Journal of mood and anxiety disorders最新文献

{"title":"A randomized controlled trial of computerized cognitive training to improve working memory in individuals with elevated repetitive negative thinking: Behavioral and neural outcomes","authors":"Jessica Bomyea ,&nbsp;Morgan M. Caudle ,&nbsp;Nathalie Dugas ,&nbsp;Raeanne C. Moore ,&nbsp;Alan N. Simmons ,&nbsp;Michael L. Thomas","doi":"10.1016/j.xjmad.2024.100095","DOIUrl":"10.1016/j.xjmad.2024.100095","url":null,"abstract":"<div><div>Individuals with mood, anxiety, and traumatic stress disorders frequently experience distressing repetitive negative thinking (RNT) symptoms, which are characterized by pervasive, uncontrollable negative thoughts. Dysfunction in executive functioning processes, particularly the ability to regulate the contents of working memory, are implicated in the development and maintenance of RNT. Guided by the National Institute of Mental Health experimental therapeutics framework, this study aimed to investigate the cognitive effects and effects of two doses of a novel working memory training (WMT) intervention in individuals with elevated RNT across mood, anxiety, and traumatic stress disorders. We conducted a three-arm randomized controlled trial with 8-session and 16-session WMT interventions and a waitlist control group (N = 73). Our primary goal was to establish target engagement of WMT as measured by behavioral and neural indicators of working memory performance. Results revealed that WMT significantly improved working memory performance and resulted in reduced frontoparietal neural activity during a working memory task compared to the waitlist control group, providing evidence of target engagement. Exploratory analyses revealed a potential transfer of training effects to fluid intelligence, a construct related to but distinct from working memory, suggesting broader cognitive benefits of WMT. These data provide evidence that WMT can enhance working memory performance in individuals with RNT. This intervention holds promise as a transdiagnostic approach for ameliorating RNT-related clinical burden, with the 8-session regimen showing pragmatic advantages. Further research is needed to elucidate its impact on clinical symptoms and explore potential cognitive benefits beyond working memory.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “North American open-label 16-week trial of the MindShift smartphone app for adult anxiety” [J Mood Anxiety Disord 4C (2023) 100036]","authors":"Lance M. Rappaport ,&nbsp;Emily Jerome ,&nbsp;Michael Van Ameringen ,&nbsp;Maureen Whittal ,&nbsp;Carmen P. McLean","doi":"10.1016/j.xjmad.2024.100093","DOIUrl":"10.1016/j.xjmad.2024.100093","url":null,"abstract":"","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100093"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents","authors":"Dana Kanel ,&nbsp;Andre Zugman ,&nbsp;Grace Stohr ,&nbsp;Beck Scheinberg ,&nbsp;Elise Cardinale ,&nbsp;Anderson M. Winkler ,&nbsp;Katharina Kircanski ,&nbsp;Nathan A. Fox ,&nbsp;Melissa A. Brotman ,&nbsp;Julia O. Linke ,&nbsp;Daniel S. Pine","doi":"10.1016/j.xjmad.2024.100094","DOIUrl":"10.1016/j.xjmad.2024.100094","url":null,"abstract":"<div><div>The study of brain connectivity, both functional and structural, can inform us on the development of psychopathology. The use of multimodal MRI methods allows us to study associations between structural and functional connectivity, and how this relates to psychopathology. This may be especially useful during childhood and adolescence, a period where most forms of psychopathology manifest for the first time. The current paper explores structure-function coupling, measured through diffusion and resting-state functional MRI, and quantified as the correlation between structural and functional connectivity matrices. We investigate associations between psychopathology and coupling in a transdiagnostic group of adolescents, including many treatment-seeking youth with relatively high levels of symptoms (<em>n</em> = 72, M_age = 13.3). We used a bifactor model to extract our main outcome measure, Negative Affectivity, from anxiety and irritability ratings. This provided the principal measure of psychopathology. Supplementary analyses investigated ‘domain-specific’ factors of anxiety and irritability. Findings indicate a positive association between negative affectivity and structure-function coupling between the default mode and the fronto-parietal control networks. Higher structure-function coupling may indicate heightened structural constraints on function, which limit functional network reorganization during adolescence required for healthy psychological outcomes.