Advances in Nutrition最新文献

{"title":"Association between Maternal Lead Exposure from Seafood Consumption and Neurodevelopment: A Systematic Review","authors":"Arin A Balalian ,&nbsp;Maureen K Spill ,&nbsp;Rachel C Thoerig ,&nbsp;Rupal Trivedi ,&nbsp;Sanjoy Saha ,&nbsp;Margaret J Foster ,&nbsp;Amanda J MacFarlane","doi":"10.1016/j.advnut.2025.100380","DOIUrl":"10.1016/j.advnut.2025.100380","url":null,"abstract":"<div><div>Despite the essential nutrients, maternal seafood consumption during pregnancy or lactation (PL) is also a potential source of toxins, including lead (Pb). The association between exposure to Pb from seafood during PL on children’s neurodevelopment is uncertain. This systematic review assessed the association of exposure to Pb from seafood during PL on children’s neurodevelopment. Embase, PubMed, CENTRAL, and PsycINFO were searched for English-language peer-reviewed articles. Two independent reviewers screened at title, abstract, and full-text levels. Experimental and observational studies comparing different levels of exposure to seafood and Pb were eligible if: <em>1</em>) the exposed population included healthy pregnant or lactating individuals from high or very high human development index countries; <em>2</em>) assessed neurodevelopment in children ≤18 y old; and <em>3</em>) measured maternal seafood intake, Pb exposure and analyzed their relationship with each other and/or their association with child neurodevelopment. The Cochrane risk of bias in nonrandomized studies - of exposure (ROBINS-E) and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tools were used to assess the risk of bias and certainty of evidence. Four included articles from 3 prospective cohort studies in Asia examined cognition, motor development, and behavior in children 12–60 mo. Only 1 study reported an analysis between seafood intake and Pb concentrations during PL, which showed a weak, nonsignificant association. Pb concentrations were not associated with child cognitive development or behavioral problems, but a weak, negative association with child motor development was reported. The certainty of the evidence was very low due to the few included studies with some or a high risk of bias. Higher seafood intake in this evidence favored positive developmental outcomes from 1 prospective cohort study, though significance varied. Overall, evidence was not available to address a direct association between Pb exposure from seafood intake during PL and child neurodevelopment. Several other limitations resulted in a very low certainty of overall evidence.</div><div>This systematic review was registered at PROSPERO as CRD42023494884.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 3","pages":"Article 100380"},"PeriodicalIF":8.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Mediterranean Lifestyle Pyramid for Children and Youth: A Critical Lifestyle Tool for Preventing Obesity and Associated Cardiometabolic Diseases in a Sustainable Context","authors":"Rosa Casas ,&nbsp;Ana María Ruiz-León ,&nbsp;Jesús Argente ,&nbsp;Cesarettin Alasalvar ,&nbsp;Aadil Bajoub ,&nbsp;Isabel Bertomeu ,&nbsp;Margherita Caroli ,&nbsp;Sara Castro-Barquero ,&nbsp;Fatima Crispi ,&nbsp;Jacques Delarue ,&nbsp;Rodrigo Fernández-Jiménez ,&nbsp;Valentin Fuster ,&nbsp;Javier Fontecha ,&nbsp;Paz Gómez-Fernández ,&nbsp;Jordi González-Juste ,&nbsp;Christina Kanaka-Gantenbein ,&nbsp;Eirini Kostopoulou ,&nbsp;Rosa M Lamuela-Raventós ,&nbsp;Yannis Manios ,&nbsp;Ascensión Marcos ,&nbsp;Ramon Estruch","doi":"10.1016/j.advnut.2025.100381","DOIUrl":"10.1016/j.advnut.2025.100381","url":null,"abstract":"<div><div>Cardiovascular disease risk factors begin in childhood and track into adulthood, increasing the possibility of impaired cardiometabolic health. Adopting healthy dietary patterns can help curb childhood obesity, a worrisome epidemic problem at present. In the era of personalized nutrition, dietary recommendations should be adapted to different stages of life, including children (older than 3 y) and adolescents. In this study, we present an updated version of the Mediterranean Lifestyle Pyramid addressed to children and adolescents, which may be used as a prevention tool by health professionals, teachers, and stakeholders. This pyramid arises from a consensus position between participants in an International Congress on Mediterranean diet held in Barcelona. During this meeting, after reviewing all literature published, a consensus was reached on the new