Journal of mood and anxiety disorders最新文献

{"title":"The structure of posttraumatic stress symptoms in youth with and without obsessive-compulsive disorder: New insights using factor and network analysis","authors":"Caitlin M. Pinciotti ,&nbsp;Matti Cervin ,&nbsp;Kendall N. Drummond ,&nbsp;Jeffrey D. Shahidullah ,&nbsp;Justin F. Rousseau ,&nbsp;Cody G. Dodd ,&nbsp;Mercedes Ramirez ,&nbsp;John M. Hettema ,&nbsp;Robyn Richmond ,&nbsp;Leslie K. Taylor ,&nbsp;Lynn Monnat ,&nbsp;Leslie Proch ,&nbsp;Fei Teng ,&nbsp;Wayne K. Goodman ,&nbsp;Eric A. Storch ,&nbsp;Andrew G. Guzick ,&nbsp;D. Jeffrey Newport ,&nbsp;Karen Dineen Wagner ,&nbsp;Charles B. Nemeroff","doi":"10.1016/j.xjmad.2025.100135","DOIUrl":"10.1016/j.xjmad.2025.100135","url":null,"abstract":"<div><div>Posttraumatic stress disorder (PTSD) and obsessive-compulsive disorder (OCD) share ostensibly similar and sometimes overlapping symptoms that complicate diagnostic assessment and conceptualization. While varying models for the symptom structure of PTSD have been proposed – including the presently used 4-factor and a more fine-grained 7-factor model – little research has focused on youth and even less is known about how these symptoms relate to one another when OCD is present. The present study used confirmatory factor analysis (CFA) and network analysis to compare PTSD symptom relations among 2066 trauma-exposed youth aged 8–20 enrolled in the Texas Childhood Trauma Research Network, of which 10.9 % met diagnostic criteria for OCD. CFA model fit was strongest for the 7-factor PTSD model, and multigroup CFA found no evidence that the structure differed as a function of OCD diagnosis, sex, nor age group. Internal consistency in the 7-factor model ranged from poor to good (α = 0.59–0.80), while all clusters of the 4-factor model demonstrated adequate internal consistency (α = 0.75–0.89). Network analysis revealed unique associations between PTSD and OCD. Specifically, having OCD was linked to more Negative Affect (edge = 0.15) and Anhedonia (edge = 0.16), which are both part of the 4-factor Negative Alterations in Cognitions and Mood symptom cluster. While the clinical relevance of the 7-factor model is still unclear, it evidenced mixed empirical support in the present sample and provided greater nuance when examining links between PTSD and OCD.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100135"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of depression treatment on subjective sleep components among primary care patients: Data from the eIMPACT trial","authors":"Matthew D. Schuiling ,&nbsp;Wei Wu ,&nbsp;Brittanny M. Polanka ,&nbsp;Aubrey L. Shell ,&nbsp;Michelle K. Williams ,&nbsp;Christopher A. Crawford ,&nbsp;Krysha L. MacDonald ,&nbsp;John I. Nurnberger Jr. ,&nbsp;Christopher M. Callahan ,&nbsp;Jesse C. Stewart","doi":"10.1016/j.xjmad.2025.100132","DOIUrl":"10.1016/j.xjmad.2025.100132","url":null,"abstract":"<div><h3>Objective</h3><div>Sleep disturbance is a multifaceted symptom of depression that disproportionately impacts marginalized groups. Depression treatment improves sleep disturbance in some individuals; however, the components of sleep disturbance improved remain unidentified. This secondary analysis of the eIMPACT randomized controlled trial examines effects of depression treatment on subjective sleep disturbance components.</div></div><div><h3>Methods</h3><div>216 primary care patients with depression from a safety net healthcare system were randomized to 12-months of modernized collaborative care (internet cognitive-behavioral therapy [CBT], telephonic CBT, and/or antidepressants; <em>n</em> = 107) or usual primary care for depression (primary care providers supported by embedded behavioral health clinicians and psychiatrists; <em>n</em> = 109). Subjective sleep disturbance components were assessed by the Pittsburgh Sleep Quality Index (PSQI).