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HLA-G and HLA-E: fundamental and pathophysiological aspects. HLA-G 和 HLA-E：基础和病理生理学方面。
Immunology today Pub Date : 2000-11-01
E D Carosella, P Paul, P Moreau, N Rouas-Freiss
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引用次数: 0
Protein kinase Cθ: a new essential superstar on the T-cell stage 蛋白激酶Cθ: t细胞阶段必不可少的新巨星
Immunology today Pub Date : 2000-11-01 DOI: 10.1016/S0167-5699(00)01749-7
Amnon Altman , Noah Isakov , Gottfried Baier
{"title":"Protein kinase Cθ: a new essential superstar on the T-cell stage","authors":"Amnon Altman ,&nbsp;Noah Isakov ,&nbsp;Gottfried Baier","doi":"10.1016/S0167-5699(00)01749-7","DOIUrl":"10.1016/S0167-5699(00)01749-7","url":null,"abstract":"<div><p>Recent studies have identified protein kinase Cθ (PKCθ), a member of the Ca<sup>2+</sup>-independent PKC family, as an essential component of the T-cell synapse that cooperates with calcineurin to activate the interleukin-2 (IL-2) gene. Several selective functions of PKCθ involved in the activation and survival of T cells are reviewed herein. Among these, the nuclear factor-κB (NF-κB) signaling cascade appears to be the most critical target of PKCθ in the T-cell receptor/CD28 costimulatory pathway that leads to T-cell activation.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 11","pages":"Pages 567-573"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01749-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21918708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 145
Towards a molecular understanding of dendritic cell immunobiology 对树突状细胞免疫生物学的分子理解
Immunology today Pub Date : 2000-11-01 DOI: 10.1016/S0167-5699(00)01736-9
Franca C Hartgers , Carl G Figdor , Gosse J Adema
{"title":"Towards a molecular understanding of dendritic cell immunobiology","authors":"Franca C Hartgers ,&nbsp;Carl G Figdor ,&nbsp;Gosse J Adema","doi":"10.1016/S0167-5699(00)01736-9","DOIUrl":"10.1016/S0167-5699(00)01736-9","url":null,"abstract":"<div><p>Dendritic cells (DCs) are professional antigen presenting cells that play a pivotal role in the control of immunity. The molecules and organization of cellular processes that render DCs so effective in stimulating immune responses are actively pursued. Here, we discuss newly identified DC-associated molecules and their role in regulating the unique behavior and function of the antigen presenting DCs.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 11","pages":"Pages 542-545"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01736-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21920018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 70
Innate immunity: a primitive system in humans 先天免疫:人类的一种原始系统
Immunology today Pub Date : 2000-11-01 DOI: 10.1016/S0167-5699(00)01726-6
Rajneesh Malhotra , Tony Merry , Keith P. Ray
{"title":"Innate immunity: a primitive system in humans","authors":"Rajneesh Malhotra ,&nbsp;Tony Merry ,&nbsp;Keith P. Ray","doi":"10.1016/S0167-5699(00)01726-6","DOIUrl":"10.1016/S0167-5699(00)01726-6","url":null,"abstract":"<div><p>A recent meeting<span><sup>*</sup></span> focused on the biochemical and functional events regulated by innate response molecules such as the complement system and Toll, and their role in regulating the adaptive immune response.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 11","pages":"Pages 534-535"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01726-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86003987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe 淋巴细胞重新排列、编辑和修改它们的抗原受体，使其有用而又安全
Immunology today Pub Date : 2000-11-01 DOI: 10.1016/S0167-5699(00)01734-5
Pamela J. Fink , Catherine J. McMahan
{"title":"Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe","authors":"Pamela J. Fink ,&nbsp;Catherine J. McMahan","doi":"10.1016/S0167-5699(00)01734-5","DOIUrl":"10.1016/S0167-5699(00)01734-5","url":null,"abstract":"<div><p>Pamela Fink and Catherine McMahan discuss how B and T cells test for useful antigen receptors and weed out potentially harmful ones, with special attention paid to T-cell receptor revision, a newly described mechanism by which mature T cells can maintain self tolerance.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 11","pages":"Pages 561-566"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01734-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21918707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 61
Innate immunity creates hope for new strategies in treatment of infections 先天免疫为治疗感染的新策略带来了希望
Immunology today Pub Date : 2000-11-01 DOI: 10.1016/S0167-5699(00)01762-X
