Journal of mood and anxiety disorders最新文献

{"title":"North American open-label 16-week trial of the MindShift smartphone app for adult anxiety","authors":"Lance M. Rappaport ,&nbsp;Emily Jerome ,&nbsp;Michael Van Ameringen ,&nbsp;Maureen Whittal ,&nbsp;Carmen P. McLean","doi":"10.1016/j.xjmad.2023.100036","DOIUrl":"10.1016/j.xjmad.2023.100036","url":null,"abstract":"<div><h3>Background</h3><p>Evidence-based treatments can effectively address anxiety and related conditions. However, new resources are needed to make psychological interventions accessible to the substantial and increasing North American population affected by anxiety and related psychopathology.</p></div><div><h3>Objective</h3><p>The present study evaluated whether use of the MindShift app (Anxiety Canada) may help reduce anxiety symptoms and related depressive symptoms, quality-of-life, and functional impairment among adults 18 years of age and older.</p></div><div><h3>Methods</h3><p>Adults ages 18–80 (N = 380) participated in an online open-label trial to evaluate change in anxiety and related distress while using the MindShift smartphone app. Inclusion criteria: residence in Canada or the USA and self-identification of anxiety or anxious distress to address during the study. Participants reported the severity of four primary outcomes at baseline and 2-, 4-, 8-, 12-, and 16-weeks after they began using the MindShift app.</p></div><div><h3>Results</h3><p>All four primary outcomes improved over the 16-week period: participants reported reduced anxiety and depressive symptoms; reduced functional impairment; and improved quality-of-life. Improvements were unrelated to the frequency with which participants used the MindShift app. Effect sizes indicated moderate change in anxiety symptoms (<em>d</em>=0.61, <em>p</em> &lt; 0.0001), depressive symptoms (<em>d</em>=0.50, <em>p</em> &lt; 0.0001), functional impairment (<em>d</em>=0.55, <em>p</em> &lt; 0.0001), an<em>d</em> quality-of-life (<em>d</em>=0.31, <em>p</em> &lt; 0.0001) at the end of the 16-week intervention; improvements were consistent with response to treatment but not remission.</p></div><div><h3>Conclusions</h3><p>Overall, the MindShift app may provide a ready to scale low-cost resource to assist in meeting the mental health needs of adults across North America, particularly those who report mild or moderate symptom severity.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"4 ","pages":"Article 100036"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004423000366/pdfft?md5=c2f1ac7253d611477db0a545a6fba183&pid=1-s2.0-S2950004423000366-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135850389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the transactional associations between anxiety sensitivity and emotion regulation over time","authors":"Leah D. Church ,&nbsp;Danielle R. Shayani ,&nbsp;Anna Stumps ,&nbsp;Nadia Bounoua ,&nbsp;Kaleigh Wieand ,&nbsp;Jeffrey M. Spielberg","doi":"10.1016/j.xjmad.2023.100037","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100037","url":null,"abstract":"<div><p>Although anxiety sensitivity (AS) and disturbances in emotion regulation (ER) are both transdiagnostic factors thought to predispose toward internalizing pathology, little is known about associations between these constructs <em>over time</em>. Further, no work has examined the modulating impact of gender on these associations, despite previous work identifying gender differences in both AS and ER. Data were collected from 275 adults (M_age = 35.7; 52% women) at two timepoints, six months apart (baseline=March 2021, follow-up=September 2021), using an online crowdsourcing platform. Multigroup cross-lagged analyses showed that, across genders, lower baseline ER predicted higher AS at follow-up (<em>p</em> &lt; .001), over and above baseline AS, but the reverse was not true. Additionally, this association was moderated by gender (∆Wald’s χ² =8.33, <em>p</em> &lt; .01), such that lower baseline ER predicted higher follow-up AS in men (<em>p</em> &lt; .001), but not women (<em>p</em> = .35). Our findings suggest the <em>p</em>resence of gender differences in the longitudinal, transactional associations between transdiagnostic risk factors important for the maintenance and exacerbation of future internalizing pathology. For example, men may be engaging in less adaptive ER strategies (e.g., suppression), resulting in a failure to downregulate future AS. Present results inform etiological models of internalizing disorders.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"4 ","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004423000378/pdfft?md5=336a8c22403f36aab21b6c90a9b0db73&pid=1-s2.0-S2950004423000378-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92047117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting anxiety-related personality traits by means of serotonergic VNTR variants STin2 and 5-HTTLPR","authors":"Andrea Felten,&nbsp;Thomas Plieger,&nbsp;Martin Reuter","doi":"10.1016/j.xjmad.2023.100031","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100031","url":null,"abstract":"<div><p>Polymorphisms of the serotonergic system are amongst the most commonly investigated genetic variants with respect to anxiety-related personality traits and affective disorders. Mostly the prominent 5-HTTLPR, a functional VNTR in the 5-HTT promoter region, is intensively analysed but effect sizes in meta-analyses are small and results are inconsistent. We reinvestigated