Journal of mood and anxiety disorders最新文献

{"title":"A multi-method assessment of emotional processes predicting longitudinal anxiety symptom trajectories in an adolescent clinical sample","authors":"Doga Cetinkaya ,&nbsp;Sydney A. DeCaro ,&nbsp;Margarid R. Turnamian ,&nbsp;Jennifer A. Poon ,&nbsp;Evan M. Kleiman ,&nbsp;Richard T. Liu","doi":"10.1016/j.xjmad.2024.100071","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100071","url":null,"abstract":"<div><h3>Objective</h3><p>Emotion recognition, reactivity, and regulation are important in the development and maintenance of anxiety disorders. Whether and how these processes differentiate between different trajectories in anxiety remain unclear. The current study examined emotional processes as prospective predictors of anxiety symptom trajectories in psychiatrically hospitalized youth.</p></div><div><h3>Method</h3><p>Participants were 180 adolescents (<em>M</em>_age = 14.89; <em>SD</em> = 1.35) from a psychiatric inpatient unit. At index hospitalization, participants completed a behavioral task assessing facial emotion recognition, and self-report measures of emotion dysregulation and reactivity. They completed a self-report measure on anxiety symptoms at baseline and 3, 6, 12, and 18 months post-discharge. Latent growth curve analysis was conducted to identify subgroups of individuals based upon their trajectory of anxiety symptoms across 18-months. ANOVAs were used to examine subgroup differences in emotional processing variables.</p></div><div><h3>Results</h3><p>Three distinct trajectories were identified, a stable moderate-to-high anxiety group, a group with moderate-to-high anxiety at baseline with symptom improvement over time, and a group characterized by relatively stable low-to-moderate anxiety throughout the study. The two initially moderate-to-high anxiety groups scored higher for emotion dysregulation and emotion reactivity at baseline compared to the low-to-moderate anxiety group. Emotion regulation difficulties relating to emotional non-acceptance were higher for the stable moderate-to-high anxiety group than for the moderate-to-high anxiety group that experience symptom improvement over time.</p></div><div><h3>Conclusions</h3><p>These findings may have clinical implications for discharge planning. Future studies should explore emotion regulation with a focus on non-acceptance of one’s emotional experiences as a potential target of intervention in individuals with elevated anxiety.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100071"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000257/pdfft?md5=d9e9e029584e14e32a78632201db6ad0&pid=1-s2.0-S2950004424000257-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing generalized anxiety disorder screening in young adults perinatally affected by HIV: A psychometric analysis","authors":"Corey Morrison ,&nbsp;Claude A. Mellins ,&nbsp;Clayton Synder ,&nbsp;Eileen Shea ,&nbsp;Luke Kluisza ,&nbsp;Reuben Robbins ,&nbsp;Ohemaa Poku ,&nbsp;Prudence Fisher ,&nbsp;Elaine Abrams ,&nbsp;Andrew Wiznia ,&nbsp;Laura Mufson","doi":"10.1016/j.xjmad.2024.100066","DOIUrl":"10.1016/j.xjmad.2024.100066","url":null,"abstract":"<div><h3>Background</h3><p>Generalized Anxiety Disorder (GAD) is prevalent among people with HIV and is associated with adverse health outcomes. This study investigates the suitability of the Generalized Anxiety Disorder Scale-7 item (GAD-7) screening tool and its 2-item (GAD-2) version for use in young adults with perinatally-acquired HIV (YAPHIV) and young adults perinatally exposed to HIV but uninfected (YAPHEU).</p></div><div><h3>Methods</h3><p>Data come from the 7th follow-up interview (FU7) from a longitudinal study of youth with PHIV and PHEU, first recruited when 9–16 years. The GAD-7 was administered along with a diagnostic psychiatric interview (DISC-IV). Receiver Operating Characteristic analysis assessed accuracy, sensitivity, and specificity of the GAD7 and GAD-2. Subgroup analyses considered HIV status, ethnicity, and race.</p></div><div><h3>Results</h3><p>At FU7, participants (n = 204) were ages 20–29; 54% female; and the majority African-American and/or Latinx. 12% met diagnostic criteria for GAD. Recommended GAD-7 (&gt;10) and GAD-2 (&gt;3) cut-scores showed suboptimal sensitivity (0.52 and 0.48, respectively) and high specificity (0.91 and 0.90, respectively). Lowering cut-scores (GAD-7 &gt;6 and GAD-2 &gt;2) improved sensitivity (0.76 and 0.80) while sacrificing specificity (0.77 and 0.78). Stratified analyses by HIV status revealed similar accuracy in YAPHIV and YAPHEU. Race/ethnicity did not significantly affect cut-scores.