Life medicine最新文献_第9页

Bone morphogenetic protein 7 derived from DPP4⁺ cells in beige fat ameliorates age-associated metabolic dysfunction. 来源于米色脂肪中DPP4 +细胞的BMP7可改善与年龄相关的代谢功能障碍

Life medicine Pub Date : 2023-07-04 eCollection Date: 2023-08-01 DOI: 10.1093/lifemedi/lnad025

Mingwei Guo, Jun Zhang, Ying Ma, Xia Wu, Jing Yao, Dongmei Wang, Jin Qiu, Peng Lu, Banru Chen, Jiqiu Wang, Lingyan Xu, Xinran Ma

引用次数: 0

Commensal bacteria and cancer immunotherapy: strategy and opportunity. 共生菌与癌症免疫治疗：策略与机遇

Life medicine Pub Date : 2023-06-23 eCollection Date: 2023-06-01 DOI: 10.1093/lifemedi/lnad024

Xusheng Zhang, Xiwen Qin, Shuo Wang

引用次数: 0

Proteomics approaches to long COVID: status and outlooks. 蛋白质组学方法治疗长冠状病毒:现状和展望

Life medicine Pub Date : 2023-06-19 eCollection Date: 2023-06-01 DOI: 10.1093/lifemedi/lnad023

Xiao Liang, Yingrui Wang, Tiannan Guo

引用次数: 0

Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy. 靶向具有细胞类型特异性功能的细胞内蛋白用于癌症免疫治疗

Life medicine Pub Date : 2023-06-17 eCollection Date: 2023-06-01 DOI: 10.1093/lifemedi/lnad019

Madison E Carelock, Rohan P Master, Myung-Chul Kim, Zeng Jin, Lei Wang, Chandra K Maharjan, Nan Hua, Umasankar De, Ryan Kolb, Yufeng Xiao, Daiqing Liao, Guangrong Zheng, Weizhou Zhang

{"title":"Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy.","authors":"Madison E Carelock, Rohan P Master, Myung-Chul Kim, Zeng Jin, Lei Wang, Chandra K Maharjan, Nan Hua, Umasankar De, Ryan Kolb, Yufeng Xiao, Daiqing Liao, Guangrong Zheng, Weizhou Zhang","doi":"10.1093/lifemedi/lnad019","DOIUrl":"10.1093/lifemedi/lnad019","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) use antibodies that block cell surface immune checkpoint proteins with great efficacy in treating immunogenic or \"immune hot\" tumors such as melanoma, kidney, and lung adenocarcinoma. ICIs have limited response rates to other non-immunogenic cancers. The tumor microenvironment (TME) consists of many cell types that collectively promote tumor progression. Cancer therapeutics are commonly designed to target one molecule in one defined cell type. There is growing evidence that long-term therapeutic responses require the targeting of cancer cells and tumor-promoting populations within the TME. The question remains whether we can identify targetable molecules/pathways that are critical for multiple cell types. Here, we will discuss several molecular targets that may fit a \"two or multiple birds, one stone\" model, including the B-cell lymphoma-2 (BCL-2) family pro-survival factors, transcriptional factors including signal transducer and activator of transcription 3, the nuclear receptor 4A family (NR4A1, NR4A2, and NR4A3), as well as epigenetic regulators such as bromodomain and extra-terminal (BET) family proteins, histone deacetylase family, SET domain bifurcated histone lysine methyltransferase 1 (SETDB1), and lysine-specific demethylase 1 (LSD1/KDM1A). We will focus on the rationale of these targets in immune modulation, as well as the strategies for targeting these important proteins for cancer therapy.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad019"},"PeriodicalIF":0.0,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42671554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytoplasmic DNA sensing boosts CD4⁺ T cell metabolism for inflammatory induction. 细胞质DNA感应促进CD4+ T细胞代谢诱导炎症

Life medicine Pub Date : 2023-06-13 eCollection Date: 2023-06-01 DOI: 10.1093/lifemedi/lnad021

Jialin Ye, Jiemeng Fu, Hui Hou, Yan Wang, Wei Deng, Shumeng Hao, Yifei Pei, Jing Xu, Mingyue Zheng, Yichuan Xiao

{"title":"Cytoplasmic DNA sensing boosts CD4+ T cell metabolism for inflammatory induction.","authors":"Jialin Ye, Jiemeng Fu, Hui Hou, Yan Wang, Wei Deng, Shumeng Hao, Yifei Pei, Jing Xu, Mingyue Zheng, Yichuan Xiao","doi":"10.1093/lifemedi/lnad021","DOIUrl":"10.1093/lifemedi/lnad021","url":null,"abstract":"DNA accumulation is associated with the development of autoimmune inflammatory diseases. However, the pathological role and underlying mechanism of cytoplasmic DNA accumulation in CD4+ T cells have not been well established. Here, we show that Trex1 deficiency-induced endogenous DNA accumulation in CD4+ T cells greatly promoted their induction of autoimmune inflammation in a lupus-like mouse model. Mechanistically, the accumulated DNA in CD4+ T cells was sensed by the KU complex, then triggered the activation of DNA-PKcs and ZAK and further facilitated the activation of AKT, which exacerbated glycolysis, thereby promoting the inflammatory responses. Accordingly, blocking the DNA sensing pathway in CD4+ T cells by genetic knockout of Zak or using our newly developed ZAK inhibitor iZAK2 attenuated all pathogenic characteristics in a lupus-like inflammation mouse model induced with Trex1-deficient CD4+ T cells. Overall, our study demonstrated a causal link between DNA-sensing and metabolic reprogramming in CD4+ T cells for inflammatory induction and suggested inhibition of the DNA sensing pathway may be a potential therapy for the treatment of inflammatory diseases.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad021"},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43307524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SenoIndex: S100A8/S100A9 as a novel aging biomarker. SenoIndex: S100A8/S100A9作为一种新的衰老生物标志物