the association of 5-HTTLPR with harm avoidance (HA) and neuroticism taking another functional 5-HTT-VNTR (STin2) into account, as both VNTRs have transcription regulating properties and research points to combinatorial effects on transcription efficacy. N = 2969 participants, among them 447 inpatients suffering from affective disorders, were genotyped and filled in the TCI, NEO-FFI personality inventories besides the CLEq measuring the extent of experienced stressful life events. Significant main effects for the 5-HTTLPR with inpatients carrying the L+ allele having lower HA scores as well as for the STin2 with healthy controls carrying at least one STin2.12R allele having lower neuroticism scores were observed. Besides no gene-interaction occurred. However, specific haplotype effects were observed in healthy participants as well as in the total sample. More specifically, the 12/L variant was associated with significant lower HA and neuroticism scores. Results highlight the multifactorial interplay of 5-HTT genetic variants and the use of haplotypes in association studies on anxiety-related personality traits with impact on affective disorders.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"4 ","pages":"Article 100031"},"PeriodicalIF":0.0,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49890716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors and outcomes of engagement in an online depression prevention program for final year secondary school students","authors":"Hayley M. Jackson ,&nbsp;Louise M. Farrer ,&nbsp;Aliza Werner-Seidler ,&nbsp;Yael Perry ,&nbsp;Helen Christensen ,&nbsp;Jeneva L. Ohan ,&nbsp;Alison L. Calear ,&nbsp;Philip J. Batterham","doi":"10.1016/j.xjmad.2023.100027","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100027","url":null,"abstract":"<div><p>Although school-based delivery of online interventions can effectively prevent depression and other common mental disorders, little is known about the characteristics of students who engage with these programs. This study aimed to identify predictors of two indicators of adolescent engagement (program usage and skill enactment) with a school-based online depression prevention program. The study also explored the association between skill enactment and mental health outcomes. Participants were 204 final-year secondary school students (<em>M</em> = 16.7 years, <em>SD</em> = 0.51 years; 111 females) from the intervention condition of a cluster randomized controlled trial conducted in 10 selective and partially selective government schools in Australia between 2015 and 2016. Program usage was measured as number of modules completed and skill enactment was assessed using a self-report questionnaire at post-intervention to determine the frequency of implementing program strategies (e.g., cognitive restructuring, activity scheduling). Predictors of engagement included demographics, mental health-related variables, and psychological factors (e.g., mastery). Regressions indicated that possible history of depression predicted fewer modules completed, whereas higher baseline anxiety, mastery, and higher perceived level of learning from the program predicted greater skill enactment. Mixed models did not show a significant effect of skill enactment on symptoms of depression, generalized anxiety, social phobia, or personal stigma. Future work is needed to investigate whether the results apply to students enrolled in non-selective programs and examine the effects of skill enactment and other possible mechanisms on outcomes in order to guide the refinement of future interventions.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"3 ","pages":"Article 100027"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50192448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and anxiety outcomes of adults undergoing intermittent theta burst stimulation (iTBS) treatment for major depressive disorder: A naturalistic study","authors":"Noah A. Lee ,&nbsp;Simon Kung ,&nbsp;Yuliang Hu ,&nbsp;Stacy E. Greenwaldt ,&nbsp;Maria I. Lapid ,&nbsp;Paul E. Croarkin","doi":"10.1016/j.xjmad.2023.100028","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100028","url":null,"abstract":"<div><h3>Background</h3><p>Standard repetitive transcranial magnetic stimulation (rTMS) and intermittent theta burst stimulation (iTBS) are approved treatments for major depressive disorder (MDD). iTBS offers shorter treatment durations and increased accessibility. This study examines the clinical outcomes of iTBS for MDD in a tertiary medical center.</p></div><div><h3>Methods</h3><p>Patients who underwent iTBS for MDD at Mayo Clinic Rochester between March 2021 and January 2023 were included. Baseline and endpoint scores of the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder 7-item (GAD-7) were compared using t-tests. Response, remission, and a single question patient-reported outcome (PRO) of \"Did the treatment help?\" were reported. Outcomes of patients with anxious depression (GAD-7 ≥10) were also reported.</p></div><div><h3>Results</h3><p>Forty-two patients (mean age 41.7 years, 59.5% female) were analyzed. iTBS resulted in a significant reduction in depression symptoms (PHQ-9: baseline mean 19.9, endpoint mean 13.0, p &lt; 0.001). The response rate was 38.1%, remission rate was 9.5%, and PRO was 57.1%. Anxiety symptoms also significantly improved (GAD-7: baseline mean 13.0, endpoint mean 9.1, p &lt; 0.001). The response rate for anxiety was 33.3%, and remission rate was 28.6%. Our response rate for depression was comparable to existing literature, while the remission rate was lower.