Journal of mood and anxiety disorders最新文献

{"title":"Familial risk for bipolar disorder, childhood trauma and anxiety in youth: Behavioral approach and inhibition systems as mediators of risk","authors":"Evangelia Argyriou ,&nbsp;Jorge R.C. Almeida ,&nbsp;Melissa P. DelBello ,&nbsp;Corey R. Jones ,&nbsp;Amy Bichlmeier ,&nbsp;Wade A. Weber ,&nbsp;Jennifer E. Siegel-Ramsay ,&nbsp;Tricia L. Nick ,&nbsp;David E. Fleck ,&nbsp;Caleb M. Adler ,&nbsp;Lucy Chibib ,&nbsp;Stephen M. Strakowski","doi":"10.1016/j.xjmad.2025.100164","DOIUrl":"10.1016/j.xjmad.2025.100164","url":null,"abstract":"<div><h3>Background</h3><div>Although the occurrence of mania defines the onset of bipolar I disorder, affected individuals often report years of prodromal psychiatric symptoms, often including anxiety and anxiety-related disorders. Moreover, rates of childhood trauma are elevated and may contribute to these conditions as well as mood symptoms. This study aimed to better understand risk factors of prodromal anxiety among youth at familial risk for bipolar disorder. In addition to the impact of trauma, we examined potential mediating roles of two motivational systems – the Behavioral Approach System (BAS) associated with reward motivation and Behavioral Inhibition Systems (BIS) associated with threat avoidance.</div></div><div><h3>Methods</h3><div>Participants were 181 youth, 14–21 years old, with and without familial risk for bipolar I disorder followed prospectively. Using linear mixed-effects models, we examined associations of childhood trauma and familial risk with BIS and BAS subscale scores (Reward Responsiveness, Drive, Fun Seeking), and anxiety measures. We examined BIS and BAS as potential mediators in the relationship between familial risk and trauma, and anxiety, followed over a one-year period.</div></div><div><h3>Results</h3><div>Results showed a positive association of familial risk with BIS (<em>b</em>=0.3, <em>p</em> = 0.02) and a negative association of familial risk with BAS Drive (<em>b</em>=-0.3, <em>p</em> = 0.03). Familial risk (<em>b</em>=0.5, <em>p</em> &lt; 0.01) and trauma (<em>b</em>=0.2, <em>p</em> &lt; 0.01) were associated with higher anxiety measures. BIS scores mediated the effect of familial risk (indirect effect: <em>b</em>=0.1, <em>p</em> = 0.03, proportion mediated=20 %), but not trauma, on anxiety ratings.</div></div><div><h3>Conclusion</h3><div>Threat avoidance may be an important mechanism through which familial risk for bipolar I disorder predisposes individuals for anxiety.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"13 ","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145884966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enduring effects of brief interpersonal therapy on depression from pregnancy through 1-year postpartum: A randomized clinical trial","authors":"Benjamin L. Hankin ,&nbsp;Catherine H. Demers ,&nbsp;Nancy Grote ,&nbsp;Mary C. Curran ,&nbsp;Robert J. Gallop ,&nbsp;M. Camille Hoffman ,&nbsp;Elysia Poggi Davis","doi":"10.1016/j.xjmad.2025.100165","DOIUrl":"10.1016/j.xjmad.2025.100165","url":null,"abstract":"<div><div>Postpartum depression is prevalent with negative consequences for both mothers and developing infants. Little is known about how much the effects of depression treatment, delivered during pregnancy, persist as relapse prevention through 1-year postpartum. This study evaluated whether improvements in depression symptoms and diagnostic status observed during pregnancy following prenatal treatment (randomized to brief Interpersonal Psychotherapy (IPT) versus Enhanced Usual Care (EUC)) persisted through 12- months postpartum. A prospective, evaluator-blinded, randomized clinical trial (RCT) was conducted among adult pregnant individuals, recruited via routine obstetric care depression screening in general practice OB/GYN clinics, reporting elevated symptoms or as clinically depressed. From this RCT, 230 participants were followed during postpartum: 114 allocated to IPT (age <em>M</em>=29.6 [5.9] years) and 116 to EUC (<em>M</em>=29.9 [5.8] years). Depression symptom scales (Symptom Checklist Depression Scale [SCL-20]; Edinburgh