Journal of mood and anxiety disorders最新文献

{"title":"Validation of modified COVID-19 Phobia Scale (MC19P-SE) to examine the relationships between corona anxiety and COVID-19 symptoms: A case-control study","authors":"Luthful Alahi Kawsar ,&nbsp;Syed Toukir Ahmed Noor ,&nbsp;Md. Atiqul Islam ,&nbsp;Mohammad Romel Bhuia","doi":"10.1016/j.xjmad.2025.100108","DOIUrl":"10.1016/j.xjmad.2025.100108","url":null,"abstract":"<div><h3>Purpose</h3><div>The main purpose of the present study is to validate the modified COVID-19 phobia scale (MC19P-SE) in Bangla and use it to identify the link between COVID-related anxiety and the onset of COVID-19 symptoms.</div></div><div><h3>Methods</h3><div>A retrospective case-control study was conducted in Sylhet, a northeastern district in Bangladesh, focusing on a population of 18 years or older. The MC19P-SE scale was used to gather data on coronaphobia among the respondents, and factor analysis was used to derive reliable factors. We employed a multivariable logistic regression model to identify the relationships between coronavirus anxiety and COVID-19 symptoms.</div></div><div><h3>Results</h3><div>Among the 482 participants, 42 % manifested COVID-19 symptoms. Factor analysis revealed four underlying factors: psychological anxiety, psychosomatic anxiety, economic anxiety, and social or excessive protective anxiety. MC19P-SE exhibited reliability with a Cronbach alpha coefficient of 0.91 for full-scale. According to the model, psychosomatic anxiety increased (AOR= 1.14, 95 % CI: 1.07, 1.22) the risk while social or excessive protective anxiety decreased (AOR=0.88, 95 % CI: 0.78, 0.99) the risk of developing COVID-19 symptoms significantly.</div></div><div><h3>Conclusion</h3><div>The research found a significant relation in the Bangladeshi district of Sylhet between the onset of COVID-19 symptoms and anxiety associated with the virus. Furthermore, the findings affirm the potential reliability and validity of the MC19P-SE scale, strengthening its efficacy for future research and evaluations.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer victimization but not social anxiety negatively influences predicted enjoyment during peer interactions","authors":"Isabel Leiva ,&nbsp;Samantha S. Reisman ,&nbsp;Chelsea Helion ,&nbsp;Vishnu P. Murty ,&nbsp;Johanna Jarcho","doi":"10.1016/j.xjmad.2025.100105","DOIUrl":"10.1016/j.xjmad.2025.100105","url":null,"abstract":"<div><div>We often underestimate how much others enjoy initial interactions with us - a phenomenon known as the liking gap. While widely documented, less research has explored how individual differences such as social anxiety and negative social experiences influence the liking gap. To test this, female and non-binary dyads (N = 23) varying in severity of social anxiety and exposure to peer victimization, completed semi-structured dialogues with strangers. Following the interaction, participants rated their own enjoyment and their assumption of their partner’s enjoyment of the interaction. Consistent with past literature, participants underestimated their partner’s enjoyment. The magnitude of the liking gap was greater for participants with more exposure to peer victimization, but not social anxiety. The relationship with peer victimization was specifically linked to incorrect perceptions about their partner’s enjoyment. This suggests that the liking gap may be susceptible to individual differences in peer victimization, rather than a broader phenotype of social anxiety.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Program evaluation of internet-delivered cognitive behavioral treatments for anxiety and depression in a digital clinic","authors":"Alexandra L. Silverman ,&nbsp;IreLee Ferguson ,&nbsp;Jacqueline R. Bullis ,&nbsp;Harris Bajwa ,&nbsp;Sara Mei ,&nbsp;Courtney Beard","doi":"10.1016/j.xjmad.2025.100106","DOIUrl":"10.1016/j.xjmad.2025.100106","url":null,"abstract":"<div><div>SilverCloud and THIS WAY UP (TWU) are two internet-delivered cognitive-behavioral therapy (iCBT) programs that have demonstrated effectiveness for anxiety and depression, yet little is known about their comparative effectiveness. This non-randomized program evaluation compared client satisfaction, subjective engagement, and treatment outcomes