Mediterranean Lifestyle Pyramid for kids including details such as labels of the pyramid, position of foods, servings, type of foods, and healthy lifestyle habits. All components of the pyramid are supported by the most recent scientifically sound research and are based upon top-level evidence in nutritional sciences. Fruit, vegetables, legumes, nuts, wholegrains, and extra-virgin olive oil continue to be at the basis of the pyramid, but the importance of an adequate intake of fish, dairy products, and meat during these particular ages, when body and brain development occurs, is also considered. The promotion of physical activity, adequate sleep, and good emotional health are emphasized, as well as the consumption of seasonal and local products, and overall sustainability. Improving dietary habits in early stages of life should increase health in adulthood and reduce future incidence of noncommunicable chronic diseases. The Mediterranean diet and its graphic representation in the Lifestyle Pyramid should be a health-fostering tool not only for adults and children but also for the entire planet because it promotes the diversity of species, respect for the earth, and the local economy.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 3","pages":"Article 100381"},"PeriodicalIF":8.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macronutrient Modulation in Metabolic Dysfunction-Associated Steatotic Liver Disease—the Molecular Role of Fatty Acids compared with Sugars in Human Metabolism and Disease Progression","authors":"Sinéad M Mullin ,&nbsp;Aidan J Kelly ,&nbsp;Méabh B Ní Chathail ,&nbsp;Suzanne Norris ,&nbsp;Christopher E Shannon ,&nbsp;Helen M Roche","doi":"10.1016/j.advnut.2025.100375","DOIUrl":"10.1016/j.advnut.2025.100375","url":null,"abstract":"<div><div>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a significant public health concern, with its progression to metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis leading to severe outcomes including cirrhosis, hepatocellular carcinoma, and liver failure. Whereas obesity and excess energy intake are well-established contributors to the development and progression of MASLD, the distinct role of specific macronutrients is less clear. This review examines the mechanistic pathways through which dietary fatty acids and sugars contribute to the development of hepatic inflammation and fibrosis, offering a nuanced understanding of their respective roles in MASLD progression. In terms of addressing potential therapeutic options, human intervention studies that investigate whether modifying the intake of dietary fats and carbohydrates affects MASLD progression are reviewed. By integrating this evidence, this review seeks to bridge the gap in the understanding between the mechanisms of macronutrient-driven MASLD progression and the effect of altering the intake of these nutrients in the clinical setting and presents a foundation for future research into targeted dietary strategies for the treatment of the disease.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 3","pages":"Article 100375"},"PeriodicalIF":8.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomics and Artificial Intelligence for Personalized Nutritional Management of Diabetes in Patients Undergoing Peritoneal Dialysis","authors":"Sara Mahdavi ,&nbsp;Nicole M Anthony ,&nbsp;Tabo Sikaneta ,&nbsp;Paul Y Tam","doi":"10.1016/j.advnut.2025.100378","DOIUrl":"10.1016/j.advnut.2025.100378","url":null,"abstract":"<div><div>Managing diabetes in patients on peritoneal dialysis (PD) is challenging due to the combined effects of dietary glucose, glucose from dialysate, and other medical complications. Advances in technology that enable continuous biological data collection are transforming traditional management approaches. This review explores how multiomics technologies and artificial intelligence (AI) are enhancing glucose management in this patient population. Continuous glucose monitoring (CGM) offers significant advantages over traditional markers, such as hemoglobin A1c (HbA1c). Unlike HbA1c, which reflects an mean glucose level, CGM provides real-time, dynamic glucose data that allow clinicians to make timely adjustments, leading to better glycemic control and outcomes. Multiomics approaches are valuable for understanding genetic factors that influence susceptibility to diabetic complications, particularly those related to advanced glycation end products (AGEs). Identifying genetic polymorphisms