Hygiene and environmental health advances最新文献

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Sex toys for pleasure, but there are risks: In silico toxicity studies of leached Micro/Nanoplastics and phthalates 性玩具能带来快乐,但也存在风险:浸出微/纳米塑料和邻苯二甲酸盐的硅学毒性研究
Hygiene and environmental health advances Pub Date : 2024-04-11 DOI: 10.1016/j.heha.2024.100092
Christian Ebere Enyoh, Qingyue Wang
{"title":"Sex toys for pleasure, but there are risks: In silico toxicity studies of leached Micro/Nanoplastics and phthalates","authors":"Christian Ebere Enyoh,&nbsp;Qingyue Wang","doi":"10.1016/j.heha.2024.100092","DOIUrl":"https://doi.org/10.1016/j.heha.2024.100092","url":null,"abstract":"<div><p>The widespread use of sex toys has sparked concerns about potential health risks associated with the leaching of micro/nanoplastics (M/NPs) and phthalates. In this <em>in silico</em> toxicity analysis, we investigated the immunotoxicity potential of compounds mechanically produced from sex toys. The research focuses on understanding their interactions with critical human cytochrome P450 enzymes (CYP34A and CYP2D6), which are central to drug metabolism and immune function. Four types of M/NPs (polyethylene terephthalate - PET, polyvinyl chloride - PVC, polydimethylsiloxane - PDMS, polyisoprene) and eight phthalates (Diethyl phthalate - DEP, Bis(4-methyl-2-pentyl) phthalate, Bis(2-methoxyethyl) phthalate, Benzyl butyl phthalate - BBP, Dibutyl Phthalate - DBP, Diethylhexyl phthalate - DEHP, Dinonyl phthalate - DNP, Di-n-octyl phthalate - DnOP) from sex toys were analyzed. Molecular dynamics and docking simulations were conducted to assess the binding affinity of these compounds to the enzymes. PET exhibited the highest toxicity, with a binding affinity of -8.3 kcal/mol and -8.9 kcal/mol for CYP3A4 and CYP2D6, respectively, surpassing control values (-7.8 kcal/mol and -6.3 kcal/mol). BBP showed considerable toxicity, binding strongly to CYP3A4 (-7.8 kcal/mol) and CYP2D6 (-9.1 kcal/mol). PDMS and DEP were the lowest toxic compounds in both groups. Molecular interactions revealed hydrogen bonds, pi interactions, and unfavorable donor-donor effects between compounds and specific amino acid residues within the enzymes. While these <em>in silico</em> findings provide insights, they underscore the need for comprehensive chemical analyses and absorption studies to validate health risks. This research emphasizes the necessity of evaluating the toxicity of M/NPs and phthalates from sex toys, promoting further investigations to protect individuals' health during product use.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"10 ","pages":"Article 100092"},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000059/pdfft?md5=a2252bdaaf9513a516dfe261d09dc81e&pid=1-s2.0-S2773049224000059-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise attenuates the association between pyrethroid exposure and sleep disorders in male adults 运动可减轻男性成年人接触拟除虫菊酯与睡眠障碍之间的关系
Hygiene and environmental health advances Pub Date : 2024-04-10 DOI: 10.1016/j.heha.2024.100091
Jing Shao , Jing Yang , Jia Lv , Tao Wang , Huiru Chen , Xinyu Zhang , Jingjing Li , Min Wang , Lihua Xu , Yichao Huang , Xiuhong Meng
{"title":"Exercise attenuates the association between pyrethroid exposure and sleep disorders in male adults","authors":"Jing Shao ,&nbsp;Jing Yang ,&nbsp;Jia Lv ,&nbsp;Tao Wang ,&nbsp;Huiru Chen ,&nbsp;Xinyu Zhang ,&nbsp;Jingjing Li ,&nbsp;Min Wang ,&nbsp;Lihua Xu ,&nbsp;Yichao Huang ,&nbsp;Xiuhong Meng","doi":"10.1016/j.heha.2024.100091","DOIUrl":"https://doi.org/10.1016/j.heha.2024.100091","url":null,"abstract":"<div><h3>Background</h3><p>Pyrethroids are widely used in agriculture and household pest management as one of the top three insecticides globally, yet the neurobehavioral impacts of human exposure to these chemicals have attracted increasing concern.</p></div><div><h3>Objective</h3><p>The purpose of this study was to examine the associations between pyrethroid exposure and sleep disorders and whether exercise could attenuate these associations.</p></div><div><h3>Methods</h3><p>We analyzed cross-sectional data from the 2007-2014 National Health and Nutrition Examination Survey to study the association between pyrethroid pesticide exposure and sleep disorders. The exposure level of pyrethroid metabolites in urine samples was measured. Physician diagnosis of sleep disorders was used to determine sleep disorders. Exercise level was judged by self-reported physical activity from the interviews.