扩展以获得控制权:tcr前如何与多个功能相关联

Immunology today Pub Date : 2000-12-01 DOI:10.1016/S0167-5699(00)01744-8

Ada M Kruisbeek , Mariëlle C Haks , Michael Carleton , David L Wiest , Alison M Michie , Juan Carlos Zúñiga-Pflücker

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引用次数: 142

摘要

在选择t细胞命运的过程中，tcr是如何实现信号特异性的?与TCR一样，这种受体控制着许多功能，最近的研究确定了哪些途径将TCR前受体与控制存活、增殖、TCRβ位点等位基因排斥和进一步分化的分子事件相结合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Branching out to gain control: how the pre-TCR is linked to multiple functions

How is signaling specificity achieved by the pre-TCR during selection of T-cell fate? Like the TCR, this receptor controls many functions, and recent studies define which pathways couple the pre-TCR to the molecular events controlling survival, proliferation, allelic exclusion at the TCRβ locus, and further differentiation.

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来源期刊

Immunology today

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