Advances in Nutrition最新文献

{"title":"A Systematic Review: The Impact of COVID-19 Policy Flexibilities on SNAP and WIC Programmatic Outcomes","authors":"Mayra Crespo-Bellido ,&nbsp;Gabby Headrick ,&nbsp;Miguel Ángel López ,&nbsp;Jennifer Holcomb ,&nbsp;Ariana Khan ,&nbsp;Shanti Sapkota ,&nbsp;Kelseanna Hollis-Hansen","doi":"10.1016/j.advnut.2024.100361","DOIUrl":"10.1016/j.advnut.2024.100361","url":null,"abstract":"<div><div>In response to the coronavirus disease 2019 (COVID-19) public health emergency (PHE), the federal government deployed policy flexibilities in food and nutrition assistance programs including the Supplemental Nutrition Assistance Program (SNAP) and Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) to meet the needs those experiencing economic hardship. Emergent literature evaluates the impact of these flexibilities on program outcomes. The objective of this study was to explore the impact of policy flexibilities deployed during the COVID-19 PHE on access, enrollment/retention, benefit utilization, and perceptions of SNAP and WIC. Keyword searches were performed in November 2023, February 2024, and August 2024. The search included peer-reviewed literature from 2020 to 2024, following Johanna Briggs Institute (JBI) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, resulting in 37 eligible articles. Twelve studies evaluated policy flexibilities in SNAP only, 21 in WIC only, and 4 in both programs. Across these, 12 studies explored program access, 7 enrollment/retention, 13 benefit utilization, and 15 program perceptions. JBI critical appraisal tools were used to assess risk of bias. The reviewed articles show that although SNAP and WIC participants identified challenges to access, there were increases in enrollment/retention due to policy flexibilities enabling remote services and reducing administrative burden in both programs. Benefit increases led to greater purchase of preferred foods in SNAP and greater access to fruit and vegetables in WIC. Overall, participants were satisfied with the flexibilities and reported most were beneficial for their households. Some implementation challenges were identified by participants and staff. A few studies showed potential risks of bias, including selection bias and confounding bias. COVID-19-related policy flexibilities in SNAP and WIC demonstrated significant improvements in selected program outcomes; however, challenges communicating policy flexibilities to authorized vendors and participants created difficulties to benefiting from the flexibilities. Findings from the evaluations of these flexibilities can inform future program enhancements and long-term regulatory changes. This study was registered in PROSPERO (CRD42023493302).</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 2","pages":"Article 100361"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Vulnerability and Child Food Insecurity in Developed Countries: A Systematic Review","authors":"Liyuwork Mitiku Dana ,&nbsp;César Ramos-García ,&nbsp;Deborah A Kerr ,&nbsp;Jane M Fry ,&nbsp;Jeromey Temple ,&nbsp;Christina M Pollard","doi":"10.1016/j.advnut.2025.100365","DOIUrl":"10.1016/j.advnut.2025.100365","url":null,"abstract":"<div><div>Food insecurity (FI) is a serious public health concern in economically developed countries, mainly due to unequal resource distribution. Identifying social vulnerability factors [i.e., characteristics of a person or group regarding their capacity to anticipate, cope with, resist, and recover from the effects of child FI (CFI)] and their positive or negative relationship with CFI is important to support targeted action with a scale and intensity that is proportionate to the level of disadvantage. This review aimed to systematically and comprehensively identify key social vulnerability contributors to CFI in economically developed countries and discuss the factors in the context of the socio-ecological model. Five research databases were searched for observational studies published in 2000 assessing social vulnerability factors related to FI in children residing in developed countries. Data screening and extraction were independently conducted by 2 reviewers who recorded factors related to CFI. The QualSyst tool was used to assess risk of bias. From the studies identified (<em>N</em> = 5689), 49 articles, predominantly from the United States and Canada, met the inclusion criteria. The identified social vulnerability factors associated with CFI were grouped into 5 based on the socio-ecological model: <em>1</em>) individual child, <em>2</em>) parental, <em>3</em>) household, <em>4</em>) community, and <em>5</em>) societal factors. The most frequently reported contributors to CFI were income (household factor). Other social vulnerability factors were identified, including the child’s age, parental depression, household crowdedness, social connection, poverty, and residential instability. The lack of consistent measures to define both social vulnerability and CFI in diverse population subgroups impeded meaningful pooling and interpretation of factors interacting with CFI. Recommendations for future studies are to use comparable measures to estimate the extent and severity of CFI and to investigate the relation between social vulnerability, severity, and trajectories of CFI in developed countries.