Journal of mood and anxiety disorders最新文献

{"title":"Keep calm and exercise on: A single bout of exercise supports executive function across a continuum of trait anxiety levels","authors":"Lian Buwadi,&nbsp;Gianna Jeyarajan,&nbsp;Alma Rahimi,&nbsp;Matthew Heath,&nbsp;Benjamin Tari","doi":"10.1016/j.xjmad.2026.100200","DOIUrl":"10.1016/j.xjmad.2026.100200","url":null,"abstract":"<div><div>Executive function (EF) is a cognitive construct supporting activities of daily living. Trait anxiety (TA) is a stable predisposition to experiencing anxiety that some work has linked to an EF deficit. In turn, a single bout of aerobic exercise elicits a postexercise EF benefit and therefore may serve as an intervention to ameliorate TA-related EF deficits. Here, we examined whether postexercise EF benefits differ across individuals along the continuum of TA. Participants (N = 31) completed a single 25-min bout of moderate-intensity aerobic exercise (via cycle ergometer) and an equivalent duration non-exercise control condition. TA was assessed via the State-Trait Anxiety Inventory (STAI) and pre- and post-condition EF was assessed via the antisaccade task. STAI values ranged from 23 to 60 and produced an average of 42 (SD = 10), and a linear mixed model employing STAI as a covariate showed that the variable was positively correlated with reaction time (RT) across all experimental conditions. Moreover, a higher-order interaction showed that the exercise condition – but not the control condition – produced a pre- to post-condition reduction in antisaccade RTs and was a result that did not vary across the continuum of participant-specific STAI values. Thus, although increased TA was associated with reduced information processing efficiency, TA status did not impact the extent to which exercise provided an EF “boost”. Accordingly, single bout and prospective chronic exercise programs may serve to ameliorate TA-based EF changes.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"15 ","pages":"Article 100200"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148951189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal ideation across pregnancy and the postpartum: Trajectories and assessment with commonly used screening tools","authors":"Rachel Vanderkruik,&nbsp;Courtney C. Louis,&nbsp;Peter Gaccione,&nbsp;Robert Gallop,&nbsp;Emma J. Grassi,&nbsp;Parker C. Killenberg,&nbsp;Hannah E. Yoon,&nbsp;Marlene P. Freeman,&nbsp;Sona Dimidjian,&nbsp;Lee S. Cohen","doi":"10.1016/j.xjmad.2026.100203","DOIUrl":"10.1016/j.xjmad.2026.100203","url":null,"abstract":"<div><div>Suicidal ideation (SI) is a public health concern that remains poorly characterized during the perinatal period. It is most often assessed by the final items in two depression screening instruments, the Edinburgh Postnatal Depression Scale (EPDS) and the Patient Health Questionnaire-9 (PHQ-9). We sought to examine and compare SI trajectories identified by these measures and their changes from pregnancy to postpartum. This study reports on data from a supplemental study to the Understanding and Preventing Women’s Relapse of Depression (UPWARD) study on perinatal depression (NIMH, NCT03623620; supplement entitled UPWARD-S). Participants were ineligible for UPWARD if they endorsed SI at baseline; but eligible for UPWARD-S if they were pregnant and had a history of major depressive disorder. Participants in UPWARD-S (N = 38) completed phone interviews and surveys from pregnancy through six months postpartum. Group-based trajectory modeling was conducted during pregnancy and postpartum using item 10 of the EPDS and item 9 of the PHQ-9. Trajectory analyses resulted in three group models. For both time periods, there were two groups showing relatively stable trajectories in the frequency of SI endorsement, one high and one low. During pregnancy, a third group began high and declined, and, during postpartum, a third group began low and increased. Trajectory patterns were broadly similar across items; however, the proportion of participants classified within each group differed by measure. Our findings demonstrated distinct and relatively stable trajectories and modest agreement between items. Findings from this study could inform larger studies to advise perinatal screening and intervention strategies.