</p></div><div><h3>Discussion</h3><p>Anxiety disorders are common in YAPHIV, and efficient screening is essential. While the GAD-7 and GAD-2 show promise, recommended cut-scores may not be optimal. Lowering cut-scores may enhance sensitivity without losing clinical utility. Further research is needed to refine cut-scores based on demographic characteristics and in global contexts, ensuring effective anxiety screening in this population.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100066"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000208/pdfft?md5=b48ae3cfe7e849065df71095aa993c1a&pid=1-s2.0-S2950004424000208-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal dynamics of positive and negative affect in adolescents: Associations with depressive disorders and risk","authors":"George Abitante ,&nbsp;David A. Cole ,&nbsp;Christian Bean ,&nbsp;Madison Politte-Corn ,&nbsp;Qimin Liu ,&nbsp;Anh Dao ,&nbsp;Lindsay Dickey ,&nbsp;Samantha Pegg ,&nbsp;Autumn Kujawa","doi":"10.1016/j.xjmad.2024.100069","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100069","url":null,"abstract":"<div><p>Alterations in dynamic affective processes are associated with dysregulated affect and depression. Although depression is often associated with heightened inertia (i.e., greater moment-to-moment correlation) and variability (i.e., larger departures from typical levels) of affect in adults, less is known about whether altered affect dynamics are present in youth at risk for depression. This study investigated the association of clinical depression and depression risk with the inertia and variability of positive and negative affect in a sample of youth at varying risk for depression. Our sample included 147 adolescents aged 14 to 17, categorized into three groups: never-depressed lower-risk, never-depressed higher-risk (based on maternal history of depression), and currently depressed adolescents. Adolescents completed ecological momentary assessments of positive and negative affect up to seven times per day for a week. Multilevel models and ANOVAs were used to examine associations of affective inertia and variability with adolescent depression and risk based on maternal history, controlling for average affect. Depressed adolescents showed more inert and diminished positive affect, and more variable and elevated negative affect compared to lower- and higher-risk youth, though associations attenuated after controlling for average affect. No differences were identified between never-depressed higher-risk and lower-risk youth. Additional longitudinal studies are needed to evaluate whether altered affect dynamics in daily life precede depression onset to understand their utility for developing preventive interventions.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100069"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000233/pdfft?md5=647d368a471b6a45377d5a2d66f2f6c0&pid=1-s2.0-S2950004424000233-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140631645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smaller hippocampal volume is associated with anxiety symptoms in high-risk Black youth","authors":"Rebecca Lipschutz ,&nbsp;Abigail Powers ,&nbsp;Sean T. Minton ,&nbsp;Anais F. Stenson ,&nbsp;Timothy D. Ely ,&nbsp;Jennifer S. Stevens ,&nbsp;Tanja Jovanovic ,&nbsp;Sanne J.H. van Rooij","doi":"10.1016/j.xjmad.2024.100065","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100065","url":null,"abstract":"<div><p>Although there is an established link between smaller hippocampal volume and anxiety, the longitudinal relations between hippocampus structure and anxiety in diverse youth are not well understood. The present longitudinal study investigated hippocampal volumes related to anxiety symptoms in a sample of Black 8–14-year-old youth (N = 64), a population historically underrepresented in neuroimaging research. Smaller hippocampal volumes were associated with greater anxiety symptoms independent of age, sex, intracranial volume and trauma exposure. Exploratory longitudinal analyses showed smaller hippocampal volume as a predictor for anxiety symptoms (n = 37) and not a consequence of anxiety symptoms (n = 32), however results were inconclusive as this finding was no longer significant after correcting for baseline anxiety symptoms. Overall, this data increases our understanding of potential neurobiological mechanisms for anxiety in a high-risk sample of Black youth and suggests future directions into studying trajectories of developmental risk.