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Follicular dendritic cells in TSE pathogenesis 卵泡树突状细胞在TSE发病机制中的作用
Immunology today Pub Date : 2000-09-01 DOI: 10.1016/S0167-5699(00)01696-0
Moira E Bruce , Karen L Brown , Neil A Mabbott , Christine F Farquhar , Martin Jeffrey
{"title":"Follicular dendritic cells in TSE pathogenesis","authors":"Moira E Bruce ,&nbsp;Karen L Brown ,&nbsp;Neil A Mabbott ,&nbsp;Christine F Farquhar ,&nbsp;Martin Jeffrey","doi":"10.1016/S0167-5699(00)01696-0","DOIUrl":"10.1016/S0167-5699(00)01696-0","url":null,"abstract":"<div><p>The pathogenesis of transmissible spongiform encephalopathies (TSEs) often includes a replication phase in lymphoid tissues before infection spreads to the central nervous system. Recent studies show that the follicular dendritic cells of the germinal centres are critical for this replication. These cells are therefore potential targets for therapy or prophylaxis in natural TSEs, such as variant Creutzfeldt-Jakob disease.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 9","pages":"Pages 442-446"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01696-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21789989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 75
Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre 解剖亲和成熟:一个解释生发中心抗体形成细胞和记忆B细胞选择的模型
Immunology today Pub Date : 2000-09-01 DOI: 10.1016/S0167-5699(00)01687-X
David M Tarlinton , Kenneth G.C Smith
{"title":"Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre","authors":"David M Tarlinton ,&nbsp;Kenneth G.C Smith","doi":"10.1016/S0167-5699(00)01687-X","DOIUrl":"10.1016/S0167-5699(00)01687-X","url":null,"abstract":"<div><p>Until recently, the relationship between apoptosis, selection in the germinal centre (GC) and production of high-affinity antibody-forming cells (AFCs) and memory B cells has been unclear. Here, Tarlinton and Smith present a model that accounts for the switch in GC production from high-affinity AFCs to memory B cells, and explain how Bcl-2, an inhibitor of apoptosis, can influence memory cells but not bone marrow AFCs.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 9","pages":"Pages 436-441"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01687-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21789988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 156
Antigen-processing machinery breakdown and tumor growth 抗原处理机制失效和肿瘤生长
Immunology today Pub Date : 2000-09-01 DOI: 10.1016/S0167-5699(00)01692-3
Barbara Seliger , Markus J Maeurer , Soldano Ferrone
{"title":"Antigen-processing machinery breakdown and tumor growth","authors":"Barbara Seliger ,&nbsp;Markus J Maeurer ,&nbsp;Soldano Ferrone","doi":"10.1016/S0167-5699(00)01692-3","DOIUrl":"10.1016/S0167-5699(00)01692-3","url":null,"abstract":"<div><p>Defects in the major histocompatibility complex (MHC) class I antigen-processing machinery (APM) have been described in tumors of different histology. Murine data suggest that defects in the MHC class II APM might also be associated with malignant transformation of human cells. This article describes the pathophysiology of the MHC class I and II APM, reviews APM abnormalities in tumor cells and discusses their role in the escape of tumor cells from <em>in vitro</em> recognition by T cells.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 9","pages":"Pages 455-464"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01692-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21789991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 485
The choreography of signaling at the plasma membrane 质膜上信号的编排
Immunology today Pub Date : 2000-09-01 DOI: 10.1016/S0167-5699(00)01702-3
Yoji Shimizu
{"title":"The choreography of signaling at the plasma membrane","authors":"Yoji Shimizu","doi":"10.1016/S0167-5699(00)01702-3","DOIUrl":"10.1016/S0167-5699(00)01702-3","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 9","pages":"Page 413"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01702-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81420664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dendritic cells: multi-lineal and multi-functional 树突状细胞:多线状和多功能
Immunology today Pub Date : 2000-09-01 DOI: 10.1016/S0167-5699(00)01694-7
Stephan Grabbe , Eckhart Kämpgen , Gerold Schuler
{"title":"Dendritic cells: multi-lineal and multi-functional","authors":"Stephan Grabbe ,&nbsp;Eckhart Kämpgen ,&nbsp;Gerold Schuler","doi":"10.1016/S0167-5699(00)01694-7","DOIUrl":"10.1016/S0167-5699(00)01694-7","url":null,"abstract":"<div><p>Evidence presented at a recent conference<span>*</span> indicated that dendritic cells should be regarded as a multi-lineage system of leukocytes with variable function rather than a homogenous cell type with predetermined functional properties.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 9","pages":"Pages 431-433"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01694-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21843980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 131