that modify a patient's response to AGEs allows for personalized treatments, potentially reducing the severity of diabetes-related pathologies. Metabolomic analyses of PD effluent are also promising, as they help identify early biomarkers of metabolic dysregulation. Early detection can lead to timely interventions and more tailored treatment strategies, improving long-term patient care. AI integration is revolutionizing diabetes management for PD patients by processing vast datasets from CGM, genetic, metabolic, and microbiome profiles. AI can identify patterns and predict outcomes that may be difficult for humans to detect, enabling highly personalized recommendations for diet, medication, and dialysis management. Furthermore, AI can assist clinicians by automating data interpretation, improving treatment plans, and enhancing patient education. Despite the promise of these technologies, there are limitations. CGM, multiomics, and AI require significant investment in infrastructure, training, and validation studies. Additionally, integrating these approaches into clinical practice presents logistical and financial challenges. Nevertheless, personalized, data-driven strategies offer great potential for improving outcomes in diabetes management for PD patients.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 3","pages":"Article 100378"},"PeriodicalIF":8.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promotion of Healthy Aging Through the Nexus of Gut Microbiota and Dietary Phytochemicals","authors":"Laura M Beaver ,&nbsp;Paige E Jamieson ,&nbsp;Carmen P Wong ,&nbsp;Mahak Hosseinikia ,&nbsp;Jan F Stevens ,&nbsp;Emily Ho","doi":"10.1016/j.advnut.2025.100376","DOIUrl":"10.1016/j.advnut.2025.100376","url":null,"abstract":"<div><div>Aging is associated with the decline of tissue and cellular functions, which can promote the development of age-related diseases like cancer, cardiovascular disease, neurodegeneration, and disorders of the musculoskeletal and immune systems. Healthspan is the length of time an individual is in good health and free from chronic diseases and disabilities associated with aging. Two modifiable factors that can influence healthspan, promote healthy aging, and prevent the development of age-related diseases, are diet and microbiota in the gastrointestinal tract (gut microbiota). This review will discuss how dietary phytochemicals and gut microbiota can work in concert to promote a healthy gut and healthy aging. First, an overview is provided of how the gut microbiota influences healthy aging through its impact on gut barrier integrity, immune function, mitochondria function, and oxidative stress. Next, the mechanisms by which phytochemicals effect gut health, inflammation, and nurture a diverse and healthy microbial composition are discussed. Lastly, we discuss how the gut microbiota can directly influence health by producing bioactive metabolites from phytochemicals in food like urolithin A, equol, hesperetin, and sulforaphane. These and other phytochemical-derived microbial metabolites that may promote healthspan are discussed. Importantly, an individual’s capacity to produce health-promoting microbial metabolites from cruciferous vegetables, berries, nuts, citrus, and soy products will be dependent on the specific bacteria present in the individual’s gut.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 3","pages":"Article 100376"},"PeriodicalIF":8.0,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Growth Monitoring and Promotion Accurately Diagnose or Screen for Inadequate Growth of Individual Children? A Critical Review of the Epidemiologic Foundations","authors":"Jef L Leroy ,&nbsp;Rebecca L Brander ,&nbsp;Edward A Frongillo ,&nbsp;Leila M Larson ,&nbsp;Marie T Ruel ,&nbsp;Rasmi Avula","doi":"10.1016/j.advnut.2025.100367","DOIUrl":"10.1016/j.advnut.2025.100367","url":null,"abstract":"<div><div>Growth monitoring and promotion (GMP), the process of periodic anthropometric measurements to assess the adequacy of individual child growth, is implemented across low-income and middle-income countries. The epidemiologic foundations of GMP (i.e., that GMP can accurately diagnose or screen for inadequate growth) have never been critically reviewed. We first assessed growth patterns of individual healthy children. Using longitudinal data from low-income, middle-income, and high-income countries, we evaluated whether commonly used GMP criteria can be used for diagnosis and