Hygiene and environmental health advances最新文献

{"title":"Drought, desiccation, dust, and aridity in the American West: A California overview of climate change exposures, regional factors, and social conditions on maternal and child health","authors":"Dharshani Pearson","doi":"10.1016/j.heha.2025.100122","DOIUrl":"10.1016/j.heha.2025.100122","url":null,"abstract":"<div><div>When addressing climate change-associated health effects in children, much of the existing literature has focused on heat exposure. The role dust, drought, wetland desiccation (exposed lakebeds), and wind may have on health has been discussed less frequently. Many of these exposures affect children in rural populations who traditionally have fewer resources and healthcare options available to them. Some of the same children also belong to marginalized groups, ethnic minorities, or have pre-existing lung health issues, and often experience health disparities. In this overview, we discuss how these exposures along with social conditions and genetic susceptibility can affect children's health in the American West, considering: dusty conditions and coccidioidomycosis (Valley fever), exposed lakebeds and lung health, environmental factors and Kawasaki disease (KD), and dust events and motor vehicle accidents. With this summary, which utilizes a multifactorial approach, we stress further research could confirm current findings in other regions of the American West in addition to California, identify more vulnerable subgroups, and inform better policy. Considering exposures other than heat in a broader, more holistic perspective can more fully and equitably address climate change and children's health, setting the stage for a better health trajectory throughout the life course, especially in rural and tribal populations.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"15 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silica nanoparticles interfere with mast cell activation by enhancing intracellular Ca2+ levels and aggravate ovalbumin-mediated asthma","authors":"Jinhua Wei ,&nbsp;Dongyuan Bian ,&nbsp;Shijian Huang ,&nbsp;Xiaobing Wu ,&nbsp;Liu Yang ,&nbsp;Shasha Li ,&nbsp;Beibei Xia ,&nbsp;Yanbo Li ,&nbsp;Guimiao Lin","doi":"10.1016/j.heha.2025.100136","DOIUrl":"10.1016/j.heha.2025.100136","url":null,"abstract":"<div><div>Silica nanoparticles (SiNPs) exist widely in the environment. The likelihood of people being exposed to SiNPs has increased dramatically, and its biosafety bring a great concern. Mast cells are a type of key effector cells that mediate the occurrence of allergic reactions through IgE and non-IgE activation pathways.To date, the effects of SiNPs on these two activation pathways of mast cells remain unclear. In this study, RBL-2H3 cells and ovalbumin (OVA) asthma mice were used to investigate the effects of SiNPs on mast cell activation and its mediating asthma. <em>in vitro</em> studies, SiNPs significantly promoted the release of inflammatory factors TNF-α and IL-1β, but didn’t affect the release of β-Hex (degranulation) in the C48/80-mediated non-IgE activation pathway. In the IgE activation pathway, SiNPs significantly enhanced the release of TNF-α and IL-1β, and also promoted mast cell degranulation by increasing intracellular Ca²⁺ levels. <em>in vivo</em> study, respiratory exposure to SiNPs significantly enhanced the serum histamine and the levels of cytokines (IL-6, TNF-α and IL-1β) in bronchoalveolar lavage fluid (BALF) from asthmatic mice sensitized, thickened the airway walls, increased the inflammatory cells infiltration and the number of mast cells, suggesting that SiNPs significantly aggravated OVA-mediated asthma in mice. These findings reveal the effects of SiNPs on mast cells and their mediated allergic reactions, providing scientific clues for the prevention and treatment of allergic diseases, especially asthma.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"15 ","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unseasonal extreme cold weather, ultrafine particles, and diabetes hospitalizations: an unexpected time window for intervention","authors":"Donghong Gao ,&nbsp;Samantha Friedman ,&nbsp;Akiko S. Hosler ,&nbsp;Scott Sheridan ,&nbsp;Wangjian Zhang ,&nbsp;Fangqun Yu ,&nbsp;Gan Luo ,&nbsp;Shao Lin","doi":"10.1016/j.heha.2025.100140","DOIUrl":"10.1016/j.heha.2025.100140","url":null,"abstract":"<div><h3>Background</h3><div>Although the associations between ambient heat and diabetes have been assessed, the odds of ambient extreme cold exposure (ECE) or ultrafine particles (UFP) on diabetes admissions are understudied.</div></div><div><h3>Objectives</h3><div>We assessed the impacts of ECE on diabetes hospitalization and evaluated the modifications of demographics, comorbidities, and UFP on ECEdiabetes associations.