between the SilverCloud and TWU programs. Participants were 195 adult patients (106 using TWU and 89 using SilverCloud) enrolled in a digital CBT clinic who completed assessment measures at pre-treatment, mid-treatment, post-treatment, and one-, two-, three-, and four-month follow-ups. As hypothesized (preregistration: <span><span>osf.io/x6bmy</span><svg><path></path></svg></span>), patients in both programs reported high client satisfaction, and experienced improvements in depression (<em>d</em>s = -0.79 and −0.78), anxiety (<em>d</em>s = -0.95 and −0.84), and functional impairment (<em>d</em>s = -0.42 and −0.45), from pre- to post-treatment that were maintained at four-month follow-up. However, according to exploratory analyses, the slope of change in treatment outcomes was not significantly different between programs during the treatment and follow-up phases. As hypothesized, patients who used SilverCloud self-reported significantly greater subjective engagement with their iCBT program compared to patients who used TWU (<em>d</em>=0.36). However, contrary to hypotheses, client satisfaction was not significantly different between programs. This non-randomized program evaluation offers minimal evidence that one program was better than the other, though findings require replication in a randomized controlled trial and larger sample. Results provide further support for iCBT as a viable option to extend access to high-quality treatment for anxiety and depression.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural activity to reward and loss predicting treatment outcomes for adults with generalized anxiety disorder: A randomized clinical trial","authors":"Hannah Berg ,&nbsp;Yu-Jin Eun ,&nbsp;Xiaoqian Yu ,&nbsp;Timothy J. McDermott ,&nbsp;Elisabeth Akeman ,&nbsp;Rayus Kuplicki ,&nbsp;Hung-Wen Yeh ,&nbsp;Wesley Thompson ,&nbsp;Christopher R. Martell ,&nbsp;Kate B. Wolitzky-Taylor ,&nbsp;Michelle G. Craske ,&nbsp;Martin P. Paulus ,&nbsp;Robin L. Aupperle","doi":"10.1016/j.xjmad.2025.100107","DOIUrl":"10.1016/j.xjmad.2025.100107","url":null,"abstract":"<div><div>Aberrant reward processing has been predominantly associated with depressive disorders, with evidence that pre-treatment abnormalities in striatal reward responsiveness relates to treatment outcomes. Emerging research also implicates reward processing differences in anxiety disorders, particularly generalized anxiety disorder (GAD). The current study examined whether pre-treatment reward- and loss- related neural activity predicts symptom improvement with behavioral activation (BA) and exposure therapy (EXP) for GAD. In this randomized clinical trial (ClinicalTrials.gov NCT02807480) conducted from 2016 to 2021, treatment-seeking adults with GAD completed the monetary incentive delay task during functional magnetic resonance imaging pre-treatment, then were randomized to 10-session EXP or BA. The primary outcome measure was the GAD-7. Of 101 participants consented, 69 completed treatment, the 46 completers with quality imaging data were included in analyses (22 EXP, 24 BA; mean 32.7 years, 10.9 % male). <em>A priori</em> region-of-interest analysis revealed that greater left caudate activity during loss receipt predicted greater symptom improvement in EXP, and did not relate to symptom change in BA (<em>F</em>(1, 428)= 5.24, <em>p</em> = 0.023), though this was not significant after correction for multiple comparisons. Whole-brain analysis further identified that greater activity during reward receipt in left frontoparietal regions and anterior insula / ventrolateral prefrontal cortex was associated with better outcomes in BA and worse outcomes in EXP. These findings highlight the role of reward and loss reactivity in GAD treatment. In particular, patients with elevated reactivity to reward salience may benefit most from BA or other reward-focused treatments. Future clinical trials are warranted to further elucidate reward-related predictors of anxiety treatment.