Journal of mood and anxiety disorders最新文献

{"title":"Individualized functional brain mapping machine learning prediction of symptom-change resulting from selective kappa-opioid antagonism in an anhedonic sample from a Fast-Fail trial","authors":"Matthew D. Sacchet ,&nbsp;Joseph L. Valenti ,&nbsp;Poorvi Keshava ,&nbsp;Shane W. Walsh ,&nbsp;Moria J. Smoski ,&nbsp;Andrew D. Krystal ,&nbsp;Diego A. Pizzagalli","doi":"10.1016/j.xjmad.2025.100126","DOIUrl":"10.1016/j.xjmad.2025.100126","url":null,"abstract":"<div><h3>Background</h3><div>Anhedonia remains a difficult-to-treat symptom and has been associated with poor clinical course transdiagnostically. Here, we applied machine learning models to individualized neural patches derived from fMRI data during the Monetary Incentive Delay Task in anhedonic participants (N = 67) recruited for a clinical trial examining K-opioid receptor (KOR) antagonism in the treatment of anhedonia.</div></div><div><h3>Methods</h3><div>Nine ensemble models were estimated using cortical, subcortical, and combined cortical subcortical features from individualized functional topographies to predict changes in symptoms of overall psychopathology (anhedonia, depression, anxiety). Analyses were performed on the KOR (N = 33) and placebo (N = 34) group.</div></div><div><h3>Results</h3><div>Initial models showed that only subcortical data predicting depression and anxiety symptom change had a significant Spearman correlation between veridical and predicted data (<em>rho</em> = 0.480 and <em>rho</em> = 0.415 respectively). Next, leave-one-out-cross-validation (LOOCV) showed that the best-performing models comprised only the subcortical individualized systems data, which correlated with clinical change for depression and anxiety scores for the KOR group with significantly higher accuracy (<em>rho</em> = 0.634 and <em>rho</em> = 0.562, respectively) compared to the placebo group (<em>rho</em> = 0.294 and <em>rho</em> = 0.034, respectively). Further, 25 subcortical neural features were identified based on correlation and ensemble determined importance in driving prediction. Final models for both depression and anxiety showed an overall higher representation of the dorsal attention network. Cortical and combined cortical-subcortical feature data showed no significant improvement in prediction of clinical change between the two groups.</div></div><div><h3>Conclusion</h3><div>Using an ensemble of machine learning approaches, we identified individual differences in subcortical individualized systems data that predicted clinical change that was specific to KOR antagonism.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural propensity for trait rumination in adolescents: A cross-sectional study with Voxel-Based Morphometry","authors":"Diane Joss ,&nbsp;Anna O. Tierney ,&nbsp;Kristina Pidvirny ,&nbsp;Nigel M. Jaffe ,&nbsp;Hannah Goodman ,&nbsp;Nicholas J. Carson ,&nbsp;Zev Schuman-Olivier ,&nbsp;Christian A. Webb","doi":"10.1016/j.xjmad.2025.100125","DOIUrl":"10.1016/j.xjmad.2025.100125","url":null,"abstract":"<div><div>Rumination is a transdiagnostic risk factor among adolescents for developing psychopathology. Despite prior research on the neuroscience of rumination in adults, more research is needed regarding the underlying structural neural correlates associated with adolescent rumination. This study analyzed the neural correlates of trait rumination among adolescents (N = 95) using Voxel-Based Morphometry. We found higher trait rumination was associated with lower gray matter density in the left orbitofrontal cortex, inferior frontal gyrus, dorsolateral prefrontal gyrus, and bilateral temporal gyrus, which are involved in inhibitory control, language processing, executive functioning, and social cognitions, respectively. Additionally, higher trait rumination was also associated with higher gray matter density in the caudate and insula, regions linked to impulsivity and negative emotions. While most of the findings are consistent with prior research on adult depression and rumination, some discrepancies may stem from differences in age and psychopathology severity across study samples. This cross-sectional study provides insights into the neural propensities of adolescent rumination.