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100094"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of mindfulness-based cognitive therapy on PTSD and depression symptoms in trauma-exposed black adults: Pilot randomized controlled trial results","authors":"Malin Au ,&nbsp;Rebecca Lipschutz ,&nbsp;Yara Mekawi ,&nbsp;Emma C. Lathan ,&nbsp;H. Drew Dixon ,&nbsp;Sierra Carter ,&nbsp;Rebecca Hinrichs ,&nbsp;Bekh Bradley ,&nbsp;Nadine J. Kaslow ,&nbsp;Nicole R. Nugent ,&nbsp;Abigail Powers","doi":"10.1016/j.xjmad.2024.100092","DOIUrl":"10.1016/j.xjmad.2024.100092","url":null,"abstract":"<div><div>Low-income, urban-dwelling Black adults are disproportionately affected by traumatic experiences, posttraumatic stress disorder (PTSD), and depression and encounter inequities in treatment access. In addition to the benefits Mindfulness-Based Cognitive Therapy (MBCT) for depression, there is preliminary evidence of successful symptom reduction in PTSD via MBCT across two prior pilot studies in veterans. Studies examining the effects of MBCT among trauma-exposed Black adults remains limited, and examination of effects across specific PTSD clusters is almost nonexistent. We examined the preliminary efficacy of adapted MBCT versus waitlist control (WLC) on PTSD and depression symptoms in a pilot randomized controlled trial (RCT). Black adults (<em>N</em> = 80; 86.10 % women) with repeated trauma exposure, who screened positive for PTSD and depression, were recruited from an urban public hospital and randomized to 8-week adapted MBCT or WLC. Symptoms were measured pretreatment and posttreatment with the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) and the Beck Depression Inventory-II (BDI-II). Mixed model analyses were conducted with an intent-to-treat approach, examining change in PTSD and depression scores between MBCT and WLC over time. There was no significant difference in total PTSD and depression symptom change between MBCT and WLC. CAPS-5 avoidance symptoms showed a nominally significant decrease in the MBCT group (<em>F</em>[1, 68.10] = 5.98, <em>p</em> = .017; <em>t</em>[71.60] = 3.61, <em>p</em> &lt; .001). Findings suggest MBCT might be helpful for addressing avoidance symptoms among Black adults with comorbid PTSD and depression. Although lacking power to draw final conclusions about treatment efficacy, this study provides preliminary data suggesting the importance of future fully powered trials.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100092"},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heteronormative and cisnormative stereotypes in commonly-used social anxiety scales: A scoping review","authors":"Chantal Kasch ,&nbsp;Cameron E. Lindsay ,&nbsp;Stefan G. Hofmann","doi":"10.1016/j.xjmad.2024.100091","DOIUrl":"10.1016/j.xjmad.2024.100091","url":null,"abstract":"<div><div>Social anxiety is a common, but under-researched topic in the LGBTQIA+ community. We conducted a scoping review of studies between January 2014 and April 2024 that included LGBTQIA+ samples with social anxiety scales evaluating scales for outdated language. The search produced 1155 results out of which 17 articles fit the inclusion criteria. The results suggest that 47 % of the measures include items that reinforce heteronormative or cisnormative stereotypes and 29.4 % of studies included scales inappropriate for the population under investigation. Therefore, the wordings of certain items need to be adapted to fit the investigated population and a re-examination of the psychometric properties of the revised scales is needed.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100091"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms and suicidal ideation in sexual minority adolescents: An examination of social reward responsiveness and support as moderators","authors":"Yinru Long ,&nbsp;Samantha Pegg ,&nbsp;Christian A.L. Bean ,&nbsp;Andrew Kittleson ,&nbsp;Kirsty Clark ,&nbsp;Autumn Kujawa","doi":"10.1016/j.xjmad.2024.100090","DOIUrl":"10.1016/j.xjmad.2024.100090","url":null,"abstract":"<div><div>Sexual minority (SM) youth are at increased risk of depression and suicidal ideation (SI), due in part to discrimination and other stressors. This raises questions about social factors that may increase risk or resilience to stressors commonly faced by SM youth. The goal of this multimethod study was to examine both neural processing of social feedback and perceived social support as potential moderators of the association between SM identity, depressive symptoms, and endorsement of SI in adolescents. For this study, 165 adolescents aged 14–17 (22.42 % identifying as SM) were oversampled for current depression. Participants self-reported social support, depressive symptoms, and SI. Electroencephalogram (EEG) was recorded while participants completed a computerized peer interaction task in which the reward positivity (RewP) component was measured in response to social acceptance vs. rejection feedback. We tested social RewP and social support as moderators of associations between SM identity, depressive symptoms, and whether SI was reported. SM youth reported lower social support and elevated depressive symptoms and were more likely to endorse SI compared to non-SM youth. Social RewP moderated the associations between SM identity, depressive symptoms, and SI such that SM youth with blunted neural responses to social acceptance had higher depression and were more likely to endorse SI. Lower social support was associated with greater depressive symptoms and SI, but social support was not a significant moderator of the association between SM identity and symptoms. This is among the first studies to use affective neuroscience methods to examine social processes in SGM youth and our findings underscore the role of social factors in SGM youth mental health.