Postnatal Depression Scale [EPDS]) were repeatedly assessed from birth through 1-year postpartum. Structured Clinical Interview for DSM-5 at 12-months postpartum ascertained (Major Depressive Disorder (MDD) rates. Results showed depression symptoms stayed significantly lower for participants who received prenatal IPT compared to EUC: SCL-20 (<em>t</em>(227) = 3.05, P = .0025; <em>d</em>= .41 [.14–.66]); IPT (16.29 [.93] vs. EUC (21.39 [.92]) and EPDS (<em>t</em>(227) = 2.77, P = .006; <em>d</em>= .37 [.11–.63]); IPT (7.33 [.33]) vs. EUC (8.82 [.32]). MDD rate by end of 1-year postpartum remained significantly lower in IPT (4.33 %) compared with EUC (12.93 %), χ²(1)= 5.29, P = .021, OR= 3.20. Findings demonstrate that brief IPT, delivered during pregnancy, exhibits enduring effects for treating prenatal depression with ongoing relapse prevention for postpartum depression.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"13 ","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145884967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconsidering the glutamate hypothesis of obsessive-compulsive disorder: A systematic review of proton magnetic resonance spectroscopy studies in unmedicated participants","authors":"Gabriella Restifo-Bernstein ,&nbsp;Jia Guo ,&nbsp;Lawrence S Kegeles ,&nbsp;Dikoma C Shungu ,&nbsp;Helen Blair Simpson","doi":"10.1016/j.xjmad.2026.100168","DOIUrl":"10.1016/j.xjmad.2026.100168","url":null,"abstract":"<div><div>Glutamatergic dysfunction in cortico-striato-thalamo-cortical (CSTC) circuits is a hypothesized cause of obsessive-compulsive disorder (OCD). Numerous proton magnetic resonance spectroscopy (¹H MRS) studies have examined this question, yet no systematic review has been conducted in unmedicated participants with OCD. We searched PubMed, Web of Science, and Embase for ¹H MRS studies examining glutamate (Glu) and the related metabolites glutamine (Gln) and γ-aminobutyric acid (GABA), which are associated with Glu in the Glu-Gln-GABA cycle, as well as the composite measure of Glu and Gln (Glx). Twenty studies were included in this systematic review; 17 examined cross-sectional differences in metabolite levels between participants with OCD and healthy controls, 12 examined associations between metabolite levels and OCD severity, and six examined treatment-associated changes in metabolite levels. Some studies assessed multiple outcomes. Findings across these ¹H MRS studies provide limited evidence to support the glutamate hypothesis of OCD and implicate GABA instead, although further studies of glutamatergic function are needed to definitively address it. Our findings highlight the need for further research on the role of GABA in OCD, involving larger samples of unmedicated participants, advanced ¹H MRS techniques, and multimodal imaging approaches to simultaneously assess metabolite levels and function.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"13 ","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective study of pre-trauma fear learning and extinction as risk factors for posttraumatic stress disorder","authors":"Dean T. Acheson ,&nbsp;Jonathon R. Howlett ,&nbsp;Katia M. Harlé ,&nbsp;Daniel M. Stout ,&nbsp;Dewleen G. Baker ,&nbsp;Caroline M. Nievergelt ,&nbsp;Mark A. Geyer ,&nbsp;Victoria B. Risbrough ,&nbsp;MRS-II Team","doi":"10.1016/j.xjmad.2025.100148","DOIUrl":"10.1016/j.xjmad.2025.100148","url":null,"abstract":"<div><div>Identifying risk for developing trauma-related disorders is a critical step in future prevention and intervention strategies. Impairments in inhibition of learned fear, such as safety signal learning and fear extinction, are suggested to be core mechanisms underlying symptom development and maintenance of posttraumatic stress disorder (PTSD). However, it is unclear if these impairments are pre-existing risk factors for PTSD, or if fear inhibition abnormalities arise only after trauma and symptom development. We utilized a prospective-longitudinal study in human, male service members at high risk for trauma exposure to test the hypothesis that learned fear impairments are pre-existing risk factors for PTSD. PTSD symptoms, fear