL4R, HLA-DPA1 and COL6A1, was related to both gain of chromatin accessibility and loss of m 6A in severe UC patients. Our finding revealed an environment-independent immune activation of CoSCs in UC and provided FTO as a potential therapeutic target.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134992460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paeoniflorin relieves arterial stiffness induced by a high-fat/high-sugar diet by disrupting the YAP-PPM1B interaction. 芍药苷通过破坏YAP-PPM1B相互作用来缓解高脂肪/高糖饮食引起的动脉硬化

Life medicine Pub Date : 2023-09-12 eCollection Date: 2023-10-01 DOI: 10.1093/lifemedi/lnad029

Zhipeng Chen, Yanan Liu, Mengke Li, Jiawei Song, Jianping Lin, Ding Ai

引用次数: 0

A framework of biomarkers for vascular aging: A consensus statement by the Aging Biomarker Consortium 血管老化的生物标志物框架:老化生物标志物联盟的共识声明

Life medicine Pub Date : 2023-08-30 DOI: 10.1093/lifemedi/lnad033

Le Zhang, Jun Guo, Yuehong Liu, Shimin Sun, Baohua Liu, Qi Yang, Jun Tao, Xiao-Li Tian, Jun Pu, Huashan Hong, Miao Wang, Hou-Zao Chen, Jie Ren, Xiaoming Wang, Zhen Liang, Yuan Wang, Kai Huang, Weiqi Zhang, Jing Qu, Zhenyu Ju, Guang-Hui Liu, Gang Pei, Jian Li, Cuntai Zhang

{"title":"A framework of biomarkers for vascular aging: A consensus statement by the Aging Biomarker Consortium","authors":"Le Zhang, Jun Guo, Yuehong Liu, Shimin Sun, Baohua Liu, Qi Yang, Jun Tao, Xiao-Li Tian, Jun Pu, Huashan Hong, Miao Wang, Hou-Zao Chen, Jie Ren, Xiaoming Wang, Zhen Liang, Yuan Wang, Kai Huang, Weiqi Zhang, Jing Qu, Zhenyu Ju, Guang-Hui Liu, Gang Pei, Jian Li, Cuntai Zhang","doi":"10.1093/lifemedi/lnad033","DOIUrl":"https://doi.org/10.1093/lifemedi/lnad033","url":null,"abstract":"Abstract Aging of the vasculature, which is integral to the functioning of literally all human organs, serves as a fundamental physiological basis for age-related alterations as well as a shared etiological mechanism for various chronic diseases prevalent in the elderly population. China, home to the world’s largest aging population, faces an escalating challenge in addressing the prevention and management of these age-related conditions. To meet this challenge, the Aging Biomarker Consortium (ABC) of China has developed an expert consensus on biomarkers of vascular aging (VA) by synthesizing literature and insights from scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with VA and presents a systemic framework to classify them into three dimensions: functional, structural and humoral. Within each dimension, the expert panel recommends the most clinically relevant VA biomarkers. For the functional domain, biomarkers reflecting vascular stiffness and endothelial function are highlighted. The structural dimension encompasses metrics for vascular structure, microvascular structure and distribution. Additionally, proinflammatory factors are emphasized as biomarkers with the humoral dimension. The aim of this expert consensus is to establish a foundation for assessing the extent of VA and conducting research related to VA, with the ultimate goal of improving the vascular health of the elderly in China and globally.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136080949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transglutaminase-crosslinked extracellular matrix in cirrhotic liver tissues provides pro-fibrotic mechano-microenvironment for cells 转谷氨酰胺酶交联的肝硬化肝组织细胞外基质为细胞提供促纤维化的机械微环境

Life medicine Pub Date : 2023-08-23 DOI: 10.1093/lifemedi/lnad030

Cheng Lyu, Wenyu Kong, Yan Zhang, Zhiqiang Liu, Kaini Liang, Yanan Du

引用次数: 0

Mutations in TUBA4A lead to human zygotic arrest and early developmental failure. TUBA4A突变导致人类受精卵停滞和早期发育失败

Life medicine Pub Date : 2023-08-23 eCollection Date: 2023-10-01 DOI: 10.1093/lifemedi/lnad032

Lin Li, Linfan Mao, Zhiguo Zhang, Yiying Yu, Miaohui Ding, Yongyan Zhi, Yunxia Cao, Beili Chen, Jie Na

引用次数: 0

Brain assembloid: a human model for neural circuits research. 脑装配体：用于神经回路研究的人体模型

Life medicine Pub Date : 2023-08-16 eCollection Date: 2023-10-01 DOI: 10.1093/lifemedi/lnad031

Shanshan Wu, Da Wang, Yan Liu

引用次数: 0

Novel single-cell mtDNA sequencing technology reveals hidden mutations in oocytes, blastoids, and stem cells. 新的单细胞mtDNA测序技术揭示卵母细胞、母细胞和干细胞中隐藏的突变

Life medicine Pub Date : 2023-07-25 eCollection Date: 2023-08-01 DOI: 10.1093/lifemedi/lnad028

Ismail M Shakir, Mo Li

引用次数: 0

Engineered biomaterials in stem cell-based regenerative medicine. 干细胞再生医学中的工程生物材料

Life medicine Pub Date : 2023-07-20 eCollection Date: 2023-08-01 DOI: 10.1093/lifemedi/lnad027

Fei Zhu, Guangjun Nie, Changsheng Liu

{"title":"Engineered biomaterials in stem cell-based regenerative medicine.","authors":"Fei Zhu, Guangjun Nie, Changsheng Liu","doi":"10.1093/lifemedi/lnad027","DOIUrl":"10.1093/lifemedi/lnad027","url":null,"abstract":"<p><p>Stem cell-based regenerative therapies, which harness the self-renewal and differentiation properties of stem cells, have been in the spotlight due to their widespread applications in treating degenerative, aging, and other, generally intractable diseases. Therapeutically effective hematopoietic stem cells, mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells have been used in numerous basic and translational studies with exciting results. However, pre-/post-transplantation issues of poor cell survival and retention, uncontrolled differentiation, and insufficient numbers of cells engrafted into host tissues are the major challenges in stem cell-based regenerative therapies. Engineered biomaterials have adjustable biochemical and biophysical properties that significantly affect cell behaviors, such as cell engraftment, survival, migration, and differentiation outcomes, thereby enhancing the engraftment of implanted stem cells and guiding tissue regeneration. Therefore, the combination of stem cell biology with bioengineered materials is a promising strategy to improve the therapeutic outcomes of stem cell-based regenerative therapy. In this review, we summarize the advances in the modulation of behaviors of stem cells via engineered biomaterials. We then present different approaches to harnessing bioengineered materials to enhance the transplantation of stem cells. Finally, we will provide future directions in regenerative therapy using stem cells.</p>","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad027"},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48720200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncovering the mystery of genetic heterogeneity in inherited peripheral neuropathies. 揭开遗传性周围神经病遗传异质性之谜

Life medicine Pub Date : 2023-07-07 eCollection Date: 2023-08-01 DOI: 10.1093/lifemedi/lnad026

Chanjuan Huo, Qinqin Cui, Ge Bai

引用次数: 0