Journal of mood and anxiety disorders最新文献

{"title":"The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders compared with diagnosis-specific protocols for anxiety disorders: A three-year follow-up","authors":"Jacqueline R. Bullis ,&nbsp;Elizabeth H. Eustis ,&nbsp;Andrew J. Curreri ,&nbsp;Nicole D. Cardona ,&nbsp;Brittany K. Woods ,&nbsp;Anthony J. Rosellini ,&nbsp;David H. Barlow ,&nbsp;Todd.J. Farchione","doi":"10.1016/j.xjmad.2023.100024","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100024","url":null,"abstract":"<div><h3>Objective</h3><p>Compare the long-term efficacy of diagnosis-specific and transdiagnostic cognitive-behavioral therapies (CBT) from a randomized equivalence trial for the treatment of heterogenous anxiety disorders.</p></div><div><h3>Method</h3><p>Participants were treatment completers (N = 80; 58.8% female) from the parent equivalence trial treated with either the Unified Protocol (UP; <em>n</em> = 44) or the single-disorder CBT protocol (SDP; <em>n</em> = 36) for their primary anxiety disorder. Clinical interviews were conducted at 24- and 36-month follow-up and self-report questionnaire batteries were completed at 18-, 24-, 30-, and 36-month follow-up. With-in condition effect sizes were calculated to determine maintenance of treatment gains in each treatment condition over time and potential differences between treatment conditions were evaluated using the principal diagnosis clinician severity rating (CSR) from the Anxiety Disorder Interview Schedule (ADIS); additional outcomes included anxiety, depression, and functional impairment.</p></div><div><h3>Results</h3><p>Treatment gains within each condition were largely maintained at three years post-treatment, with small fluctuations in subclinical symptoms. At 36-month follow-up, the UP and SDP treatment conditions remained comparable on the principal diagnosis ADIS CSR. Although there were some differences on secondary outcomes favoring the SDP condition at intermediate time points, there were no significant differences between the UP and SDP conditions on ADIS CSR or any secondary outcomes at 36-month follow-up.</p></div><div><h3>Conclusions</h3><p>Results further support the utility of the UP as a single intervention that produces durable treatment effects for the most commonly occurring psychological disorders through demonstration of outcomes commensurate with current first-line SDPs.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"3 ","pages":"Article 100024"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50193009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of COVID-19 related lifestyle disruptions and their associations with mental health outcomes among youth and young adults","authors":"Michael G. Curtis ,&nbsp;Ysabel Beatrice Floresca ,&nbsp;Shahin Davoudpour ,&nbsp;Jiayi Xu ,&nbsp;Gregory Phillips II","doi":"10.1016/j.xjmad.2023.100029","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100029","url":null,"abstract":"<div><p>The COVID-19 pandemic is a socionatural disaster that has disrupted the lives of individuals, families, and communities. Youth and young adults (YYA) were uniquely vulnerable to the proximal mental health effects of the pandemic; however, few studies have examined the long-term mental health effects of the pandemic. In the present study, we sought to (a) identity distinctive profiles of COVID-related lifestyle disruptions experienced by YYA, (b) investigate sociodemographic characteristics correlates of profile membership, and (c) examine the extent to which profile membership was prospectively associated with changes in depressive and anxiety symptoms. Hypothesis were tested using latent profile analysis with data from 1055 YYA collected across two time-points, 6-months apart. Results produced a three-class model: low- (11%), moderate- (61%), and high-levels of (28%) disruption. Members of the high levels of disruption group were more likely to identify as Black or Latinx American, bisexual/pansexual, or as transgender or gender diverse in comparison to the low levels of disruption group. Inclusion in the high levels of disruption group was associated with increases in depressive and anxiety symptoms from T1 to T2. YYA from multiple marginalize communities (i. e. those who identified as both racial/ethnic and sexual/gender minorities) experienced the greatest levels of lifestyle disruption related to COVID-19. Consequently, disruptive effects of the COVID-19 pandemic prospectively eroded their mental health. YYA are in urgent need of developmentally appropriate resources to effectively recovery from the pandemic.