learning, and fear extinction were assessed prior to a 7-month combat deployment to Afghanistan and 4–6 months after return (final N = 643). Fear learning and extinction were measured by fear-potentiated startle, self-reported anxiety, and threat expectancy ratings. Poor discrimination between threat and safety signals before trauma predicted higher likelihood for development of new onset PTSD after trauma, but not PTSD severity. This effect remained when controlling for trauma exposure. Lower fear extinction learning rate at the pre-trauma time-point predicted PTSD severity but not PTSD status. These findings support the hypothesis that both overgeneralization of fear and/or poor safety signal learning as well as slower fear extinction learning may predispose individuals for development of PTSD. These findings support further study of cue discrimination and slow fear extinction learning as “intermediate phenotypes” for intervention strategies and mechanistic studies targeting the neurobiology of risk and resilience to trauma-related disorders.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"12 ","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145227021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of postpartum depression symptoms among mothers in Mogadishu, Somalia: A Hospital‐based Cross‐sectional Study","authors":"Rahma Yusuf Haji Mohamud ,&nbsp;Nur Adam Mohamed ,&nbsp;Yusuf Abdirisak Mohamed ,&nbsp;Khadija Yusuf Ali ,&nbsp;Amal Nor Ali ,&nbsp;Said Mohamed Mohamud ,&nbsp;Serpil Doğan ,&nbsp;Nazan Karahan ,&nbsp;Said Abdirahman Ahmed ,&nbsp;Alia Ismail Hashi ,&nbsp;Zerife Orhan ,&nbsp;Mohamed Yaqub Hassan","doi":"10.1016/j.xjmad.2025.100157","DOIUrl":"10.1016/j.xjmad.2025.100157","url":null,"abstract":"<div><h3>Introduction</h3><div>Postpartum depression (PPD) is a major public health concern, affecting an estimated 10–15 % of women worldwide, with higher rates consistently reported in low- and middle-income countries. This study sought to estimate the prevalence of PPD symptoms and identify associated risk factors among postpartum mothers in Mogadishu, Somalia.</div></div><div><h3>Methods</h3><div>A hospital-based cross-sectional study was conducted at Erdogan Hospital, Mogadishu, between November 1 and December 31, 2023. Using systematic sampling, 271 postpartum mothers were recruited. Data were collected through structured questionnaires assessing sociodemographic, obstetric, and infant-related characteristics. The Edinburgh Postnatal Depression Scale (EPDS) was used to screen for PPD symptoms, while the Maternity Social Support Scale (MSSS) measured perceived social support. Bivariate and multivariable logistic regression analyses were performed to identify factors associated with PPD., and results were reported as adjusted odds ratios (AOR) with 95 % confidence intervals (CIs). Statistical significance was set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>Of the 271 participants, 26.6 % (95 % CI: 21.4 %–32.2 %) screened positive for PPD symptoms. Significant variables associated with PPD symptoms included stressful life events (AOR = 14.46; 95 % CI: 5.75–36.34), history of depression (AOR = 3.11; 95 % CI: 1.36–7.08), infant sleep difficulties (AOR = 2.53; 95 % CI: 1.27–5.05), pregnancy complications (AOR = 2.55; 95 % CI: 1.12–5.82), and low (AOR = 12.72; 95 % CI: 3.77–42.90) or moderate (AOR = 2.67; 95 % CI: 1.28–5.60) levels of social support.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that more than one in four mothers in Mogadishu experience symptoms of postpartum depression. The findings underscore the need for healthcare professionals to prioritize routine screening for psychological distress, closely monitor women at higher risk, provide timely interventions, and strengthen social support systems. Integrating targeted psychoeducational programs into perinatal care and developing culturally sensitive mental health services could play a critical role in reducing the burden of PPD in Somalia.