Peter Garred
{"title":"Innate immunity creates hope for new strategies in treatment of infections","authors":"Peter Garred","doi":"10.1016/S0167-5699(00)01762-X","DOIUrl":"10.1016/S0167-5699(00)01762-X","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 11","pages":"Page 531"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01762-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21920015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
HLA-G and HLA-E: fundamental and pathophysiological aspects HLA-G和HLA-E:基础和病理生理方面
Immunology today Pub Date : 2000-11-01 DOI: 10.1016/S0167-5699(00)01707-2
Edgardo D. Carosella , Pascale Paul , Philippe Moreau , Nathalie Rouas-Freiss
{"title":"HLA-G and HLA-E: fundamental and pathophysiological aspects","authors":"Edgardo D. Carosella ,&nbsp;Pascale Paul ,&nbsp;Philippe Moreau ,&nbsp;Nathalie Rouas-Freiss","doi":"10.1016/S0167-5699(00)01707-2","DOIUrl":"10.1016/S0167-5699(00)01707-2","url":null,"abstract":"<div><p>The First International Conference on HLA-G, held in 1998, led us to the conclusion that HLA-G is a tolerance molecule from the major histocompatibility complex (MHC) that plays an important role in maternal–fetal tolerance and probably in tumors and transplantation. The Second International Conference on HLA-G<span><sup>*</sup></span> focused on the pathophysiology of HLA-G and was extended to HLA-E and HLA-F.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 11","pages":"Pages 532-534"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01707-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76126612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 110
Hijacking a chaperone: manipulation of the MHC class II presentation pathway 劫持伴侣:MHC II类呈递通路的操纵
Immunology today Pub Date : 2000-11-01 DOI: 10.1016/S0167-5699(00)01717-5
Norbert Koch , Ian R van Driel , Paul A Gleeson
{"title":"Hijacking a chaperone: manipulation of the MHC class II presentation pathway","authors":"Norbert Koch ,&nbsp;Ian R van Driel ,&nbsp;Paul A Gleeson","doi":"10.1016/S0167-5699(00)01717-5","DOIUrl":"10.1016/S0167-5699(00)01717-5","url":null,"abstract":"<div><p>Novel antigen delivery systems are currently being developed by genetic manipulation of the MHC class II trafficking pathway. Specific targeting of endogenously synthesized antigens to the class II loading compartment can result in massively enhanced presentation of peptide epitopes. This emerging technology holds promise for a variety of clinical applications including vaccine development, cancer therapies and control of autoimmune diseases.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 11","pages":"Pages 546-550"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01717-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21918704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Thymocyte differentiation: a new way of thinking 胸腺细胞分化:一种新思路
Immunology today Pub Date : 2000-11-01 DOI: 10.1016/S0167-5699(00)01765-5
William R Heath
{"title":"Thymocyte differentiation: a new way of thinking","authors":"William R Heath","doi":"10.1016/S0167-5699(00)01765-5","DOIUrl":"10.1016/S0167-5699(00)01765-5","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 11","pages":"Page 530"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01765-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21920012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sphingolipids: second messengers, mediators and raft constituents in signaling 鞘脂:信号传导中的第二信使、介质和筏成分
Immunology today Pub Date : 2000-11-01 DOI: 10.1016/S0167-5699(00)01725-4
Eva E Prieschl , Thomas Baumruker
{"title":"Sphingolipids: second messengers, mediators and raft constituents in signaling","authors":"Eva E Prieschl ,&nbsp;Thomas Baumruker","doi":"10.1016/S0167-5699(00)01725-4","DOIUrl":"10.1016/S0167-5699(00)01725-4","url":null,"abstract":"<div><p>Recently, evidence has accumulated to show that sphingolipids exert an important function in signaling. These lipids serve as intracellular second messengers and as extracellular mediators. Furthermore, glycosylated sphingolipids are essential components of membrane rafts, which serve as platforms for the initiation of signaling cascades. Here, Eva Prieschl and Thomas Baumruker summarize current findings in leukocytes illustrating these different facets.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 11","pages":"Pages 555-560"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01725-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21918706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 57
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