Journal of mood and anxiety disorders最新文献

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Racial discrimination and anxiety in African American youth: Risk, resilience, and intervention 非裔美国青年的种族歧视和焦虑:风险、恢复力和干预
Journal of mood and anxiety disorders Pub Date : 2025-02-28 DOI: 10.1016/j.xjmad.2025.100115
Joya N. Hampton-Anderson , Briana Woods-Jaeger , Troy B. Maxwell , W. Edward Craighead
{"title":"Racial discrimination and anxiety in African American youth: Risk, resilience, and intervention","authors":"Joya N. Hampton-Anderson ,&nbsp;Briana Woods-Jaeger ,&nbsp;Troy B. Maxwell ,&nbsp;W. Edward Craighead","doi":"10.1016/j.xjmad.2025.100115","DOIUrl":"10.1016/j.xjmad.2025.100115","url":null,"abstract":"<div><div>Among African American youth, experiences of discrimination are related to having an anxiety disorder with significant impairment. Although incorporating culturally relevant treatment components (e.g., race socialization) that address experiences of discrimination might better serve minority youth, current evidence based interventions for anxiety in outpatient settings typically fail to include those culturally relevant components. This manuscript, noting the role of racial discrimination, outlines indicators of risk and resilience for diagnosis and prognosis of anxiety disorders among African American youth. Qualitative examples, provided from a sample of community stakeholders and African American youth seeking services for an anxiety disorder, describe specific associations between experiences of racial discrimination and anxiety. We conclude that identification and inclusion of culturally specific risk and protective factors in the development, implementation, and evaluation of anxiety-focused intervention programs in outpatient settings that target culturally specific protective factors will better serve African American youth experiencing anxiety disorders.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults 在包括丹麦和冰岛成年人在内的三个基于人口的大队列中,康纳-戴维森弹性量表的心理测量特性和社会人口学相关性
Journal of mood and anxiety disorders Pub Date : 2025-02-17 DOI: 10.1016/j.xjmad.2025.100112
Maria Didriksen , Hilda Daníelsdottir , Marín Dögg Bjarnadóttir , Cassie Overstreet , Karmel W. Choi , Lea Arregui Nordahl Christoffersen , Christina Mikkelsen , Thor Aspelund , Arna Hauksdóttir , Edda Bjork Thordardottir , Jóhanna Jakobsdóttir , Gunnar Tómasson , Christian Erikstrup , Bitten Aagaard , Mie T. Bruun , Henrik Ullum , Erik Sørensen , Ian C. Fischer , Robert H. Pietrzak , Joel Gelernter , Andrew J. Schork
{"title":"Psychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults","authors":"Maria Didriksen ,&nbsp;Hilda Daníelsdottir ,&nbsp;Marín Dögg Bjarnadóttir ,&nbsp;Cassie Overstreet ,&nbsp;Karmel W. Choi ,&nbsp;Lea Arregui Nordahl Christoffersen ,&nbsp;Christina Mikkelsen ,&nbsp;Thor Aspelund ,&nbsp;Arna Hauksdóttir ,&nbsp;Edda Bjork Thordardottir ,&nbsp;Jóhanna Jakobsdóttir ,&nbsp;Gunnar Tómasson ,&nbsp;Christian Erikstrup ,&nbsp;Bitten Aagaard ,&nbsp;Mie T. Bruun ,&nbsp;Henrik Ullum ,&nbsp;Erik Sørensen ,&nbsp;Ian C. Fischer ,&nbsp;Robert H. Pietrzak ,&nbsp;Joel Gelernter ,&nbsp;Andrew J. Schork","doi":"10.1016/j.xjmad.2025.100112","DOIUrl":"10.1016/j.xjmad.2025.100112","url":null,"abstract":"<div><div>Identifying specific factors affecting psychological resilience could be instrumental in developing new therapeutic strategies for improving and maintaining mental and physical health. To achieve this, an adequate measure of psychological resilience is essential. We studied the psychometric properties of the 10-item Connor-Davidson Resilience Scale (CD-RISC-10) across three population-based cohorts. The study included adult Danish individuals in the Danish Blood Donor Study (DBDS, N = 57,031), and the Icelandic cohorts Stress-And-Gene Analysis cohort (SAGA, N = 27,236), and