Hygiene and environmental health advances最新文献

{"title":"Volatile organic compounds (VOCs) in residential indoor air during interior finish period: Sources, variations, and health risks","authors":"Jin-Long Mai ,&nbsp;Wei-Wei Yang ,&nbsp;Yuan Zeng ,&nbsp;Yu-Feng Guan ,&nbsp;She-Jun Chen","doi":"10.1016/j.heha.2023.100087","DOIUrl":"10.1016/j.heha.2023.100087","url":null,"abstract":"<div><p>Building and furniture materials are significant sources of volatile organic compounds (VOCs) and determine their long-time indoor levels. However, the variations of indoor VOCs and associated health risks of interior finishers during the construction stages are poorly understood. In this study, VOCs in the indoor microenvironments were measured at different interior finishing stages at two renovated residences using thermal desorption and gas chromatography-mass spectrometry. The mean concentrations of the Σ15 VOCs were 118.2 μg/m³ in Home A and 232.5 μg/m³ in Home B. The simultaneous outdoor levels were approximately three times lower than indoors. The VOC concentrations were obviously lower than previous measurements in newly renovated residences, reflecting reduced use of these VOCs in interior materials. Temporal variations in the VOC concentrations during the interior finish period were compound- or room-dependent at each residence The remarkable rise in the VOC concentrations was largely affected by furniture installation at both residences. The non-cancer risks of VOC exposure were lower for both interior finishers and occupants. However, the cumulative cancer risks for interior finishers (1.2 × 10⁻⁴) exceed the acceptable threshold limit. The occupational exposure at the wall painting stage was the highest, and formaldehyde is the most significant contributor to both cancer and noncancer risks. This study also highlights the importance of detecting novel VOCs that may be present in interior finish materials as indicated by the TVOC measurements.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100087"},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000430/pdfft?md5=0a90a13d749306b6bad4ff55d9247d1a&pid=1-s2.0-S2773049223000430-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138614024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polybrominated diphenyl ethers in aquatic products of Guangzhou city, South China: Accumulation, distribution and health risk","authors":"Min Zhang ,&nbsp;Dan Cai ,&nbsp;Lijuan Zhang ,&nbsp;Qian Zhang ,&nbsp;Ping Ding ,&nbsp;Xiaoxia Chen ,&nbsp;Chushan Huang ,&nbsp;Guocheng Hu ,&nbsp;Tingzhen Li","doi":"10.1016/j.heha.2023.100085","DOIUrl":"10.1016/j.heha.2023.100085","url":null,"abstract":"<div><p>Studies have shown that consuming aquatic products is the primary pathway for human uptake of polybrominated diphenyl ethers (PBDEs). This study collected seven types of aquatic products eaten in Guangzhou City. Gas chromatography‒mass spectrometry (GC/MS) was used to investigate eight PBDE congeners to analyze their concentration, distribution, and potential risk. The concentration of PBDEs in aquatic products ranged from 1.92 to 91.11 ng/g lw, with BDE–209, BDE–99, and BDE–154 as the predominant PBDE congeners. Moreover, the concentrations and congener profiles of these contaminants vary in aquatic products. The highest accumulation level was found in shrimp and clams, primarily attributed to dietary habits, metabolic capacity, and accumulation of xenobiotics. According to the dietary questionnaire, the total consumption of aquatic animals was 82.64 g/day, with a significant non-carcinogenic risk to consumers in Guangzhou at higher levels of consumption (HI ≥ 1). Therefore, the maximum allowable daily consumption of grass carp, crucian carp, tilapia, Japanese seaperch, shrimp, clam and crab is 33.33, 55.00, 67.50, 44.44, 41.67, and 51.67 g/day, corresponding to daily intake frequencies of 5, 8, 10, 6, 6, 7, and 5 times/month, respectively. Our results could provide reasonable dietary advice for humans.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100085"},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000417/pdfft?md5=e1e8cae69a5cf9d437902d3d6be1d983&pid=1-s2.0-S2773049223000417-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138609411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applying hair exposome for linking environmental exposure to reproductive health: A comprehensive review and research perspective","authors":"Mengyuan Ren ,&nbsp;Mingliang Fang ,&nbsp;Jing Liu ,&nbsp;Qun Lu ,&nbsp;Hongchu Bao ,&nbsp;Lili Zhuang ,&nbsp;Fangang Meng ,&nbsp;Bo Pan ,&nbsp;Lailai Yan ,&nbsp;Zhiwen Li ,&nbsp;Jia Xu ,&nbsp;Bin Han ,&nbsp;Zhipeng Bai ,&nbsp;Chan Tian ,&nbsp;Ying Wang ,&nbsp;Bin Wang","doi":"10.1016/j.heha.2023.100086","DOIUrl":"10.1016/j.heha.2023.100086","url":null,"abstract":"<div><p>Increasing