</div></div><div><h3>Methods</h3><div>A time-stratified case-crossover study was conducted by using mandatory New York State (NYS) admission data (principal diagnosis, 2013–2020) and temperature and simulated UPF data from NYS Mesonet and a global chemistry transport model, respectively. We defined ECE as &lt;5th percentile of daily mean temperature and UFP-high as &gt;50th percentile of the daily mean UFP. After adjusting for air pollutants, humidity, and holidays, we conducted conditional logistic regressions to investigate ECE-diabetes associations, additive and multiplicative interactions between UFP, demographics/comorbidities, and ECE.</div></div><div><h3>Results</h3><div>Diabetes admissions associated with ECE were significantly elevated in winter months (ranges of odds ratios (ORs): 1.099–1.104, <em>P</em> &lt; 0.05 in January and February) but the associations increased more consistently across multiple lag days in March (ranges of ORs: 1.068–1.129, <em>P</em> &lt; 0.05). ECE-diabetes associations were significant among patients with peripheral circulatory complications and hyperglycemia compared to those without these complications. UFP-diabetes associations were significant in November (OR: 1.052, 95 % confidence interval (CI): 1.012–1.093) and December (OR: 1.045, 95 % CI: 1.003–1.088). Additionally, ECE-UFP interactions on diabetes were significant at both additive (95 % CI &gt;0 for the attributable proportion to interactions and relative excess risk index) and multiplicative (<em>P</em> &lt; 0.05 for product terms) scales. Furthermore, females, older adults, urban residents, and patients with multiple comorbidities were more vulnerable to ECE than other groups.</div></div><div><h3>Conclusions</h3><div>ECE-diabetes associations were significant in winter months, but the increased associations occurred more persistently in March. While synergistic and additive interactions between ECE and UFP on diabetes were found, ECE-diabetes ssociations were also modified by demographics and comorbidities.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"15 ","pages":"Article 100140"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Escherichia coli in drinking water: A comparative study of indoor and outdoor sources over four years across Bahia, Brazil","authors":"Danilo Moreira Vilas Boas ,&nbsp;Wilson José Fernandes Lemos Junior ,&nbsp;Joselene Nascimento ,&nbsp;Clícia Leite ,&nbsp;Juliana Matos ,&nbsp;Francine Paz ,&nbsp;Anderson S. Sant'Ana ,&nbsp;Alaíse Gil Guimarães","doi":"10.1016/j.heha.2025.100121","DOIUrl":"10.1016/j.heha.2025.100121","url":null,"abstract":"<div><div>Waterborne diseases, such as cholera and typhoid fever, pose significant health risks, particularly in areas with inadequate sanitation and contaminated water sources. The Northeast region of Brazil, characterized by limited water resources and high population density, faces challenges in maintaining water quality and distribution. This study aims to evaluate the microbiological quality of drinking water and its relation to the occurrence of waterborne diseases in outdoor environments over a four-year period. A total of 8497 water samples were analyzed, comprising 7912 outdoor and indoor samples and 585 longitudinal indoor samples from a resort-type hotel complex. The study focused on outdoor water sources such as swimming pools, rivers, lakes, and seas. An experimental design was further implemented to assess the microbiological quality of indoor water sources through a longitudinal case study. Among the 7912 outdoor and indoor samples, 1603 showed total coliforms, 501 exhibited growth of thermotolerant coliforms, and 106 tested positive for <em>Escherichia coli</em> (EC). In contrast, indoor samples demonstrated better microbiological quality, with only 18 samples containing total coliforms and none testing positive for EC. Ensuring the microbiological quality of drinking water is vital for public health and the prevention of waterborne diseases. The presence of contaminants in outdoor sources highlights the need for rigorous control mechanisms and monitoring, especially in high-risk regions. Indoor water sources, when properly maintained, can significantly reduce contamination risks, emphasizing the importance of stringent water treatment and hygiene practices.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"15 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent bone health under threat: PFAS mixtures as drivers of skeletal fragility","authors":"Jing Li ,&nbsp;Shaowei Wu ,&nbsp;Tingyu Li ,&nbsp;Zichang Liu ,&nbsp;Chuchu Kang ,&nbsp;Hongli Tan","doi":"10.1016/j.heha.2025.100133","DOIUrl":"10.1016/j.heha.2025.100133","url":null,"abstract":"<div><div>Evidence regarding the effect of per- and poly-fluoroalkyl substances (PFASs) on bone minerals density (BMD) at various bone sites and the combined effects of PFAS mixtures is limited, particularly during the critical period of skeletal development. To address this gap, we conducted a cross-sectional study involving 1212 adolescents aged 12−19 years in NHANES 2011−2018 to examine the associations of single PFAS and PFAS mixtures with BMD at 11 bone sites and two comprehensive BMD indices. Multiple