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"15 ","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148951190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive childhood experiences relate to prenatal mental health symptoms and diagnoses independent of childhood maltreatment","authors":"Jessica A. Marino ,&nbsp;Angela Narayan ,&nbsp;Anna M. Zhou ,&nbsp;Ella-Marie P. Hennessey ,&nbsp;Jenalee R. Doom ,&nbsp;Benjamin L. Hankin ,&nbsp;Elysia Poggi Davis","doi":"10.1016/j.xjmad.2026.100186","DOIUrl":"10.1016/j.xjmad.2026.100186","url":null,"abstract":"<div><h3>Purpose</h3><div>Prenatal mental health problems often impair maternal functioning and offspring development. Maternal childhood maltreatment is a well-established risk factor for prenatal mental health problems; however, growing evidence supports the health-promoting role of positive childhood experiences (PCEs) for better prenatal mental health. Yet joint effects of childhood maltreatment and PCEs on prenatal mental illness diagnoses, in addition to symptoms, are not understood.</div></div><div><h3>Methods</h3><div>This study examined associations between childhood maltreatment and PCEs on prenatal mental health symptoms and clinical diagnoses in 234 pregnant individuals (<em>M</em> gestational age: 16.7 weeks). Childhood maltreatment, PCEs, and prenatal depression, anxiety, and posttraumatic stress disorder (PTSD) symptoms were assessed with standardized self-report measures. Prenatal Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) during adulthood were assessed during pregnancy via structured clinical interviews.</div></div><div><h3>Results</h3><div>Higher levels of childhood maltreatment predicted greater symptom levels of depression, anxiety, and PTSD during pregnancy (effect sizes: 0.17–0.23) and elevated of prenatal MDD and adult GAD (ORs: 1.31, 1.32). In contrast, higher levels of PCEs predicted less symptom severity across all domains (effect sizes: −0.31 to −0.38) and lower MDD and GAD rates (ORs: 0.68, 0.70). When maltreatment and PCEs were modeled simultaneously, PCEs were the only significant predictor of fewer symptoms and diagnoses across all domains (effect sizes: −0.29 to −0.35; ORs: 0.68, 0.70), whereas effects of childhood maltreatment dropped to non-significance.</div></div><div><h3>Conclusion</h3><div>Positive childhood experiences have enduring effects, predicting both dimensional and categorical prenatal mental health above and beyond childhood maltreatment.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"14 ","pages":"Article 100186"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148241275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom benchmarks of improved quality of life among military veterans with PTSD","authors":"Paula P. Schnurr ,&nbsp;Carole A. Lunney ,&nbsp;Kathleen M. Chard ,&nbsp;Josef I. Ruzek ,&nbsp;Brian P. Marx ,&nbsp;Thomas M. Crow","doi":"10.1016/j.xjmad.2026.100183","DOIUrl":"10.1016/j.xjmad.2026.100183","url":null,"abstract":"<div><h3>Objective</h3><div>To optimize treatment outcome and promote recovery, it is necessary to understand how clinical indicators of improvement translate into meaningful differences in the lives of individuals with posttraumatic stress disorder (PTSD). Prior research has suggested that treatment response alone is insufficient and that more substantial improvement is needed, but data are limited. This study addressed the gap through secondary analysis of a pragmatic comparative effectiveness trial of Cognitive Processing Therapy (CPT) and Prolonged Exposure (PE) in veterans.</div></div><div><h3>Methods</h3><div>Participants were 597 male and female US military veterans who were randomized to receive CPT or PE. PTSD symptom change from pre- to posttreatment was categorized into four mutually exclusive categories: No Response, Response, Loss of Diagnosis, and Remission. Analyses compared each category to the prior one to identify the effect of attaining a higher benchmark on experiencing clinically meaningful improvements and good endpoints (no/little impairment in functioning or ≥70% on a QoL scale) on clinician-rated and self-reported measures.</div></div><div><h3>Results</h3><div>Response was associated with improvement on most outcomes, but with a good endpoint on only one. Loss of Diagnosis added little benefit beyond response. Remission was associated with increased likelihood of meaningful improvement (OR=2.31–23.65, lowest <em>p</em> &lt; .001) and a good endpoint (OR=3.37–13.50, lowest <em>p</em> &lt; .001) on all measures.</div></div><div><h3>Conclusions</h3><div>Response without more substantial improvement following PTSD treatment is insufficient for helping patients achieve good QoL. Findings support the position that focusing on more than symptom change and response alone is necessary when setting treatment goals for individual patients and for evaluating treatments.