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"4 ","pages":"Article 100029"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49890715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of psychedelic-assisted therapy among Black Americans","authors":"Sierra Carter ,&nbsp;Grace Packard ,&nbsp;Callan Coghlan ,&nbsp;Jamilah R. George ,&nbsp;Ashanti J. Brown ,&nbsp;Terence H.W. Ching ,&nbsp;Jacob Julian ,&nbsp;Jessica L. Maples-Keller","doi":"10.1016/j.xjmad.2023.100023","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100023","url":null,"abstract":"<div><p>The present study investigated differences in perceptions of psychedelic-assisted therapy between Black and White Americans, as well as factors that may influence these perceptions. A final sample of 294 adults (42% female, 44% Black/African American or Mixed Race (of Black/African ancestry), 56% White American; M_age = 36.3 years) completed an online survey which assessed baseline knowledge and views of psychedelic-assisted therapy. Participants were then provided brief psychoeducation related to MDMA and psilocybin-assisted therapy. After psychoeducation, participants were queried on their perceptions of psychedelic-assisted therapy and factors potentially influencing these perceptions, including trauma history, current depressive and PTSD symptoms, perceived stress, and perceived barriers to psychological treatments. Psychoeducation had a positive impact on both level of interest and positivity of views of psychedelic-assisted therapy across groups. Black American participants reported <em>more</em> positive views of psychedelic-assisted therapy than White participants following psychoeducation. Greater depression and PTSD symptom severity was associated with greater baseline interest in Black and White Americans and there was significant interactions in predicting baseline view and interest, such that Black participants who reported greater depression symptom severity were more interested and had more positive views of PAT. Despite historical exclusion from psychedelic clinical trials and experiences of unethical treatment in research, Black Americans demonstrate more positive views of psychedelic therapy, and Black Americans more in need of novel mental health care demonstrate more interest and more positive views. Our findings demonstrate that the onus for diversification of psychedelic research samples is on research groups. These findings also provide an impetus for the psychedelic research community to rebuild trust in psychedelic research among Black Americans, conduct outreach, and provide culturally attuned psychedelic-assisted interventions that are accessible to Black Americans.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"4 ","pages":"Article 100023"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49890714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood adversity and the cortisol awakening response in depression: A meta-analysis","authors":"Ellen Jopling,&nbsp;Joelle LeMoult","doi":"10.1016/j.xjmad.2023.100014","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100014","url":null,"abstract":"<div><p>Although cortisol awakening response (CAR) dysregulation is frequently documented among individuals with depression, there is conflicting evidence regarding the direction and degree of dysregulation, which impedes our ability to provide personalized and efficacious treatment. Childhood adversity is posited to explain variability within the CAR-depression literature, but the effect of childhood adversity on the CAR in depression has not yet been quantified. We meta-analyzed 19 studies (<em>n</em> = 2053) examining the association between childhood adversity and the CAR among individuals with depression. Data were pooled using random-effects models for childhood adversity overall, childhood adversity characterized by threat, and childhood adversity characterized by deprivation. Among individuals with depression, greater exposure to childhood adversity was associated with a steeper CAR. Further, in line with hypotheses, among individuals with depression, greater exposure to childhood adversity characterized by threat was associated with a steeper CAR, whereas greater exposure to adversity characterized by deprivation was not. These results support the proposition that greater childhood adversity, and in particular adversity characterized by threat, could lead to a distinct presentation of depression characterized by dysregulated diurnal HPA axis activity, as evidenced by a steeper CAR. These findings suggest specificity in the associations between types of childhood adversity and the CAR and could inform growing efforts towards personalized medicine in the treatment of depression.