HLA-G and HLA-E: fundamental and pathophysiological aspects

Abstract

The First International Conference on HLA-G, held in 1998, led us to the conclusion that HLA-G is a tolerance molecule from the major histocompatibility complex (MHC) that plays an important role in maternal–fetal tolerance and probably in tumors and transplantation. The Second International Conference on HLA-G^* focused on the pathophysiology of HLA-G and was extended to HLA-E and HLA-F.