发布求助
文献互助 智能选刊 最新文献

Immunology today最新文献

筛选
英文 中文
Monoclonal antibodies and the FACS: complementary tools for immunobiology and medicine 单克隆抗体和FACS:免疫生物学和医学的互补工具
Immunology today Pub Date : 2000-08-01 DOI: 10.1016/S0167-5699(00)01678-9
Leonore A Herzenberg, Stephen C De Rosa, Leonard A Herzenberg
{"title":"Monoclonal antibodies and the FACS: complementary tools for immunobiology and medicine","authors":"Leonore A Herzenberg,&nbsp;Stephen C De Rosa,&nbsp;Leonard A Herzenberg","doi":"10.1016/S0167-5699(00)01678-9","DOIUrl":"10.1016/S0167-5699(00)01678-9","url":null,"abstract":"<div><p>The histories of monoclonal antibodies and the fluorescence activated cell sorter (FACS) are as closely intertwined as their current uses in biology and medicine. Here, Leonore Herzenberg, Stephen De Rosa and Leonard Herzenberg recount the meeting and the mating of these two technologies, whose offspring now populate clinical and research laboratories throughout the world.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 8","pages":"Pages 383-390"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01678-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21756784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 100
Of mice and men: hybridoma and recombinant antibodies 小鼠和人:杂交瘤和重组抗体
Immunology today Pub Date : 2000-08-01 DOI: 10.1016/S0167-5699(00)01668-6
M Little , S.M Kipriyanov , F Le Gall , G Moldenhauer
{"title":"Of mice and men: hybridoma and recombinant antibodies","authors":"M Little ,&nbsp;S.M Kipriyanov ,&nbsp;F Le Gall ,&nbsp;G Moldenhauer","doi":"10.1016/S0167-5699(00)01668-6","DOIUrl":"10.1016/S0167-5699(00)01668-6","url":null,"abstract":"<div><p>Thousands of mouse monoclonal antibodies have been produced from hybridomas over the past 25 years. The same technique can now be used to clone human antibodies from transgenic mice. Full-length antibodies and recombinant fragments engineered for various diagnostic and therapeutic applications can be obtained in reasonably large amounts after expression in mammalian cells, milk and plants.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 8","pages":"Pages 364-370"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01668-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21756781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 176
Antibody humanization: a case of the ‘Emperor’s new clothes’? 抗体人性化:“皇帝的新衣”案例?
Immunology today Pub Date : 2000-08-01 DOI: 10.1016/S0167-5699(00)01680-7
Mike Clark
{"title":"Antibody humanization: a case of the ‘Emperor’s new clothes’?","authors":"Mike Clark","doi":"10.1016/S0167-5699(00)01680-7","DOIUrl":"10.1016/S0167-5699(00)01680-7","url":null,"abstract":"<div><p>The antiglobulin response is perceived as a major problem in the clinical development of therapeutic antibodies. Successive technical developments such as chimeric, humanized and, now, fully human antibodies claim to offer improved solutions to this problem. Although there is clear evidence that chimeric antibodies are less immunogenic than murine monoclonal antibodies, little evidence exists to support claims for further improvements as a result of more elaborate humanization protocols.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 8","pages":"Pages 397-402"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01680-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21756786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 259
A homing selection hypothesis for T-cell trafficking t细胞运输的归巢选择假说
Immunology today Pub Date : 2000-07-01 DOI: 10.1016/S0167-5699(00)01644-3
Miles P. Davenport, Michael C. Grimm, Andrew R. Lloyd
{"title":"A homing selection hypothesis for T-cell trafficking","authors":"Miles P. Davenport,&nbsp;Michael C. Grimm,&nbsp;Andrew R. Lloyd","doi":"10.1016/S0167-5699(00)01644-3","DOIUrl":"10.1016/S0167-5699(00)01644-3","url":null,"abstract":"<div><p>Current theories of T-cell migration are essentially ‘template’ or ‘instructional’ models of lymphocyte homing. However, like antigen specificity, lymphocyte homing may be based on clonal selection from a diverse repertoire of homing specificities.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 7","pages":"Pages 315-317"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01644-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21714381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
The mouse as a model for the effects of MHC genes on human disease 将小鼠作为研究MHC基因对人类疾病影响的模型
Immunology today Pub Date : 2000-07-01 DOI: 10.1016/S0167-5699(00)01654-6
Richard J.N. Allcock , Annalise M. Martin , Patricia Price
{"title":"The mouse as a model for the effects of MHC genes on human disease","authors":"Richard J.N. Allcock ,&nbsp;Annalise M. Martin ,&nbsp;Patricia Price","doi":"10.1016/S0167-5699(00)01654-6","DOIUrl":"10.1016/S0167-5699(00)01654-6","url":null,"abstract":"<div><p>As mice are often used to model human major histocompatibility complex (MHC)-associated diseases, it is important to understand how their MHC regions differ at the DNA level. The sequencing of the mouse MHC (H2 region) has enabled a detailed map of this region to be assembled for comparison with the human MHC. Here, Richard Allcock and colleagues outline the similarities between the human and mouse MHC regions and discuss notable differences that might affect disease models.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 7","pages":"Pages 328-332"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01654-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21714383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 37
