{"title":"黑色素瘤的自然史:序列基因表达分析","authors":"Ena Wang, Francesco M. Marincola","doi":"10.1016/S0167-5699(00)01724-2","DOIUrl":null,"url":null,"abstract":"<div><p>Ena Wang and Francesco Marincola propose a novel strategy whereby tumor–host interactions are studied within the melanoma microenvironment by serial gene expression analysis. Methodological constraints and ways to circumvent them are discussed. This approach might improve our understanding of the molecular basis of tumor regression in response to immune manipulation.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 12","pages":"Pages 619-623"},"PeriodicalIF":0.0000,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01724-2","citationCount":"68","resultStr":"{\"title\":\"A natural history of melanoma: serial gene expression analysis\",\"authors\":\"Ena Wang, Francesco M. Marincola\",\"doi\":\"10.1016/S0167-5699(00)01724-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Ena Wang and Francesco Marincola propose a novel strategy whereby tumor–host interactions are studied within the melanoma microenvironment by serial gene expression analysis. Methodological constraints and ways to circumvent them are discussed. This approach might improve our understanding of the molecular basis of tumor regression in response to immune manipulation.</p></div>\",\"PeriodicalId\":73346,\"journal\":{\"name\":\"Immunology today\",\"volume\":\"21 12\",\"pages\":\"Pages 619-623\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01724-2\",\"citationCount\":\"68\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunology today\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0167569900017242\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunology today","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167569900017242","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 68
摘要
Ena Wang和Francesco Marincola提出了一种新的策略，即通过序列基因表达分析在黑色素瘤微环境中研究肿瘤-宿主相互作用。讨论了方法上的限制和规避这些限制的方法。这种方法可能会提高我们对免疫操作下肿瘤消退的分子基础的理解。
A natural history of melanoma: serial gene expression analysis
Ena Wang and Francesco Marincola propose a novel strategy whereby tumor–host interactions are studied within the melanoma microenvironment by serial gene expression analysis. Methodological constraints and ways to circumvent them are discussed. This approach might improve our understanding of the molecular basis of tumor regression in response to immune manipulation.
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