</p></div><div><h3>Conclusion</h3><p>iTBS demonstrated significant reductions in depression and anxiety symptoms among patients with MDD, and in the subset of patients with anxious depression. The single question PRO can be a practical aid in patient discussions. These findings contribute to the growing body of literature on iTBS for MDD.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"3 ","pages":"Article 100028"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50193015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Unified Protocol modules exert general or unique effects on anxiety, depression, and transdiagnostic targets?","authors":"Matthew W. Southward ,&nbsp;Sean P. Lane ,&nbsp;Sara E. Shroyer ,&nbsp;Shannon Sauer-Zavala","doi":"10.1016/j.xjmad.2023.100022","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100022","url":null,"abstract":"<div><p>Several transdiagnostic cognitive-behavior therapies include multiple treatment components. However, it is unclear whether some components are more efficacious than others at reducing symptoms or whether these components uniquely influence their putative mechanism of change. Participants (<em>N</em> = 70; <em>M</em>_age = 33.7; 67.1% female, 74.3% White) with a primary anxiety or depressive disorder were randomized to one of three standard or personalized sequences of core Unified Protocol modules. Using hierarchical linear modeling, we tested (a) whether the average session-to-session change in anxiety and depression differed between modules and (b) whether the average session-to-session change in the putative mechanism of each module differed between modules. All modules led to similar changes in anxiety, but Confronting Physical Sensations led to significantly less change in depression than other modules. There were no significant differences among modules predicting putative mechanisms of change, although there was a trend for Mindful Emotion Awareness to predict greater improvements in mindfulness than Understanding Emotions. Consistent with its transdiagnostic nature, UP modules may exert similar effects on anxiety and putative mechanisms of change, although interoceptive exposures may be less impactful for changing depressive symptoms and the mindfulness module may promote relatively specific improvements in mindfulness.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"3 ","pages":"Article 100022"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50192440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing positive and negative valence systems function in adolescent depression: An RDoC-informed approach integrating multiple neural measures","authors":"Kaylin E. Hill,&nbsp;Samantha Pegg,&nbsp;Anh Dao,&nbsp;Emma Boldwyn,&nbsp;Lindsay Dickey,&nbsp;Lisa Venanzi,&nbsp;Alexandra Argiros,&nbsp;Autumn Kujawa","doi":"10.1016/j.xjmad.2023.100025","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100025","url":null,"abstract":"<div><p>Depression is a prevalent, debilitating, and costly disorder that often manifests in adolescence. There is an urgent need to understand core pathophysiological processes for depression to inform more targeted intervention efforts. The Research Domain Criteria (RDoC) Positive Valence Systems (PVS) and Negative Valence Systems (NVS) have both been implicated in depression symptomatology and vulnerability; however, the nature of NVS alterations is unclear across studies, and associations between single neural measures and symptoms are often small in magnitude and inconsistent. The present study advances characterization of depression in adolescence via an innovative data-driven approach to identifying subgroups of PVS and NVS function by integrating multiple neural measures (assessed by electroencephalogram [EEG]) relevant to depression in adolescents oversampled for clinical depression and depression risk based on maternal history (<em>N</em> = 129; 14–17 years old). Results of the <em>k</em>-means cluster analysis supported a two-cluster solution wherein one cluster was characterized by relatively attenuated reward and emotion responsiveness across valences and the other by relatively intact responsiveness. Youth in the attenuated responsiveness cluster reported significantly greater depressive symptoms and were more likely to have major depressive disorder diagnoses than youth in the intact responsiveness cluster. In contrast, associations of individual neural measures with depressive symptoms were non-significant. The present study highlights the importance of innovative neuroscience approaches to characterize emotional processing in depression across domains, which is imperative to advancing the clinical utility of RDoC-informed research.