</div></div><div><h3>Results</h3><div>Mixed-effect models examined intervention effects on changes in subjective sleep disturbance components. The intervention improved PSQI global scores, sleep onset latency, subjective sleep quality, and daytime dysfunction across 24-months, and these effects diminished after treatment termination. At post-treatment, intervention participants had greater improvements in PSQI global scores (<em>p</em> &lt; 0.001, <em>d</em>=-0.62), sleep onset latency (<em>p</em> &lt; 0.01, <em>d</em>=-0.43), daytime dysfunction (<em>p</em> &lt; 0.01, <em>d</em>=-0.35), and sleep disturbances (<em>p</em> = 0.01, <em>d</em>=-0.26) compared to usual care, but no differences in subjective sleep quality, total sleep time, sleep efficiency, or sleep medication use. Intervention effects were not moderated by race, education, or income. Pre- to post-treatment improvements in depressive symptoms were associated with improvements in some sleep disturbance components.</div></div><div><h3>Conclusions</h3><div>Depression treatment improves some, not all, subjective sleep disturbance components, with benefits diminishing after termination. Adjunctive interventions are likely needed to address the lingering components of sleep disturbance.</div></div><div><h3>ClinicalTrials.gov Idenifier</h3><div>NCT02458690</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in ventral prefrontal-subcortical network connectivity during the course of remission from bipolar mania","authors":"Jennifer E. Siegel-Ramsay ,&nbsp;Elizabeth Lippard ,&nbsp;Thomas Blom ,&nbsp;Wade Webber ,&nbsp;Cal Adler ,&nbsp;David E. Fleck ,&nbsp;Melissa P. DelBello ,&nbsp;Jorge R.C. Almeida ,&nbsp;Stephen M. Strakowski","doi":"10.1016/j.xjmad.2025.100131","DOIUrl":"10.1016/j.xjmad.2025.100131","url":null,"abstract":"<div><h3>Background</h3><div>Dysregulated ventral prefrontal-subcortical networks are implicated in bipolar disorder, although how connectivity changes within these networks during the emergence and resolution of affective episodes is unclear. To address this knowledge gap, in this post-hoc study, we investigated longitudinal changes in prefrontal-subcortical connectivity during remission from mania in individuals with bipolar I disorder.</div></div><div><h3>Methods</h3><div>We followed 35 individuals with bipolar I disorder through eight weeks of treatment for a manic episode. Using mixed models, we compared changes in ventral prefrontal-subcortical connectivity between individuals who remitted (n = 16, Young Mania Rating Scale/Hamilton Depression Rating Scale &lt; 10 by week eight) and those who did not (n = 19) during emotional distractor conditions of the continuous performance task (CPT-END), a cognitive attentional task with emotional and neutral distractors; at baseline, one and eight weeks of treatment covarying for age and sex.</div></div><div><h3>Results</h3><div>During the eight-week trial, significant group-by-time interactions were found between medial prefrontal cortex and right inferior frontal gyrus pars triangularis. There was also a group-by-time interaction in connectivity between prefrontal cortex and left thalamus, bilateral amygdala, and pregenual anterior cingulate cortex.</div></div><div><h3>Conclusion</h3><div>These results highlight distinct ventral prefrontal-subcortical connectivity patterns characterizing the remitted state in bipolar disorder during tasks requiring focused attention amid emotional distractions. In the context of previous research, remission was associated with more normative connectivity between medial prefrontal and both thalamus and ventrolateral prefrontal cortex. However, while ventral prefrontal–paralimbic/limbic connectivity may show improvement with symptom remission, it may not fully normalize, suggesting residual functional abnormalities despite clinical recovery.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100131"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is latent about trauma exposure? Commentary on the use of latent class analysis for identifying trauma subtypes","authors":"Erika J. Wolf ,&nbsp;Mark W. Miller","doi":"10.1016/j.xjmad.2025.100130","DOIUrl":"10.1016/j.xjmad.2025.100130","url":null,"abstract":"<div><div>Latent class analysis (LCA) is a “person-centered” analytic method designed to identify subgroups of individuals defined by a common characteristic that distinguishes them from other groups within a larger population. Many recent studies have applied LCA to data from self-report trauma exposure measures in an effort to identify clinically useful and/or nosologically informative trauma history “types.” In this article, we provide a non-technical overview of this analytic approach and its application to trauma exposure