linear regression showed that serum PFAS concentrations were inversely associated with BMD, with variations according to the specific PFAS and bone site, and exhibiting a sex-specific pattern. Additionally, these associations differed significantly between obese and non-obese individuals, which was confined to boys. Mixture analysis using weighted quantile sum regression and Bayesian kernel machine regression revealed inverse associations between PFAS mixtures and BMD at specific bone sites, and 2-(N-methylperfluoroctanesulfonamido)acetic acid (Me-PFOSA-AcOH) and perfluorodecanoic acid (PFDeA) were identified as the dominant contributors to the combined effect of PFAS mixtures on BMD among all participants and girls, respectively. These findings lay a critical foundation for future environmental epidemiology studies and necessitate further exploration and validation of mechanisms through laboratory research.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"15 ","pages":"Article 100133"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do weekends matter in unraveling the impact of acute temperature exposure on the risk of daily mortality?","authors":"Keita Wagatsuma ,&nbsp;Takahisa Ogawa ,&nbsp;Yi-Sheng Yang ,&nbsp;Kensuke Uraguchi ,&nbsp;Mami Hitachi ,&nbsp;Susana Silva ,&nbsp;Erik Pieter de Jong ,&nbsp;Ya-Yun Cheng ,&nbsp;Aurelio Tobias ,&nbsp;Masahiro Hashizume","doi":"10.1016/j.heha.2025.100134","DOIUrl":"10.1016/j.heha.2025.100134","url":null,"abstract":"","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"15 ","pages":"Article 100134"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicology research on the effects of environmental pollutants on the retina: A review","authors":"Tiantian Chen ,&nbsp;Wei Zhang ,&nbsp;Yifan Li ,&nbsp;Jin Zhou ,&nbsp;Shu Guo","doi":"10.1016/j.heha.2025.100143","DOIUrl":"10.1016/j.heha.2025.100143","url":null,"abstract":"<div><h3>Background</h3><div>As the key sensory tissue in the eye, the retina is vulnerable to environmental pollutants, with laboratory studies demonstrating their potential to disrupt retinal structure and function. To comprehensively understand the toxic effects and potential mechanisms of pollutants, this review studied the effects of major environmental pollutants, including heavy metals (cadmium, mercury, lead), organic compounds (bisphenol compounds, polychlorinated biphenyls, triclosan, chlorpyrifos), and microplastics, on the structure and function of the retina.</div></div><div><h3>Methods</h3><div>Using PubMed, Web of Science, and CNKI databases, search for keywords such as \"retina,\" \"toxicity,\" \"environmental pollutants,\" \"oxidative stress,\" \"cell apoptosis,\" \"visual function,\" and their combinations. Include original research and reviews evaluating the retinal toxicity of specific environmental pollutants, rigorously screen literature for in-depth analysis.</div></div><div><h3>Results</h3><div>Comprehensive analysis confirms that target environmental pollutants can induce significant retinal toxicity effects, including retinal developmental disorders, tissue structure damage, loss of photoreceptor cell specificity, and ultimately leading to visual dysfunction and visual related behavioral abnormalities.</div></div><div><h3>Conclusion</h3><div>This review integrates mechanistic insights from experimental toxicology research, providing a preclinical framework for understanding pollutant induced retinal damage and laying an important foundation for developing protective strategies against environmental retinal damage.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"15 ","pages":"Article 100143"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights into cobalt-induced lung injury: An integrated network toxicology and bioinformatics approach","authors":"Hongyan Yu ,&nbsp;Yingzhu Wang ,&nbsp;Yidi Chen ,&nbsp;Rong Zhang ,&nbsp;Shanfa Yu ,&nbsp;Xiaoting Jin ,&nbsp;Yuxin Zheng","doi":"10.1016/j.heha.2025.100130","DOIUrl":"10.1016/j.heha.2025.100130","url":null,"abstract":"<div><h3>Background</h3><div>The widespread environmental contamination by cobalt compounds, coupled with their documented respiratory toxicities, has become a pressing public health concern. Current mechanistic research on the health impacts of these substances lacks coherence and integration, highlighting the need for a comprehensive investigation into the mechanisms of cobalt-induced lung injury.</div></div><div><h3>Methods</h3><div>Utilizing CTDbase and NetInfer databases, we obtained target genes of cobalt and its compound and ascertained their associated lung adverse outcomes. Disease-related targets were retrieved from OMIM, DisGeNet, GeneCards, and NCBI databases. A protein-protein interaction (PPI) network was constructed to identify the core targets between compounds and diseases. Based on the DAVID database, enrichment pathways were evaluated by GO and KEGG analyses. Finally, single-cell analysis was conducted to investigate specific cell types implicated in the cobalt-induced lung hazards.