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Stress-free T-cell development: glucocorticoids are not obligatory 无压力t细胞发育:糖皮质激素不是必须的
Immunology today Pub Date : 2000-12-01 DOI: 10.1016/S0167-5699(00)01741-2
Dale I Godfrey , Jared F Purton , Richard L Boyd , Timothy J Cole
{"title":"Stress-free T-cell development: glucocorticoids are not obligatory","authors":"Dale I Godfrey ,&nbsp;Jared F Purton ,&nbsp;Richard L Boyd ,&nbsp;Timothy J Cole","doi":"10.1016/S0167-5699(00)01741-2","DOIUrl":"10.1016/S0167-5699(00)01741-2","url":null,"abstract":"<div><p>A role for glucocorticoids in thymopoiesis has been suggested by studies using glucocorticoid receptor (GR) anti-sense transgenic mice, glucocorticoid synthesis inhibitors and GR antagonists. Unfortunately, no consensus has been reached on exactly how glucocorticoids influence T-cell development. The most recent approach, using GR knockout (GR<sup>−/−</sup>) mice, indicates that GR signaling is, in fact, dispensable in this entire process.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 12","pages":"Pages 606-611"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01741-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21937345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 54
Into the third century of complement research 进入了补体研究的第三个世纪
Immunology today Pub Date : 2000-12-01 DOI: 10.1016/S0167-5699(00)01742-4
B. Paul Morgan , Moh Daha , Seppo Meri , Anne Nicholson-Weller
{"title":"Into the third century of complement research","authors":"B. Paul Morgan ,&nbsp;Moh Daha ,&nbsp;Seppo Meri ,&nbsp;Anne Nicholson-Weller","doi":"10.1016/S0167-5699(00)01742-4","DOIUrl":"10.1016/S0167-5699(00)01742-4","url":null,"abstract":"<div><p>The complement system is established as a major homeostatic system and a factor in diverse pathologies. Some 500 delegates attended a recent meeting<span><sup>1</sup></span> to discuss the latest findings in complement research, ranging from studies in sea squirts through to therapeutic trials of inhibitors. Here, we review some of the key topics discussed at the workshop.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 12","pages":"Pages 603-605"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01742-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86031663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Reply to Ashwell, Vacchio and Galon 回复阿什维尔，瓦奇奥和盖伦
Immunology today Pub Date : 2000-12-01 DOI: 10.1016/S0167-5699(00)01757-6
Dale I Godfrey
{"title":"Reply to Ashwell, Vacchio and Galon","authors":"Dale I Godfrey","doi":"10.1016/S0167-5699(00)01757-6","DOIUrl":"10.1016/S0167-5699(00)01757-6","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 12","pages":"Pages 645-646"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01757-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79192500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Do glucocorticoids participate in thymocyte development? 糖皮质激素参与胸腺细胞发育吗?
Immunology today Pub Date : 2000-12-01 DOI: 10.1016/S0167-5699(00)01758-8
Jonathan D Ashwell , Melanie S Vacchio , Jérôme Galon
{"title":"Do glucocorticoids participate in thymocyte development?","authors":"Jonathan D Ashwell ,&nbsp;Melanie S Vacchio ,&nbsp;Jérôme Galon","doi":"10.1016/S0167-5699(00)01758-8","DOIUrl":"10.1016/S0167-5699(00)01758-8","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 12","pages":"Pages 644-645"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01758-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84405572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 37
Sticky moments with sticky molecules 粘性矩和粘性分子
Immunology today Pub Date : 2000-12-01 DOI: 10.1016/S0167-5699(00)01752-7
Christopher D. Buckley , David L. Simmons
{"title":"Sticky moments with sticky molecules","authors":"Christopher D. Buckley ,&nbsp;David L. Simmons","doi":"10.1016/S0167-5699(00)01752-7","DOIUrl":"10.1016/S0167-5699(00)01752-7","url":null,"abstract":"<div><p>A recent meeting<span><sup>*</sup></span> illustrated the extensive cross-talk that exists between adhesion receptors, G-protein-coupled chemokine receptors, growth factor receptors and cell surface proteinases.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 12","pages":"Pages 601-603"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01752-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72660269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
A natural history of melanoma: serial gene expression analysis 黑色素瘤的自然史:序列基因表达分析
Immunology today Pub Date : 2000-12-01 DOI: 10.1016/S0167-5699(00)01724-2
Ena Wang, Francesco M. Marincola