data. We raise concerns about the use of LCA for identifying trauma exposure types relating to: (a) the application of a person-centered approach to variables that reflect environmental exposures; (b) lack of evidence that use of LCA is more informative than other more straightforward and generalizable methods for quantifying trauma exposure; (c) failure to show meaningful differences in the correlates (e.g., risk factors, outcomes, treatment response) of latent classes; (d) forcing severity-based categories on variables that are dimensional, promotion of small classes, and misinterpretation of fit statistics; and (e) interpretation of changing class definitions over time as individual-level changes. Collectively, these concerns lead us to ask, “what is latent about trauma exposure?” and suggest the need for alternative approaches to quantifying and summarizing trauma exposure.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100130"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmenting single-session behavioral activation for depression with delta-beta tACS: Preliminary investigation of a double-blind placebo-controlled randomized pilot clinical trial","authors":"Corinne N. Carlton ,&nbsp;Erin Bondy ,&nbsp;Justin Riddle ,&nbsp;David Mahan ,&nbsp;Stacey Daughters ,&nbsp;Crystal Schiller ,&nbsp;Flavio Frohlich","doi":"10.1016/j.xjmad.2025.100127","DOIUrl":"10.1016/j.xjmad.2025.100127","url":null,"abstract":"<div><div>Single-session behavioral activation (BA) and transcranial alternating current stimulation (tACS) are promising interventions for major depressive disorder (MDD). However, the synergy of combined single-session BA and tACS has not yet been evaluated. This pilot study assessed whether tACS augments the efficacy of single-session BA in individuals with MDD. N = 30 (<em>M</em>_age=36, <em>SD</em>=15; 70 % female) participants with MDD were randomized to receive either: 1) tACS with BA or 2) sham tACS with BA. Change in depression and anhedonia symptoms were assessed (preregistration: NCT05693922). Clinician-rated depression and anhedonia showed significant effects of time, but no significant differences between conditions, with the exception of dysphoria. Specifically, between baseline and two-week follow-up, those in the verum condition demonstrated significantly less dysphoria than those in the sham condition; however, these significant differences did not maintain at one-month follow-up. While preliminary, this is the first study to assess the augmentation of psychotherapy with tACS for MDD and it further serves as a template for future studies using combined interventions to treat depression.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100127"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice-based research examining effectiveness of exposure-based CBT for youth in a community mental health setting","authors":"Emily M. Becker-Haimes ,&nbsp;Michal Weiss ,&nbsp;Temma Schaechter ,&nbsp;Sophia Young ,&nbsp;Amanda L. Sanchez","doi":"10.1016/j.xjmad.2025.100129","DOIUrl":"10.1016/j.xjmad.2025.100129","url":null,"abstract":"<div><div>We examined the naturalistic effectiveness of exposure-based cognitive behavioral therapy (Ex-CBT) for pediatric anxiety and obsessive-compulsive disorder in a community mental health setting. We also characterized adaptations made to Ex-CBT and whether treatment factors varied by whether youth were Medicaid recipients or not. To do so, we conducted a three-year, retrospective chart review of consecutively treated youth in an Ex-CBT treatment center embedded in a community mental health setting (<em>N</em> = 94; 72.3 % Medicaid recipients, 68.1 % female). We abstracted baseline demographic and clinical characteristics, treatment techniques delivered, and treatment process and response variables to examine whether these varied as a function of Medicaid status and identify predictors of treatment response. Medicaid youth were more racially and linguistically diverse than non-Medicaid youth; there otherwise were no differences in baseline demographic and clinical variables. Ex-CBT was delivered in more than twice as many sessions compared to typical clinical trials. Coded session data indicated a more diverse suite of techniques delivered by clinicians not typically included in Ex-CBT protocols (e.g., case management, discussion of cultural and contextual factors) alongside Ex-CBT. Techniques employed by clinicians varied by insurance status. However, response rates were comparable to those seen in clinical trials (51–70 %, depending on response definition). Receiving a higher dose of exposure predicted greater likelihood of treatment response, as did younger age and male gender; Medicaid status and racial/ethnic minority status did not predict response. Overall, data supported Ex-CBT effectiveness in this setting. Ex-CBT was adapted in ways that differed based on whether youth were Medicaid recipients or not.