COVID-19 National Resilience cohort (C19-Resilience, N = 20,373). Exploratory factor analysis revealed a consistent one-factor fit across cohorts. The scale demonstrated good internal consistency (Cronbach's alpha: 0.88–0.90) and longitudinal stability (Spearman correlation coefficients in DBDS: 0.71 across 1.5 years, 0.66 across two years). Mean CD-RISC-10 scores were consistent with previously reported scores in European populations. Lower scores were observed among participants with probable major depressive disorder, and higher scores were found with increasing age. Further evidence for construct validity was revealed as CD-RISC-10 scores moderated the association between financial trouble and depressive symptoms across all cohorts. Psychometric properties of the CD-RISC-10 were similar among women and men. Our findings support the use of the CD-RISC-10 as a reliable and valid unidimensional measure of psychological resilience in Danish and Icelandic populations.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between pre- and postpartum posttraumatic stress symptoms and maternal functioning in Black trauma-exposed women 受过创伤的黑人妇女产前和产后创伤后应激症状与产妇功能之间的关系
Journal of mood and anxiety disorders Pub Date : 2025-02-11 DOI: 10.1016/j.xjmad.2025.100111
Rebecca Lipschutz , Meghna Ravi , Emma C. Lathan , Monica Duan , Sriya Karra , Shimarith Wallace , Merom Arthur , Abby Britt , Abigail Powers , Vasiliki Michopoulos
{"title":"Associations between pre- and postpartum posttraumatic stress symptoms and maternal functioning in Black trauma-exposed women","authors":"Rebecca Lipschutz ,&nbsp;Meghna Ravi ,&nbsp;Emma C. Lathan ,&nbsp;Monica Duan ,&nbsp;Sriya Karra ,&nbsp;Shimarith Wallace ,&nbsp;Merom Arthur ,&nbsp;Abby Britt ,&nbsp;Abigail Powers ,&nbsp;Vasiliki Michopoulos","doi":"10.1016/j.xjmad.2025.100111","DOIUrl":"10.1016/j.xjmad.2025.100111","url":null,"abstract":"","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduced neural activation during positive social approach is associated with better response to approach avoidance training for social anxiety disorder 积极社交接近过程中神经活动的减少与社交焦虑障碍回避训练的良好反应有关
Journal of mood and anxiety disorders Pub Date : 2025-02-07 DOI: 10.1016/j.xjmad.2025.100110
Christopher Hunt , Morgan M. Caudle , Martin P. Paulus , Murray B. Stein , Charles T. Taylor , Jessica Bomyea
{"title":"Reduced neural activation during positive social approach is associated with better response to approach avoidance training for social anxiety disorder","authors":"Christopher Hunt ,&nbsp;Morgan M. Caudle ,&nbsp;Martin P. Paulus ,&nbsp;Murray B. Stein ,&nbsp;Charles T. Taylor ,&nbsp;Jessica Bomyea","doi":"10.1016/j.xjmad.2025.100110","DOIUrl":"10.1016/j.xjmad.2025.100110","url":null,"abstract":"<div><h3>Introduction</h3><div>Accumulating evidence suggests that social anxiety disorder (SAD) is characterized by diminished approach of positive social stimuli. Approach-positive approach-avoidance training (AP-AAT) may reduce this bias, but its results have been mixed. AP-AAT might be more effective for patients with deficits in the neural approach processes AP-AAT targets. Here, we attempted to identify neural areas underlying reduced approach of positive social stimuli in SAD and explore whether activity in such areas predicted response to AP-AAT.</div></div><div><h3>Method</h3><div>This was a secondary analysis of an AP-AAT clinical trial involving 40 SAD participants and 22 healthy controls (HCs). A social approach-avoidance task was completed during fMRI to identify neural activation differences between SAD and HC subjects when approaching positive social cues. SAD participants were then randomized to AP-AAT (<em>n</em> = 18) or sham training (<em>n</em> = 22). Treatment response was assessed by changes in positive affect and social connection from pre-to-post treatment.