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dopamine function in adolescent social anxiety: Insights from neuromelanin-sensitive MRI","authors":"Margherita L. Calderaro ,&nbsp;Ronan M. Cunningham ,&nbsp;Megan Quarmley ,&nbsp;Tessa Clarkson ,&nbsp;Helen Schmidt ,&nbsp;Clifford M. Cassidy ,&nbsp;Johanna M. Jarcho","doi":"10.1016/j.xjmad.2025.100124","DOIUrl":"10.1016/j.xjmad.2025.100124","url":null,"abstract":"<div><h3>Background</h3><div>Social anxiety typically onsets in adolescence as salience of peer feedback increases. While dopamine system function has been linked to social anxiety, such mechanisms are rarely tested in youth due to the invasiveness of traditional methods. Neuromelanin-sensitive MRI (NM-MRI), a non-invasive proxy measure of central dopamine system function in the substantia nigra (SN), offers a novel approach.</div></div><div><h3>Methods</h3><div>Adolescents (N = 43; M = 12.40 ± 1.45 years) with varying levels of social anxiety underwent NM-MRI. Relations between NM signal intensity in SN and symptom severity were assessed. Effect specificity was tested with generalized anxiety symptoms.</div></div><div><h3>Results</h3><div>Higher NM signal intensity was associated with more severe symptoms of social (p = .03) but not generalized anxiety (p = .93).</div></div><div><h3>Discussion</h3><div>These preliminary results suggest specificity for neural mechanisms associated with adolescent social and generalized anxiety and provide a new avenue for testing symptom etiology and developing targeted treatment.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality traits as predictors of PTSD and depression symptoms following exposure-based treatment in an intensive outpatient program","authors":"Courtland S. Hyatt ,&nbsp;Brinkley M. Sharpe ,&nbsp;Colin E. Vize ,&nbsp;Julie R. Chrysosferidis ,&nbsp;Martha Fiskeaux ,&nbsp;Stephanie M. Haft ,&nbsp;Natalie M. Hellman ,&nbsp;Meagan C. Dove ,&nbsp;Sheila A.M. Rauch ,&nbsp;Barbara O. Rothbaum ,&nbsp;Jessica L. Maples-Keller","doi":"10.1016/j.xjmad.2025.100123","DOIUrl":"10.1016/j.xjmad.2025.100123","url":null,"abstract":"<div><div>We aimed to assess the associations between pre-treatment personality traits on symptoms of posttraumatic stress disorder (PTSD) and depression before and after an intensive outpatient treatment program (IOP). In a secondary data analysis of a sample of <em>N</em> = 665 veteran or active-duty U.S. military servicemembers who completed IOP treatment (65.7 % male; mean age = 41.8; 57.0 % White), we used multiple regression analyses and latent change score models to investigate pre-treatment measures of Five Factor Model traits, psychopathy, and narcissism as predictors of PTSD and depression symptoms across timepoints (i.e., from pre-treatment up to 12-months post-treatment) following completion of exposure-based, cognitive-behavioral IOP treatment. Neuroticism and Extraversion were positively and negatively, respectively, associated with PTSD and depression symptoms at all timepoints, and facets from other domains (e.g., trust, self-efficacy) also bore medium-to-large associations with these symptoms at each timepoint. Psychopathy and narcissism bore null-to-small relations with psychopathology. Pre-treatment PTSD and depression symptoms were consistent predictors of post-treatment symptoms, as well as of greater symptom reduction from pre- to post-treatment, pre-treatment to 12-month follow-up, and post-treatment to 12-month follow up. Higher Extraversion was significantly related to greater change in PTSD and depression symptoms from pre- to post-treatment. No other personality traits were related to symptom change beyond pre-treatment symptoms on any timescale. Personality traits have large associations with PTSD and depression symptoms over time, but the degree to which they account for IOP treatment response beyond baseline symptoms is relatively small.