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100129"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between PACAP levels and psychophysiological indicators of fear and arousal in adults with posttraumatic stress symptoms","authors":"Antonia V. Seligowski ,&nbsp;Kevin J. Clancy ,&nbsp;Eylül Akman ,&nbsp;Michael Lewis ,&nbsp;Victor May ,&nbsp;Caitlin Ravichandran ,&nbsp;Sydney A. Jobson ,&nbsp;Daniel E. Bradford ,&nbsp;Sayamwong E. Hammack ,&nbsp;William A. Carlezon Jr. ,&nbsp;Kerry J. Ressler ,&nbsp;Scott L. Rauch ,&nbsp;Isabelle M. Rosso","doi":"10.1016/j.xjmad.2025.100128","DOIUrl":"10.1016/j.xjmad.2025.100128","url":null,"abstract":"<div><div>Posttraumatic stress disorder (PTSD) is associated with heightened fear responding and decreased fear regulation, as demonstrated with psychophysiological measures (e.g., autonomic function) and circulating biomarkers of stress, such as pituitary adenylate cyclase-activating polypeptide (PACAP). The current study examined associations between PACAP levels and psychophysiological indicators of arousal in a sample of 168 trauma-exposed adults with a range of PTSD symptoms. We also examined sex differences in these relationships. Psychophysiological indicators included fear-potentiated startle (FPS), heart rate (HR), and heart rate variability (HRV) during a fear acquisition and extinction paradigm. PACAP levels were derived from fasting blood samples. PACAP levels were positively correlated with FPS during acquisition and HR during extinction, and negatively correlated with HRV during extinction. There were no significant PACAP-by-sex interaction effects in FPS, HR, or HRV models. Our results in the total sample are consistent with prior work demonstrating associations between PACAP and psychophysiological arousal. They add to previous evidence that circulating PACAP levels are associated with biological markers of centromedial amygdala-dependent functioning. Future research is needed among larger samples, including longitudinal designs to better determine causal relationships between PACAP levels and fear-related arousal.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144177656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized functional brain mapping machine learning prediction of symptom-change resulting from selective kappa-opioid antagonism in an anhedonic sample from a Fast-Fail trial","authors":"Matthew D. Sacchet ,&nbsp;Joseph L. Valenti ,&nbsp;Poorvi Keshava ,&nbsp;Shane W. Walsh ,&nbsp;Moria J. Smoski ,&nbsp;Andrew D. Krystal ,&nbsp;Diego A. Pizzagalli","doi":"10.1016/j.xjmad.2025.100126","DOIUrl":"10.1016/j.xjmad.2025.100126","url":null,"abstract":"<div><h3>Background</h3><div>Anhedonia remains a difficult-to-treat symptom and has been associated with poor clinical course transdiagnostically. Here, we applied machine learning models to individualized neural patches derived from fMRI data during the Monetary Incentive Delay Task in anhedonic participants (N = 67) recruited for a clinical trial examining K-opioid receptor (KOR) antagonism in the treatment of anhedonia.</div></div><div><h3>Methods</h3><div>Nine ensemble models were estimated using cortical, subcortical, and combined cortical subcortical features from individualized functional topographies to predict changes in symptoms of overall psychopathology (anhedonia, depression, anxiety). Analyses were performed on the KOR (N = 33) and placebo (N = 34) group.