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"2 ","pages":"Article 100014"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49899585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic and prescriptive predictors of PTSD response to prolonged exposure and sertraline","authors":"Peter L. Rosencrans ,&nbsp;Natalia M. Garcia ,&nbsp;Andrew A. Cooper ,&nbsp;Elizabeth Lehinger ,&nbsp;Jenna Bagley ,&nbsp;Daniella Levine ,&nbsp;Rosemary M. Walker ,&nbsp;Alex O. Rothbaum ,&nbsp;Elizabeth H. Marks ,&nbsp;Jenna Mohr ,&nbsp;Sinan Payat ,&nbsp;Michele Bedard-Gilligan ,&nbsp;Matig Mavissakalian ,&nbsp;Peter P. Roy-Byrne ,&nbsp;Norah C. Feeny ,&nbsp;Lori A. Zoellner","doi":"10.1016/j.xjmad.2023.100008","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100008","url":null,"abstract":"<div><p>In developing personalized care for PTSD, baseline predictors that inform clinicians' and patients' decision making across treatment options are limited. In 200 individuals with PTSD in a multi-site, doubly randomized preference trial, baseline psychopathology, personality/mood regulation, health/social functioning, treatment credibility and history, and demographic factors predicted PTSD severity from baseline, ten sessions, to post-treatment. Using a stepwise prognostic and prescriptive modeling approach, rates of change and post-treatment outcomes between prolonged exposure [PE] vs sertraline and preferred vs non-preferred treatments were examined. Stronger credibility of PE predicted faster improvement (<em>b</em> = −0.28, <em>SE</em> = 0.10) and lower post-treatment scores (<em>b</em> = −2.40, <em>SE</em> = 1.08). Higher avoidance predicted poorer outcomes for those who did not receive their preferred treatment (<em>b</em> = −5.33, <em>SE</em> = 2.42). Similarly, being psychiatric medication naïve predicted poorer response for those who did not receive their preferred treatment (<em>b</em> = −13.03, <em>SE</em> = 5.71). Across a range of baseline predictors, stronger credibility of PE, potentially reflecting the patient's perceived need to actively discuss and process the trauma memory, emerged as one of the best predictors of PTSD treatment outcome. Particular attention should be paid to matching more avoidant and medication-naïve patients to their preferred treatment.</p></div><div><h3>Data Availability</h3><p>All data, program code, and other methods developed by others have been cited appropriately in text. The dataset for this study comes from a previously published clinical trial [NCT00127673, 29] and is available by request by competent researchers. Computer syntax used for this study is available upon request. Research materials, including treatment rationales and manuals, are available upon request.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"2 ","pages":"Article 100008"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49899583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosing major depressive disorder and substance use disorder using the electronic health record: A preliminary validation study","authors":"Vinod Rao ,&nbsp;Sylvia Lanni ,&nbsp;Amy M. Yule ,&nbsp;Maura DiSalvo ,&nbsp;Mira Stone ,&nbsp;Amy F. Berger ,&nbsp;Timothy E. Wilens","doi":"10.1016/j.xjmad.2023.100007","DOIUrl":"10.1016/j.xjmad.2023.100007","url":null,"abstract":"<div><h3>Background</h3><p>One mechanism to examine if major depressive disorder (MDD) is related to the development of substance use disorder (SUD) is by leveraging naturalistic data available in the electronic health record (EHR). Rules for data extraction and variable construction linked to psychometrics validating their use are needed to extract data accurately.</p></div><div><h3>Objective</h3><p>We propose and validate a methodologic framework for using EHR variables to identify patients with MDD and non-nicotine SUD.</p></div><div><h3>Methods</h3><p>Proxy diagnoses and index dates of MDD and/or SUD were established using billing codes, problem lists, patient-reported outcome measures, and prescriptions. Manual chart reviews were conducted for the 1-year period surrounding each index date to determine (1) if proxy diagnoses were supported by chart notes and (2) if the index dates accurately captured disorder onset.</p></div><div><h3>Results</h3><p>The results demonstrated 100% positive predictive value for proxy diagnoses of MDD. The proxy diagnoses for SUD exhibited strong agreement (Cohen's kappa of 0.84) compared to manual chart review and 92% sensitivity, specificity, positive predictive value, and negative predictive value. Sixteen percent of patients showed inaccurate SUD index dates generated by EHR extraction with discrepancies of over 6 months compared to SUD onset identified through chart review.