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"11 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An examination of symptoms, function and quality of life as conjoint clinical outcome domains for treatment-resistant depression","authors":"Charles R. Conway ,&nbsp;A. John Rush ,&nbsp;Charles Gordon ,&nbsp;Sheldon H. Preskorn ,&nbsp;Harold A. Sackeim ,&nbsp;Scott T. Aaronson ,&nbsp;Roger S. McIntyre ,&nbsp;Ying-Chieh (Lisa) Lee ,&nbsp;Olivia Shy ,&nbsp;Quyen Tran ,&nbsp;Jeffrey Way ,&nbsp;Mark T. Bunker","doi":"10.1016/j.xjmad.2025.100121","DOIUrl":"10.1016/j.xjmad.2025.100121","url":null,"abstract":"<div><h3>Objective</h3><div>The treatment of depression aims to improve depressive symptoms, daily function and quality of life (QoL). These exploratory analyses of a database of convenience from the RECOVER trial evaluated how a “tripartite” metric based on these 3 outcome domains might perform in treatment-resistant depression (TRD).</div></div><div><h3>Methods</h3><div>Outcome domains included depressive symptoms (MADRS, QIDS-C, QIDS-SR), function (WPAI item-6) and QoL (Mini-Q-LES-Q) obtained at months 3, 6, 9 and 12 in outpatients with markedly TRD in the double-blind RECOVER trial that compared sham to active adjunctive vagus nerve stimulation (VNS). For each domain, clinically meaningful differences were defined <em>a priori</em>. Analyses addressed 3 questions: 1) Does each domain detect meaningful benefits undetected by the other domains? 2) Is the tripartite metric validated by an independent clinician-rated global index of improvement (CGI-I)? 3) How well does the tripartite metric detect treatment group differences in the RECOVER trial?</div></div><div><h3>Results</h3><div>Clinically meaningful reductions in depressive symptoms alone missed 25–51 % of all participants who evidenced clinically meaningful benefits in depressive symptoms, function or QoL. The tripartite metric strongly correlated with CGI-I ratings (tetrachoric r = 0.73–0.85), with stronger relationships than each component individually. The tripartite metric successfully separated active from sham adjunctive VNS in a 1-year trial of patients with markedly TRD.</div></div><div><h3>Conclusion</h3><div>Symptoms, function and QoL capture distinct, clinically significant and valid outcomes that identify persons with markedly TRD with a range of clinically meaningful benefits. Whether these results pertain to other major depressive disorder patient groups and treatments deserves study.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interacting immediate and long-term action regulation in suicidal behavior","authors":"Nicholas Murphy ,&nbsp;George Kypriotakis ,&nbsp;Marijn Lijffijt ,&nbsp;Sidra Iqbal ,&nbsp;Tabish Iqbal ,&nbsp;Dania Amarneh ,&nbsp;Brittany O’Brien ,&nbsp;Amanda Tamman ,&nbsp;Ynhi Thomas ,&nbsp;Nidal Moukaddam ,&nbsp;Thomas R. Kosten ,&nbsp;Lynnette A. Averill ,&nbsp;Sanjay Mathew ,&nbsp;Alan C. Swann","doi":"10.1016/j.xjmad.2025.100118","DOIUrl":"10.1016/j.xjmad.2025.100118","url":null,"abstract":"<div><h3>Background</h3><div>Suicide is a prominent cause of death across the lifespan, especially between 10 and 34 years old. Most suicides are first attempts, during crises with unpredictably fluctuating risk, arising insidiously from mechanisms related to long-term exposure to psycho-bio-social risk factors. Identifying susceptibility from interacting immediate and long-term mechanisms of action regulation could prevent suicidal crises.</div></div><div><h3>Methods</h3><div>We investigated interacting immediate and long-term regulation of action in risk for suicide. Immediate processes were assessed through affective and behavioral symptoms and a computer measure of impaired action-regulation, the Immediate Memory Task (IMT). Long-term processes included history of trauma, stress, and addictive behaviors. We used Beck Suicidal Ideation at its Worst (SSI-W) to measure global suicidal behavior. Participants were 28 survivors of medically severe suicide attempt (MSSA) within the previous 9 months compared to 23 age, sex, and diagnosis-similar psychiatric controls with previous suicidal ideation but without attempt (NA).</div></div><div><h3>Results</h3><div>MSSA was related, independent of SSI-W, to IMT impulsive responses, Internal State Scale (ISS) activation, and Lifetime Cumulative Adversity (LCA). MSSA was indirectly related, through SSI-W, to depression, aggression, alcohol-use severity and IMT stimulus discrimination. Minimization-denial of childhood trauma directly increased MSSA,but indirectly reduced apparent MSSA through reduced SSI-W reporting.