Journal of mood and anxiety disorders最新文献

{"title":"Feasibility and acceptability of a virtual mindfulness intervention for Black adults with PTSD and depression: Randomized controlled trial","authors":"Abigail Powers ,&nbsp;Emma C. Lathan ,&nbsp;Elizabeth McAfee ,&nbsp;Yara Mekawi ,&nbsp;H. Drew Dixon ,&nbsp;Estefania Lopez ,&nbsp;Shifa Ali ,&nbsp;Rebecca Hinrichs ,&nbsp;Bekh Bradley ,&nbsp;Sierra Carter ,&nbsp;Nadine J. Kaslow","doi":"10.1016/j.xjmad.2024.100048","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100048","url":null,"abstract":"<div><p>Mindfulness-based cognitive therapy (MBCT) offers promise as a group-based intervention to alleviate posttraumatic stress disorder (PTSD) and depression symptoms in traumatized Black adults. Given the high level of barriers that exist for low-income Black adults, virtual delivery of MBCT may be helpful. This pilot randomized controlled trial assessed feasibility and acceptability of an adapted 8-week virtual MBCT group intervention for Black adults screening positive for PTSD and depression. Forty-six participants (89.3% women) recruited from an urban safety net hospital were randomized to MBCT or waitlist control (WLC). Overall feasibility was fair (70%); however, completion rates were higher for WLC than MBCT (90% vs. 54%). Group acceptability was high across quantitative and qualitative measures for study completers. Perceived barriers to psychological treatment were high (&gt;9). While showing potential via improved coping skills and positive health changes, this intervention's success hinges on mitigating engagement barriers for future delivery; additional studies are warranted.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"5 ","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000026/pdfft?md5=d8251ec0c87ea7abc5e4896b8dd7af11&pid=1-s2.0-S2950004424000026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139473298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological effects of trauma negative and positive coping, resilience, and psychological distress among Chinese healthcare workers during the COVID-19 pandemic","authors":"Shujing Zhang ,&nbsp;Daphne Y. Liu ,&nbsp;Jinbing Bai ,&nbsp;Jia-Chen Fu ,&nbsp;Feng Jiang ,&nbsp;Eric Nehl ,&nbsp;Huanzhong Liu ,&nbsp;Yanqun Liu ,&nbsp;Chunhua Zhang ,&nbsp;Yi-lang Tang ,&nbsp;Nadine J. Kaslow","doi":"10.1016/j.xjmad.2023.100046","DOIUrl":"10.1016/j.xjmad.2023.100046","url":null,"abstract":"<div><h3>Background</h3><p>Limited data are available on risk (psychological effects of trauma, negative coping) and protective (resilience, positive coping) factors for psychological distress among Chinese healthcare workers (HCWs) during the pandemic. Thus, this study investigated the: (1) association between both the psychological effects of trauma and negative coping and psychological distress; and (2) moderating effects of resilience and positive coping on these associations.</p></div><div><h3>Methods</h3><p>Participants (<em>n</em> = 196; <em>M</em>_age = 32.8; <em>SD</em> _age = 7.5; 77% female) from two hospitals in China completed self-report measures of the psychological effects of trauma (Impact of Event Scale-Revised), negative and positive coping (Simplified Coping Style Questionnaire), resilience (Connor Davidson Resilience Scale) and distress (Depression, Anxiety, and Stress Scale; Patient Health Questionnaire-9) in March 2022.</p></div><div><h3>Results</h3><p>Results from this cross-sectional study revealed that HCWs who endorsed greater psychological effects of trauma had more psychological distress when they had lower levels of positive coping ((DASS-21 (<em>b</em> = −0.03, <em>SE</em> = 0.01, <em>p</em> = .007); PHQ-9 (<em>b</em> = −0.005, <em>SE</em> = 0.002, <em>p</em> = .015)). HCWs who endorsed more negative coping had more psychological distress when they were less resilient ((DASS-21 (<em>b</em> = −0.02, <em>SE</em> = 0.01, <em>p</em> = .035); PHQ-9 ((<em>b</em> = −0.01, <em>SE</em> = 0.002, <em>p</em> = .031)) and used less positive coping ((DASS-21 (<em>b</em> = −0.13, <em>SE</em> = 0.03, <em>p</em> &lt; .001); PHQ-9 (<em>b</em> = −0.02, <em>SE</em> = 0.006, <em>p</em> &lt; .001)).</p></div><div><h3>Conclusions</h3><p>Psychological distress level was higher among HCWs who experienced more trauma or used negative coping strategies. They also had lower resilience and relied less on positive coping strategies. To help HCWs in China during public health crises, interventions must bolster their resilience and positive coping skills.