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100065"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000191/pdfft?md5=1f33074d0b5b457e8d37b1b1c8101dc1&pid=1-s2.0-S2950004424000191-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140141873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective measurement of skin conductance response during trauma interview predicts future PTSD severity in trauma exposed children","authors":"Sattvik Basarkod ,&nbsp;Shaurel Valbrun ,&nbsp;Charis Wiltshire ,&nbsp;John McClellan France ,&nbsp;William Davie ,&nbsp;Sterling Winters ,&nbsp;Sophie A. George ,&nbsp;Anais F. Stenson ,&nbsp;Tanja Jovanovic","doi":"10.1016/j.xjmad.2024.100061","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100061","url":null,"abstract":"<div><p>Previous cross-sectional studies have shown that sympathetic nervous system (SNS) arousal is positively associated with posttraumatic stress disorder (PTSD) symptoms in children with trauma exposure. One of the ways that SNS activity is measured is through skin conductance response (SCR), which has been shown to predict future PTSD severity in adults. In this study, we explored the utility of a novel, low-cost mobile SCR device, eSense, to predict future PTSD symptom severity in trauma exposed children. We recruited children (N = 43, age 9 years at initial visit) for a longitudinal study in which SCR was recorded at baseline visit, and PTSD symptoms were assessed two years later. Results indicated an interaction between SCR and trauma exposure, such that children with lower trauma exposure who demonstrated greater SCR reported higher PTSD severity two years later. This association remained significant even after controlling for baseline PTSD symptoms. Children with higher levels of trauma exposure did not show this association, potentially due to ceiling effects of PTSD symptoms. Together these findings suggest the utility of SCR as a biomarker for predicting trauma related disorders in children, and that it may be a valuable tool in clinical interventions targeting sympathetic arousal.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100061"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000154/pdfft?md5=8dac04e991170b0303f1ee1b445296ec&pid=1-s2.0-S2950004424000154-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative affect influences suicide-specific attentional biases","authors":"Beverlin Rosario-Williams,&nbsp;Regina Miranda","doi":"10.1016/j.xjmad.2024.100081","DOIUrl":"10.1016/j.xjmad.2024.100081","url":null,"abstract":"<div><h3>Background</h3><p>Studies using tasks that measure suicide-specific attentional biases have not specified which attentional processes are related to risk for suicidal thoughts and behaviors. This study distinguished suicide-specific engagement and disengagement biases from other forms of cognitive processing and investigated under which affective conditions suicide-specific biases emerged.</p></div><div><h3>Method</h3><p>An ethnoracially and socioeconomically diverse sample of 153 young adults (87 % female; 52 % Non-Hispanic White), ages 18–34, with moderate-to-high symptoms of anxiety, depression, or recent suicide ideation were randomly assigned to experience positive, negative, or neutral affect, completed cognitive tasks of attention, construct accessibility, and threat bias, and self-report measures.</p></div><div><h3>Results</h3><p>Individuals with recent ideation displayed facilitated disengagement from suicide-specific stimuli irrespective of affective state. Those with distal ideation showed slower disengagement from suicide-specific stimuli in the sad condition only.</p></div><div><h3>Conclusions</h3><p>Individuals with recent suicide ideation display automatic processing of suicide-related information, perhaps due to recent rehearsal of suicide-related content. In contrast, individuals with distal ideation experiencing negative affect appear to have difficulty disengaging attention from suicide-related content. Limits to generalizability of the findings include a predominantly female sample, although the sample’s racial, ethnic, and socioeconomic diversity increase generality of the research.