Life medicine最新文献_第9页

A Gas-only Bioreactor System Maintains Stable Culture Environments and Reveals that Moderate pH deviations Trigger Transcriptome-wide Responses in Human Cells Cultured in Physioxia and Physiological Buffers 一个纯气体生物反应器系统维持稳定的培养环境，并揭示适度的pH偏差触发在生理和生理缓冲液中培养的人类细胞的转录组全响应

Life medicine Pub Date : 2022-11-22 DOI: 10.1093/lifemedi/lnac056

S. Arossa, Samhan M. Alsolami, Shannon G. Klein, Yingzi Zhang, G. Ramos-Mandujano, A. Steckbauer, Anieka J Parry, J. C. I. Belmonte, C. Duarte, Mo Li

引用次数: 0

Genetic Enhancement: a New Avenue to Combat Aging-related Diseases 基因增强:对抗衰老相关疾病的新途径

Life medicine Pub Date : 2022-11-22 DOI: 10.1093/lifemedi/lnac054

Yusheng Cai, Zhejun Ji, Si Wang, Weiqi Zhang, J. Qu, J. C. I. Belmonte, Guang-Hui Liu

{"title":"Genetic Enhancement: a New Avenue to Combat Aging-related Diseases","authors":"Yusheng Cai, Zhejun Ji, Si Wang, Weiqi Zhang, J. Qu, J. C. I. Belmonte, Guang-Hui Liu","doi":"10.1093/lifemedi/lnac054","DOIUrl":"https://doi.org/10.1093/lifemedi/lnac054","url":null,"abstract":"\u0000 Aging is a major risk factor for multiple diseases, including cardiovascular disease, neurodegenerative disorders, osteoarthritis, and cancer. It is accompanied by the dysregulation of stem cells and other differentiated cells, and/or the impairment of their microenvironment. Cell therapies to replenish the abovementioned cells provide a promising approach to restore tissue homeostasis and alleviate aging and aging-related chronic diseases. Importantly, by leveraging gene editing technologies, genetic enhancement, an enhanced strategy for cell therapy, can be developed to improve the safety and efficacy of transplanted therapeutic cells. In this review, we provide an overview and discussion of the current progress in the genetic enhancement field, including genetic modifications of mesenchymal stem cells, neural stem cells, vascular cells, hematopoietic stem cells and T cells to target aging and aging-associated diseases. We also outline questions regarding safety and current limitations that need to be addressed for the continued development of genetic enhancement strategies for cell therapy to enable its further applications in clinical trials to combat aging-related diseases.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45050928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The Potential Effects of the United States Abortion Ruling on Global Embryo/Foetal and Stem Cell Research 美国堕胎裁决对全球胚胎/胎儿和干细胞研究的潜在影响

Life medicine Pub Date : 2022-11-18 DOI: 10.1093/lifemedi/lnac052

Zhenyu Xiao, Jianwei Lv, Siqi Zhao, Rosario Isasi, Xinwei Xie, Lei Dong, Yaojin Peng

引用次数: 0

Spatiotemporal Omics-Refining the landscape of precision medicine 时空奥密克戎提炼精准医学版图

Life medicine Pub Date : 2022-11-14 DOI: 10.1093/lifemedi/lnac053

Jiajun Zhang, Jianhua Yin, Yang Heng, Ken Xie, Ao Chen, I. Amit, Xiuwu Bian, XunHua Xu

{"title":"Spatiotemporal Omics-Refining the landscape of precision medicine","authors":"Jiajun Zhang, Jianhua Yin, Yang Heng, Ken Xie, Ao Chen, I. Amit, Xiuwu Bian, XunHua Xu","doi":"10.1093/lifemedi/lnac053","DOIUrl":"https://doi.org/10.1093/lifemedi/lnac053","url":null,"abstract":"\u0000 Current streamline of precision medicine uses histomorphological and molecular information to indicate individual phenotypes and genotypes to achieve optimal outcome of treatment. The knowledge of detected mutations and alteration can hardly describe molecular interaction and biological process which can finally be manifested as a disease. With molecular diagnosis revising the modalities of disease, there is a trend in precision medicine to apply multi-omic and multi-dimensional information to decode tumors, regarding heterogeneity, pathogenesis, prognosis, etc. Emerging state-of-art spatiotemporal omics provides a novel vision for in discovering clinicopathogenesis associated findings, some of which show a promising potential to be translated to facilitate clinical practice. Here, we summarize the available spatiotemporal omic technologies and algorithms, highlight the novel scientific findings and explore potential applications in the clinical scenario. Spatiotemporal omics present the ability to provide impetus to rewrite clinical pathology and to answer outstanding clinical questions. This review emphasizes the novel vision of spatiotemporal omics to refine the landscape of precision medicine in the clinic.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45250385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Neuron-periphery mitochondrial stress communication in aging and diseases 衰老和疾病中的神经元-外周线粒体应激通讯