</p></div><div><h3>Conclusions</h3><p>Our methodology was very effective in identifying patients with MDD with or without SUD and moderately effective in identifying SUD onset date. These findings support the use of EHR data to make proxy diagnoses of MDD with or without SUD.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"2 ","pages":"Article 100007"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10293962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increases in poor mental health, mental distress, and depression symptoms among U.S. adults, 1993–2020","authors":"Nikhila S. Udupa ,&nbsp;Jean M. Twenge ,&nbsp;Cooper McAllister ,&nbsp;Thomas E. Joiner","doi":"10.1016/j.xjmad.2023.100013","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100013","url":null,"abstract":"<div><p>Across three nationally representative surveys (<em>N</em> = 9.2 million), U.S. adults reported increasingly poor mental health between 1993 and 2020. In the Behavioral Risk Factor Surveillance Survey, poor mental health days rose from 3 to 4 days per month, and from 3.55 to 6.02 days per month among young adults ages 18–25. Twice as many young adults spent half or more of their days in poor mental health in 2018–20 compared to 1993–99. Nearly all of the increase occurred before the COVID-19 pandemic began in 2020. In the National Health Interview Survey, 30% more young adults and prime-age adults (ages 26–49) reported moderate to high mental distress in 2017–18 compared to 1997–99. In the National Health and Nutrition Examination Survey, more than twice as many young adults, and 50% more prime-age and older (50 +) adults, fit criteria for moderate to severe depression in 2017–20 compared to 2006–07. The pronounced increase in mood disorder symptoms identified among adolescents has now moved up the age scale to younger adults.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"2 ","pages":"Article 100013"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49899584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the revised children’s anxiety and depression scale (RCADS) for autistic youth without co-occurring intellectual disability","authors":"Nasim Khalfe ,&nbsp;Amy R. Goetz ,&nbsp;Erika S. Trent ,&nbsp;Andrew G. Guzick ,&nbsp;Orri Smarason ,&nbsp;Minjee Kook ,&nbsp;Sean Olsen ,&nbsp;Ana C. Ramirez ,&nbsp;Saira A. Weinzimmer ,&nbsp;Leandra Berry ,&nbsp;Sophie C. Schneider ,&nbsp;Wayne K. Goodman ,&nbsp;Eric A. Storch","doi":"10.1016/j.xjmad.2023.100017","DOIUrl":"10.1016/j.xjmad.2023.100017","url":null,"abstract":"<div><p>Autistic youth often present with comorbid anxiety and depression yet there is a dearth of validated assessment tools. The Revised Children’s Anxiety and Depression Scale (RCADS) assesses internalizing symptoms but there is little psychometric data in autistic youth. Treatment-seeking autistic youth with anxiety or obsessive-compulsive symptoms (<em>N</em> = 74; age 6–14 years), and caregivers, were administered the RCADS-Parent, RCADS-Child, and assessments of internalizing, externalizing symptoms and social impairment indicative of autism. RCADS-Parent and RCADS-Child total anxiety scores demonstrated excellent internal consistency, and the six subscales demonstrated acceptable-to-good internal consistency. The RCADS-Child and Parent total anxiety scores were weakly correlated, and neither child age nor gender altered the strength of this association. Convergent validity was supported by moderate-to-strong correlations with clinician and parent-reported anxiety symptoms. Support for divergent validity was mixed. Results provide support for the RCADS-Parent and RCADS-Child as reliable, valid measures of internalizing symptoms in autistic youth.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"2 ","pages":"Article 100017"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/20/35/nihms-1927934.PMC10486182.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10588045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of aerobic exercise on model-based decision making in women with posttraumatic stress disorder","authors":"Kevin M. Crombie ,&nbsp;Ameera Azar ,&nbsp;Chloe Botsford ,&nbsp;Mickela Heilicher ,&nbsp;Jaryd Hiser ,&nbsp;Nicole Moughrabi ,&nbsp;Tijana Sagorac Gruichich ,&nbsp;Chloe M. Schomaker ,&nbsp;Josh M. Cisler","doi":"10.1016/j.xjmad.2023.100015","DOIUrl":"10.1016/j.xjmad.2023.100015","url":null,"abstract":"<div><p>Individuals with PTSD often exhibit deficits in executive functioning. An unexplored aspect of neurocognitive functions associated with PTSD is the type of learning system engaged in during decision-making. A