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between depressive symptoms and limitations in disability domains among US adults","authors":"Shakila Meshkat ,&nbsp;Qiaowei Lin ,&nbsp;Vanessa K. Tassone ,&nbsp;Reinhard Janssen-Aguilar ,&nbsp;Wendy Lou ,&nbsp;Venkat Bhat","doi":"10.1016/j.xjmad.2024.100103","DOIUrl":"10.1016/j.xjmad.2024.100103","url":null,"abstract":"<div><div>This study aims to evaluate the association of depressive symptoms and their severity with overall disability and disability domains, and to assess temporal changes in these associations. Data from the National Health and Nutrition Examination Survey (NHANES) 2013–2018 were analyzed. A total of 15,565 participants were included, with 1383 (8.19 %) reporting depressive symptoms. Depressive symptoms were strongly associated with overall disability (aOR = 7.82; 95 % CI = 6.27, 9.75; p &lt; 0.001) and with six specific domains (aOR = 2.54 for hearing, 2.84 for seeing, 10.53 for concentrating, 4.42 for walking, 6.01 for dressing or bathing, and 7.36 for doing errands alone; all p &lt; 0.001). Each unit increase in PHQ-9 score was linked to a 21 % increase in the odds of overall disability (aOR = 1.21; 95 % CI = 1.19, 1.23; p &lt; 0.001) and to a 9 %-25 % increase in the odds of domain-specific difficulties. Both cognitive-affective (aOR = 1.35; 95 % CI = 1.30, 1.40) and somatic scores (aOR = 1.36; 95 % CI = 1.33, 1.39) were associated with overall disability and domain-specific difficulties, with each unit increase linked to 13 %-45 % higher odds. Temporal analysis indicated that depressive symptoms are linked to a higher prevalence of disability, with this association persisting and slightly increasing over time. Our findings indicated the association between depressive symptoms and disability. Future studies should further replicate our results and evaluate the mechanisms underlying this phenomenon.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric evaluation of a novel measure of trauma-related eating to cope","authors":"Sage E. Hawn ,&nbsp;Taylor Kliebhan ,&nbsp;Niya Richardson ,&nbsp;Mellyssa Deoliveira ,&nbsp;Kristin E. Heron ,&nbsp;Karen Mitchell","doi":"10.1016/j.xjmad.2024.100102","DOIUrl":"10.1016/j.xjmad.2024.100102","url":null,"abstract":"<div><div>Posttraumatic stress disorder (PTSD) and disordered eating often co-occur, and this comorbidity is linked to a heightened clinical burden compared to either condition alone. One possible explanation for this co-occurrence is the self-medication model, which proposes that individuals may use food to cope with PTSD symptoms, a concept we refer to as trauma-related eating to cope. Although there is both theoretical and empirical support for this construct, no specific measure has been developed until now. In this study, we aimed to create and validate a novel measure, the Trauma-Related Eating to Cope (TREC) questionnaire, among a diverse sample of 726 trauma-exposed undergraduate students (<em>M</em>_age=22.87, <em>SD</em>=7.20; 49.9 % White; 77 % women). Our data support the 20-item TREC questionnaire as a four-factor scale that can be used to evaluate eating to cope with symptoms specific to each of the four <em>DSM-5</em> PTSD symptom clusters (χ²(164)= 330.23, <em>p</em> &lt; .001; CFI= .959; TLI= .953; RMSEA= .038). The study findings indicate that the TREC questionnaire is a more precise and targeted tool for measuring eating to cope with PTSD symptoms compared to existing measures of eating to cope motives. Strong evidence was found for the construct and criterion validity of the TREC questionnaire, particularly in relation to PTSD symptoms and a range of disordered eating behaviors, including binge eating, caloric restriction, and emotional eating. These results underscore the potential of the TREC questionnaire for future research on self-medication and its clinical utility as a screening tool for identifying individuals with PTSD who are at risk for developing pathological eating behaviors.