evidences have revealed a close relationship between various environmental exposures and reproductive health. The real-world complex exposure scenario along with intricate interactions effects of these exposures has high demands of exposome-wide association studies for human risk assessment. With the development of exposomic studies, applying hair exposome to link environmental factors and reproductive health outcomes has obvious potential advantages. However, the reliability of utilizing hair to characterize exposome is always of high concern for researchers. In this review, we briefly summarized studies about the effects of environmental exposures on several typical reproductive health outcomes, described state-of-the-art situation of applying hair exposome for reproductive health risk assessment, elucidated the advantages (e.g., containing abundant exposure factors, low expenses for sampling, and tracing exposure history), and proposed the unsolved issues in this area. We also conducted a comprehensive discussion about the reliability of various hair biomarkers and primarily established the biomarker databases. Finally, a standardized framework on using hair exposome for reproductive health study was proposed to provide fundamental approach for future studies. We concluded that it is promising to apply hair exposome to evaluate the effects of the environmental factors on human reproductive health.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100086"},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000429/pdfft?md5=ac091d74bccc4a0b12af9120214b4092&pid=1-s2.0-S2773049223000429-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138626926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CHECH study: A prospective pregnancy cohort study on CHemical exposure and children's health in Tianjin, China","authors":"Yuxuan Zhao ,&nbsp;Jing Wang ,&nbsp;Gongshu Liu ,&nbsp;Yeganeh Ataei ,&nbsp;Carl-Gustaf Bornehag ,&nbsp;Wei Liu ,&nbsp;Qinghao Zhang ,&nbsp;Jianjun Huang ,&nbsp;Peizhe Sun ,&nbsp;Yuexia Sun","doi":"10.1016/j.heha.2023.100084","DOIUrl":"https://doi.org/10.1016/j.heha.2023.100084","url":null,"abstract":"<div><p>The CHemical Exposure and Children's Health (CHECH) study is an ongoing pregnancy cohort study in Tianjin, China. This paper describes the background, aim and the study design, which can be followed by future researchers to design and conduct similar studies. The abundance and the potential adverse health outcomes of endocrine disrupting chemicals (EDCs) is concerning. More notably, developing fetuses and infants are more vulnerable to EDCs exposure. The CHECH study aims to investigate the importance of early life exposure to multiple EDCs (phthalates and their metabolites, bisphenol A and their substitutes, perfluorinated compounds and poly brominated diphenyl ethers) for multiple health outcomes in Chinese children, namely sexual development, neurodevelopment, metabolism and growth, as well as asthma and allergy. A total of 2238 pregnant women were recruited in Tianjin from May 2017 to April 2021 with a response rate of 90 %. Among these women, 2255 children were born with available information, including 47 pairs of twins. Urine samples were collected from pregnant women and children, while air and dust samples were obtained from the home environment during pregnancy and infancy periods. Information on children's health was gathered through physical examinations and questionnaires. The CHECH study, which collected exposure information and health outcomes at multiple time points, will contribute to the understanding of prenatal exposure to EDCs and their impact on children's health, thereby facilitating the development of risk assessments aimed at reducing exposure and associated health risks.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100084"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000405/pdfft?md5=46a5699788d9c492a359cce94921c2e3&pid=1-s2.0-S2773049223000405-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138558634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison study of environmental health related issues and policies between private and public U.S. schools using multi-level data","authors":"Yi Lu ,&nbsp;Christine Bozlak ,&nbsp;Erin Bell ,&nbsp;Haider A. Khwaja ,&nbsp;Shao Lin","doi":"10.1016/j.heha.2023.100079","DOIUrl":"10.1016/j.heha.2023.100079","url":null,"abstract":"<div><h3>Objective</h3><p>Little is known about school environmental health (EH) problems in private schools. This study identified and compared the school EH related issues and policies between private and public schools in the U.S.