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"12 ","pages":"Article 100157"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in psychosocial target processes during prenatal depression intervention: A randomized clinical trial","authors":"Karl E. Conroy ,&nbsp;Benjamin L. Hankin ,&nbsp;Julianne M. Griffith ,&nbsp;Catherine H. Demers ,&nbsp;R. Chris Fraley ,&nbsp;Mary Curran ,&nbsp;Nancy Grote ,&nbsp;Elysia Poggi Davis","doi":"10.1016/j.xjmad.2025.100159","DOIUrl":"10.1016/j.xjmad.2025.100159","url":null,"abstract":"<div><div>Prenatal depression is one of the most common obstetric complications. Psychotherapies alleviate depression during pregnancy, yet less is known about which psychosocial processes are changed during treatment and which psychotherapeutic targets associate with depression symptom improvement. This study addressed these questions using data from a prospective randomized clinical trial (RCT). Adult pregnant individuals, randomized to brief Interpersonal Therapy (IPT; n = 115; age <em>M</em>=29.7 [5.9] years) or active comparison condition of Enhanced Usual Care (EUC; n = 119; <em>M</em>=30.1 [5.9] years) which included integrated maternity support services plus one-on-one counseling session and written psychoeducation, completed measures assessing multiple forms of social support, perceived stress, rumination, attachment styles, and various coping skills at baseline (<em>M</em>=16.7 gestational weeks) and post-intervention at end of gestation <em>(M</em>=35.8 weeks; near term) alongside depression symptom scales across pregnancy. Results of linear mixed-effects models showed that most social support dimensions improved, perceived stress and rumination decreased, and multiple forms of coping changed for participants in both IPT and EUC across pregnancy. Perceived stress and emotionally-supportive coping changed more in the IPT group relative to EUC. Change in depression symptoms across pregnancy was predicted by change in social support dimensions of tangible and positive interactions, perceived stress, rumination, and less behavioral-disengagement coping. Causal mediation analyses showed rumination mediated the link between randomization to treatment group and reduced depression symptoms. Results identifying which psychosocial processes were changed during prenatal depression treatment and associate with symptom relief can inform future clinical research aiming at these target processes to enhance outcomes for distressed pregnant patients.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"12 ","pages":"Article 100159"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social well-being moderates behavioral therapy response for generalized anxiety disorder","authors":"Jacob D. Armstrong ,&nbsp;Nicole R. Baughman ,&nbsp;Ricardo A. Wilhelm ,&nbsp;Dalia El-Shafie ,&nbsp;Hannah Berg ,&nbsp;Hung-Wen Yeh ,&nbsp;Elisabeth Akeman ,&nbsp;Christopher Martell ,&nbsp;Kate B. Wolitzky-Taylor ,&nbsp;Michelle G. Craske ,&nbsp;Martin P. Paulus ,&nbsp;Robin Aupperle","doi":"10.1016/j.xjmad.2025.100160","DOIUrl":"10.1016/j.xjmad.2025.100160","url":null,"abstract":"<div><h3><u>Introduction</u></h3><div>Identifying moderators of treatment outcome for depression and anxiety offers promise for personalizing treatment or providing novel intervention targets. Indices of social well-being have emerged as candidate moderators due to their robust impact on mental health and quality of life. Here, we examine whether measures of social support, isolation, and loneliness moderate outcomes to behavioral activation (BA) and exposure-based therapy (EXP) for individuals with GAD.</div></div><div><h3><u>Methods</u></h3><div>This secondary analysis of a randomized clinical trial included 69 participants (31 EXP, 38 BA). Participants completed the GAD-7, along with NIH PROMIS (Depression; Social Isolation; and Emotional, Instrumental, and Informational Support) and NIH Toolbox (Friendship; Loneliness) scales. Regularized factor analysis identified two factors: social support and isolation/loneliness.