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295000442400035X/pdfft?md5=3efed9b660dcd1c99fb9b7203c99d195&pid=1-s2.0-S295000442400035X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social support mediates the effects of childhood unpredictability on anhedonia: A retrospective investigation in an online adult community sample","authors":"Kaylee E. Null ,&nbsp;Jessica M. Duda ,&nbsp;Diego A. Pizzagalli","doi":"10.1016/j.xjmad.2024.100057","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100057","url":null,"abstract":"<div><p>Increasingly, research is highlighting the implications of exposure to unpredictable environments during childhood (i.e., “childhood unpredictability”) on outcomes in adulthood. Converging evidence from preclinical and clinical studies has implicated childhood unpredictability in disrupted reward processing and anhedonia. From the stress generation literature, altered social support has emerged as a possible mechanism by which this effect may occur. In the current study, our goal was to understand whether the pathway from childhood unpredictability to anhedonia occurs through reduced perceptions of social support. Toward this end, we recruited an online community sample of adults in the US (<em>N</em> = 242) to complete surveys assessing childhood unpredictability, depressive symptoms, anhedonia, and social support, as well as a novel online version of the Probabilistic Reward Task. We found that childhood unpredictability was associated with increased depressive symptoms and anhedonia (but not objective measure of anhedonia), and reduced perceptions of social support in adulthood. Mediation analyses revealed a significant indirect effect of perceived social support on the association between childhood unpredictability and anhedonia, controlling for age, sex, and non-anhedonic depressive symptoms. Unexpectedly, measures of reward responsiveness from the behavioral task were not related to childhood unpredictability. The current findings replicate previous reports linking childhood unpredictability and self-reported anhedonia, and extend them to incorporate the potential mediating pathway of reduced social support. Implications for treatment for anhedonia are discussed.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000117/pdfft?md5=13a70927f42aadd0e8274e9946cf7a7f&pid=1-s2.0-S2950004424000117-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139935899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions between anxiety and impulsive dimensions are differentially associated with experiential avoidance","authors":"Sonalee A. Joshi ,&nbsp;D. Angus Clark ,&nbsp;James L. Abelson ,&nbsp;Elizabeth R. Duval","doi":"10.1016/j.xjmad.2024.100067","DOIUrl":"10.1016/j.xjmad.2024.100067","url":null,"abstract":"<div><p>Anxiety and impulsivity often co-occur, but due to broad conceptualizations of impulsive behavior, it remains unclear whether anxiety could be positively associated with global impulsivity or specific facets of impulsivity. Negative urgency, or rash behavior that specifically occurs during negative emotional states, may provide common ground to examine the overlap between high anxiety and high impulsivity. Limited work has examined relationships between negative urgency and behavioral processes that are often associated with both anxiety and global impulsivity, such as experiential avoidance. In this study, we examined self-report data collected from a non-clinical sample of adult participants (n = 589) to test relationships between anxiety and experiential avoidance through both negative urgency and global impulsivity. Contrary to hypotheses, we found that negative urgency alone did not alter the relationship between anxiety and experiential avoidance. However, follow-up analyses including data-driven factors of impulsivity revealed that in combination, anxiety and both emotion-based impulsivity (i.e. negative and positive urgency) and hyperactivity were linked to greater experiential avoidance. By contrast, anxiety and non-planning were associated with lower experiential avoidance. These results provide targets for future studies to examine individual differences in profiles of co-occurring anxiety and impulsivity.