Sage E. Hawn , Xiang Zhao , Mark W. Miller , Sara Wallander , Christine Govan , Anjanette Stone , Steven A. Schichman , Mark W. Logue , Erika J. Wolf
{"title":"创伤后应激障碍和酒精使用障碍预测细胞衰老的速度","authors":"Sage E. Hawn , Xiang Zhao , Mark W. Miller , Sara Wallander , Christine Govan , Anjanette Stone , Steven A. Schichman , Mark W. Logue , Erika J. Wolf","doi":"10.1016/j.xjmad.2023.100026","DOIUrl":null,"url":null,"abstract":"<div><p>Advanced epigenetic age is associated with psychopathology and may help to explain the link between psychopathology and physical health morbidity and mortality. Using a longitudinal sample of 171 trauma-exposed Veterans, we modeled the rate of change in epigenetic age across two time points (averaging 5.58 years apart) using two epigenetic age algorithms (GrimAge and Horvath) and tested associations with posttraumatic stress disorder (PTSD), alcohol use disorder (AUD), and depression. Results showed that PTSD (β = .199) and AUD (β = .186) were associated with a quickened <em>pace</em> of epigenetic aging over time (<em>ps</em> <.021). Results replicate and extend prior work and offer foundational support for identifying interventions that slow the pace of biological aging among those with psychopathology.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"3 ","pages":"Article 100026"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"PTSD and alcohol use disorders predict the pace of cellular aging\",\"authors\":\"Sage E. Hawn , Xiang Zhao , Mark W. Miller , Sara Wallander , Christine Govan , Anjanette Stone , Steven A. Schichman , Mark W. Logue , Erika J. Wolf\",\"doi\":\"10.1016/j.xjmad.2023.100026\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Advanced epigenetic age is associated with psychopathology and may help to explain the link between psychopathology and physical health morbidity and mortality. Using a longitudinal sample of 171 trauma-exposed Veterans, we modeled the rate of change in epigenetic age across two time points (averaging 5.58 years apart) using two epigenetic age algorithms (GrimAge and Horvath) and tested associations with posttraumatic stress disorder (PTSD), alcohol use disorder (AUD), and depression. Results showed that PTSD (β = .199) and AUD (β = .186) were associated with a quickened <em>pace</em> of epigenetic aging over time (<em>ps</em> <.021). Results replicate and extend prior work and offer foundational support for identifying interventions that slow the pace of biological aging among those with psychopathology.</p></div>\",\"PeriodicalId\":73841,\"journal\":{\"name\":\"Journal of mood and anxiety disorders\",\"volume\":\"3 \",\"pages\":\"Article 100026\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of mood and anxiety disorders\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950004423000263\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of mood and anxiety disorders","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950004423000263","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
PTSD and alcohol use disorders predict the pace of cellular aging
Advanced epigenetic age is associated with psychopathology and may help to explain the link between psychopathology and physical health morbidity and mortality. Using a longitudinal sample of 171 trauma-exposed Veterans, we modeled the rate of change in epigenetic age across two time points (averaging 5.58 years apart) using two epigenetic age algorithms (GrimAge and Horvath) and tested associations with posttraumatic stress disorder (PTSD), alcohol use disorder (AUD), and depression. Results showed that PTSD (β = .199) and AUD (β = .186) were associated with a quickened pace of epigenetic aging over time (ps <.021). Results replicate and extend prior work and offer foundational support for identifying interventions that slow the pace of biological aging among those with psychopathology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