</p></div><div><h3>Results</h3><p>Of the 5947 participants, sleep disorders had a weighted prevalence of 9.0 %, representing an approximation of 186,140,757 patients nationwide. We found a sex-specific association between high levels of 3-PBA and elevated risk of sleep disorders diagnosis in men (OR: 1.87; 95 % CI: 1.150–3.042; <em>P</em> = 0.01). In addition, less physical activity was associated with higher rates of sleep disorders as pyrethroid exposure levels increased (OR: 1.98; 95 % CI: 1.152–3.388; <em>P</em> = 0.02).</p></div><div><h3>Conclusion</h3><p>This study further confirmed that pyrethroid exposure is associated with an elevated risk of sleep disorders in men. More importantly, we reported for the first time that vigorous physical activity attenuates the correlation between pyrethroid exposure and sleep disorders.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"10 ","pages":"Article 100091"},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000047/pdfft?md5=ca407c61ebfb2d5f28868cc8f2ac11d2&pid=1-s2.0-S2773049224000047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood lead levels in the general population and vulnerable sub-populations and related risk factors for lead exposure in Canada 加拿大普通人群和弱势亚人群的血铅水平以及铅暴露的相关风险因素
Hygiene and environmental health advances Pub Date : 2024-02-01 DOI: 10.1016/j.heha.2024.100088
Kathy C. Nguyen , Subramanian Karthikeyan , Ellen J.D. Lye , Huda Masoud , Janine Clarke , Julie L. Yome , Djordje Vladisavljevic , Laurie H.M. Chan , Annie St-Amand
{"title":"Blood lead levels in the general population and vulnerable sub-populations and related risk factors for lead exposure in Canada","authors":"Kathy C. Nguyen ,&nbsp;Subramanian Karthikeyan ,&nbsp;Ellen J.D. Lye ,&nbsp;Huda Masoud ,&nbsp;Janine Clarke ,&nbsp;Julie L. Yome ,&nbsp;Djordje Vladisavljevic ,&nbsp;Laurie H.M. Chan ,&nbsp;Annie St-Amand","doi":"10.1016/j.heha.2024.100088","DOIUrl":"10.1016/j.heha.2024.100088","url":null,"abstract":"<div><p>Lead is an environmental contaminant that is considered a major public health concern due to its effects on various body systems, such as the neurological, cardiovascular, immune and renal systems. Scientific evidence indicates that health effects occur in people at blood lead levels (BLLs) lower than those previously established as levels of concern; no safe level of lead exposure has been established. Lead has been monitored as part of various national and international biomonitoring programs. The aims of this study were: (1) to examine BLLs in the Canadian general population and vulnerable sub-populations between 2007 and 2013 using data from the Canadian Health Measures Survey (CHMS); and (2) to assess factors that are associated with elevated BLLs in these populations. BLLs in Canadians were in a decreasing trend over the study period. BLLs in Canadians varied by age and sex. Those aged 60 to 79 years had the highest BLLs, while the 12 to 19 years age group had the lowest BLLs. Males exhibited significantly higher BLLs than females. In young children aged 3 to 5 years, 99.9 % had BLLs below 5 µg/dL (blood lead reference level for children). BLLs in pregnant women were lower than those in non-pregnant women in the same age range. Multivariable regression analysis suggested that factors such as immigration status, household income, educational level, age of dwelling, smoking status, second-hand smoke exposure, alcohol consumption, and fish and shellfish consumption, were significantly associated with BLLs. This study presents the first robust analysis of BLLs in the Canadian vulnerable populations and assessment of factors associated with elevated BLLs. This information may be useful to identify population subgroups who are differentially exposed to lead based on various exposure factors and are at risk for lead exposure in Canada.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100088"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000011/pdfft?md5=ca6f5b9ed2a6d123df5ddc569e174d5a&pid=1-s2.0-S2773049224000011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139684797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wipe sampling of antineoplastic drugs from workplace surfaces: A review of analytical methods and recommendations 对工作场所表面的抗肿瘤药物进行擦拭取样:分析方法和建议综述
Hygiene and environmental health advances Pub Date : 2024-02-01 DOI: 10.1016/j.heha.2024.100089
Melissa L. Vermette , Mason R. Hicks , Keyvan Khoroush , Mark Y. Teo , Byron D. Gates