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100067"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295000442400021X/pdfft?md5=15e7e0ab14cbfab3d3da642818d4e6b3&pid=1-s2.0-S295000442400021X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal neural sensitivity to rewards as a candidate process of high depression risk in the FMR1 premutation: A pilot study","authors":"Roslyn Harold ,&nbsp;Bridgette Kelleher ,&nbsp;Keisha Novak ,&nbsp;Wei Siong Neo ,&nbsp;Teagan Stump ,&nbsp;Taylor Lee ,&nbsp;Tessa Garwood ,&nbsp;Elizabeth Berry-Kravis ,&nbsp;Dan Foti","doi":"10.1016/j.xjmad.2024.100068","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100068","url":null,"abstract":"<div><p>The etiological heterogeneity of depression poses a challenge for prevention and intervention efforts. One solution is to map unique etiological pathways for subgroups defined by a singular risk factor. A relevant population for this approach is women who carry the premutation of the <em>fragile X messenger ribonucleoprotein</em> 1 (<em>FMR</em>1) gene, who are at high risk for adult-onset depression. This study explores a candidate neurophysiological marker of depression risk: reduced reward sensitivity, indexed by the reward positivity (RewP). The RewP has been linked to depression risk in the general population, but is unexplored within <em>FMR</em>1 premutation carriers. 16 women with the <em>FMR</em>1 premutation and a matched control group completed a simple guessing task while the electroencephalogram was recorded. Among premutation carriers, RewP difference score (win versus loss) was reduced. These preliminary finding suggest that the <em>FMR</em>1 premutation may confer increased risk for depression in part through abnormal neural sensitivity to rewards.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100068"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000221/pdfft?md5=27a3828560b7939a7261f4feff08f003&pid=1-s2.0-S2950004424000221-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140348331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood unpredictability is associated with increased risk for long- and short-term depression and anhedonia symptoms following combat deployment","authors":"Christopher Hunt ,&nbsp;Meghan Vinograd ,&nbsp;Laura M. Glynn ,&nbsp;Elysia Poggi Davis ,&nbsp;Tallie Z. Baram ,&nbsp;Hal Stern ,&nbsp;Caroline Nievergelt ,&nbsp;Bruna Cuccurazzu ,&nbsp;Cindy Napan ,&nbsp;Dylan Delmar ,&nbsp;Dewleen G. Baker ,&nbsp;Victoria B. Risbrough","doi":"10.1016/j.xjmad.2023.100045","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100045","url":null,"abstract":"<div><p>High unpredictability has emerged as a dimension of early-life adversity that may contribute to a host of deleterious consequences later in life. Early-life unpredictability affects development of limbic and reward circuits in both rodents and humans, with a potential to increase sensitivity to stressors and mood symptoms later in life. Here, we examined the extent to which unpredictability during childhood was associated with changes in mood symptoms (anhedonia and general depression) after two adult life stressors, combat deployment and civilian reintegration, which were assessed ten years apart. We also examined how perceived stress and social support mediated and /or moderated links between childhood unpredictability and mood symptoms. To test these hypotheses, we leveraged the Marine Resiliency Study, a prospective longitudinal study of the effects of combat deployment on mental health in Active-Duty Marines and Navy Corpsman. Participants (<em>N</em> = 273) were assessed for depression and anhedonia before (pre-deployment) and 3–6 months after (acute post-deployment) a combat deployment. Additional assessment of depression and childhood unpredictability were collected 10 years post-deployment (chronic post-deployment). Higher childhood unpredictability was associated with higher anhedonia and general depression at both acute and chronic post-deployment timepoints (<em>β</em>s <u>&gt;</u> 0.16, <em>p</em>s <u>&lt;</u>.007). The relationship between childhood unpredictability and subsequent depression at acute post-deployment was partially mediated by lower social support (<em>b</em> = 0.07, 95% CI [0.03, 0.15]) while depression at chronic post-deployment was fully mediated by a combination of lower social support (<em>b</em> = 0.14, 95% CI [0.07, 0.23]) and higher perceived stress (<em>b</em> = 0.09, 95% CI [0.05, 0.15]). These findings implicate childhood unpredictability as a potential risk factor for depression in adulthood and suggest that increasing the structure and predictability of childhood routines and developing social support interventions after life stressors could be helpful for preventing adult depression.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100045"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004423000457/pdfft?md5=ebed24e0834e247233b508ef00594226&pid=1-s2.0-S2950004423000457-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141429020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}