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"14 ","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world evidence of SAINT® effectiveness in a heterogenous clinical population with psychiatric and medical comorbidities: A multicenter, open-label, community-based study","authors":"Michael T. Feyder ,&nbsp;Katy H. Stimpson ,&nbsp;Andrew D. Geoly ,&nbsp;T.J. Ford ,&nbsp;Adi Maron-Katz ,&nbsp;Evan Lutkenhoff ,&nbsp;Robert G. Bota ,&nbsp;David M. Carreon ,&nbsp;Owen S. Muir ,&nbsp;Carlene MacMillan ,&nbsp;Ian A. Cook ,&nbsp;Hugh B. Solvason ,&nbsp;Rebecca M. Allen ,&nbsp;Roger Pottanat ,&nbsp;Tracy Barbour ,&nbsp;Nolan R. Williams ,&nbsp;Brandon S. Bentzley","doi":"10.1016/j.xjmad.2026.100184","DOIUrl":"10.1016/j.xjmad.2026.100184","url":null,"abstract":"<div><h3>Objective</h3><div>SAINT®, a functional connectivity-guided, accelerated form of intermittent theta-burst stimulation, has shown high efficacy in depression in open-label and randomized controlled trials. To evaluate real-world effectiveness across diverse clinical practice settings, an open-label, multicenter study was conducted.</div></div><div><h3>Methods</h3><div>Adult patients with major depressive disorder who failed to achieve satisfactory improvement from prior antidepressant medication in the current episode were enrolled across 7 private psychiatric clinics in the U.S. All participants received a 5-day course of SAINT. The primary outcome was the Clinical Global Impressions Scale of Improvement (CGI-I) score following the final treatment session with CGI-S (measure of severity) collected as a secondary measure.</div></div><div><h3>Results</h3><div>A per protocol analysis of the acute outcomes data included 101 participants. All patients who initiated SAINT treatment completed the full 5-day protocol, with no treatment discontinuations due to adverse events or tolerability concerns. At the primary endpoint, treatment day 5, 68.3% of participants achieved CGI-I ≤ 2 (“much improved”) with a mean CGI-I of 2.32. Meaningful clinical benefit (≥1 point reduction in CGI-S from baseline through 5 days following treatment) was observed in 89.1% of participants. Improvement rates did not significantly differ by baseline severity or across clinical sites.</div></div><div><h3>Conclusions</h3><div>This analysis of the primary outcome includes the largest cohort of patients treated with SAINT to date. The results support previously reported rapid and significant improvements in depressive symptoms and extend these findings to a more clinically representative population.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"14 ","pages":"Article 100184"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence and burden of generalized anxiety disorder in the United States healthcare system: Real-world prevalence and incidence from 2020 to 2023","authors":"Erin Ferries ,&nbsp;Susan Suponcic ,&nbsp;Derek Louie ,&nbsp;Katie Robinson ,&nbsp;Felix Lam ,&nbsp;Abigail Silber ,&nbsp;Matthew O’Hara ,&nbsp;Phong Duong ,&nbsp;Roger S. McIntyre ,&nbsp;Jeffrey R. Strawn","doi":"10.1016/j.xjmad.2026.100172","DOIUrl":"10.1016/j.xjmad.2026.100172","url":null,"abstract":"<div><h3>Background</h3><div>Generalized anxiety disorder (GAD) is characterized by persistent, difficult-to-control worry that is often accompanied by substantial comorbidity, impairment, and reduced quality of life. Yet, its prevalence in the United States remains uncertain and may be underestimated.</div></div><div><h3>Methods</h3><div>We estimated the prevalence and incidence of diagnosed GAD among adults in the U.S. healthcare system using payer-complete closed claims data from the Komodo Healthcare Map™ database from January 1, 2020 to December 31, 2023. Patients with GAD were identified using ICD-10 code F41.1. Annual and three-year prevalence, as well as annual incidence rates, were calculated and projected to the U.S. adult population.</div></div><div><h3>Results</h3><div>From 2021–2023, most patients diagnosed with GAD were women, middle-aged, and commercially insured with women diagnosed at more than twice the rate of men. Projected annual prevalence increased from 5.4% in 2020–6.6% in 2023, with a 3-year prevalence of 10.3% over the 2021–2023 period. The projected annual incidence ranged from 2.1% to 2.3%.