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"5 ","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004423000469/pdfft?md5=227a590c031a41f66c9817c39b69811f&pid=1-s2.0-S2950004423000469-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139392234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of US nationally representative data sources of child and adolescent anxiety","authors":"Katharine B. Parodi ,&nbsp;Emily D. Barnes ,&nbsp;Jennifer Greif Green,&nbsp;Melissa K. Holt,&nbsp;Amie E. Grills","doi":"10.1016/j.xjmad.2024.100047","DOIUrl":"10.1016/j.xjmad.2024.100047","url":null,"abstract":"<div><p>Anxiety is one of the most prevalent mental health conditions among youth; however, scholars have commented on the limited data collection of anxiety measures in United States (US) nationally representative surveys. Inadequate data has hampered researchers’ ability to estimate recent prevalence and track changes over time. Monitoring anxiety, particularly among children and adolescents, including subpopulations facing marked mental health disparities (e.g., females, sexual and gender diverse youth), is crucial for informing policies which direct healthcare provision and tailoring prevention and intervention. This study describes a comprehensive review of US nationally representative datasets that could be used to generate prevalence estimates of anxiety symptoms and/or disorders among children and adolescents from 2011 to present. Results of this five-step search process identified 11 data series meeting inclusion criteria. Of these, seven data series included a valid measure of mental, emotional, or behavioral health, which included at least one anxiety-related question in the scale. This overview of US population-based data on child and adolescent anxiety symptoms and disorders contributes to the field by identifying data sources that could be used to estimate recent prevalence and highlighting gaps in the availability of empirically validated instruments of anxiety in US nationally representative data sets.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"5 ","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000014/pdfft?md5=40513584aa34614f062b175c06e2d0d8&pid=1-s2.0-S2950004424000014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skill use mediates the within-person effect of the alliance on session-to-session changes in anxiety and depression in the Unified Protocol","authors":"Martina Fruhbauerova ,&nbsp;Douglas R. Terrill ,&nbsp;Stephen A. Semcho ,&nbsp;Nicole E. Stumpp ,&nbsp;Jesse P. McCann ,&nbsp;Shannon Sauer-Zavala ,&nbsp;Matthew W. Southward","doi":"10.1016/j.xjmad.2023.100043","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100043","url":null,"abstract":"<div><h3>Objective</h3><p>Both the therapeutic alliance and the specific skills taught in treatment are thought to contribute to change in cognitive-behavior therapy (CBT), but it is unclear if or how these processes influence each other and outcomes in treatment. We tested the hypothesis that the degree to which patients used CBT skills would mediate the relation between the alliance and session-to-session changes in anxiety and depression.</p></div><div><h3>Method</h3><p>Adult participants (<em>N</em> = 70; <em>M</em>_age = 33.74, 67% female, 70% White) with emotional disorders were randomized to receive 6 or 12 sessions of the Unified Protocol. Before each session, participants reported anxiety and depression severity and past-week skillfulness. After each session, participants rated the strength of the alliance. We tested whether greater within-person skillfulness mediated the relation between within-person alliance strength and session-to-session changes in anxiety and depression.</p></div><div><h3>Results</h3><p>Skillfulness significantly mediated the effect of the alliance on session-to-session changes in anxiety, <em>ab</em> = –.02, <em>p</em> = .04, and depression, <em>ab</em> = –.02, <em>p</em> = .02, such that a stronger alliance predicted greater next-session skillfulness, which predicted session-to-session decreases in anxiety and depression. When alliance subscales were examined separately, the strongest effect was observed for agreement on therapy tasks.</p></div><div><h3>Conclusions</h3><p>Improvements in the alliance may facilitate skill use and indirectly predict reductions in anxiety and depression through skill use in CBT. We encourage research on how to enhance both the alliance and skillfulness in CBT.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"5 ","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004423000433/pdfft?md5=24d5de372d1c8ca56d5f6ec8e836dc60&pid=1-s2.0-S2950004423000433-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138839394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Providers’ perspectives on the impact of culture in the recognition and diagnosis of anxiety","authors":"Darius B. Dawson ,&nbsp;Christie G.-J. Tsao ,&nbsp;Patricia Chen ,&nbsp;Traber D. Giardina ,&nbsp;Terri L. Fletcher","doi":"10.1016/j.xjmad.2023.100030","DOIUrl":"10.1016/j.xjmad.2023.100030","url":null,"abstract":"<div><h3>Objectives</h3><p>We examined providers’ perspectives about how culture affects diagnosing and recognizing anxiety.</p></div><div><h3>Methods</h3><p>We interviewed providers about diagnosing anxiety (“How do you think culture impacts expression and diagnosis of anxiety?”) and used inductive analysis, with open coding, to allow themes to emerge organically.</p></div><div><h3>Results</h3><p>We identified three themes: (1) Impartiality toward Culture: downplaying culture in recognizing or diagnosing anxiety and not acknowledging necessary cultural diagnostic considerations; (2) Acknowledgment of Cultural Impact: detailed variations across different cultural communities in how patients present with and describe anxiety, with differing levels of stigma associated with expressing and treating anxiety; (3) Culturally Integrated Practice: implement culturally informed diagnosis and treatment, with training and self-directed processing on culture and bias.