screening; i.e., whether they accurately identify current, or predict subsequent, inadequate growth in individual children. The growth of individual healthy children does not track along a specific growth curve, which challenges the notion that growth measurements alone can be used to distinguish between healthy and inadequate growth. We demonstrated that GMP criteria do not provide meaningful diagnostic information and that GMP is not a meaningful screening activity: commonly used GMP criteria are inaccurate predictors of (inadequate) growth later in childhood, and collecting individual children’s weight and height does not help to identify who needs support or who will benefit. Our results do not undermine the importance of dedicated programs to diagnose wasting in individual children nor do they challenge the need for well-child care to support parents and to ensure children’s optimal nutrition, health, and development. Our findings, however, highlight the need to carefully reconsider the current design of GMP in low-income and middle-income countries.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 3","pages":"Article 100367"},"PeriodicalIF":8.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Management of Very Sick Patients: Paradigm Changes and Needs for Further Research","authors":"Steven A Abrams ,&nbsp;Jaclyn L Albin","doi":"10.1016/j.advnut.2024.100348","DOIUrl":"10.1016/j.advnut.2024.100348","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 1","pages":"Article 100348"},"PeriodicalIF":8.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Optimization of the Surgical Patient: A Narrative Review","authors":"Olivia Heutlinger ,&nbsp;Nischal Acharya ,&nbsp;Amanda Tedesco ,&nbsp;Ashish Ramesh ,&nbsp;Brian Smith ,&nbsp;Ninh T Nguyen ,&nbsp;Paul E Wischmeyer","doi":"10.1016/j.advnut.2024.100351","DOIUrl":"10.1016/j.advnut.2024.100351","url":null,"abstract":"<div><div>An increasing body of literature supports the clinical benefit of nutritional assessment and optimization in surgical patients; however, this data has yet to be consolidated in a practical fashion for use by surgeons. In this narrative review, we concisely aggregate emerging data to highlight the role of nutritional optimization as a promising, practical perioperative intervention to reduce complications and improve outcomes in surgical patients. This review of the surgical nutrition literature was conducted via large database review. There were no distinct inclusion/exclusion criteria for this review; however, we focused on adult populations using up-to-date literature from high-quality systematic reviews or randomized controlled trials when available. Current perioperative management focuses on the mitigation of intraoperative and immediate postoperative complications. Well-defined risk calculators attempt to stratify patient surgical risk preoperatively to reduce adverse events directly related to surgical procedures, such as hemorrhage, cardiopulmonary compromise, or infection. However, there is a lack of standardization of prognostic tools, nutritional protocols, and guidelines governing the assessment, composition, and administration of nutritional supplementation. Substantial data exist demonstrating the clinical benefit in the operative setting. In this work, we provide a fundamental primer for surgeons to understand the clinical importance of nutritional optimization along with practical prognostic tools and recommendations for use in their practice. While the extent to which nutritional optimization improves patient outcomes is debatable, the evidence clearly demonstrates a clinically meaningful benefit. Evaluating nutritional status differs based on disease severity and etiology of presentation, thus surgeons must select the appropriate prognostic tools to assess their patients during the perioperative period. This information will catalyze subsequent work with a multidisciplinary team to provide personalized dietary plans for patients and spark research to establish protocols for specific presentations.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 1","pages":"Article 100351"},"PeriodicalIF":8.