Life medicine Pub Date : 2022-11-11 DOI: 10.1093/lifemedi/lnac051

Jiasheng Li, Jimeng Cui, Ye Tian

引用次数: 3

Nestin prevents mesenchymal stromal cells from apoptosis in LPS-induced lung injury via inhibition of unfolded protein response sensor IRE1α 巢蛋白通过抑制未折叠蛋白反应传感器IRE1α防止LPS诱导的肺损伤中间充质基质细胞凋亡

Life medicine Pub Date : 2022-11-04 DOI: 10.1093/lifemedi/lnac049

Hong Wang, Chenhao Jiang, Jianye Cai, Qiying Lu, Y. Qiu, Yi Wang, Yinong Huang, Yong Xiao, Boyan Wang, Xiaoyue Wei, Jiahao Shi, Xingqiang Lai, Tao Wang, Jiancheng Wang, A. Xiang

{"title":"Nestin prevents mesenchymal stromal cells from apoptosis in LPS-induced lung injury via inhibition of unfolded protein response sensor IRE1α","authors":"Hong Wang, Chenhao Jiang, Jianye Cai, Qiying Lu, Y. Qiu, Yi Wang, Yinong Huang, Yong Xiao, Boyan Wang, Xiaoyue Wei, Jiahao Shi, Xingqiang Lai, Tao Wang, Jiancheng Wang, A. Xiang","doi":"10.1093/lifemedi/lnac049","DOIUrl":"https://doi.org/10.1093/lifemedi/lnac049","url":null,"abstract":"\u0000 The clinical applications of MSC therapy have been intensely investigated in acute respiratory distress syndrome. However, clinical studies have fallen short of expectations despite encouraging preclinical results. One of the key problems is that transplanted stem cells can hardly survive in the harsh inflammatory environment. Prolonging the survival of transplanted MSCs might be a promising strategy to enhance the therapeutic efficacy of MSC therapy. Here, we identified Nestin, a class VI intermediate filament, as a positive regulator of MSC survival in the inflammatory microenvironment. We showed that Nestin knockout led to a significant increase of MSC apoptosis, which hampered the therapeutic effects in an LPS-induced lung injury model. Mechanistically, Nestin knockout induced a significant elevation of endoplasmic reticulum (ER) stress level. Further investigations showed that Nestin could bind to IRE1α and inhibit ER stress-induced apoptosis under stress. Furthermore, pretreatment with IRE1α inhibitor 4μ8C improved MSC survival and improved therapeutic effect. Our data suggests that Nestin enhances stem cell survival after transplantation by inhibiting ER stress-induced apoptosis, improving protection and repair of the lung inflammatory injury.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43543619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Biallelic mutations in IQCN, encoding a novel acroplaxome protein, lead to fertilization failure and male infertility with defects in the acrosome and shaping of the spermatid head in humans and mice IQCN的双等位基因突变编码一种新的顶体蛋白，可导致人类和小鼠受精失败和男性不育，并伴有顶体缺陷和精子头成形

Life medicine Pub Date : 2022-11-04 DOI: 10.1093/lifemedi/lnac050

Y. Sha, Yongjie Chen, Xiong Wang, R. Meng, Xiaoyan Yang, Youzhu Li, P. Jin, Shanze Li, Jie Chen, Tianyu Shao, Dan Xu, Yibiao Guo, Zhaodi Jiang, Yuhua Li, Shuntai Yu, Lin Li, Fengchao Wang

引用次数: 3

The natural product rotundic acid treats both aging and obesity by inhibiting PTP1B 天然产物圆霉菌酸通过抑制PTP1B治疗衰老和肥胖

Life medicine Pub Date : 2022-10-27 DOI: 10.1093/lifemedi/lnac044

Jie Zhu, Yongpan An, Xin Wang, Liting Huang, Weikaixin Kong, Miaomiao Gao, Jingxiang Wang, Xinpei Sun, Sujie Zhu, Zhengwei Xie