</div></div><div><h3>Results</h3><div>Initial models showed that only subcortical data predicting depression and anxiety symptom change had a significant Spearman correlation between veridical and predicted data (<em>rho</em> = 0.480 and <em>rho</em> = 0.415 respectively). Next, leave-one-out-cross-validation (LOOCV) showed that the best-performing models comprised only the subcortical individualized systems data, which correlated with clinical change for depression and anxiety scores for the KOR group with significantly higher accuracy (<em>rho</em> = 0.634 and <em>rho</em> = 0.562, respectively) compared to the placebo group (<em>rho</em> = 0.294 and <em>rho</em> = 0.034, respectively). Further, 25 subcortical neural features were identified based on correlation and ensemble determined importance in driving prediction. Final models for both depression and anxiety showed an overall higher representation of the dorsal attention network. Cortical and combined cortical-subcortical feature data showed no significant improvement in prediction of clinical change between the two groups.</div></div><div><h3>Conclusion</h3><div>Using an ensemble of machine learning approaches, we identified individual differences in subcortical individualized systems data that predicted clinical change that was specific to KOR antagonism.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural propensity for trait rumination in adolescents: A cross-sectional study with Voxel-Based Morphometry","authors":"Diane Joss ,&nbsp;Anna O. Tierney ,&nbsp;Kristina Pidvirny ,&nbsp;Nigel M. Jaffe ,&nbsp;Hannah Goodman ,&nbsp;Nicholas J. Carson ,&nbsp;Zev Schuman-Olivier ,&nbsp;Christian A. Webb","doi":"10.1016/j.xjmad.2025.100125","DOIUrl":"10.1016/j.xjmad.2025.100125","url":null,"abstract":"<div><div>Rumination is a transdiagnostic risk factor among adolescents for developing psychopathology. Despite prior research on the neuroscience of rumination in adults, more research is needed regarding the underlying structural neural correlates associated with adolescent rumination. This study analyzed the neural correlates of trait rumination among adolescents (N = 95) using Voxel-Based Morphometry. We found higher trait rumination was associated with lower gray matter density in the left orbitofrontal cortex, inferior frontal gyrus, dorsolateral prefrontal gyrus, and bilateral temporal gyrus, which are involved in inhibitory control, language processing, executive functioning, and social cognitions, respectively. Additionally, higher trait rumination was also associated with higher gray matter density in the caudate and insula, regions linked to impulsivity and negative emotions. While most of the findings are consistent with prior research on adult depression and rumination, some discrepancies may stem from differences in age and psychopathology severity across study samples. This cross-sectional study provides insights into the neural propensities of adolescent rumination.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dopamine function in adolescent social anxiety: Insights from neuromelanin-sensitive MRI","authors":"Margherita L. Calderaro ,&nbsp;Ronan M. Cunningham ,&nbsp;Megan Quarmley ,&nbsp;Tessa Clarkson ,&nbsp;Helen Schmidt ,&nbsp;Clifford M. Cassidy ,&nbsp;Johanna M. Jarcho","doi":"10.1016/j.xjmad.2025.100124","DOIUrl":"10.1016/j.xjmad.2025.100124","url":null,"abstract":"<div><h3>Background</h3><div>Social anxiety typically onsets in adolescence as salience of peer feedback increases. While dopamine system function has been linked to social anxiety, such mechanisms are rarely tested in youth due to the invasiveness of traditional methods. Neuromelanin-sensitive MRI (NM-MRI), a non-invasive proxy measure of central dopamine system function in the substantia nigra (SN), offers a novel approach.</div></div><div><h3>Methods</h3><div>Adolescents (N = 43; M = 12.40 ± 1.45 years) with varying levels of social anxiety underwent NM-MRI. Relations between NM signal intensity in SN and symptom severity were assessed. Effect specificity was tested with generalized anxiety symptoms.</div></div><div><h3>Results</h3><div>Higher NM signal intensity was associated with more severe symptoms of social (p = .03) but not generalized anxiety (p = .93).</div></div><div><h3>Discussion</h3><div>These preliminary results suggest specificity for neural mechanisms associated with adolescent social and generalized anxiety and provide a new avenue for testing symptom etiology and developing targeted treatment.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}