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"3 ","pages":"Article 100025"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50192442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screen media activity in youth: A critical review of mental health and neuroscience findings","authors":"Martin P. Paulus ,&nbsp;Yihong Zhao ,&nbsp;Marc N. Potenza ,&nbsp;Robin L. Aupperle ,&nbsp;Kara S. Bagot ,&nbsp;Susan F. Tapert","doi":"10.1016/j.xjmad.2023.100018","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100018","url":null,"abstract":"<div><p>This review has two primary objectives: (1) to offer a balanced examination of recent findings on the relationship between screen media activity (SMA) in young individuals and outcomes such as sleep patterns, mood disturbances, anxiety-related concerns, and cognitive processes; and (2) to introduce a novel multi-level system model that integrates these findings, resolves contradictions in the literature, and guides future studies in examining key covariates affecting the SMA-mental health relationship. Key findings include: (1) Several meta-analyses reveal a significant association between SMA and mental health issues, particularly anxiety and depression, including specific negative effects linked to prolonged screen time; (2) substantial evidence indicates that SMA has both immediate and long-term impacts on sleep duration and quality; (3) the relationship between SMA and cognitive functioning is complex, with mixed findings showing both positive and negative associations; and (4) the multifaceted relationship between SMA and various aspects of adolescent life is influenced by a wide range of environmental and contextual factors. SMA in youth is best understood within a complex system encompassing individual, caregiver, school, peer, and environmental factors, as framed by Bronfenbrenner's ecological systems theory, which identifies five interrelated systems (microsystem, mesosystem, exosystem, macrosystem, and chronosystem) that influence development across both proximal and distal levels of the environment. This model provides a framework for future research to examine these interactions, considering moderating factors, and to develop targeted interventions that can mitigate potential adverse effects of SMA on mental well-being.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"3 ","pages":"Article 100018"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50193016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PTSD and alcohol use disorders predict the pace of cellular aging","authors":"Sage E. Hawn ,&nbsp;Xiang Zhao ,&nbsp;Mark W. Miller ,&nbsp;Sara Wallander ,&nbsp;Christine Govan ,&nbsp;Anjanette Stone ,&nbsp;Steven A. Schichman ,&nbsp;Mark W. Logue ,&nbsp;Erika J. Wolf","doi":"10.1016/j.xjmad.2023.100026","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100026","url":null,"abstract":"<div><p>Advanced epigenetic age is associated with psychopathology and may help to explain the link between psychopathology and physical health morbidity and mortality. Using a longitudinal sample of 171 trauma-exposed Veterans, we modeled the rate of change in epigenetic age across two time points (averaging 5.58 years apart) using two epigenetic age algorithms (GrimAge and Horvath) and tested associations with posttraumatic stress disorder (PTSD), alcohol use disorder (AUD), and depression. Results showed that PTSD (β = .199) and AUD (β = .186) were associated with a quickened <em>pace</em> of epigenetic aging over time (<em>ps</em> &lt;.021). Results replicate and extend prior work and offer foundational support for identifying interventions that slow the pace of biological aging among those with psychopathology.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"3 ","pages":"Article 100026"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50193017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intolerance of uncertainty, perfectionism, and coping as predictors of depression diagnosis and severity","authors":"Kanika Choudhary ,&nbsp;Geneva Mason ,&nbsp;Alethea Correa ,&nbsp;Kathryn Fotinos ,&nbsp;Sachinthya Lokuge ,&nbsp;Alexandria Greifenberger ,&nbsp;Elssa Toumeh ,&nbsp;Sherinne Clarissa ,&nbsp;Irvin Epstein ,&nbsp;Tia Sternat ,&nbsp;Martin A. Katzman","doi":"10.1016/j.xjmad.2023.100019","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100019","url":null,"abstract":"<div><p>Major Depressive Disorder (MDD) is the leading cause of disability worldwide, affecting 3.8% of the global population. Despite its prevalence, less than half of those diagnosed with MDD receive treatment and remission rates remain low. Given these poor outcomes for individuals with depression and the findings of our previous study examining the role of certain psychological phenomena on the incidence of obsessive-compulsive disorder (OCD), the present study aims to examine whether intolerance of uncertainty, perfectionism, and coping strategies can together predict the diagnosis and severity of MDD. Participants were outpatients (<em>N</em> = 549) referred to a tertiary care clinic in Toronto, Canada between 2011 and 2014. After undergoing a diagnostic assessment, participants were administered a series of self-report questionnaires that measured intolerance of uncertainty, perfectionism, and coping. Results demonstrate that task-oriented coping and emotion-oriented coping significantly predicted depression diagnosis, while avoidant coping, perfectionism, and intolerance of uncertainty did not. As for depression severity, significant predictors included perfectionism, task-oriented coping, emotion-oriented coping, and avoidant coping. Further research is needed to identify interactions between the subscales of these constructs to determine how they work in tandem to influence MDD. Our findings indicate a need for more personalized interventions in the treatment of this disorder.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"3 ","pages":"Article 100019"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50192441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}