Life medicine Pub Date : 2023-06-13 eCollection Date: 2023-08-01 DOI: 10.1093/lifemedi/lnad022

Baohu Zhang, Haoteng Yan, Xiaoqian Liu, Liang Sun, Shuai Ma, Si Wang, Jing Qu, Guang-Hui Liu, Weiqi Zhang

引用次数: 0

Interactions between the host dietary habits and the gut microbiota influence weight management. 宿主饮食习惯和肠道菌群之间的相互作用影响体重管理

Life medicine Pub Date : 2023-06-06 eCollection Date: 2023-06-01 DOI: 10.1093/lifemedi/lnad020

Yuhua Gao, Jun Lin, Frank J Gonzalez, Changtao Jiang

引用次数: 0

Mosaic somatic HRAS mutation causes unilateral psoriasis. 镶嵌体细胞HRAS突变导致单侧银屑病

Life medicine Pub Date : 2023-05-10 eCollection Date: 2023-06-01 DOI: 10.1093/lifemedi/lnad018

Rina Su, Huanwei Huang, Ying Chang, Yi Yu, Jun Cui, Ting Chen, Bin Li, Wenhui Wang

引用次数: 0

A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium. 脑老化生物标志物框架:老化生物标志物联盟的共识声明

Life medicine Pub Date : 2023-05-06 eCollection Date: 2023-06-01 DOI: 10.1093/lifemedi/lnad017

Yu-Juan Jia, Jun Wang, Jun-Rong Ren, Piu Chan, Shengdi Chen, Xiao-Chun Chen, Jagadish K Chhetri, Junhong Guo, Qihao Guo, Lingjing Jin, Qiang Liu, Qiang Liu, Wenlin Ma, Zhiyong Mao, Moshi Song, Weihong Song, Yi Tang, Difei Wang, Peijun Wang, Lize Xiong, Keqiang Ye, Junjian Zhang, Weiqi Zhang, Xiaoqing Zhang, Yunwu Zhang, Zhanjun Zhang, Zhuohua Zhang, Jialin Zheng, Guang-Hui Liu, Yi Eve Sun, Yan-Jiang Wang, Gang Pei

{"title":"A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium.","authors":"Yu-Juan Jia, Jun Wang, Jun-Rong Ren, Piu Chan, Shengdi Chen, Xiao-Chun Chen, Jagadish K Chhetri, Junhong Guo, Qihao Guo, Lingjing Jin, Qiang Liu, Qiang Liu, Wenlin Ma, Zhiyong Mao, Moshi Song, Weihong Song, Yi Tang, Difei Wang, Peijun Wang, Lize Xiong, Keqiang Ye, Junjian Zhang, Weiqi Zhang, Xiaoqing Zhang, Yunwu Zhang, Zhanjun Zhang, Zhuohua Zhang, Jialin Zheng, Guang-Hui Liu, Yi Eve Sun, Yan-Jiang Wang, Gang Pei","doi":"10.1093/lifemedi/lnad017","DOIUrl":"10.1093/lifemedi/lnad017","url":null,"abstract":"China and the world are facing severe population aging and an increasing burden of age-related diseases. Aging of the brain causes major age-related brain diseases, such as neurodegenerative diseases and stroke. Identifying biomarkers for the effective assessment of brain aging and establishing a brain aging assessment system could facilitate the development of brain aging intervention strategies and the effective prevention and treatment of aging-related brain diseases. Thus, experts from the Aging Biomarker Consortium (ABC) have combined the latest research results and practical experience to recommend brain aging biomarkers and form an expert consensus, aiming to provide a basis for assessing the degree of brain aging and conducting brain-aging-related research with the ultimate goal of improving the brain health of elderly individuals in both China and the world.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":"lnad017"},"PeriodicalIF":0.0,"publicationDate":"2023-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43449316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human oocyte microtubule organizing center: a newly identified driver for meiotic spindle assembly in female oocytes. 人卵母细胞微管组织中心:新发现的雌性卵母细胞减数分裂纺锤体组装驱动因子

Life medicine Pub Date : 2023-04-26 eCollection Date: 2023-06-01 DOI: 10.1093/lifemedi/lnad016

Jie Dong, Tianyu Wu, Qing Sang, Lei Wang

引用次数: 0