model-free (MF) system is habitual in nature and involves trial-and-error learning that is often updated based on the most recent experience (e.g., repeat action if rewarded). A model-based (MB) system is goal-directed in nature and involves the development of an abstract representation of the environment to facilitate decisions (e.g., choose sequence of actions according to current contextual state and predicted outcomes). The existing neurocognitive literature on PTSD suggests the hypothesis of greater reliance on MF vs MB learning strategies when navigating their environment. While MF systems may be more cognitively efficient, they do not afford flexibility when making prospective predictions about likely outcomes of different decision-tree branches. Emerging research suggests that an acute bout of aerobic exercise improves certain aspects of neurocognition, and thereby could promote the utilization of MB over MF systems during decision making, although prior research has not yet tested this hypothesis. Accordingly, the current study administered a lab-based two-stage Markov decision-making task capable of discriminating MF vs MB decision making, in order to determine if moderate-intensity aerobic exercise (either shortly after or 30-minutes after the exercise bout has ended) promotes greater engagement in MB behavioral strategies compared to light-intensity aerobic exercise in adult women with and without PTSD (N = 61). Results revealed that control women generally displayed higher levels of MB behavior that was further increased following immediate exercise, particularly moderate-intensity exercise. By contrast, the PTSD group generally displayed lower levels of MB behavior, and exhibited greater MB behavior when completing the task following moderate-intensity aerobic exercise compared to light-intensity aerobic exercise regardless of whether there was a short or long delay between exercise and the task. Additionally, women with PTSD demonstrated less impairment in MB decision-making compared to controls following moderate-intensity aerobic exercise. These results suggest that an acute bout of moderate-intensity aerobic exercise boosts MB behavior in women with PTSD, and suggests that aerobic exercise may play an important role in enhancing cognitive outcomes for PTSD.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"2 ","pages":"Article 100015"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433398/pdf/nihms-1921471.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10104028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpersonal stress and proinflammatory activity in emerging adults with a history of suicide risk: A pilot study","authors":"Annamarie B. Defayette ,&nbsp;Christianne Esposito-Smythers ,&nbsp;Ian Cero ,&nbsp;Katherine M. Harris ,&nbsp;Emma D. Whitmyre ,&nbsp;Roberto López Jr.","doi":"10.1016/j.xjmad.2023.100016","DOIUrl":"10.1016/j.xjmad.2023.100016","url":null,"abstract":"<div><p>Interpersonal stress during adolescence and young adulthood can threaten healthy developmental trajectories. A “primed” proinflammatory response to acute stress may serve as an underlying process that results in negative outcomes for youth. The present pilot study examined the relation between interpersonal stress and two proinflammatory cytokines in a sample of 42 university-recruited emerging adults with recent suicidal thoughts and behaviors. Participants completed self-report measures of mood, suicidal thoughts and behaviors, recent peer-related stressors, and interpersonal sensitivity. They also participated in an acute laboratory social stress task and provided three saliva samples to measure their proinflammatory responses (IL-6 and TNF-α) to the stressor. Participants reported significant increases in sadness and exclusion, and significant decreases in inclusion, following task participation. Importantly, no participants reported an increase in or onset of suicidal thoughts. No significant associations between interpersonal stress and proinflammatory cytokines were found. Changes in affect during the task coupled with lack of increased suicidal thoughts indicate it is acceptable to use this exclusion and rejection paradigm with this population, with proper debriefing and positive mood induction procedures. Given all other nonsignificant associations, future research considerations are discussed, including impact of COVID-19 on task potency and incorporation of multiple stress response systems.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"2 ","pages":"Article 100016"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10588047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}