</div><div>This trial was registered at PROSPERO as CRD42022291638.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 2","pages":"Article 100365"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. Salvador Villalpando Hernández","authors":"Steven A Abrams","doi":"10.1016/j.advnut.2024.100349","DOIUrl":"10.1016/j.advnut.2024.100349","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 2","pages":"Article 100349"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Vegetarian and Vegan Dietary Patterns to Treat Adult Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials’ [Advances in Nutrition. 2024;15(10)]","authors":"Nanci S Guest ,&nbsp;Sudha Raj ,&nbsp;Matthew J Landry ,&nbsp;A Reed Mangels ,&nbsp;Roman Pawlak ,&nbsp;Katelyn E Senkus ,&nbsp;Deepa Handu ,&nbsp;Mary Rozga","doi":"10.1016/j.advnut.2025.100379","DOIUrl":"10.1016/j.advnut.2025.100379","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 2","pages":"Article 100379"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Maternal Lead Exposure from Seafood Consumption and Neurodevelopment: A Systematic Review","authors":"Arin A Balalian ,&nbsp;Maureen K Spill ,&nbsp;Rachel C Thoerig ,&nbsp;Rupal Trivedi ,&nbsp;Sanjoy Saha ,&nbsp;Margaret J Foster ,&nbsp;Amanda J MacFarlane","doi":"10.1016/j.advnut.2025.100380","DOIUrl":"10.1016/j.advnut.2025.100380","url":null,"abstract":"<div><div>Despite the essential nutrients, maternal seafood consumption during pregnancy or lactation (PL) is also a potential source of toxins, including lead (Pb). The association between exposure to Pb from seafood during PL on children’s neurodevelopment is uncertain. This systematic review assessed the association of exposure to Pb from seafood during PL on children’s neurodevelopment. Embase, PubMed, CENTRAL, and PsycINFO were searched for English-language peer-reviewed articles. Two independent reviewers screened at title, abstract, and full-text levels. Experimental and observational studies comparing different levels of exposure to seafood and Pb were eligible if: <em>1</em>) the exposed population included healthy pregnant or lactating individuals from high or very high human development index countries; <em>2</em>) assessed neurodevelopment in children ≤18 y old; and <em>3</em>) measured maternal seafood intake, Pb exposure and analyzed their relationship with each other and/or their association with child neurodevelopment. The Cochrane risk of bias in nonrandomized studies - of exposure (ROBINS-E) and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tools were used to assess the risk of bias and certainty of evidence. Four included articles from 3 prospective cohort studies in Asia examined cognition, motor development, and behavior in children 12–60 mo. Only 1 study reported an analysis between seafood intake and Pb concentrations during PL, which showed a weak, nonsignificant association. Pb concentrations were not associated with child cognitive development or behavioral problems, but a weak, negative association with child motor development was reported. The certainty of the evidence was very low due to the few included studies with some or a high risk of bias. Higher seafood intake in this evidence favored positive developmental outcomes from 1 prospective cohort study, though significance varied. Overall, evidence was not available to address a direct association between Pb exposure from seafood intake during PL and child neurodevelopment. Several other limitations resulted in a very low certainty of overall evidence.</div><div>This systematic review was registered at PROSPERO as CRD42023494884.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 3","pages":"Article 100380"},"PeriodicalIF":8.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Mediterranean Lifestyle Pyramid for Children and Youth: A Critical Lifestyle Tool for Preventing Obesity and Associated Cardiometabolic Diseases in a Sustainable Context","authors":"Rosa Casas ,&nbsp;Ana María Ruiz-León ,&nbsp;Jesús Argente ,&nbsp;Cesarettin Alasalvar ,&nbsp;Aadil Bajoub ,&nbsp;Isabel Bertomeu ,&nbsp;Margherita Caroli ,&nbsp;Sara Castro-Barquero ,&nbsp;Fatima Crispi ,&nbsp;Jacques Delarue ,&nbsp;Rodrigo Fernández-Jiménez ,&nbsp;Valentin Fuster ,&nbsp;Javier Fontecha ,&nbsp;Paz Gómez-Fernández ,&nbsp;Jordi González-Juste ,&nbsp;Christina Kanaka-Gantenbein ,&nbsp;Eirini Kostopoulou ,&nbsp;Rosa M Lamuela-Raventós ,&nbsp;Yannis Manios ,&nbsp;Ascensión Marcos ,&nbsp;Ramon Estruch","doi":"10.1016/j.advnut.2025.100381","DOIUrl":"10.1016/j.advnut.2025.100381","url":null,"abstract":"<div><div>Cardiovascular disease risk factors begin in childhood and track into adulthood, increasing the possibility of impaired cardiometabolic health. Adopting healthy dietary patterns can help curb childhood obesity, a worrisome epidemic problem at present. In the era of personalized nutrition, dietary recommendations should be adapted to different stages of life, including children (older than 3 y) and adolescents. In this study, we present an updated version of the Mediterranean Lifestyle Pyramid addressed to children and adolescents, which may be used as a prevention