</div></div><div><h3>Results</h3><div>Pulmonary hypertension (PH) was determined as the most critical lung injury associated with cobalt compounds. In total, we identified 275 compound-related and 3146 PH-related targets, ultimately pinpointing 169 overlapping targets. Among these, 28 pivotal co-targets were implicated in cobalt and its compound-induced PH, including IL6, AKT1, TNF, TP53, NFKB1, HIF1A, etc., which were primarily involved in the IL-17, TNF, and HIF-1 signaling pathways. Moreover, monocytes and macrophages were recognized as effector cells underlying the induction of PH by cobalt exposure, with CXCL8 and HIF1A serving as signature genes.</div></div><div><h3>Conclusion</h3><div>Our study not only elucidates pivotal target genes, pathways, and specific cell types involved in cobalt-induced lung hazards, but also establishes a novel approach to clarify the mechanisms underlying metal toxicity.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"15 ","pages":"Article 100130"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heat vulnerability assessment: A systematic review of critical metrics","authors":"Yuchen Qian,&nbsp;Tiedong Liu","doi":"10.1016/j.heha.2025.100138","DOIUrl":"10.1016/j.heha.2025.100138","url":null,"abstract":"<div><div>Research on heat vulnerability provides a scientific foundation for identifying heatwave-sensitive areas and vulnerable populations, thereby enabling targeted climate adaptation. Standardizing and refining metric selection is crucial for constructing effective heat vulnerability assessment systems. To boost the precision of heat vulnerability assessments, this research explores current limitations in metric selection. We systematically reviewed metrics from 31 studies across environmental, demographic, and socioeconomic dimensions. Our analysis reveals three main challenges: variations in indicator selection, classification, and processing; correlations between indicators and regional characteristics; and inter-metric correlations of conceptual redundancy and oversimplification. These discrepancies and deficiencies may affect the robustness of assessments and increase the difficulty of subsequent discussions, diminishing the policy relevance. Our review identifies and summarizes context-specific indicators, highlights issues of metric redundancy and oversimplification along with corresponding solutions, and establishes guidelines for metric selection. This facilitates the selection of concise, representative metrics for developing more accurate heat vulnerability indices, ultimately enabling targeted interventions to mitigate heatwave impacts.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"15 ","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dose-dependent effect of acute ozone exposure on lung function and the efficacy of a Boysenberry apple powder blend (BerriQi®) in reducing throat irritation and symptom recovery time in healthy adults","authors":"Dominic Lomiwes ,&nbsp;Matthew Barnes ,&nbsp;Grayson Nicholls ,&nbsp;Nayer Ngametua ,&nbsp;Greg Sawyer ,&nbsp;Alexander P. Kanon ,&nbsp;Gowthami Vangala ,&nbsp;Odette Shaw","doi":"10.1016/j.heha.2025.100132","DOIUrl":"10.1016/j.heha.2025.100132","url":null,"abstract":"<div><div>Urbanization and industrialization have impacted air quality and health, with ozone exposure linked to reduced lung function and increased respiratory issues. This study characterised the dose-dependent effect of acute, controlled ambient ozone exposure in an environmental chamber on lung function, then investigated the effect of BerriQi® Boysenberry and apple powder (BerriQi) ozone-induced respiratory irritation symptoms. In an incremental dose study, healthy adults were exposed to 0.1, 0.2 or 0.3 ppm ozone for 2 h. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were measured at designated timepoints up to 48 h after ozone exposure. This was followed by a randomised, double-blind, placebo-controlled crossover trial, with healthy adults (<em>n</em> = 20) who consumed either BerriQi or a placebo daily for 5 days before being exposed to 0.2 ppm ozone for 2 h. Respiratory irritation symptoms, including throat irritation (TI), soreness of cough (SOC), shortness of breath (SOB), and pain on deep inspiration (PODI), were assessed at designated timepoints up to 48 h after ozone exposure. Our results showed that 0.2 ppm ozone was the maximum tolerated dose that elicited a temporal decline in lung function in healthy participants and that BerriQi supplementation significantly reduced TI (<em>p</em> = 0.04), and may expedite the resolution of SOC, SOB and PODI after acute ozone exposure. These findings suggest that BerriQi may alleviate the severity and duration of ozone-induced respiratory irritation and highlights the potential of BerriQi as a dietary intervention for mitigating the respiratory effects of air pollution.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"15 ","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}