</div></div><div><h3>Results</h3><div>Compared to HCs, SAD patients exhibited significantly less activation in the left paracentral lobule (PCL), right superior parietal lobule (SPL), and left lingual gyrus (LG) when approaching relative to avoiding positive social cues. Lower activation in the right SPL (b=-7.15, p = .022) and left LG (b=-6.93, p = .007) during social approach versus avoidance predicted greater improvement in positive affect (but not social connection) in the AP-AAT group relative to sham.</div></div><div><h3>Conclusions</h3><div>Lower neural activation during positive social approach at baseline predicted better AP-AAT response. AP-AAT may be particularly well-suited to SAD patients exhibiting the neural approach deficits that the treatment putatively targets.</div></div><div><h3>ClinicalTrials.gov Identifier</h3><div>NCT02136212</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applying large language models to stratify suicide risk using narrative clinical notes 应用大型语言模型,利用临床叙事笔记对自杀风险进行分层
Journal of mood and anxiety disorders Pub Date : 2025-01-31 DOI: 10.1016/j.xjmad.2025.100109
Thomas H. McCoy , Roy H. Perlis
{"title":"Applying large language models to stratify suicide risk using narrative clinical notes","authors":"Thomas H. McCoy ,&nbsp;Roy H. Perlis","doi":"10.1016/j.xjmad.2025.100109","DOIUrl":"10.1016/j.xjmad.2025.100109","url":null,"abstract":"<div><div>We investigated whether large language models can stratify risk for suicide following hospital discharge. We drew on a very large cohort of 458,053 adults discharged from two academic medical centers between January 4, 2005 and January 2, 2014, linked to administrative vital status data. From this sample, each of the 1995 individuals who died by suicide or accident was matched with 5 control individuals on the basis of age, sex, race and ethnicity, admitting hospital, insurance, comorbidity index, and discharge year. We applied a HIPAA-compliant large language model (gpt-4–1106-preview) to estimate risk for suicide based on narrative discharge summaries. In the resulting cohort (n = 11,970), median age was 57 (IQR 44 –76); 4536 (38 %) were women; 348 (3 %) had a primary psychiatric admission diagnosis. For the model-predicted risk, time to 90 % survival was 1588 days (IQR 1374–1905) in the lowest-risk quartile, 1432 (IQR 1157–1651) in the 2nd quartile, 661 (IQR 538–820) in the 3rd quartile, and 302 (IQR 260–362) in the top quartile (p &lt; .001). In Fine and Gray competing risk regression, predicted hazard was significantly associated with observed risk (unadjusted HR 7.66 [95 % CI 6.40–9.27]; adjusted for sociodemographic features and utilization, HR 8.86 (7.00–11.2)). Estimated risks were significantly greater scores among individuals who were Black or Hispanic (p &lt; .005 for each, versus white individuals). Overall, a large language model (LLM) was able to stratify risk for suicide and accidental death among individuals discharged from academic medical centers beyond that afforded by simple sociodemographic and clinical features medical centers.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of modified COVID-19 Phobia Scale (MC19P-SE) to examine the relationships between corona anxiety and COVID-19 symptoms: A case-control study 修订的COVID-19恐惧量表(MC19P-SE)验证冠状病毒焦虑与COVID-19症状之间的关系:一项病例对照研究
Journal of mood and anxiety disorders Pub Date : 2025-01-16 DOI: 10.1016/j.xjmad.2025.100108
Luthful Alahi Kawsar , Syed Toukir Ahmed Noor , Md. Atiqul Islam , Mohammad Romel Bhuia