{"title":"A natural history of melanoma: serial gene expression analysis","authors":"Ena Wang,&nbsp;Francesco M. Marincola","doi":"10.1016/S0167-5699(00)01724-2","DOIUrl":"10.1016/S0167-5699(00)01724-2","url":null,"abstract":"<div><p>Ena Wang and Francesco Marincola propose a novel strategy whereby tumor–host interactions are studied within the melanoma microenvironment by serial gene expression analysis. Methodological constraints and ways to circumvent them are discussed. This approach might improve our understanding of the molecular basis of tumor regression in response to immune manipulation.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 12","pages":"Pages 619-623"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01724-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21937348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 68
Branching out to gain control: how the pre-TCR is linked to multiple functions 扩展以获得控制权:tcr前如何与多个功能相关联
Immunology today Pub Date : 2000-12-01 DOI: 10.1016/S0167-5699(00)01744-8
Ada M Kruisbeek , Mariëlle C Haks , Michael Carleton , David L Wiest , Alison M Michie , Juan Carlos Zúñiga-Pflücker
{"title":"Branching out to gain control: how the pre-TCR is linked to multiple functions","authors":"Ada M Kruisbeek ,&nbsp;Mariëlle C Haks ,&nbsp;Michael Carleton ,&nbsp;David L Wiest ,&nbsp;Alison M Michie ,&nbsp;Juan Carlos Zúñiga-Pflücker","doi":"10.1016/S0167-5699(00)01744-8","DOIUrl":"10.1016/S0167-5699(00)01744-8","url":null,"abstract":"<div><p>How is signaling specificity achieved by the pre-TCR during selection of T-cell fate? Like the TCR, this receptor controls many functions, and recent studies define which pathways couple the pre-TCR to the molecular events controlling survival, proliferation, allelic exclusion at the TCRβ locus, and further differentiation.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 12","pages":"Pages 637-644"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01744-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21937351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 142
Natural antibodies and complement link innate and acquired immunity 天然抗体和补体连接先天免疫和获得性免疫
Immunology today Pub Date : 2000-12-01 DOI: 10.1016/S0167-5699(00)01754-0
Adrian F Ochsenbein, Rolf M Zinkernagel
{"title":"Natural antibodies and complement link innate and acquired immunity","authors":"Adrian F Ochsenbein,&nbsp;Rolf M Zinkernagel","doi":"10.1016/S0167-5699(00)01754-0","DOIUrl":"10.1016/S0167-5699(00)01754-0","url":null,"abstract":"<div><p>Natural or spontaneous antibodies are an essential part of the first line of defense against hematogenically spreading infections, including viruses. These antibodies target virus–antibody complexes and complement to the spleen. This prevents infections from reaching vital organs and enhances neutralizing antibody responses, particularly when the antibody is bound to a highly repetitive antigen.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 12","pages":"Pages 624-630"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01754-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21937349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 544
Lymphocytes with a complex: adapter proteins in antigen receptor signaling 淋巴细胞与复合物:抗原受体信号转导中的适配蛋白
Immunology today Pub Date : 2000-11-01 DOI: 10.1016/S0167-5699(00)01716-3
Michael G. Tomlinson , Joseph Lin , Arthur Weiss
{"title":"Lymphocytes with a complex: adapter proteins in antigen receptor signaling","authors":"Michael G. Tomlinson ,&nbsp;Joseph Lin ,&nbsp;Arthur Weiss","doi":"10.1016/S0167-5699(00)01716-3","DOIUrl":"10.1016/S0167-5699(00)01716-3","url":null,"abstract":"<div><p>Adapters can be defined as proteins that mediate intermolecular interactions within a signal transduction pathway and that lack both intrinsic enzymatic and transcriptional activity. Their essential role in lymphocyte signaling was revealed by recent analyses of mice and cell lines deficient in LAT, SLP-76 and BLNK. These and other adapters nucleate signaling complexes and facilitate coupling of antigen receptor triggering to functional responses in lymphocytes.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 11","pages":"Pages 584-591"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01716-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21918710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 136
Developmentally regulated TCR efficiency 发展调节TCR效率
Immunology today Pub Date : 2000-11-01 DOI: 10.1016/S0167-5699(00)01766-7
Martin Bachmann
{"title":"Developmentally regulated TCR efficiency","authors":"Martin Bachmann","doi":"10.1016/S0167-5699(00)01766-7","DOIUrl":"10.1016/S0167-5699(00)01766-7","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 11","pages":"Page 529"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01766-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21920009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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