Unraveling Spinal Cord Injury Nutrition: Effects of Diet on the Host and Microbiome

IF 9.2 1区医学 Q1 NUTRITION & DIETETICS

Advances in Nutrition Pub Date : 2025-05-16 DOI:10.1016/j.advnut.2025.100448

ZeHui Li , XiaoXin Wang , HuaYong Du , WuBo Liu , ChunJia Zhang , Zuliyaer Talifu , Xin Xu , Yunzhu Pan , JinMing Zhang , Han Ke , DeGang Yang , Feng Gao , Yan Yu , YingLi Jing , JianJun Li

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引用次数: 0

Abstract

Spinal cord injury (SCI) leads to severe neurological dysfunction with significant nutritional alterations. These alterations are closely associated with gut dysbiosis and neurogenic gut dysfunction after SCI, creating complex interactions that further exacerbate metabolic disturbances and impede neurological recovery. In the context of SCI, diet not only fulfills basic nutritional needs but also serves as an important therapeutic tool to modulate these interactions. This review provides a broad overview of existing research findings, analyzes the impact of existing dietary interventions on SCI, and attempts to clarify the complex relationship between diet and host and gut microbiota. We hope to provide a clear direction for future research and a scientific basis for the development of personalized dietary interventions to improve the nutritional status of patients with SCI, reduce the incidence of complications such as metabolic disorders, and promote the recovery of neurological function and overall quality of life of patients with SCI.

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解开脊髓损伤营养：饮食对宿主和微生物组的影响。

脊髓损伤（SCI）导致严重的神经功能障碍和显著的营养改变。这些改变与脊髓损伤后的肠道生态失调和神经源性肠道功能障碍密切相关，产生复杂的相互作用，进一步加剧代谢紊乱，阻碍神经系统恢复。在脊髓损伤的背景下，饮食不仅满足基本的营养需求，而且作为调节这些相互作用的重要治疗工具。本文综述了现有研究成果，分析了现有饮食干预对脊髓损伤的影响，并试图阐明饮食与宿主和肠道微生物群之间的复杂关系。希望为今后的研究提供明确的方向，为制定个性化的饮食干预措施提供科学依据，以改善SCI患者的营养状况，减少代谢紊乱等并发症的发生，促进SCI患者神经功能的恢复和整体生活质量。意义声明：本综述评估了脊髓损伤患者的营养变化，从宿主和肠道微生物群的角度全面阐明了饮食干预对脊髓损伤患者的影响。通过揭示它们之间复杂的相互作用，它为制定个性化的营养干预策略奠定了基础，以优化恢复并改善未来的长期健康结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Nutrition 医学-营养学

CiteScore

17.40

自引率

2.20%

发文量

117

审稿时长

56 days

期刊介绍： Advances in Nutrition (AN/Adv Nutr) publishes focused reviews on pivotal findings and recent research across all domains relevant to nutritional scientists and biomedical researchers. This encompasses nutrition-related research spanning biochemical, molecular, and genetic studies using experimental animal models, domestic animals, and human subjects. The journal also emphasizes clinical nutrition, epidemiology and public health, and nutrition education. Review articles concentrate on recent progress rather than broad historical developments. In addition to review articles, AN includes Perspectives, Letters to the Editor, and supplements. Supplement proposals require pre-approval by the editor before submission. The journal features reports and position papers from the American Society for Nutrition, summaries of major government and foundation reports, and Nutrient Information briefs providing crucial details about dietary requirements, food sources, deficiencies, and other essential nutrient information. All submissions with scientific content undergo peer review by the Editors or their designees prior to acceptance for publication.