{"title":"Validation of modified COVID-19 Phobia Scale (MC19P-SE) to examine the relationships between corona anxiety and COVID-19 symptoms: A case-control study","authors":"Luthful Alahi Kawsar ,&nbsp;Syed Toukir Ahmed Noor ,&nbsp;Md. Atiqul Islam ,&nbsp;Mohammad Romel Bhuia","doi":"10.1016/j.xjmad.2025.100108","DOIUrl":"10.1016/j.xjmad.2025.100108","url":null,"abstract":"<div><h3>Purpose</h3><div>The main purpose of the present study is to validate the modified COVID-19 phobia scale (MC19P-SE) in Bangla and use it to identify the link between COVID-related anxiety and the onset of COVID-19 symptoms.</div></div><div><h3>Methods</h3><div>A retrospective case-control study was conducted in Sylhet, a northeastern district in Bangladesh, focusing on a population of 18 years or older. The MC19P-SE scale was used to gather data on coronaphobia among the respondents, and factor analysis was used to derive reliable factors. We employed a multivariable logistic regression model to identify the relationships between coronavirus anxiety and COVID-19 symptoms.</div></div><div><h3>Results</h3><div>Among the 482 participants, 42 % manifested COVID-19 symptoms. Factor analysis revealed four underlying factors: psychological anxiety, psychosomatic anxiety, economic anxiety, and social or excessive protective anxiety. MC19P-SE exhibited reliability with a Cronbach alpha coefficient of 0.91 for full-scale. According to the model, psychosomatic anxiety increased (AOR= 1.14, 95 % CI: 1.07, 1.22) the risk while social or excessive protective anxiety decreased (AOR=0.88, 95 % CI: 0.78, 0.99) the risk of developing COVID-19 symptoms significantly.</div></div><div><h3>Conclusion</h3><div>The research found a significant relation in the Bangladeshi district of Sylhet between the onset of COVID-19 symptoms and anxiety associated with the virus. Furthermore, the findings affirm the potential reliability and validity of the MC19P-SE scale, strengthening its efficacy for future research and evaluations.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peer victimization but not social anxiety negatively influences predicted enjoyment during peer interactions 同伴受害而非社交焦虑负向影响同伴互动中的预期享受
Journal of mood and anxiety disorders Pub Date : 2025-01-09 DOI: 10.1016/j.xjmad.2025.100105
Isabel Leiva , Samantha S. Reisman , Chelsea Helion , Vishnu P. Murty , Johanna Jarcho
{"title":"Peer victimization but not social anxiety negatively influences predicted enjoyment during peer interactions","authors":"Isabel Leiva ,&nbsp;Samantha S. Reisman ,&nbsp;Chelsea Helion ,&nbsp;Vishnu P. Murty ,&nbsp;Johanna Jarcho","doi":"10.1016/j.xjmad.2025.100105","DOIUrl":"10.1016/j.xjmad.2025.100105","url":null,"abstract":"<div><div>We often underestimate how much others enjoy initial interactions with us - a phenomenon known as the liking gap. While widely documented, less research has explored how individual differences such as social anxiety and negative social experiences influence the liking gap. To test this, female and non-binary dyads (N = 23) varying in severity of social anxiety and exposure to peer victimization, completed semi-structured dialogues with strangers. Following the interaction, participants rated their own enjoyment and their assumption of their partner’s enjoyment of the interaction. Consistent with past literature, participants underestimated their partner’s enjoyment. The magnitude of the liking gap was greater for participants with more exposure to peer victimization, but not social anxiety. The relationship with peer victimization was specifically linked to incorrect perceptions about their partner’s enjoyment. This suggests that the liking gap may be susceptible to individual differences in peer victimization, rather than a broader phenotype of social anxiety.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Program evaluation of internet-delivered cognitive behavioral treatments for anxiety and depression in a digital clinic 数字化诊所中网络提供的焦虑和抑郁认知行为治疗的项目评估
Journal of mood and anxiety disorders Pub Date : 2025-01-09 DOI: 10.1016/j.xjmad.2025.100106