tool by health professionals, teachers, and stakeholders. This pyramid arises from a consensus position between participants in an International Congress on Mediterranean diet held in Barcelona. During this meeting, after reviewing all literature published, a consensus was reached on the new Mediterranean Lifestyle Pyramid for kids including details such as labels of the pyramid, position of foods, servings, type of foods, and healthy lifestyle habits. All components of the pyramid are supported by the most recent scientifically sound research and are based upon top-level evidence in nutritional sciences. Fruit, vegetables, legumes, nuts, wholegrains, and extra-virgin olive oil continue to be at the basis of the pyramid, but the importance of an adequate intake of fish, dairy products, and meat during these particular ages, when body and brain development occurs, is also considered. The promotion of physical activity, adequate sleep, and good emotional health are emphasized, as well as the consumption of seasonal and local products, and overall sustainability. Improving dietary habits in early stages of life should increase health in adulthood and reduce future incidence of noncommunicable chronic diseases. The Mediterranean diet and its graphic representation in the Lifestyle Pyramid should be a health-fostering tool not only for adults and children but also for the entire planet because it promotes the diversity of species, respect for the earth, and the local economy.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 3","pages":"Article 100381"},"PeriodicalIF":8.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macronutrient Modulation in Metabolic Dysfunction-Associated Steatotic Liver Disease—the Molecular Role of Fatty Acids compared with Sugars in Human Metabolism and Disease Progression","authors":"Sinéad M Mullin ,&nbsp;Aidan J Kelly ,&nbsp;Méabh B Ní Chathail ,&nbsp;Suzanne Norris ,&nbsp;Christopher E Shannon ,&nbsp;Helen M Roche","doi":"10.1016/j.advnut.2025.100375","DOIUrl":"10.1016/j.advnut.2025.100375","url":null,"abstract":"<div><div>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a significant public health concern, with its progression to metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis leading to severe outcomes including cirrhosis, hepatocellular carcinoma, and liver failure. Whereas obesity and excess energy intake are well-established contributors to the development and progression of MASLD, the distinct role of specific macronutrients is less clear. This review examines the mechanistic pathways through which dietary fatty acids and sugars contribute to the development of hepatic inflammation and fibrosis, offering a nuanced understanding of their respective roles in MASLD progression. In terms of addressing potential therapeutic options, human intervention studies that investigate whether modifying the intake of dietary fats and carbohydrates affects MASLD progression are reviewed. By integrating this evidence, this review seeks to bridge the gap in the understanding between the mechanisms of macronutrient-driven MASLD progression and the effect of altering the intake of these nutrients in the clinical setting and presents a foundation for future research into targeted dietary strategies for the treatment of the disease.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 3","pages":"Article 100375"},"PeriodicalIF":8.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomics and Artificial Intelligence for Personalized Nutritional Management of Diabetes in Patients Undergoing Peritoneal Dialysis","authors":"Sara Mahdavi ,&nbsp;Nicole M Anthony ,&nbsp;Tabo Sikaneta ,&nbsp;Paul Y Tam","doi":"10.1016/j.advnut.2025.100378","DOIUrl":"10.1016/j.advnut.2025.100378","url":null,"abstract":"<div><div>Managing diabetes in patients on peritoneal dialysis (PD) is challenging due to the combined effects of dietary glucose, glucose from dialysate, and other medical complications. Advances in technology that enable continuous biological data collection are transforming traditional management approaches. This review explores how multiomics technologies and artificial intelligence (AI) are enhancing glucose management in this patient population. Continuous glucose monitoring (CGM) offers significant advantages over traditional markers, such as hemoglobin A1c (HbA1c). Unlike HbA1c, which reflects an mean glucose level, CGM provides real-time, dynamic glucose data that allow clinicians to make timely adjustments, leading to better glycemic control and outcomes. Multiomics approaches are valuable for understanding genetic factors that influence susceptibility to diabetic complications, particularly those related to advanced glycation end products (AGEs). Identifying genetic polymorphisms that modify a patient's response to AGEs allows for personalized treatments, potentially reducing the severity of diabetes-related pathologies. Metabolomic analyses of PD effluent are also promising, as they help identify early biomarkers of metabolic dysregulation. Early detection can lead to timely interventions and more tailored treatment strategies, improving long-term patient care. AI integration is revolutionizing diabetes management for PD