</div></div><div><h3>Conclusion</h3><div>The increasing prevalence of GAD diagnoses may reflect multiple converging factors, including increased screening and recognition. Together, these updated national estimates highlight not only the increasing prevalence of GAD but also the need to expand access to care and improve the effectiveness of treatments.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"13 ","pages":"Article 100172"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic disparities, healthcare system trust, and social support in mental health treatment among U.S. adults with depressive or anxiety symptoms","authors":"Anudeepa K. Ramachandiran ,&nbsp;Faith Gunning ,&nbsp;Mauricio Santillana ,&nbsp;Matthew A. Baum ,&nbsp;Pilar F. Verhaak ,&nbsp;James N. Druckman ,&nbsp;Katherine Ognyanova ,&nbsp;David Lazer ,&nbsp;Roy H. Perlis","doi":"10.1016/j.xjmad.2026.100166","DOIUrl":"10.1016/j.xjmad.2026.100166","url":null,"abstract":"<div><div>Large and persistent sociodemographic disparities in rates of mental health treatment in the United States have been reported, but whether these differences reflect institutional mistrust or limited social support remains unclear. This study described current treatment use among American adults with moderate-to-severe depressive or anxiety symptoms and examined whether trust in health care institutions and availability of emotional support were associated with lack of treatment. A cross-sectional analysis was conducted using data from a nationally distributed, web-based opinion survey of 9733 American adults with moderate-to-severe depressive or anxiety symptoms (Patient Health Questionnaire-9 score ≥10 and/or Generalized Anxiety Disorder-2 score ≥3). The survey was fielded April 10th–28th, 2025, using quota sampling for age, gender, race, ethnicity, education, U.S. census region, and urbanicity; post-stratification weights approximated the U.S. adult population. The primary outcome was no current mental health treatment (neither antidepressant nor psychotherapy use). Weighted logistic regression estimated odds ratios for treatment absence by sociodemographic characteristics, trust in physicians and hospitals, scientists and researchers, the Centers for Disease Control and Prevention, pharmaceutical companies, and emotional support. Among 9733 adults with elevated symptoms, 66.3 % reported no current treatment. Racial and ethnic minority groups, men, and those born outside the United States had higher odds of being untreated, while public insurance predicted lower odds. Lower trust in doctors and hospitals, lower trust in science, and lack of emotional support each independently predicted treatment absence, but inclusion of these variables did not meaningfully attenuate sociodemographic disparities.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"13 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anhedonia and altered reward responsiveness: Relations to psychosocial functioning","authors":"Molly H. Sapperstein ,&nbsp;Michelle Thai ,&nbsp;Yuen-Siang Ang ,&nbsp;Diego A. Pizzagalli","doi":"10.1016/j.xjmad.2026.100169","DOIUrl":"10.1016/j.xjmad.2026.100169","url":null,"abstract":"<div><h3>Background</h3><div>Anhedonia—a core symptom of Major Depressive Disorder—is associated with poorer clinical outcomes, lower quality of life, and disrupted reward processing. However, putative relationships among self-reported anhedonia, well-being and anhedonic phenotypes (specifically, reward learning) remain largely unexplored. The main goal of the current study was to fill this gap in a large online adult community sample (N = 478).</div></div><div><h3>Methods</h3><div>To evaluate how different approaches to assessing anhedonia may capture these relationships, we administered the Probabilistic Reward Task (PRT) to probe reward learning and two clinical scales: the Snaith-Hamilton Pleasure Scale (SHAPS) and the Dimensional Anhedonia Rating Scale (DARS). In a first step, the SHAPS was administered to identify anhedonic vs. non-anhedonic individuals, who then performed an online PRT.</div></div><div><h3>Results</h3><div>Both scales were significantly associated with lower self-reported quality of life (QoL), as measured by the Quality of Life Enjoyment and Satisfaction Questionnaire Short Form (QLESQ-SF), with the SHAPS showing a stronger relationship to both QoL and reward learning. Follow-up computational modeling indicated the anhedonic group showed a significantly higher level of uncertainty while completing the PRT compared to the non-anhedonic group. Moreover, trial-by-trial analyses revealed group differences in PRT response patterns, such that anhedonic individuals were less likely to incorrectly indicate that they had seen the more frequently rewarded “rich” stimulus on trials that actually presented the less frequently rewarded “lean” stimulus.