Human NK-cell receptors 人类nk细胞受体
Immunology today Pub Date : 2000-09-01 DOI: 10.1016/S0167-5699(00)01673-X
Lorenzo Moretta , Roberto Biassoni , Cristina Bottino , Maria C Mingari , Alessandro Moretta
{"title":"Human NK-cell receptors","authors":"Lorenzo Moretta ,&nbsp;Roberto Biassoni ,&nbsp;Cristina Bottino ,&nbsp;Maria C Mingari ,&nbsp;Alessandro Moretta","doi":"10.1016/S0167-5699(00)01673-X","DOIUrl":"10.1016/S0167-5699(00)01673-X","url":null,"abstract":"<div><p>Natural killer (NK) cells have often been regarded as somewhat ‘primitive’ and ‘nonspecific’; however, new data have revealed an unexpected complexity and a sophisticated capability of detecting potentially dangerous cells.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 9","pages":"Pages 420-422"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01673-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21789984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 196
Immunity 2000 2000年的免疫力
Immunology today Pub Date : 2000-09-01 DOI: 10.1016/S0167-5699(00)01671-6
Rolf M Zinkernagel
{"title":"Immunity 2000","authors":"Rolf M Zinkernagel","doi":"10.1016/S0167-5699(00)01671-6","DOIUrl":"10.1016/S0167-5699(00)01671-6","url":null,"abstract":"<div><p>This short article highlights the principal elements of a lecture that will be delivered by Rolf M. Zinkernagel at EFIS 2000 in Poland.</p><p>An improved understanding of cell biology, genetics, and molecular and developmental biology, together with an appreciation of the fact that immunity is the result of coevolution, are leading to a better understanding of the rules and exceptions of immunity.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 9","pages":"Pages 422-423"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01671-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21789985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Viral mechanisms of immune evasion 免疫逃避的病毒机制
Immunology today Pub Date : 2000-09-01 DOI: 10.1016/S0167-5699(00)01699-6
Antonio Alcami , Ulrich H. Koszinowski
{"title":"Viral mechanisms of immune evasion","authors":"Antonio Alcami ,&nbsp;Ulrich H. Koszinowski","doi":"10.1016/S0167-5699(00)01699-6","DOIUrl":"10.1016/S0167-5699(00)01699-6","url":null,"abstract":"<div><p>During the millions of years they have coexisted with their hosts, viruses have learned how to manipulate host immune control mechanisms. Viral gene functions provide an overview of many relevant principles in cell biology and immunology. Our knowledge of viral gene functions must be integrated into virus–host interaction networks to understand viral pathogenesis, and could lead to new anti-viral strategies and the ability to exploit viral functions as tools in medicine.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 9","pages":"Pages 447-455"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01699-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21789990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 572
The biology of recognitive repertoires 识别谱的生物学
Immunology today Pub Date : 2000-09-01 DOI: 10.1016/S0167-5699(00)01677-7
Melvin Cohn (regular visiting fellow at the Gulbenkian Science Institute, Oeiras, Portugal.)
{"title":"The biology of recognitive repertoires","authors":"Melvin Cohn (regular visiting fellow at the Gulbenkian Science Institute, Oeiras, Portugal.)","doi":"10.1016/S0167-5699(00)01677-7","DOIUrl":"10.1016/S0167-5699(00)01677-7","url":null,"abstract":"<div><p>By examining immunoglobulin (Ig) and T-cell receptor (TCR) gene loci and their rearrangement patterns in many species, and by imposing evolutionary principles, we can determine fundamentals regarding the behavior and properties of recognitive repertoires. A recent meeting<span>*</span> addressed the opposing selection pressures that determine the size of the repertoire, the characterization of specificity and the rules for effector function.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 9","pages":"Pages 433-435"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01677-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21843981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Secondary lymphoid tissues – not so secondary after all 继发性淋巴组织,毕竟不是继发性的
Immunology today Pub Date : 2000-09-01 DOI: 10.1016/S0167-5699(00)01704-7
Matthias Gunzer, Stephan Grabbe
{"title":"Secondary lymphoid tissues – not so secondary after all","authors":"Matthias Gunzer,&nbsp;Stephan Grabbe","doi":"10.1016/S0167-5699(00)01704-7","DOIUrl":"10.1016/S0167-5699(00)01704-7","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 9","pages":"Page 414"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01704-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89615017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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