patients by processing vast datasets from CGM, genetic, metabolic, and microbiome profiles. AI can identify patterns and predict outcomes that may be difficult for humans to detect, enabling highly personalized recommendations for diet, medication, and dialysis management. Furthermore, AI can assist clinicians by automating data interpretation, improving treatment plans, and enhancing patient education. Despite the promise of these technologies, there are limitations. CGM, multiomics, and AI require significant investment in infrastructure, training, and validation studies. Additionally, integrating these approaches into clinical practice presents logistical and financial challenges. Nevertheless, personalized, data-driven strategies offer great potential for improving outcomes in diabetes management for PD patients.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 3","pages":"Article 100378"},"PeriodicalIF":8.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promotion of Healthy Aging Through the Nexus of Gut Microbiota and Dietary Phytochemicals","authors":"Laura M Beaver ,&nbsp;Paige E Jamieson ,&nbsp;Carmen P Wong ,&nbsp;Mahak Hosseinikia ,&nbsp;Jan F Stevens ,&nbsp;Emily Ho","doi":"10.1016/j.advnut.2025.100376","DOIUrl":"10.1016/j.advnut.2025.100376","url":null,"abstract":"<div><div>Aging is associated with the decline of tissue and cellular functions, which can promote the development of age-related diseases like cancer, cardiovascular disease, neurodegeneration, and disorders of the musculoskeletal and immune systems. Healthspan is the length of time an individual is in good health and free from chronic diseases and disabilities associated with aging. Two modifiable factors that can influence healthspan, promote healthy aging, and prevent the development of age-related diseases, are diet and microbiota in the gastrointestinal tract (gut microbiota). This review will discuss how dietary phytochemicals and gut microbiota can work in concert to promote a healthy gut and healthy aging. First, an overview is provided of how the gut microbiota influences healthy aging through its impact on gut barrier integrity, immune function, mitochondria function, and oxidative stress. Next, the mechanisms by which phytochemicals effect gut health, inflammation, and nurture a diverse and healthy microbial composition are discussed. Lastly, we discuss how the gut microbiota can directly influence health by producing bioactive metabolites from phytochemicals in food like urolithin A, equol, hesperetin, and sulforaphane. These and other phytochemical-derived microbial metabolites that may promote healthspan are discussed. Importantly, an individual’s capacity to produce health-promoting microbial metabolites from cruciferous vegetables, berries, nuts, citrus, and soy products will be dependent on the specific bacteria present in the individual’s gut.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 3","pages":"Article 100376"},"PeriodicalIF":8.0,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Growth Monitoring and Promotion Accurately Diagnose or Screen for Inadequate Growth of Individual Children? A Critical Review of the Epidemiologic Foundations","authors":"Jef L Leroy ,&nbsp;Rebecca L Brander ,&nbsp;Edward A Frongillo ,&nbsp;Leila M Larson ,&nbsp;Marie T Ruel ,&nbsp;Rasmi Avula","doi":"10.1016/j.advnut.2025.100367","DOIUrl":"10.1016/j.advnut.2025.100367","url":null,"abstract":"<div><div>Growth monitoring and promotion (GMP), the process of periodic anthropometric measurements to assess the adequacy of individual child growth, is implemented across low-income and middle-income countries. The epidemiologic foundations of GMP (i.e., that GMP can accurately diagnose or screen for inadequate growth) have never been critically reviewed. We first assessed growth patterns of individual healthy children. Using longitudinal data from low-income, middle-income, and high-income countries, we evaluated whether commonly used GMP criteria can be used for diagnosis and screening; i.e., whether they accurately identify current, or predict subsequent, inadequate growth in individual children. The growth of individual healthy children does not track along a specific growth curve, which challenges the notion that growth measurements alone can be used to distinguish between healthy and inadequate growth. We demonstrated that GMP criteria do not provide meaningful diagnostic information and that GMP is not a meaningful screening activity: commonly used GMP criteria are inaccurate predictors of (inadequate) growth later in childhood, and collecting individual children’s weight and height does not help to identify who needs support or who will benefit. Our results do not undermine the importance of dedicated programs to diagnose wasting in individual children nor do they challenge the need for well-child care to support parents and to ensure children’s optimal nutrition, health, and development. Our findings, however, highlight the need to carefully reconsider the current design of GMP in low-income and middle-income countries.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 3","pages":"Article 100367"},"PeriodicalIF":8.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}