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Care trajectories of people with mood disorders in Quebec using latent class and latent profile analysis methods","authors":"Christian Roger Claver Kouakou ,&nbsp;Matea Bélan ,&nbsp;Thomas G. Poder ,&nbsp;Maude Laberge","doi":"10.1016/j.xjmad.2024.100101","DOIUrl":"10.1016/j.xjmad.2024.100101","url":null,"abstract":"<div><div>The prevalence of mood disorders has increased globally. People with mood disorders have been found to use more health services than the general population, although a mood disorder diagnosis does not necessarily entail utilization of health services. This heterogeneity in health services utilization could make it difficult for governments to plan resources to meet the needs of people with mood disorders. A patient-level linked database from residents of Quebec, Canada was used to model care trajectories of people who self-reported having been diagnosed with a mood disorder. The data from the Canadian Community Health Survey were linked to health administrative data for a 21-year period. We used latent class analysis and latent profile analysis to group people into categories. Four care trajectories were identified using the latent class analysis: 1) people who only used services of a general practitioner; 2) people having seen a psychiatrist or having at least one ED visit or hospitalization; 3) people consulting other types of specialists; 4) null utilization. The latent profile analysis on medical services yielded four profiles, with average numbers of services of 41, 33, 7, and 1, while that on hospitalization yielded two profiles, with 20 % of the population having had at least one hospitalization and the remainder none. By classifying people into service utilization groups, these methods enable determining needs for a given population and can support resource allocation for health care decision makers.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of reduction in self-judgment after mindful self-compassion training: A pilot study with resting state fMRI","authors":"Diane Joss ,&nbsp;Michael Datko ,&nbsp;Charisma I. Washington ,&nbsp;Mary A. Tresvalles ,&nbsp;Mihriye Mete ,&nbsp;Sara W. Lazar ,&nbsp;Zev Schuman-Olivier ,&nbsp;Elizabeth A. Hoge","doi":"10.1016/j.xjmad.2024.100096","DOIUrl":"10.1016/j.xjmad.2024.100096","url":null,"abstract":"<div><div>Self-judgment is a trans-diagnostic symptom among various psychological disorders, therefore can be a therapeutic target for many common psychiatric conditions. Self-judgment often arises among those who experienced childhood maltreatment, which increases the risk for developing comorbid psychiatric disorders that are resistant to traditional pharmacological and psychological interventions. Understanding the neural correlates of the therapeutic effect of behavioral interventions for reducing self-judgment is key for developing and refining evidence-based intervention programs. This single arm pilot study (N = 24) explored the neural correlates of reduction in self-judgment after an eight-week mindful self-compassion (MSC) intervention program for a sample of adult patients with either anxiety or depressive disorders, with 83 % having more than one diagnoses. The results demonstrated significant reduction of self-judgment after the intervention (<em>p</em> &lt; 0.001, <em>d</em> = −1.04) along with increased self-compassion (<em>p</em> &lt; 0.001, <em>d</em> =1.20); in particular, participants with above median score on the Childhood Trauma Questionnaire had significantly more improvement than those with below median scores (<em>p</em> &lt; 0.05). Resting state fMRI was used to study neural correlates and showed that reduced self-judgment was associated with increased posterior cingulate cortex functional connectivity with dorsal lateral prefrontal cortex, inferior frontal gyrus, and dorsal medial prefrontal cortex, accompanied by reduced posterior cingulate cortex functional connectivity with the amygdala-hippocampal complex. These findings suggest reduced self-judgment after MSC training was substantiated by reduced fear circuitry influences on self-referential processes along with enhanced frontal regulation from the executive network and language network.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Driven by rewards or punishments? Understanding real world social functioning in anxiety and depressive disorders","authors":"Angie M. Gross ,&nbsp;Madeleine Rassaby ,&nbsp;Samantha N. Hoffman ,&nbsp;Colin A. Depp ,&nbsp;Raeanne C. Moore ,&nbsp;Charles T. Taylor","doi":"10.1016/j.xjmad.2024.100097","DOIUrl":"10.1016/j.xjmad.2024.100097","url":null,"abstract":"<div><h3>Background</h3><div>Social disconnection is prevalent in anxiety and depressive disorders and adversely impacts well-being. Prevailing treatment approaches assume social disconnection is a by-product of anxiety or depressive symptoms; however, social impairments often persist following symptom reduction. To advance understanding of why people with anxiety or depression experience social disconnection, we tested a framework in which daily social experiences were predicted from dispositional sensitivities to positive (rewarding) vs. negative (aversive) outcomes.