</p></div><div><h3>Conclusions</h3><p>While most providers acknowledge that culture impacts accurate diagnosis of anxiety, they vary in how they integrate cultural information. It is important to deliver culturally informed care.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"4 ","pages":"Article 100030"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004423000305/pdfft?md5=48d1711beca0438320afe1c15f6e2ede&pid=1-s2.0-S2950004423000305-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135588291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-efficacy, stress, and symptoms of depression and anxiety in adolescents: An epidemiological cohort study with ecological momentary assessment","authors":"Sophia Fürtjes ,&nbsp;Catharina Voss ,&nbsp;Frank Rückert ,&nbsp;Stephanie K.V. Peschel ,&nbsp;Hanna Kische ,&nbsp;Theresa M. Ollmann ,&nbsp;Johanna Berwanger ,&nbsp;Katja Beesdo-Baum","doi":"10.1016/j.xjmad.2023.100039","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100039","url":null,"abstract":"<div><p>Self-efficacy (confidence in one’s abilities to execute behavior to reach ones goals) has been reported to reduce the impact of stress on symptoms of depression and anxiety. However, findings have been inconsistent regarding the two different conditions and the temporal resolution (individual situations [micro-level] vs. general disposition [macro-level], cross-sectional vs. longitudinal). By analyzing available data from an epidemiological cohort study, we explored the impact of self-efficacy, stress, and their interaction on symptoms of depression and anxiety in <em>N</em> = 1072 adolescents (age 14–21) from the general population. We conducted questionnaire assessments (macro-level) and ecological momentary assessment (EMA; micro-level). Multiple linear regressions and hierarchical linear modeling were applied to explore cross-sectional and longitudinal associations on both levels. On the micro-level, cross-sectional results indicate that self-efficacy lowers the impact of stress on depression, but not anxiety, during everyday life. Longitudinal effects were not found. On the macro-level, cross-sectional analyses revealed a buffering effect of self-efficacy against stress for anxiety, but not depression. Longitudinally, only direct effects could be observed for self-efficacy on anxiety and for stress on depression and anxiety. It appears that the adverse impact of stress on depression might be too strong to be buffered by self-efficacy in general, but only on a micro-level. The macro-level protective effect of self-efficacy regarding anxiety on the other hand might not be retrievable during everyday life. Results imply that therapy of depression might benefit from strategies to lower stress, whereas treatment of anxiety might focus on increasing self-efficacy to reduce avoidant behavior.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"4 ","pages":"Article 100039"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004423000391/pdfft?md5=2094225bb4170224c5821c45d1e845db&pid=1-s2.0-S2950004423000391-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138466528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"North American open-label 16-week trial of the MindShift smartphone app for adult anxiety","authors":"Lance M. Rappaport ,&nbsp;Emily Jerome ,&nbsp;Michael Van Ameringen ,&nbsp;Maureen Whittal ,&nbsp;Carmen P. McLean","doi":"10.1016/j.xjmad.2023.100036","DOIUrl":"10.1016/j.xjmad.2023.100036","url":null,"abstract":"<div><h3>Background</h3><p>Evidence-based treatments can effectively address anxiety and related conditions. However, new resources are needed to make psychological interventions accessible to the substantial and increasing North American population affected by anxiety and related psychopathology.</p></div><div><h3>Objective</h3><p>The present study evaluated whether use of the MindShift app (Anxiety Canada) may help reduce anxiety symptoms and related depressive symptoms, quality-of-life, and functional impairment among adults 18 years of age and older.</p></div><div><h3>Methods</h3><p>Adults ages 18–80 (N = 380) participated in an online open-label trial to evaluate change in anxiety and related distress while using the MindShift smartphone app. Inclusion criteria: residence in Canada or the USA and self-identification of anxiety or anxious distress to address during the study. Participants reported the severity of four primary outcomes at baseline and 2-, 4-, 8-, 12-, and 16-weeks after they began using the MindShift app.</p></div><div><h3>Results</h3><p>All four primary outcomes improved over the 16-week period: participants reported reduced anxiety and depressive symptoms; reduced functional impairment; and improved quality-of-life. Improvements were unrelated to the frequency with which participants used the MindShift app. Effect sizes indicated moderate change in anxiety symptoms (<em>d</em>=0.61, <em>p</em> &lt; 0.0001), depressive symptoms (<em>d</em>=0.50, <em>p</em> &lt; 0.0001), functional impairment (<em>d</em>=0.55, <em>p</em> &lt; 0.0001), an<em>d</em> quality-of-life (<em>d</em>=0.31, <em>p</em> &lt; 0.0001) at the end of the 16-week intervention; improvements were consistent with response to treatment but not remission.