{"title":"The natural product rotundic acid treats both aging and obesity by inhibiting PTP1B","authors":"Jie Zhu, Yongpan An, Xin Wang, Liting Huang, Weikaixin Kong, Miaomiao Gao, Jingxiang Wang, Xinpei Sun, Sujie Zhu, Zhengwei Xie","doi":"10.1093/lifemedi/lnac044","DOIUrl":"https://doi.org/10.1093/lifemedi/lnac044","url":null,"abstract":"\u0000 The occurrence of obesity is associated with age. But their interplay remains mysterious. Here, we discovered that rotundic acid (RA), a plant-derived pentacyclic triterpene, was a powerful agent for both anti-aging and treating obesity. Considering that obese individuals decrease the appetite-suppressing and energy-expenditure-enhancing functions of leptin leading to obesity, we found RA was a leptin sensitizer, evidenced by observations that RA enhanced the leptin sensitivity to normal diet-induced obese (DIO) mice, and had minimal or no use to normal lean mice, leptin receptor-deficient (db/db) mice and leptin-deficient (ob/ob) mice. Simultaneously, RA significantly increased energy expenditure, BAT thermogenesis and glucose metabolism in DIO mice, as the results of enhancing leptin sensitivity. Regarding mode of action, we demonstrated that RA is a noncompetitive inhibitor of leptin negative regulators protein tyrosine phosphatase 1B (PTP1B) and T-cell PTP (TCPTP) through interaction with their C-terminus, thus leading to weight loss through enhancing leptin sensitivity. Besides, we showed that deletion of yPTP1 in yeast completely abolished the lifespan extension effect of RA, celstrol and withaferin A, while these compounds exhibited PTP1B inhibition activity. Furthermore, PTP1B knockdown extend lifespan in yeast and human cells, indicating PTP1B is an important factor regulating cellular aging.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43936108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

NAD + is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1 通过sirt1依赖性的AceCS1去乙酰化，NAD +对维持胚胎干细胞中乙酰辅酶a和H3K27ac至关重要

Life medicine Pub Date : 2022-10-26 DOI: 10.1093/lifemedi/lnac046

Yi Wu, Yang Liu, Zhihong Hao, Xingguo Liu

引用次数: 1

A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats 二甲双胍与烟酰胺核苷缓解大鼠组织衰老的比较研究

Life medicine Pub Date : 2022-10-26 DOI: 10.1093/lifemedi/lnac045

Lingling Geng, Bin Zhang, Haisong Liu, Si Wang, Yusheng Cai, Kuan Yang, Zhiran Zou, Xiaoyu Jiang, Zunpeng Liu, Wei Li, Zeming Wu, Xiaoqian Liu, Qun Chu, Guang-Hui Liu, J. Qu, Weiqi Zhang

{"title":"A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats","authors":"Lingling Geng, Bin Zhang, Haisong Liu, Si Wang, Yusheng Cai, Kuan Yang, Zhiran Zou, Xiaoyu Jiang, Zunpeng Liu, Wei Li, Zeming Wu, Xiaoqian Liu, Qun Chu, Guang-Hui Liu, J. Qu, Weiqi Zhang","doi":"10.1093/lifemedi/lnac045","DOIUrl":"https://doi.org/10.1093/lifemedi/lnac045","url":null,"abstract":"\u0000 Metformin (MET) and nicotinamide riboside (NR) have both been reported to exert geroprotective effects in multiple species. However, the mechanism by which MET and NR reconnect the aging program and delay aging in multiple tissues remains unclear. Here, we demonstrated that MET and NR attenuate aging features in human mesenchymal stem cells. Moreover, by systematically investigating the pathophysiological changes in different tissues from aged rats after oral administration of MET and NR, we showed that both MET and NR treatment alleviated various aging-related characteristics in multiple tissues, including inflammation, fibrosis, and protein aggregates. Consistently, MET or NR treatment partially rescued aging-related gene expression changes in aged rats. Collectively, we report that both MET and NR attenuate senescence phenotypes in human stem cells in vitro and in a variety of rodent tissues in vivo, thus providing a valuable resource and foundation for further evaluation of these two compounds against aging.","PeriodicalId":74073,"journal":{"name":"Life medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45256153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9