</div></div><div><h3>Method</h3><div>Adults (<em>N</em> = 112; aged 18–55) seeking treatment for anxiety or depression completed a measure assessing approach temperament (i.e., general sensitivity to positive outcomes) and avoidance temperament (i.e., general sensitivity to negative outcomes). They subsequently received 20 ecological momentary assessment (EMA) surveys over five consecutive days measuring current social activity, perceived connectedness, loneliness, and positive and negative affect.</div></div><div><h3>Results</h3><div>Individuals higher in approach temperament reported greater momentary social connectedness, lower loneliness, and more frequent social interactions (medium to large effects). They also experienced greater momentary positive affect, which was associated with all real-time social outcomes (medium to large effects). Avoidance temperament overall was not associated with daily social experiences nor affect; however, in subjects with low approach temperament, higher avoidance temperament predicted greater momentary negative affect. Real-time loneliness was linked to momentary negative affect, but only when momentary positive affect was low.</div></div><div><h3>Limitations</h3><div>The study was correlational; thus, causal claims cannot be made.</div></div><div><h3>Conclusions</h3><div>Approach temperament and its associated affective states may be uniquely related to daily social experiences in anxiety and depression and could serve as targets for interventions intended to remediate social disconnection.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled trial of computerized cognitive training to improve working memory in individuals with elevated repetitive negative thinking: Behavioral and neural outcomes","authors":"Jessica Bomyea ,&nbsp;Morgan M. Caudle ,&nbsp;Nathalie Dugas ,&nbsp;Raeanne C. Moore ,&nbsp;Alan N. Simmons ,&nbsp;Michael L. Thomas","doi":"10.1016/j.xjmad.2024.100095","DOIUrl":"10.1016/j.xjmad.2024.100095","url":null,"abstract":"<div><div>Individuals with mood, anxiety, and traumatic stress disorders frequently experience distressing repetitive negative thinking (RNT) symptoms, which are characterized by pervasive, uncontrollable negative thoughts. Dysfunction in executive functioning processes, particularly the ability to regulate the contents of working memory, are implicated in the development and maintenance of RNT. Guided by the National Institute of Mental Health experimental therapeutics framework, this study aimed to investigate the cognitive effects and effects of two doses of a novel working memory training (WMT) intervention in individuals with elevated RNT across mood, anxiety, and traumatic stress disorders. We conducted a three-arm randomized controlled trial with 8-session and 16-session WMT interventions and a waitlist control group (N = 73). Our primary goal was to establish target engagement of WMT as measured by behavioral and neural indicators of working memory performance. Results revealed that WMT significantly improved working memory performance and resulted in reduced frontoparietal neural activity during a working memory task compared to the waitlist control group, providing evidence of target engagement. Exploratory analyses revealed a potential transfer of training effects to fluid intelligence, a construct related to but distinct from working memory, suggesting broader cognitive benefits of WMT. These data provide evidence that WMT can enhance working memory performance in individuals with RNT. This intervention holds promise as a transdiagnostic approach for ameliorating RNT-related clinical burden, with the 8-session regimen showing pragmatic advantages. Further research is needed to elucidate its impact on clinical symptoms and explore potential cognitive benefits beyond working memory.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}