{"title":"Wipe sampling of antineoplastic drugs from workplace surfaces: A review of analytical methods and recommendations","authors":"Melissa L. Vermette ,&nbsp;Mason R. Hicks ,&nbsp;Keyvan Khoroush ,&nbsp;Mark Y. Teo ,&nbsp;Byron D. Gates","doi":"10.1016/j.heha.2024.100089","DOIUrl":"https://doi.org/10.1016/j.heha.2024.100089","url":null,"abstract":"<div><p>Antineoplastic drugs (ADs) are primarily used to manage cancer and are becoming more prevalent as cancer cases increase globally. A primary route of exposure for workers administering these hazardous drugs is <em>via</em> dermal absorption from contact with contaminated surfaces. To assess the risk in a workplace, wipe sampling is used to inspect and assess suspect workplace surfaces (i.e., as a form of worker exposure and environmental monitoring). Despite widespread use of ADs, there are no standards or proficiency testing programs (at this time) for surface wipe sampling protocols specifically for residues that contain ADs. Current literature provides many different analytical methods developed by research groups for detecting one or more ADs in residue found in the workplace. These studies contain significant variability in the techniques and materials used and, therefore, also vary in their outcomes. This review highlights the variability observed in the results obtained from current methods and points to opportunities that might assist in addressing these inconsistencies towards preparing standard methodologies for wipe sampling of ADs. This review also discusses critical factors to consider when optimizing the steps performed for surface wipe sampling. The inter-dependent steps discussed in this review for surface wipe sampling are: (i) adsorption of analyte onto a wipe; (ii) desorption of the analyte from the wipe; and (iii) detection of the sampled analyte. The first two steps require optimization of both chemical and physical factors to create a successful sampling method. The detection step has largely been optimized due in part to the sensitivity of analytical instrumentation, but there remain opportunities to develop more effective methodologies for timely feedback and an increased sensitivity to platinum-based ADs. This review also provides additional recommendations to improve reporting of results from the wipe sampling of ADs and highlights the need for additional research on the occupational and surface exposure limits for ADs.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100089"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000023/pdfft?md5=04c1448545d432d4e198c003ded2eb39&pid=1-s2.0-S2773049224000023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139743771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital anomalies in Baghdad children born near US military burn-pits: A case-control study showing tungsten and chromium association with increased odds of disease 在美军烧伤坑附近出生的巴格达儿童先天畸形:病例对照研究显示钨和铬与患病几率增加有关
Hygiene and environmental health advances Pub Date : 2024-02-01 DOI: 10.1016/j.heha.2024.100090
M. Savabieasfahani , F.Basher Ahamadani , Ban Talib Fadhel
{"title":"Congenital anomalies in Baghdad children born near US military burn-pits: A case-control study showing tungsten and chromium association with increased odds of disease","authors":"M. Savabieasfahani ,&nbsp;F.Basher Ahamadani ,&nbsp;Ban Talib Fadhel","doi":"10.1016/j.heha.2024.100090","DOIUrl":"https://doi.org/10.1016/j.heha.2024.100090","url":null,"abstract":"<div><p>Increases in congenital anomalies were reported from Iraq post-2003. We investigated associations of residential proximity to two US military bases – Camp Victory and Base Falcon – and metal levels in hair samples of children with congenital anomalies (22 cases and 9 controls). We developed mixed effects logistic regression models with village as the random effect, congenital anomalies as the outcome and distance to the closest US base and hair metal levels (one at a time) as the exposure, controlling for child's age, sex, and paternal education. We explored the mediation of the association between proximity to the base and congenital anomalies by hair metal levels. Children with higher tungsten (W) in hair had marginally higher odds of congenital anomalies (OR=1.32, 95 %CI = (1.01,2.02), <em>P</em>=.10). One µg/kg increase in W was associated with 41 % higher odds of a congenital abnormality (95 %CI=(1.08,2.33), <em>P</em>=.04). But proximity to military bases didn't have any effect on congenital anomalies. Higher hair chromium (Cr) marginally increased the odds of congenital anomalies (OR=1.02, 95 %CI=(1.00,.05), <em>P</em>=.09). Children with one µg/kg higher concentration of Cr in hair had 3 % higher odds of having congenital anomalies (95 %CI=(1.01,1.07), <em>P</em>=.04). Analyses were conducted by Inductively Coupled Plasma Mass Spectrometry.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100090"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000035/pdfft?md5=c04a701ff6d76ddc9009ace6400e739b&pid=1-s2.0-S2773049224000035-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139700287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Volatile organic compounds (VOCs) in residential indoor air during interior finish period: Sources, variations, and health risks 室内装修期间住宅室内空气中的挥发性有机化合物 (VOC):来源、变化和健康风险