Alexandra L. Silverman , IreLee Ferguson , Jacqueline R. Bullis , Harris Bajwa , Sara Mei , Courtney Beard
{"title":"Program evaluation of internet-delivered cognitive behavioral treatments for anxiety and depression in a digital clinic","authors":"Alexandra L. Silverman ,&nbsp;IreLee Ferguson ,&nbsp;Jacqueline R. Bullis ,&nbsp;Harris Bajwa ,&nbsp;Sara Mei ,&nbsp;Courtney Beard","doi":"10.1016/j.xjmad.2025.100106","DOIUrl":"10.1016/j.xjmad.2025.100106","url":null,"abstract":"<div><div>SilverCloud and THIS WAY UP (TWU) are two internet-delivered cognitive-behavioral therapy (iCBT) programs that have demonstrated effectiveness for anxiety and depression, yet little is known about their comparative effectiveness. This non-randomized program evaluation compared client satisfaction, subjective engagement, and treatment outcomes between the SilverCloud and TWU programs. Participants were 195 adult patients (106 using TWU and 89 using SilverCloud) enrolled in a digital CBT clinic who completed assessment measures at pre-treatment, mid-treatment, post-treatment, and one-, two-, three-, and four-month follow-ups. As hypothesized (preregistration: <span><span>osf.io/x6bmy</span><svg><path></path></svg></span>), patients in both programs reported high client satisfaction, and experienced improvements in depression (<em>d</em>s = -0.79 and −0.78), anxiety (<em>d</em>s = -0.95 and −0.84), and functional impairment (<em>d</em>s = -0.42 and −0.45), from pre- to post-treatment that were maintained at four-month follow-up. However, according to exploratory analyses, the slope of change in treatment outcomes was not significantly different between programs during the treatment and follow-up phases. As hypothesized, patients who used SilverCloud self-reported significantly greater subjective engagement with their iCBT program compared to patients who used TWU (<em>d</em>=0.36). However, contrary to hypotheses, client satisfaction was not significantly different between programs. This non-randomized program evaluation offers minimal evidence that one program was better than the other, though findings require replication in a randomized controlled trial and larger sample. Results provide further support for iCBT as a viable option to extend access to high-quality treatment for anxiety and depression.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural activity to reward and loss predicting treatment outcomes for adults with generalized anxiety disorder: A randomized clinical trial 神经活动奖励和损失预测成人广泛性焦虑障碍的治疗结果:一项随机临床试验
Journal of mood and anxiety disorders Pub Date : 2025-01-08 DOI: 10.1016/j.xjmad.2025.100107
Hannah Berg , Yu-Jin Eun , Xiaoqian Yu , Timothy J. McDermott , Elisabeth Akeman , Rayus Kuplicki , Hung-Wen Yeh , Wesley Thompson , Christopher R. Martell , Kate B. Wolitzky-Taylor , Michelle G. Craske , Martin P. Paulus , Robin L. Aupperle
{"title":"Neural activity to reward and loss predicting treatment outcomes for adults with generalized anxiety disorder: A randomized clinical trial","authors":"Hannah Berg ,&nbsp;Yu-Jin Eun ,&nbsp;Xiaoqian Yu ,&nbsp;Timothy J. McDermott ,&nbsp;Elisabeth Akeman ,&nbsp;Rayus Kuplicki ,&nbsp;Hung-Wen Yeh ,&nbsp;Wesley Thompson ,&nbsp;Christopher R. Martell ,&nbsp;Kate B. Wolitzky-Taylor ,&nbsp;Michelle G. Craske ,&nbsp;Martin P. Paulus ,&nbsp;Robin L. Aupperle","doi":"10.1016/j.xjmad.2025.100107","DOIUrl":"10.1016/j.xjmad.2025.100107","url":null,"abstract":"<div><div>Aberrant reward processing has been predominantly associated with depressive disorders, with evidence that pre-treatment abnormalities in striatal reward responsiveness relates to treatment outcomes. Emerging research also implicates reward processing differences in anxiety disorders, particularly generalized anxiety disorder (GAD). The current study examined whether pre-treatment reward- and loss- related