Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40

Abstract

Given the importance of responding to infections with the right defensive strategy, much interest has focused on cytokine differentiation in CD4⁺ T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4⁺ T cells to B-cell follicles.