</div></div><div><h3>Conclusions</h3><div>Findings highlight the utility of combining subjective and behavioral measures to better understand the impact of anhedonia on daily functioning and reinforcement learning processes.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"13 ","pages":"Article 100169"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential developmental influences on anxiety in adulthood: Behavioral inhibition moderates the dimensions of social involvement predicting anxiety in adulthood","authors":"Anjali D. Poe ,&nbsp;Parmis Khosravi ,&nbsp;Sara Kirschner ,&nbsp;Tahl I. Frenkel ,&nbsp;Selin Zeytinoglu ,&nbsp;Andrea Chronis-Tuscano ,&nbsp;Kathryn A. Degnan ,&nbsp;Heather A. Henderson ,&nbsp;Katharina Kircanski ,&nbsp;Nathan A. Fox ,&nbsp;Daniel S. Pine","doi":"10.1016/j.xjmad.2025.100161","DOIUrl":"10.1016/j.xjmad.2025.100161","url":null,"abstract":"<div><div>The current 20-year longitudinal study examined whether behavioral inhibition (BI), a temperament identified in late infancy/early childhood, moderates the associations between a) peer connectedness (feelings of closeness, ease, and availability of meaningful social bonds), b) frequency of functional support (how often interpersonal supportive behaviors are received) throughout middle childhood and adolescence, and c) adulthood anxiety. Data from 291 participants were analyzed. Participants were selected during infancy based on their level of reactivity to novel social and nonsocial stimuli, and BI was measured in toddlerhood. Participants completed questionnaires assessing social involvement throughout middle childhood and adolescence, and anxiety in early adulthood. Confirmatory factor analyses extracted factor scores from multiple indicators for peer connectedness, frequency of functional support, and anxiety. Multiple linear regression analyses were used to examine the moderating effects of toddlerhood BI on the association between indices of social involvement and adulthood anxiety. BI moderates the relations between social involvement and adulthood anxiety; higher frequency of functional support in the presence of relatively low BI predicted lower adulthood anxiety (<em>t</em> = -2.49, <em>SE</em> =.010, <em>p</em> = .014). Peer connectedness directly and positively predicted adulthood anxiety (<em>ß =</em> 0.24, <em>p=</em>.016), but, BI did not moderate this association (<em>p</em> = .606), nor was there a main effect of BI on adult anxiety (<em>p</em> = .129). Complex relations manifest among toddlerhood BI, social involvement across development, and anxiety in adulthood. These relations reflect interacting risk and protective factors operating in a developmental context. Implications of these findings are discussed.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"13 ","pages":"Article 100161"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric comorbidity in DiGeorge association: Suicidal ideation and bipolar disorder","authors":"Roman Nakhamiyayev ,&nbsp;Michelle Perry ,&nbsp;Sahil Sood ,&nbsp;Shivam Kamboj ,&nbsp;Emmanuel Khodra ,&nbsp;Bamidele Agada","doi":"10.1016/j.xjmad.2026.100170","DOIUrl":"10.1016/j.xjmad.2026.100170","url":null,"abstract":"<div><div>DiGeorge syndrome, also known as 22q11.2 deletion syndrome, is a multisystem condition associated with congenital cardiac defects, craniofacial abnormalities, immune dysfunction, endocrine disturbances, and a high lifetime risk of psychiatric disorders. Bipolar I Disorder is a severe mood disorder with a substantially elevated risk of suicidal ideation and attempts, especially during manic episodes with psychotic features. This report describes a woman in her 20’s with 22q11.2 Deletion Syndrome and Bipolar I Disorder who presented with acute suicidal ideation in the context of a manic episode. She responded to inpatient stabilization and responded well to valproic acid and olanzapine. This case highlights the substantial clinical impact of psychiatric illness in 22q11.2 deletion syndrome and reinforces the need for heightened attention to mood instability and suicide risk in affected individuals.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"13 ","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147397155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}