</div></div><div><h3><u>Results</u></h3><div>Social support (<em>p</em> &lt; .001, η² = 0.19) and isolation/loneliness (<em>p</em> &lt; .001, η² = 0.33) improved over time, regardless of treatment condition. Lower baseline social support related to more GAD-7 improvement to BA and less improvement to EXP (<em>p</em> = 0.030, <em>d</em> = 0.17). Greater baseline isolation/loneliness related to more PROMIS Depression improvement to BA and less improvement to EXP (<em>p</em> = 0.025, <em>d</em> = 0.17). Individuals reporting baseline isolation/loneliness ≥ 0.22 standard deviations above the sample mean exhibited no significant depression symptom reduction with EXP.</div></div><div><h3><u>Conclusions</u></h3><div>Measures of social well-being moderate treatment outcome to behavioral therapy for GAD, providing valuable information for personalized treatment. Results suggest, for individuals reporting low social support and/or high isolation and loneliness, exposure-based treatment outcomes may benefit from early or adjunctive intervention strategies targeting social well-being.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"12 ","pages":"Article 100160"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and neurocognitive correlates of obsessive-compulsive personality disorder symptoms: A transdiagnostic study in individuals with compulsive behaviors","authors":"H. Nur Eken ,&nbsp;Shabnam Hossein ,&nbsp;Apphia Freeman ,&nbsp;Danielle Nebril ,&nbsp;Kevin Do-Nguyen ,&nbsp;Elizabeth Bell ,&nbsp;Luna Malloy ,&nbsp;Mohemmed Aslam ,&nbsp;Nastasia Mcdonald ,&nbsp;Marlee Renard ,&nbsp;Victoria Shaffer ,&nbsp;Crystal Spotts ,&nbsp;Rebecca B. Price","doi":"10.1016/j.xjmad.2025.100155","DOIUrl":"10.1016/j.xjmad.2025.100155","url":null,"abstract":"<div><h3>Background</h3><div>Obsessive-Compulsive Personality Disorder (OCPD) is characterized by a lifelong pattern of excessive attention to detail, rigidity and perfectionism. Although OCPD was historically linked to Obsessive-Compulsive and Related Disorders (OCRDs), this connection lacks consistent evidence. Compulsive behaviors, core to OCRDs, are repetitive actions aimed at reducing distress. To elucidate mechanistic links between OCPD and compulsive behaviors, this study examined relationships between OCPD traits, OCRD symptom domains, and cognitive functioning.</div></div><div><h3>Methods</h3><div>In a transdiagnostic sample of 229 adults with reported compulsive behaviors (CBs) enrolled in a larger clinical trial, we assessed maladaptive OCPD traits using the Pathological Obsessive Compulsive Personality Scale (POPS) and examined their associations with a range of OCRD self-report scales, including measures of hair pulling and skin picking. We evaluated cognitive performance using two NIH toolbox tests and a “two-step” reinforcement learning task.</div></div><div><h3>Results</h3><div>OCPD symptom scores correlated positively with OCD symptom severity on the OCI-R (r = 0.42, p &lt; .001) and YBOCS (r = 0.38, p &lt; .001). Higher OCPD scores were also associated with having a larger number of discrete OCRD symptom domains (r = 0.39, p &lt; .001), and with higher scores across the majority of OCRD scales examined. OCPD scores, unlike OCD scores, showed no significant association with Flanker test or two-step task performance.</div></div><div><h3>Discussion</h3><div>Severity of pathological OCPD traits was related to overall higher severity of OCD symptoms, and linked to several individual domains of OCRDs. Neurocognitive indices showed modest relationships with OCRD symptom severity but not with OCPD. These findings contribute to our understanding of how these phenotypes may co-occur, and help guide future research.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"12 ","pages":"Article 100155"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal depressive symptom networks in older adults during the COVID-19 pandemic","authors":"Michael Odenthal ,&nbsp;Pascal Schlechter ,&nbsp;Christoph Benke ,&nbsp;Christiane A. Melzig","doi":"10.1016/j.xjmad.2025.100156","DOIUrl":"10.1016/j.xjmad.2025.100156","url":null,"abstract":"<div><h3>Background</h3><div>Older adults show high rates of depression with an increase during the COVID-19 pandemic. Social isolation and lifestyle disruptions contributed to loneliness, symptoms of depression, and reduced activity. For interventions, it is crucial to understand the development of symptoms of depression networks and changes over time under stressors such as pandemics. Yet, no COVID-19 longitudinal depression network study in older people exists. We therefore aimed to investigate changes in relationships between symptoms of depression in older adults during compared to the pre-COVID-19 period.