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Immunotherapeutic perspective for bispecific antibodies 双特异性抗体的免疫治疗前景
Immunology today Pub Date : 2000-08-01 DOI: 10.1016/S0167-5699(00)01659-5
Annemiek B van Spriel , Heidi H van Ojik , Jan G.J van de Winkel
{"title":"Immunotherapeutic perspective for bispecific antibodies","authors":"Annemiek B van Spriel ,&nbsp;Heidi H van Ojik ,&nbsp;Jan G.J van de Winkel","doi":"10.1016/S0167-5699(00)01659-5","DOIUrl":"10.1016/S0167-5699(00)01659-5","url":null,"abstract":"<div><p>Bispecific antibodies (BsAb) can, by virtue of combining two binding specificities, improve the selectivity and efficacy of antibody-based treatment of human disease. Recent studies underline the importance of both the ‘anti-trigger’ and ‘anti-target’ modalities of BsAb for therapeutic efficacy. Several BsAb induce effective cytotoxicity as well as ‘vaccine effects’ <em>in vivo</em>. Here, Annemiek van Spriel and colleagues discuss how these results have catalysed renewed efforts to translate BsAb concepts into effective therapies.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 8","pages":"Pages 391-397"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01659-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21756785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 88
Recombinant antibodies, by Frank Breitling and Stefan Dübel 重组抗体，作者Frank Breitling和Stefan d<e:1> bel
Immunology today Pub Date : 2000-08-01 DOI: 10.1016/S0167-5699(00)01682-0
Mike Clark
{"title":"Recombinant antibodies, by Frank Breitling and Stefan Dübel","authors":"Mike Clark","doi":"10.1016/S0167-5699(00)01682-0","DOIUrl":"https://doi.org/10.1016/S0167-5699(00)01682-0","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 8","pages":"Page 412"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01682-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91680090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recombinant antibodies, by Frank Breitling and Stefan Dübel 重组抗体，作者Frank Breitling和Stefan d<e:1> bel
Immunology today Pub Date : 2000-08-01 DOI: 10.1016/S0167-5699(00)01682-0
M. Clark
{"title":"Recombinant antibodies, by Frank Breitling and Stefan Dübel","authors":"M. Clark","doi":"10.1016/S0167-5699(00)01682-0","DOIUrl":"https://doi.org/10.1016/S0167-5699(00)01682-0","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"15 1","pages":"412"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90337744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibodies in diagnostics – from immunoassays to protein chips 诊断中的抗体——从免疫测定到蛋白质芯片
Immunology today Pub Date : 2000-08-01 DOI: 10.1016/S0167-5699(00)01683-2
Carl A.K Borrebaeck
{"title":"Antibodies in diagnostics – from immunoassays to protein chips","authors":"Carl A.K Borrebaeck","doi":"10.1016/S0167-5699(00)01683-2","DOIUrl":"10.1016/S0167-5699(00)01683-2","url":null,"abstract":"<div><p>Antibodies are used extensively as diagnostic tools in a wide array of different analyses. Monoclonal and recombinant antibodies provide a never ending source of molecules and can produce endless possibilities for novel genetic constructs. Antibodies are still very much in vogue and are now also being used in microarray analysis of the proteome using protein chips. Here, recent opportunities presented by antibodies as diagnostic tools are reviewed.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 8","pages":"Pages 379-382"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01683-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21756783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 302
Clinical trials of antibody therapy 抗体治疗的临床试验
Immunology today Pub Date : 2000-08-01 DOI: 10.1016/S0167-5699(00)01669-8
Martin J Glennie , Peter W.M Johnson
{"title":"Clinical trials of antibody therapy","authors":"Martin J Glennie ,&nbsp;Peter W.M Johnson","doi":"10.1016/S0167-5699(00)01669-8","DOIUrl":"10.1016/S0167-5699(00)01669-8","url":null,"abstract":"<div><p>Much of the 25 years since Kohler and Milstein first described making monoclonal antibodies (mAbs) has been spent trying to develop these reagents to treat human disease. Until recently, progress has been frustratingly slow and by 1994 only one mAb, anti-CD3 (OKT3), had been licensed for clinical use. In the past five years, however, the situation has changed dramatically, with numerous mAbs now showing clinical potential, and a further seven approved for human treatment. Furthermore, all indications are that this upward trend will continue, with a quarter of all new biological products currently undergoing clinical development being antibody based.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 8","pages":"Pages 403-410"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01669-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21756787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 309