</p></div><div><h3>Methods</h3><p>School EH information was collected from school administrators on two levels – in New York State (NYS) and nationwide. In NYS, questionnaires were developed and distributed to administrators from both public and private schools via conferences (2015–2016). Nationwide survey data were obtained from the 2014 School Health Policies and Practices Study. We compared the perceived school environment as well as policies related to identification and training on EH issues between private and public schools both in NYS and nationwide.</p></div><div><h3>Results</h3><p>In NYS, both private and public schools reported limited use of proactive approaches in identifying EH issues. Compared to public schools, more private school respondents reported poorer perceived indoor air quality (IAQ) (30% vs. 0%), along with less routine training and lower use of policies that help improve air quality in school. Nationwide, fewer private schools implemented indoor air quality management programs (18% vs. 58%) and were able to always meet ventilation standards (44% vs. 64%) than public schools. Staff members in private schools received less required training on a wide range of EH issues than staff members in public schools.</p></div><div><h3>Conclusion</h3><p>U.S. private schools reported worse perceived indoor air quality than public schools and a lack of awareness and protective policies. Future environmental research and implementation of policies are needed in private schools.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000351/pdfft?md5=93dabc13a3c9148e6d3737c335a69b98&pid=1-s2.0-S2773049223000351-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42927410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible hazardous components in dental alginates: Physicochemical properties by a mineralogical and spectroscopic investigation","authors":"Matteo Ardit ,&nbsp;Tommaso Baroni ,&nbsp;Fabio Capacci ,&nbsp;Giulio Arcangeli ,&nbsp;Maurizio Romanelli ,&nbsp;Alfonso Zoleo ,&nbsp;Silvana Capella ,&nbsp;Elena Belluso ,&nbsp;Pietro Gabellini ,&nbsp;Raffaello Cioni ,&nbsp;Francesco Di Benedetto","doi":"10.1016/j.heha.2023.100083","DOIUrl":"10.1016/j.heha.2023.100083","url":null,"abstract":"<div><p>Alginates are products used as impression materials in dentistry and prosthetics. They consist of polymers, calcium alginates mixed with diatomite and additives. Recently, the occurrence of severe silicosis associated with exposure to respirable dust of such materials has increased the scientific interest in understanding how these materials may pose a toxicological problem to workers. The primary objective of this study is to improve the understanding of both the existence and the characteristics of the toxicant(s) contained in these materials, with the goal of better defining the risk assessment for this occupational setting.</p><p>Two commercial dental alginates were subjected to a mineralogical, microchemical and spectroscopic investigation. The results indicate the presence of a significant amount of diatomite, clearly identified by micromorphology and formed mainly by cristobalite. The respirable fraction of the dust represents at least 30  % of the total number of particles, and this fraction contains a relevant amount of crystalline silica particles. Conversely, the investigated alginate materials do not exhibit the presence of radical species.</p><p>The results obtained confirm that the cristobalite detected originates from the high-temperature transformation of amorphous silica during the calcination process of diatomite, prior to mixing with the other components. The same process also produces wollastonite (CaSiO₃), which, like cristobalite, is a crystalline phase known for its toxicological effects. The present findings call for a rethinking of dental alginates with regard to the definition of their health risks for technical operators.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100083"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000399/pdfft?md5=50894293228e154b1fe3583c48795e26&pid=1-s2.0-S2773049223000399-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135714983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding missing declaration of competing interest statements and ethical statements in previously published articles","authors":"","doi":"10.1016/j.heha.2023.100082","DOIUrl":"https://doi.org/10.1016/j.heha.2023.100082","url":null,"abstract":"","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100082"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000387/pdfft?md5=d23238212462f43f62f029ebe4c53afe&pid=1-s2.0-S2773049223000387-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92108562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for elevated blood lead levels using single hair strands: Accounting for external