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100090"},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting OCD severity from religiosity and personality: A machine learning and neural network approach","authors":"Brian A. Zaboski ,&nbsp;Alixandra Wilens ,&nbsp;Joseph P.H. McNamara ,&nbsp;Gregory N. Muller","doi":"10.1016/j.xjmad.2024.100089","DOIUrl":"10.1016/j.xjmad.2024.100089","url":null,"abstract":"<div><div>Obsessive-compulsive disorder (OCD) affects a significant portion of the United States population. The present study investigated the complex relationships among OCD severity, personality traits, religiosity, and spirituality with a dataset of 229 participants. We applied advanced machine and deep learning techniques to identify key predictors of OCD severity, uncovering nuanced relationships and unexpected findings. Notably, item-level features were more influential than aggregate scores, challenging traditional analytical approaches. Moreover, a neural network model, despite not surpassing a linear regression in predictive accuracy, provided a more comprehensive understanding of OCD’s heterogeneity and of the nonlinear relationships between our variables. The inclusion of demographic factors provided further explanatory power for predicting OCD severity, emphasizing the multifaceted nature of the disorder. Our results show that machine learning models can nearly match traditional linear models in predictive power while retaining nonlinear relationships essential to understanding OCD. Our study advocates for the adoption of sophisticated predictive models in examining complex psychological phenomena, encouraging a reevaluation of conventional analytical approaches when prediction is central to research questions.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100089"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing social anhedonia in a transdiagnostic sample: Insights from a computational psychiatry lens.","authors":"Katia M. Harlé ,&nbsp;Danielle N. Dun ,&nbsp;Andrea D. Spadoni ,&nbsp;Jonathon R. Howlett ,&nbsp;Alan N. Simmons","doi":"10.1016/j.xjmad.2024.100088","DOIUrl":"10.1016/j.xjmad.2024.100088","url":null,"abstract":"<div><p>Anhedonia, a reduced ability to experience positive affect and seek rewards, is present across many psychiatric disorders, notably among individuals who experienced trauma. Within the social domain, anhedonia manifests as an altered sense of belonging and social isolation and is associated with poorer clinical outcomes. Yet, mechanistic operationalizations of social anhedonia are lacking, limiting our understanding of the relationship between these mechanisms and affective symptoms. To address these questions, we developed a social reward exploration task which was administered to a transdiagnostic sample of trauma-exposed Veterans (N = 33) while they underwent functional magnetic resonance imaging. The goal was to maximize compliments from two unknown partners, as participants were told these partners selected compliments based on seeing their picture. A Bayesian reinforcement learning modeling approach was used to extract cognitive and neural markers of compliment (reward) exploration. To address these questions, we developed a social reward exploration task which was administered to a transdiagnostic sample of trauma-exposed Veterans (N = 33) while they underwent functional magnetic resonance imaging. The goal was to maximize compliments from two unknown partners, as participants were told these partners selected compliments based on seeing their picture. A Bayesian reinforcement learning modeling approach was used to extract cognitive and neural markers of compliment (reward) exploration. Higher social connectedness (β = 0.51; 95 % CI=[0.11,0.94]) and anxiety (β = 0.57; 95 % CI=[0.13,1.00]) were independently associated with more model-based choices of the partner they anticipated to be most complimenting. In the dorsal anterior cingulate cortex (ACC; z = 3.89, <em>p</em> .001) and left inferior parietal lobule (z = 3.96, <em>p</em> .001), neural responses to reward prediction errors (RPE) were more positive in response to compliment relative to non-compliment outcomes. Greater positive RPE ACC activation was associated with lower anxiety (β = −0.51; 95 % CI=[−0.99,−0.10]. Computational approaches to social reinforcement learning can help identify important neurocognitive differences in social reward sensitivity among individuals with complex affective profiles, such as trauma-exposed individuals. Understanding these differences may help develop new prediction and treatment tools for social anhedonia.