</p></div><div><h3>Conclusions</h3><p>Overall, the MindShift app may provide a ready to scale low-cost resource to assist in meeting the mental health needs of adults across North America, particularly those who report mild or moderate symptom severity.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"4 ","pages":"Article 100036"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004423000366/pdfft?md5=c2f1ac7253d611477db0a545a6fba183&pid=1-s2.0-S2950004423000366-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135850389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding previously published articles","authors":"","doi":"10.1016/j.xjmad.2023.100035","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100035","url":null,"abstract":"","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"4 ","pages":"Article 100035"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004423000354/pdfft?md5=3dec8a2307ab4b86cd19e44be3cc7651&pid=1-s2.0-S2950004423000354-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138558507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the transactional associations between anxiety sensitivity and emotion regulation over time","authors":"Leah D. Church ,&nbsp;Danielle R. Shayani ,&nbsp;Anna Stumps ,&nbsp;Nadia Bounoua ,&nbsp;Kaleigh Wieand ,&nbsp;Jeffrey M. Spielberg","doi":"10.1016/j.xjmad.2023.100037","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100037","url":null,"abstract":"<div><p>Although anxiety sensitivity (AS) and disturbances in emotion regulation (ER) are both transdiagnostic factors thought to predispose toward internalizing pathology, little is known about associations between these constructs <em>over time</em>. Further, no work has examined the modulating impact of gender on these associations, despite previous work identifying gender differences in both AS and ER. Data were collected from 275 adults (M_age = 35.7; 52% women) at two timepoints, six months apart (baseline=March 2021, follow-up=September 2021), using an online crowdsourcing platform. Multigroup cross-lagged analyses showed that, across genders, lower baseline ER predicted higher AS at follow-up (<em>p</em> &lt; .001), over and above baseline AS, but the reverse was not true. Additionally, this association was moderated by gender (∆Wald’s χ² =8.33, <em>p</em> &lt; .01), such that lower baseline ER predicted higher follow-up AS in men (<em>p</em> &lt; .001), but not women (<em>p</em> = .35). Our findings suggest the <em>p</em>resence of gender differences in the longitudinal, transactional associations between transdiagnostic risk factors important for the maintenance and exacerbation of future internalizing pathology. For example, men may be engaging in less adaptive ER strategies (e.g., suppression), resulting in a failure to downregulate future AS. Present results inform etiological models of internalizing disorders.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"4 ","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004423000378/pdfft?md5=336a8c22403f36aab21b6c90a9b0db73&pid=1-s2.0-S2950004423000378-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92047117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting anxiety-related personality traits by means of serotonergic VNTR variants STin2 and 5-HTTLPR","authors":"Andrea Felten,&nbsp;Thomas Plieger,&nbsp;Martin Reuter","doi":"10.1016/j.xjmad.2023.100031","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100031","url":null,"abstract":"<div><p>Polymorphisms of the serotonergic system are amongst the most commonly investigated genetic variants with respect to anxiety-related personality traits and affective disorders. Mostly the prominent 5-HTTLPR, a functional VNTR in the 5-HTT promoter region, is intensively analysed but effect sizes in meta-analyses are small and results are inconsistent. We reinvestigated the association of 5-HTTLPR with harm avoidance (HA) and neuroticism taking another functional 5-HTT-VNTR (STin2) into account, as both VNTRs have transcription regulating properties and research points to combinatorial effects on transcription efficacy. N = 2969 participants, among them 447 inpatients suffering from affective disorders, were genotyped and filled in the TCI, NEO-FFI personality inventories besides the CLEq measuring the extent of experienced stressful life events. Significant main effects for the 5-HTTLPR with inpatients carrying the L+ allele having lower HA scores as well as for the STin2 with healthy controls carrying at least one STin2.12R allele having lower neuroticism scores were observed. Besides no gene-interaction occurred. However, specific haplotype effects were observed in healthy participants as well as in the total sample. More specifically, the 12/L variant was associated with significant lower HA and neuroticism scores. Results highlight the multifactorial interplay of 5-HTT genetic variants and the use of haplotypes in association studies on anxiety-related personality traits with impact on affective disorders.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"4 ","pages":"Article 100031"},"PeriodicalIF":0.0,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49890716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}