neural activity predicts symptom improvement with behavioral activation (BA) and exposure therapy (EXP) for GAD. In this randomized clinical trial (ClinicalTrials.gov NCT02807480) conducted from 2016 to 2021, treatment-seeking adults with GAD completed the monetary incentive delay task during functional magnetic resonance imaging pre-treatment, then were randomized to 10-session EXP or BA. The primary outcome measure was the GAD-7. Of 101 participants consented, 69 completed treatment, the 46 completers with quality imaging data were included in analyses (22 EXP, 24 BA; mean 32.7 years, 10.9 % male). <em>A priori</em> region-of-interest analysis revealed that greater left caudate activity during loss receipt predicted greater symptom improvement in EXP, and did not relate to symptom change in BA (<em>F</em>(1, 428)= 5.24, <em>p</em> = 0.023), though this was not significant after correction for multiple comparisons. Whole-brain analysis further identified that greater activity during reward receipt in left frontoparietal regions and anterior insula / ventrolateral prefrontal cortex was associated with better outcomes in BA and worse outcomes in EXP. These findings highlight the role of reward and loss reactivity in GAD treatment. In particular, patients with elevated reactivity to reward salience may benefit most from BA or other reward-focused treatments. Future clinical trials are warranted to further elucidate reward-related predictors of anxiety treatment.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between depressive symptoms and limitations in disability domains among US adults 美国成年人抑郁症状与残疾领域限制之间的关系
Journal of mood and anxiety disorders Pub Date : 2024-12-30 DOI: 10.1016/j.xjmad.2024.100103
Shakila Meshkat , Qiaowei Lin , Vanessa K. Tassone , Reinhard Janssen-Aguilar , Wendy Lou , Venkat Bhat
{"title":"The association between depressive symptoms and limitations in disability domains among US adults","authors":"Shakila Meshkat ,&nbsp;Qiaowei Lin ,&nbsp;Vanessa K. Tassone ,&nbsp;Reinhard Janssen-Aguilar ,&nbsp;Wendy Lou ,&nbsp;Venkat Bhat","doi":"10.1016/j.xjmad.2024.100103","DOIUrl":"10.1016/j.xjmad.2024.100103","url":null,"abstract":"<div><div>This study aims to evaluate the association of depressive symptoms and their severity with overall disability and disability domains, and to assess temporal changes in these associations. Data from the National Health and Nutrition Examination Survey (NHANES) 2013–2018 were analyzed. A total of 15,565 participants were included, with 1383 (8.19 %) reporting depressive symptoms. Depressive symptoms were strongly associated with overall disability (aOR = 7.82; 95 % CI = 6.27, 9.75; p &lt; 0.001) and with six specific domains (aOR = 2.54 for hearing, 2.84 for seeing, 10.53 for concentrating, 4.42 for walking, 6.01 for dressing or bathing, and 7.36 for doing errands alone; all p &lt; 0.001). Each unit increase in PHQ-9 score was linked to a 21 % increase in the odds of overall disability (aOR = 1.21; 95 % CI = 1.19, 1.23; p &lt; 0.001) and to a 9 %-25 % increase in the odds of domain-specific difficulties. Both cognitive-affective (aOR = 1.35; 95 % CI = 1.30, 1.40) and somatic scores (aOR = 1.36; 95 % CI = 1.33, 1.39) were associated with overall disability and domain-specific difficulties, with each unit increase linked to 13 %-45 % higher odds. Temporal analysis indicated that depressive symptoms are linked to a higher prevalence of disability, with this association persisting and slightly increasing over time. Our findings indicated the association between depressive symptoms and disability. Future studies should further replicate our results and evaluate the mechanisms underlying this phenomenon.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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