Hygiene and environmental health advances Pub Date : 2023-12-08 DOI: 10.1016/j.heha.2023.100087
Jin-Long Mai , Wei-Wei Yang , Yuan Zeng , Yu-Feng Guan , She-Jun Chen
{"title":"Volatile organic compounds (VOCs) in residential indoor air during interior finish period: Sources, variations, and health risks","authors":"Jin-Long Mai ,&nbsp;Wei-Wei Yang ,&nbsp;Yuan Zeng ,&nbsp;Yu-Feng Guan ,&nbsp;She-Jun Chen","doi":"10.1016/j.heha.2023.100087","DOIUrl":"10.1016/j.heha.2023.100087","url":null,"abstract":"<div><p>Building and furniture materials are significant sources of volatile organic compounds (VOCs) and determine their long-time indoor levels. However, the variations of indoor VOCs and associated health risks of interior finishers during the construction stages are poorly understood. In this study, VOCs in the indoor microenvironments were measured at different interior finishing stages at two renovated residences using thermal desorption and gas chromatography-mass spectrometry. The mean concentrations of the Σ15 VOCs were 118.2 μg/m<sup>3</sup> in Home A and 232.5 μg/m<sup>3</sup> in Home B. The simultaneous outdoor levels were approximately three times lower than indoors. The VOC concentrations were obviously lower than previous measurements in newly renovated residences, reflecting reduced use of these VOCs in interior materials. Temporal variations in the VOC concentrations during the interior finish period were compound- or room-dependent at each residence The remarkable rise in the VOC concentrations was largely affected by furniture installation at both residences. The non-cancer risks of VOC exposure were lower for both interior finishers and occupants. However, the cumulative cancer risks for interior finishers (1.2 × 10<sup>−4</sup>) exceed the acceptable threshold limit. The occupational exposure at the wall painting stage was the highest, and formaldehyde is the most significant contributor to both cancer and noncancer risks. This study also highlights the importance of detecting novel VOCs that may be present in interior finish materials as indicated by the TVOC measurements.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100087"},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000430/pdfft?md5=0a90a13d749306b6bad4ff55d9247d1a&pid=1-s2.0-S2773049223000430-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138614024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polybrominated diphenyl ethers in aquatic products of Guangzhou city, South China: Accumulation, distribution and health risk 华南广州市水产品中的多溴联苯醚:积累、分布和健康风险
Hygiene and environmental health advances Pub Date : 2023-12-05 DOI: 10.1016/j.heha.2023.100085
Min Zhang , Dan Cai , Lijuan Zhang , Qian Zhang , Ping Ding , Xiaoxia Chen , Chushan Huang , Guocheng Hu , Tingzhen Li
{"title":"Polybrominated diphenyl ethers in aquatic products of Guangzhou city, South China: Accumulation, distribution and health risk","authors":"Min Zhang ,&nbsp;Dan Cai ,&nbsp;Lijuan Zhang ,&nbsp;Qian Zhang ,&nbsp;Ping Ding ,&nbsp;Xiaoxia Chen ,&nbsp;Chushan Huang ,&nbsp;Guocheng Hu ,&nbsp;Tingzhen Li","doi":"10.1016/j.heha.2023.100085","DOIUrl":"10.1016/j.heha.2023.100085","url":null,"abstract":"<div><p>Studies have shown that consuming aquatic products is the primary pathway for human uptake of polybrominated diphenyl ethers (PBDEs). This study collected seven types of aquatic products eaten in Guangzhou City. Gas chromatography‒mass spectrometry (GC/MS) was used to investigate eight PBDE congeners to analyze their concentration, distribution, and potential risk. The concentration of PBDEs in aquatic products ranged from 1.92 to 91.11 ng/g lw, with BDE–209, BDE–99, and BDE–154 as the predominant PBDE congeners. Moreover, the concentrations and congener profiles of these contaminants vary in aquatic products. The highest accumulation level was found in shrimp and clams, primarily attributed to dietary habits, metabolic capacity, and accumulation of xenobiotics. According to the dietary questionnaire, the total consumption of aquatic animals was 82.64 g/day, with a significant non-carcinogenic risk to consumers in Guangzhou at higher levels of consumption (HI ≥ 1). Therefore, the maximum allowable daily consumption of grass carp, crucian carp, tilapia, Japanese seaperch, shrimp, clam and crab is 33.33, 55.00, 67.50, 44.44, 41.67, and 51.67 g/day, corresponding to daily intake frequencies of 5, 8, 10, 6, 6, 7, and 5 times/month, respectively. Our results could provide reasonable dietary advice for humans.