</div></div><div><h3>Methods</h3><div>We conducted cross-lagged panel network analyses in four waves from the English Longitudinal Study of Ageing (ELSA), a representative dataset of the UK population over 50 years (initial <em>N</em> = 7223). We examined networks (1) between two pre-pandemic points, (2) from the second pre-pandemic to the first pandemic wave as maximum stressor, and (3) between two pandemic waves as repeated stressor.</div></div><div><h3>Results</h3><div>While the pre- and pandemic networks showed consistent overall structures, some differences emerged. In the pre-pandemic network, <em>feeling lonely</em> and <em>could not get going</em> were the only nodes with positive out-expected influence, suggesting a central activating role. During the pandemic, additional symptoms developed stronger outgoing connections, suggesting a shift toward a broader set of symptoms driving network dynamics under prolonged stress.</div></div><div><h3>Discussion</h3><div>Loneliness appears to play a key role in symptom development under acute and repeated stress. Findings suggest that dynamics in symptoms of depression networks in older adults are relatively stable, even during acute and repeated stress during the COVID-19 pandemic.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"12 ","pages":"Article 100156"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and accuracy of the ASERT digital questionnaire in mood tracking for a longitudinal research study on bipolar disorder","authors":"Isaac Lynch ,&nbsp;Gail I.S. Harmata ,&nbsp;Ercole John Barsotti ,&nbsp;Jess G. Fiedorowicz ,&nbsp;Aislinn J. Williams ,&nbsp;Cari Linkenmeyer ,&nbsp;Sarah Smith ,&nbsp;Spencer Smith ,&nbsp;Jenny Gringer Richards ,&nbsp;Jeffrey D. Long ,&nbsp;Soňa Sikorová ,&nbsp;Eduard Bakstein ,&nbsp;John A. Wemmie ,&nbsp;Vincent A. Magnotta","doi":"10.1016/j.xjmad.2025.100145","DOIUrl":"10.1016/j.xjmad.2025.100145","url":null,"abstract":"<div><h3>Background</h3><div>It is challenging for bipolar disorder (BD) studies to capture multiple mood states within a participant at in-person visits. Mood tracking could aid scheduling, but evaluation is usually done using clinical assessments inconvenient for participants to undergo often. However, frequent assessments are necessary to capture dynamic mood changes typical of BD. The Aktibipo Self-Rating Questionnaire (ASERT) is a simple, self-report mood survey. We examined the utility of collecting the ASERT weekly to assess mood changes and schedule follow-up visits.</div></div><div><h3>Methods</h3><div>Sixty-one participants with BD completed the ASERT and were administered the Montgomery-Åsberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) during a baseline visit. Participants were then sent weekly text messages with an ASERT survey link. If participants exhibited at least a 5-point (later 8-point) change from baseline on either the mania or depression subscale, they were called and administered the MADRS or YMRS. A 10-point change on either phone-delivered clinical scale prompted a follow-up visit. Associations between ASERT subscales and clinical scales were evaluated using Spearman’s correlation and robust regression.</div></div><div><h3>Results</h3><div>Mean completion rate was 94.8 % and median completion time was 67 s. The ASERT depression and mania subscales correlated with the MADRS and YMRS at baseline and all follow-up time points. Our screening method aided scheduling, with 15 of 19 participants exhibiting a 10-point change or greater on the MADRS and/or YMRS at Visit 2.</div></div><div><h3>Conclusions</h3><div>The ASERT can be feasibly deployed to track mood and can help schedule follow-up assessments in BD longitudinal studies.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"12 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}