</div></div><div><h3>Discussion</h3><div>MSSA combines characteristics independent of and dependent on SSI-W, reinforced by minimization/denial of childhood trauma. Stress-related hyperarousal and denial of early trauma facilitate MSSA through ISS activation, LHA, and impulsive IMT responses. These characteristics can identify individuals who, without previous suicide attempt or conventional psychiatric diagnosis, need preventive treatment of suicide risk.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100118"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and longitudinal associations with obsessive-compulsive disorder in youth exposed to trauma","authors":"Caitlin M. Pinciotti ,&nbsp;Paul J. Rathouz ,&nbsp;Andrew G. Guzick ,&nbsp;Jeffrey D. Shahidullah ,&nbsp;Emily J. Bivins ,&nbsp;David B. Riddle ,&nbsp;Ogechi “Cynthia” Onyeka ,&nbsp;Eric A. Storch ,&nbsp;Wayne K. Goodman ,&nbsp;Kelli Franco ,&nbsp;Justin F. Rousseau ,&nbsp;D. Jeffrey Newport ,&nbsp;Karen Dineen Wagner ,&nbsp;Charles B. Nemeroff","doi":"10.1016/j.xjmad.2025.100117","DOIUrl":"10.1016/j.xjmad.2025.100117","url":null,"abstract":"<div><div>Childhood trauma exposure is associated with posttraumatic stress symptoms (PTSS) and suicidality, however it is also a risk factor for obsessive-compulsive disorder (OCD) in adults. Research examining the relationship between childhood trauma and OCD in youth is mixed, and there is a dearth of research examining the associations among OCD, PTSS, and suicidality. As a result, conclusions have been drawn from primarily cross-sectional adult samples. No study has examined the clinical characteristics associated with OCD in trauma-exposed youth, nor its associations with PTSS and suicidality over time. To address this gap, the present study used logistic regressions and generalized estimating equations in 2068 trauma-exposed youth aged 8—20 who completed assessments at baseline, 6-month, and 12-month follow-ups. In total, trauma-exposed youth with OCD (<em>n</em> = 222, 10.7 %) were more likely to be female (OR = 0.646), had more severe PTSS (OR = 1.032), and more psychiatric comorbidities (OR = 1.391) compared to trauma-exposed youth without OCD. Interpersonal traumas (OR = 1.549) and bullying (OR = 1.294) were associated with a greater likelihood of having OCD; however, these effects were nonsignificant when adjusting for other mental health symptoms. There was no evidence that OCD was associated with the trajectory of PTSS nor suicidality at 6- and 12-month follow-ups. Trauma-exposed youth with OCD may cross-sectionally have more severe clinical presentations overall, but OCD may not be related to the trajectory of these symptoms over time. Future research is needed to understand the directionality of clinical characteristics associated with pediatric OCD and whether interpersonal traumas convey risk uniquely for OCD or for distress in general.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weighing the predictive role of neural factors for adolescent anhedonia in the presence of demographic and clinical factors","authors":"Anisha Reddy ,&nbsp;Michele Bertocci ,&nbsp;Tina Gupta ,&nbsp;Kristen L. Eckstrand ,&nbsp;Manivel Rengasamy ,&nbsp;Erika E. Forbes","doi":"10.1016/j.xjmad.2025.100116","DOIUrl":"10.1016/j.xjmad.2025.100116","url":null,"abstract":"<div><div>Anhedonia, a transdiagnostic symptom of psychopathology associated with pernicious clinical course, has putative mechanisms in neural reward systems and emerges during adolescence. However, the relative contributions of neural, demographic, and clinical factors to its development are unclear. 73 adolescents (13–19 years) at varying familial risk for developing anhedonia reported demographic and clinical characteristics at study entry, reported anhedonia up to three times annually, and underwent fMRI during a monetary reward paradigm. Least absolute shrinkage and selection operator (LASSO) regression, which allows for a large number of intercorrelated predictors for feature selection, revealed that among demographic, clinical, and neural factors, 10 features predicted peak anhedonia over two years: impulsivity; activation in dorsal caudate, sub-gyral temporal lobe, and cuneus; and negative FC between the ventral striatum and six regions implicated in motor and/or decision-making aspects of reward. Neural factors explained an additional 40 % of variance above impulsivity. Findings indicate that in adolescents at risk for severe mental illness, disrupted motor and decision-making reward pathways could contribute to the development of anhedonia. Additionally, anhedonia should be defined in multiple domains, beyond mere phenomenology.