Cross-reactivity and polyreactivity: the two sides of a coin 交叉反应性和多反应性:硬币的两面
Immunology today Pub Date : 2000-08-01 DOI: 10.1016/S0167-5699(00)01679-0
Jean-Pierre Bouvet , Guillaume Dighiero
{"title":"Cross-reactivity and polyreactivity: the two sides of a coin","authors":"Jean-Pierre Bouvet ,&nbsp;Guillaume Dighiero","doi":"10.1016/S0167-5699(00)01679-0","DOIUrl":"10.1016/S0167-5699(00)01679-0","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 8","pages":"Pages 411-412"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01679-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21756788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Hybridoma technology: a view from the patent arena 杂交瘤技术:从专利领域的观点
Immunology today Pub Date : 2000-08-01 DOI: 10.1016/S0167-5699(00)01688-1
Phillip R.J. Ansell
{"title":"Hybridoma technology: a view from the patent arena","authors":"Phillip R.J. Ansell","doi":"10.1016/S0167-5699(00)01688-1","DOIUrl":"10.1016/S0167-5699(00)01688-1","url":null,"abstract":"<div><p>The patenting of biological molecules, such as hybridomas and monoclonal antibodies, has become an important issue in biology. While challenging cherished beliefs and practices of many biologists, it has been a central issue for hybridoma and monoclonal antibody research.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 8","pages":"Pages 357-358"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01688-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21756779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
With the benefit of hindsight 事后看来
Immunology today Pub Date : 2000-08-01 DOI: 10.1016/S0167-5699(00)01660-1
César Milstein
{"title":"With the benefit of hindsight","authors":"César Milstein","doi":"10.1016/S0167-5699(00)01660-1","DOIUrl":"10.1016/S0167-5699(00)01660-1","url":null,"abstract":"<div><p>The development of a method to produce monoclonal antibodies against a defined antigen has had profound impact in many branches of research and signalled a shift in the analysis of biological problems. This article describes the background to these developments and their important practical applications that impinge on the relationship between the world of basic science and commerce.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 8","pages":"Pages 359-364"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01660-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21756780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
The antibody web 抗体网
Immunology today Pub Date : 2000-08-01 DOI: 10.1016/S0167-5699(00)01681-9
Stefan Dübel
{"title":"The antibody web","authors":"Stefan Dübel","doi":"10.1016/S0167-5699(00)01681-9","DOIUrl":"10.1016/S0167-5699(00)01681-9","url":null,"abstract":"<div><p>The internet has evolved to play a central role in the lives of immunologists. Powerful search engines facilitate the location of references or suppliers at the click of a mouse. Specialized websites provide reviews for many immunological topics and links for fast navigation to related information. This article highlights websites related to monoclonal and recombinant antibodies.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 8","pages":"Pages 355-357"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01681-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21756778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Natural and designer binding sites made by phage display technology 噬菌体展示技术制备的天然和设计结合位点
Immunology today Pub Date : 2000-08-01 DOI: 10.1016/S0167-5699(00)01667-4
Hennie R Hoogenboom , Patrick Chames
{"title":"Natural and designer binding sites made by phage display technology","authors":"Hennie R Hoogenboom ,&nbsp;Patrick Chames","doi":"10.1016/S0167-5699(00)01667-4","DOIUrl":"10.1016/S0167-5699(00)01667-4","url":null,"abstract":"<div><p>In the past decade, the drive to develop completely human antibodies for human therapy has led to the development of phage display technology. This technology is able to deliver the ultimate in antibody engineering, that is, high-affinity fully human antibodies to any antigen of choice. Here, this application of phage display technology is reviewed, and the many other antibody-engineering avenues this technology offers are highlighted.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 8","pages":"Pages 371-378"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01667-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21756782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 225
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