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100085"},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000417/pdfft?md5=e1e8cae69a5cf9d437902d3d6be1d983&pid=1-s2.0-S2773049223000417-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138609411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applying hair exposome for linking environmental exposure to reproductive health: A comprehensive review and research perspective 应用毛发暴露组将环境暴露与生殖健康联系起来:全面回顾与研究视角
Hygiene and environmental health advances Pub Date : 2023-12-05 DOI: 10.1016/j.heha.2023.100086
Mengyuan Ren , Mingliang Fang , Jing Liu , Qun Lu , Hongchu Bao , Lili Zhuang , Fangang Meng , Bo Pan , Lailai Yan , Zhiwen Li , Jia Xu , Bin Han , Zhipeng Bai , Chan Tian , Ying Wang , Bin Wang
{"title":"Applying hair exposome for linking environmental exposure to reproductive health: A comprehensive review and research perspective","authors":"Mengyuan Ren ,&nbsp;Mingliang Fang ,&nbsp;Jing Liu ,&nbsp;Qun Lu ,&nbsp;Hongchu Bao ,&nbsp;Lili Zhuang ,&nbsp;Fangang Meng ,&nbsp;Bo Pan ,&nbsp;Lailai Yan ,&nbsp;Zhiwen Li ,&nbsp;Jia Xu ,&nbsp;Bin Han ,&nbsp;Zhipeng Bai ,&nbsp;Chan Tian ,&nbsp;Ying Wang ,&nbsp;Bin Wang","doi":"10.1016/j.heha.2023.100086","DOIUrl":"10.1016/j.heha.2023.100086","url":null,"abstract":"<div><p>Increasing evidences have revealed a close relationship between various environmental exposures and reproductive health. The real-world complex exposure scenario along with intricate interactions effects of these exposures has high demands of exposome-wide association studies for human risk assessment. With the development of exposomic studies, applying hair exposome to link environmental factors and reproductive health outcomes has obvious potential advantages. However, the reliability of utilizing hair to characterize exposome is always of high concern for researchers. In this review, we briefly summarized studies about the effects of environmental exposures on several typical reproductive health outcomes, described state-of-the-art situation of applying hair exposome for reproductive health risk assessment, elucidated the advantages (e.g., containing abundant exposure factors, low expenses for sampling, and tracing exposure history), and proposed the unsolved issues in this area. We also conducted a comprehensive discussion about the reliability of various hair biomarkers and primarily established the biomarker databases. Finally, a standardized framework on using hair exposome for reproductive health study was proposed to provide fundamental approach for future studies. We concluded that it is promising to apply hair exposome to evaluate the effects of the environmental factors on human reproductive health.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100086"},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000429/pdfft?md5=ac091d74bccc4a0b12af9120214b4092&pid=1-s2.0-S2773049223000429-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138626926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The CHECH study: A prospective pregnancy cohort study on CHemical exposure and children's health in Tianjin, China CHECH 研究:中国天津妊娠期前瞻性队列研究:氯暴露与儿童健康
Hygiene and environmental health advances Pub Date : 2023-12-01 DOI: 10.1016/j.heha.2023.100084
Yuxuan Zhao , Jing Wang , Gongshu Liu , Yeganeh Ataei , Carl-Gustaf Bornehag , Wei Liu , Qinghao Zhang , Jianjun Huang , Peizhe Sun , Yuexia Sun