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100116"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"de novo KDM5B Mutation in a Patient with Autism Spectrum Disorder and Obsessive-Compulsive Disorder: Case Report","authors":"Niki P. Sabetfakhri,&nbsp;Stephen J. Guter Jr,&nbsp;Sandra H. Reyes Pinzon,&nbsp;Olusola A. Ajilore,&nbsp;Edwin H. Cook,&nbsp;Fedra Najjar","doi":"10.1016/j.xjmad.2025.100114","DOIUrl":"10.1016/j.xjmad.2025.100114","url":null,"abstract":"<div><h3>Background</h3><div>The <em>KDM5B</em> gene encodes a lysine histone demethylase that is essential in epigenetic regulation and human development. Homozygous and compound heterozygous variants of <em>KDM5B</em> have been associated with a distinct syndrome characterized by developmental delay, intellectual disability, and dysmorphic features. However, phenotypic presentations associated with heterozygous (HET) protein-truncating variants (PTVs) have been inconsistent, ranging from moderate to severe autism spectrum disorder (ASD) and intellectual disability (ID), to some individuals being unaffected with ASD or ID.</div></div><div><h3>Case presentation</h3><div>We report a <em>de novo</em> HET PTV (NM_006618.5 c.1708 C&gt;T; p.R570X) in <em>KDM5B</em> in an 18-year-old Caucasian female patient, who presented with ASD, and then developed severe obsessive-compulsive disorder (OCD) and leading to depression and emotion dysregulation</div></div><div><h3>Conclusions</h3><div>This case suggests a potential role for HET PTVs in the <em>KDM5B</em> gene in OCD pathogenesis and marks the first report of co-occurring ASD and OCD associated with a <em>KDM5B</em> variant.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rollercoaster of obsessive-compulsive disorder: How chronotype and time of day affect behavioral inhibition in adults with OCD","authors":"Eyal Kalanthroff ,&nbsp;Yuval Seror ,&nbsp;Noa Sagi ,&nbsp;Shachar Hochman ,&nbsp;Omer Linkovski ,&nbsp;Hadar Naftalovich ,&nbsp;Helen Blair Simpson","doi":"10.1016/j.xjmad.2025.100113","DOIUrl":"10.1016/j.xjmad.2025.100113","url":null,"abstract":"<div><div>Chronotype, a person's circadian preference, reflects individuals’ natural pattern of alertness levels throughout the day. It has been shown that chronotype contributes to within-day symptom fluctuations in obsessive-compulsive disorder (OCD). However, the underlying mechanism of this effect is not yet clear. Inhibitory control, an executive function crucial for suppressing unwanted behaviors and thoughts, is essential for managing OCD symptoms and is highly influenced by alertness levels. Hence, the current study investigated the impact of chronotype and time of day on inhibitory control in OCD patients, particularly in response to individually tailored symptom-provoking images, using a novel version of the stop signal task. Ninety-three treatment-seeking OCD patients completed an individually tailored Symptom-Provocation Stop-Signal Task, every morning and evening for four consecutive days. Chronotype was assessed using the Morningness-Eveningness Questionnaire (MEQ). Stop-signal reaction time (SSRT) was assessed for neutral and individually tailored symptom-provoking images separately. Patients exhibited longer SSRTs (worse inhibition) to symptom-provoking trials compared to neutral trials. Most importantly, chronotype and time of day significantly interacted to affect SSRTs in the symptom-provocation condition: A significant correlation was found between optimal alertness periods and improved inhibitory control in the symptom-provocation condition. Taken together, these results indicate that inhibitory control in OCD varies with chronotype and time of day. These findings suggest that aligning treatment sessions with patients' chronotype may enhance therapeutic outcomes and that heightening alertness—by increasing the chances of successful inhibition—might be a way to mitigate the vicious cycle of OCD.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}