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seafood Toxicant Exposure During Pregnancy, Lactation, and Childhood and Child Outcomes: A Scoping Review","authors":"Rupal Trivedi ,&nbsp;Maureen K Spill ,&nbsp;Sanjoy Saha ,&nbsp;Rachel C Thoerig ,&nbsp;Julie S Davis ,&nbsp;Amanda J MacFarlane","doi":"10.1016/j.advnut.2024.100353","DOIUrl":"10.1016/j.advnut.2024.100353","url":null,"abstract":"<div><div>Determining dietary recommendations for seafood consumed during pregnancy, lactation, and childhood requires consideration of the known nutritional benefits and potential harm due to toxicant exposure as they relate to child outcomes. This study aimed to describe the scope of the evidence associated with seafood-related toxicant exposure and child outcomes and to identify toxicant–outcome pairs that may have sufficient evidence to conduct a systematic review. We included studies examining seafood toxicant exposure during pregnancy, lactation, and childhood, and child outcomes. In total, 81 studies were included: 69 studies on exposure during pregnancy and lactation and 14 on exposure during childhood. The number of studies varied by toxicant and exposure population (maternal; child): mercury (<em>n</em> = 49; 7), methylmercury (<em>n</em> = 13; 3), polychlorinated biphenyls (PCBs; <em>n</em> = 11; 1), selenium (<em>n</em> = 11; 1), lead (<em>n</em> = 9; 3), perfluoroalkyl and polyfluoroalkyl substances (<em>n</em> = 8; 2), dichlorodiphenyltrichloroethane (<em>n</em> = 5; 1), arsenic (<em>n</em> = 4; 4), cadmium (<em>n</em> = 4; 4), zinc (<em>n</em> = 3; 2), polybrominated diphenyl ethers (<em>n</em> = 3; 1), dioxin-like compounds (<em>n</em> = 3; 0), iron (<em>n</em> = 2; 1), and magnesium (<em>n</em> = 1; 1). No studies examined polybrominated biphenyls, polycyclic aromatic hydrocarbons, iodine, aldrin, dieldrin, chlordane, chlorpyrifos, or microplastic exposures. Outcomes also varied by exposure population (maternal;child): neurodevelopment (<em>n</em> = 35; 9), child exposure biomarkers (<em>n</em> = 22; 4), growth (<em>n</em> = 17; 1), other adverse events (<em>n</em> = 4; 0), cardiometabolic (<em>n</em> = 3; 2), chronic disease indicators (<em>n</em> = 2; 0), and immune-related (<em>n</em> = 1; 2). Twelve maternal toxicant–outcome pairs had ≥3 studies, including mercury, methylmercury, lead, PCBs, perfluoroalkyl and polyfluoroalkyl substances, and arsenic as exposures and neurodevelopment, child exposure biomarkers, growth, and cardiometabolic as outcomes. For child exposure, only mercury and neurodevelopment had ≥3 studies. In conclusion, this scoping review shows relevant evidence for 14 of the 22 toxicants. Only 12 maternal and 1 child toxicant–outcome pairs, the majority of which examined maternal (methyl)mercury exposure, had ≥3 studies, our cutoff for consideration for systematic review. This scoping review indicates a paucity of research examining seafood toxicants beyond mercury and exposure during childhood. Systematic reviews are required to evaluate the associations for each toxicant–outcome pairs.</div><div>The protocol was registered at Open Science Framework (<span><span>https://doi.org/10.17605/OSF.IO/FQZTA</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 1","pages":"Article 100353"},"PeriodicalIF":8.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Polyphenols as Potential Therapeutic Agents in Type 2 Diabetes Management: Advances and Opportunities","authors":"Sisir Kumar Barik ,&nbsp;Srabasti Sengupta ,&nbsp;Rakesh Arya ,&nbsp;Surendra Kumar ,&nbsp;Jong Joo Kim ,&nbsp;Reetika Chaurasia","doi":"10.1016/j.advnut.2024.100346","DOIUrl":"10.1016/j.advnut.2024.100346","url":null,"abstract":"<div><div>Poor dietary intake or unhealthy lifestyle contributes to various health disorders, including postprandial hyperglycemia, leading to type 2 diabetes mellitus (T2DM). Reduction of postprandial glucose concentrations through diet is a key strategy for preventing and managing T2DM. Thus, it is essential to understand how dietary components affect glycemic regulation. Dietary polyphenols (DPs), such as anthocyanins and other phenolics found in various fruits and vegetables, are often recommended for their potential health benefits, although their systemic effectiveness is subject to ongoing debate. Therefore, this review assesses the current and historical evidence of DPs bioactivities, which regulate crucial metabolic markers to lower postprandial hyperglycemia. Significant bioactivities such as modulation of glucose transporters, activation of AMP kinase, and regulation of incretins are discussed, along with prospects for diet-induced therapeutics to prevent the onset of T2DM.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"16 1","pages":"Article 100346"},"PeriodicalIF":8.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}