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100088"},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000427/pdfft?md5=fa995f6e76f3d9693b000dc7e18cf59f&pid=1-s2.0-S2950004424000427-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review on the bidirectional relationship between trauma-related psychopathology and reproductive aging","authors":"Amanda R. Arnold ,&nbsp;Trinidi Prochaska ,&nbsp;Maximilian Fickenwirth ,&nbsp;Abigail Powers ,&nbsp;Alicia K. Smith ,&nbsp;E. Britton Chahine ,&nbsp;Jennifer S. Stevens ,&nbsp;Vasiliki Michopoulos","doi":"10.1016/j.xjmad.2024.100082","DOIUrl":"10.1016/j.xjmad.2024.100082","url":null,"abstract":"<div><h3>Objective</h3><p>Natural variation in ovarian steroid hormones across the female lifespan contributes to an increased risk for depressive and posttraumatic stress disorder (PTSD) symptoms in women. However, minimal work has focused on understanding the impacts of reproductive aging on the brain and behavioral health of trauma-exposed women. This systematic review examines the bidirectional relationship between trauma-related psychopathology and reproductive aging.</p></div><div><h3>Method</h3><p>Following PRISMA guidelines, a systematic review of PubMed, PsychInfo, and Medline databases was undertaken to identify controlled studies on how trauma history impacts psychopathology and menopause symptoms during reproductive aging.</p></div><div><h3>Results</h3><p>Twenty-one studies met the eligibility criteria, with only four utilizing the gold standard STRAW+ 10 criteria for defining reproductive aging stages. The peri and postmenopausal periods appear to be particularly vulnerable phases for individuals with trauma exposure. Menopause symptoms and trauma-related psychopathology symptom severity increase during reproductive aging with increases in the degree of trauma exposure. However, mechanistic insights that may explain this interaction are currently neglected in this area of research.</p></div><div><h3>Conclusion</h3><p>There is a significant lack of understanding regarding how reproductive aging and its related neuroendocrine changes impact the brain to influence PTSD and depression symptoms related to trauma exposure. This lack of basic understanding impedes the ability to identify, assess, and treat PTSD and depressive symptoms in trauma-exposed women most effectively, and mitigate the long-term consequences of these behavioral health symptoms on morbidity and mortality in aging women.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100082"},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000361/pdfft?md5=fbe0427ff840923868dc6c2ed86f7afd&pid=1-s2.0-S2950004424000361-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative affect influences suicide-specific attentional biases","authors":"Beverlin Rosario-Williams,&nbsp;Regina Miranda","doi":"10.1016/j.xjmad.2024.100081","DOIUrl":"10.1016/j.xjmad.2024.100081","url":null,"abstract":"<div><h3>Background</h3><p>Studies using tasks that measure suicide-specific attentional biases have not specified which attentional processes are related to risk for suicidal thoughts and behaviors. This study distinguished suicide-specific engagement and disengagement biases from other forms of cognitive processing and investigated under which affective conditions suicide-specific biases emerged.</p></div><div><h3>Method</h3><p>An ethnoracially and socioeconomically diverse sample of 153 young adults (87 % female; 52 % Non-Hispanic White), ages 18–34, with moderate-to-high symptoms of anxiety, depression, or recent suicide ideation were randomly assigned to experience positive, negative, or neutral affect, completed cognitive tasks of attention, construct accessibility, and threat bias, and self-report measures.</p></div><div><h3>Results</h3><p>Individuals with recent ideation displayed facilitated disengagement from suicide-specific stimuli irrespective of affective state. Those with distal ideation showed slower disengagement from suicide-specific stimuli in the sad condition only.</p></div><div><h3>Conclusions</h3><p>Individuals with recent suicide ideation display automatic processing of suicide-related information, perhaps due to recent rehearsal of suicide-related content. In contrast, individuals with distal ideation experiencing negative affect appear to have difficulty disengaging attention from suicide-related content. Limits to generalizability of the findings include a predominantly female sample, although the sample’s racial, ethnic, and socioeconomic diversity increase generality of the research.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295000442400035X/pdfft?md5=3efed9b660dcd1c99fb9b7203c99d195&pid=1-s2.0-S295000442400035X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}