Deconstructing the KIR–HLA complex 解构KIR-HLA复合物
Immunology today Pub Date : 2000-07-01 DOI: 10.1016/S0167-5699(00)01684-4
Elaine Bell
{"title":"Deconstructing the KIR–HLA complex","authors":"Elaine Bell","doi":"10.1016/S0167-5699(00)01684-4","DOIUrl":"10.1016/S0167-5699(00)01684-4","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 7","pages":"Page 309"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01684-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84749299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40 t细胞对生发中心的共同刺激和选择:CD28和OX40的作用
Immunology today Pub Date : 2000-07-01 DOI: 10.1016/S0167-5699(00)01636-4
Lucy S.K Walker , Adam Gulbranson-Judge , Sarah Flynn , Thomas Brocker , Peter J.L Lane
{"title":"Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40","authors":"Lucy S.K Walker ,&nbsp;Adam Gulbranson-Judge ,&nbsp;Sarah Flynn ,&nbsp;Thomas Brocker ,&nbsp;Peter J.L Lane","doi":"10.1016/S0167-5699(00)01636-4","DOIUrl":"10.1016/S0167-5699(00)01636-4","url":null,"abstract":"<div><p>Given the importance of responding to infections with the right defensive strategy, much interest has focused on cytokine differentiation in CD4<sup>+</sup> T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4<sup>+</sup> T cells to B-cell follicles.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 7","pages":"Pages 333-337"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01636-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21714385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 108
IFN-α and IFN-β: a link between immune memory and chronic inflammation IFN-α和IFN-β:免疫记忆和慢性炎症之间的联系
Immunology today Pub Date : 2000-07-01 DOI: 10.1016/S0167-5699(00)01652-2
Arne N Akbar , Janet M Lord , Mike Salmon
{"title":"IFN-α and IFN-β: a link between immune memory and chronic inflammation","authors":"Arne N Akbar ,&nbsp;Janet M Lord ,&nbsp;Mike Salmon","doi":"10.1016/S0167-5699(00)01652-2","DOIUrl":"10.1016/S0167-5699(00)01652-2","url":null,"abstract":"<div><p>The majority of expanded T cells generated during an immune response are cleared by apoptosis. Prevention of death in some activated T cells enables the persistence of a memory T-cell pool. Here, observations that IFN-α and IFN-β inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-α or IFN-γ secretion might lead to chronic inflammation.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 7","pages":"Pages 337-342"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01652-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21714912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 147
A conformational change in the Fc precludes the binding of two Fcγ receptor molecules to one IgG Fc的构象变化阻止了两个Fcγ受体分子与一个IgG的结合
Immunology today Pub Date : 2000-07-01 DOI: 10.1016/S0167-5699(00)01666-2
Koichi Kato , Wolf H Fridman , Yoji Arata , Catherine Sautès-Fridman
{"title":"A conformational change in the Fc precludes the binding of two Fcγ receptor molecules to one IgG","authors":"Koichi Kato ,&nbsp;Wolf H Fridman ,&nbsp;Yoji Arata ,&nbsp;Catherine Sautès-Fridman","doi":"10.1016/S0167-5699(00)01666-2","DOIUrl":"10.1016/S0167-5699(00)01666-2","url":null,"abstract":"<div><p>Recent NMR analyses of IgG–FcγR interactions in solution have identified the FcγR-binding site on the Fc region and provided evidence for a conformational change in the Fc occurring during the interaction. Here, Koichi Kato and colleagues discuss how this conformational change explains the incapacity of IgG molecules to trigger responses deleterious to the organism, in the absence of antigen cross-linking.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 7","pages":"Pages 310-312"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01666-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21714379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Interleukin 18: a pleiotropic participant in chronic inflammation 白细胞介素18:慢性炎症的多效性参与者
Immunology today Pub Date : 2000-07-01 DOI: 10.1016/S0167-5699(00)01648-0
Iain B. McInnes, J.Alastair Gracie, Bernard P. Leung, Xiao-Qing Wei, Foo Y. Liew
{"title":"Interleukin 18: a pleiotropic participant in chronic inflammation","authors":"Iain B. McInnes,&nbsp;J.Alastair Gracie,&nbsp;Bernard P. Leung,&nbsp;Xiao-Qing Wei,&nbsp;Foo Y. Liew","doi":"10.1016/S0167-5699(00)01648-0","DOIUrl":"10.1016/S0167-5699(00)01648-0","url":null,"abstract":"<div><p>The wide-ranging effects of interleukin 18 as a regulator of innate and acquired immune responses, and particularly its role in human autoimmune diseases, suggest its potential importance as a therapeutic target.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 7","pages":"Pages 312-315"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01648-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21714380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 199
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信