{"title":"The CHECH study: A prospective pregnancy cohort study on CHemical exposure and children's health in Tianjin, China","authors":"Yuxuan Zhao ,&nbsp;Jing Wang ,&nbsp;Gongshu Liu ,&nbsp;Yeganeh Ataei ,&nbsp;Carl-Gustaf Bornehag ,&nbsp;Wei Liu ,&nbsp;Qinghao Zhang ,&nbsp;Jianjun Huang ,&nbsp;Peizhe Sun ,&nbsp;Yuexia Sun","doi":"10.1016/j.heha.2023.100084","DOIUrl":"https://doi.org/10.1016/j.heha.2023.100084","url":null,"abstract":"<div><p>The CHemical Exposure and Children's Health (CHECH) study is an ongoing pregnancy cohort study in Tianjin, China. This paper describes the background, aim and the study design, which can be followed by future researchers to design and conduct similar studies. The abundance and the potential adverse health outcomes of endocrine disrupting chemicals (EDCs) is concerning. More notably, developing fetuses and infants are more vulnerable to EDCs exposure. The CHECH study aims to investigate the importance of early life exposure to multiple EDCs (phthalates and their metabolites, bisphenol A and their substitutes, perfluorinated compounds and poly brominated diphenyl ethers) for multiple health outcomes in Chinese children, namely sexual development, neurodevelopment, metabolism and growth, as well as asthma and allergy. A total of 2238 pregnant women were recruited in Tianjin from May 2017 to April 2021 with a response rate of 90 %. Among these women, 2255 children were born with available information, including 47 pairs of twins. Urine samples were collected from pregnant women and children, while air and dust samples were obtained from the home environment during pregnancy and infancy periods. Information on children's health was gathered through physical examinations and questionnaires. The CHECH study, which collected exposure information and health outcomes at multiple time points, will contribute to the understanding of prenatal exposure to EDCs and their impact on children's health, thereby facilitating the development of risk assessments aimed at reducing exposure and associated health risks.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100084"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000405/pdfft?md5=46a5699788d9c492a359cce94921c2e3&pid=1-s2.0-S2773049223000405-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138558634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparison study of environmental health related issues and policies between private and public U.S. schools using multi-level data 使用多层次数据对美国私立和公立学校环境健康相关问题和政策的比较研究
Hygiene and environmental health advances Pub Date : 2023-12-01 DOI: 10.1016/j.heha.2023.100079
Yi Lu , Christine Bozlak , Erin Bell , Haider A. Khwaja , Shao Lin
{"title":"A comparison study of environmental health related issues and policies between private and public U.S. schools using multi-level data","authors":"Yi Lu ,&nbsp;Christine Bozlak ,&nbsp;Erin Bell ,&nbsp;Haider A. Khwaja ,&nbsp;Shao Lin","doi":"10.1016/j.heha.2023.100079","DOIUrl":"10.1016/j.heha.2023.100079","url":null,"abstract":"<div><h3>Objective</h3><p>Little is known about school environmental health (EH) problems in private schools. This study identified and compared the school EH related issues and policies between private and public schools in the U.S.</p></div><div><h3>Methods</h3><p>School EH information was collected from school administrators on two levels – in New York State (NYS) and nationwide. In NYS, questionnaires were developed and distributed to administrators from both public and private schools via conferences (2015–2016). Nationwide survey data were obtained from the 2014 School Health Policies and Practices Study. We compared the perceived school environment as well as policies related to identification and training on EH issues between private and public schools both in NYS and nationwide.</p></div><div><h3>Results</h3><p>In NYS, both private and public schools reported limited use of proactive approaches in identifying EH issues. Compared to public schools, more private school respondents reported poorer perceived indoor air quality (IAQ) (30% vs. 0%), along with less routine training and lower use of policies that help improve air quality in school. Nationwide, fewer private schools implemented indoor air quality management programs (18% vs. 58%) and were able to always meet ventilation standards (44% vs. 64%) than public schools. Staff members in private schools received less required training on a wide range of EH issues than staff members in public schools.</p></div><div><h3>Conclusion</h3><p>U.S. private schools reported worse perceived indoor air quality than public schools and a lack of awareness and protective policies. Future environmental research and implementation of policies are needed in private schools.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000351/pdfft?md5=93dabc13a3c9148e6d3737c335a69b98&pid=1-s2.0-S2773049223000351-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42927410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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