contamination","authors":"Jennie R. Christensen ,&nbsp;Geriene O. LaBine ,&nbsp;Joyce McBeth","doi":"10.1016/j.heha.2023.100081","DOIUrl":"10.1016/j.heha.2023.100081","url":null,"abstract":"<div><p>Hair has long been explored as a potential biomarker of lead exposure since lead is readily adsorbed into hair's keratinous matrix; however, the utility of hair as a biomarker for lead exposure is hampered by its susceptibility to external contamination: lead particles attach to the exposed hair surface, confounding estimates of endogenous concentrations. This study describes the development of a hair screening tool, in which the confounding influence of external contamination are mitigated by focusing on the unexposed hair root, to predict elevated blood lead levels (BLLs). This tool requires a single strand of scalp hair, which is analyzed using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Forty-four (44) workers with high potential for lead exposure, and 63 reference individuals (with no known lead exposure) volunteered for the study. Hair lead level (HLL) thresholds were developed using methods from clinical assessment to screen exceedances of BLL thresholds at 10 and 15 µg/dL. Hair from both groups showed significantly lower lead concentrations in below-scalp portions compared to above the scalp (above-scalp was 11.2 times higher in workers, and 3.7 times higher in reference group). Hair lead concentrations below the scalp in workers significantly predicted BLLs. HLL thresholds for screening BLLs were 0.60 mg/kg and 0.75 mg/kg for BLLs of 10 µg/dL and 15 µg/dL, respectively. These HLL thresholds yielded high sensitivity (&gt;85%), and slightly lower specificity (67% and 33%, for BLL thresholds of 10 µg/dL and 15 µg/dL, respectively). This study provides reference HLLs in non-contaminated portions of hair (&lt;0.097 mg/kg), shows the significance of external contamination on exposed portions of hair even in a reference population, and assesses the effectiveness of below-scalp hair as a biomarker of elevated lead exposure. This hair screening tool effectively predicted BLL exceedances and could be considered as a non-invasive alternative to blood sampling.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48693017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agribusiness in Brazil and its dependence on the use of pesticides","authors":"Shaiane Carla Gaboardi ,&nbsp;Luciano Zanetti Pessôa Candiotto ,&nbsp;Carolina Panis","doi":"10.1016/j.heha.2023.100080","DOIUrl":"10.1016/j.heha.2023.100080","url":null,"abstract":"<div><p>By virtue of its availability of arable land, tropical climate, and abundance of water resources, Brazil is one of the largest agricultural and livestock producers in the world, with agribusiness geared towards global trade. Consequently, the country appears on the international scene as one of the main consumers of pesticides. This article presents the current panorama of pesticide use in Brazil and highlights the tendency of government permissiveness and support in this sector, through the increase in the number of registrations granted annually and strategies to modify the current legislation. The methodological procedures were: discussion about causes and consequences of pesticide use, considering economic interests, social and environmental impacts; collection and analysis of data made available by official Brazilian agencies on the pesticides marketing and main cultivated products; study of Bill 6,299/2002; and positioning of public institutions linked to work, health and the environment, through the technical notes issued by them. Conceptually, we found our arguments on Political Ecology and Geography ideas to demonstrate that the exacerbated use of pesticides in Brazil is a great environmental and social injustice, contaminating natural resources and the Brazilian population that handles or consumes food and water with high levels of residues. The data reveal that the productive specialization has led to a progressive increase in the use of pesticides in Brazil, and the government has been extremely permissive of, and even conniving with, the interests of companies linked to agribusiness, making the process of evaluating and releasing pesticide products even less rigid.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100080"},"PeriodicalIF":0.0,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44312400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity assessment of CeO₂ and CuO nanoparticles at the air-liquid interface using bioinspired condensational particle growth","authors":"Trevor B. Tilly ,&nbsp;Ryan X. Ward ,&nbsp;Alyssa F. Morea ,&nbsp;M. Tyler Nelson ,&nbsp;Sarah E. Robinson ,&nbsp;Arantzazu Eiguren-Fernandez ,&nbsp;Gregory S. Lewis ,&nbsp;John A. Lednicky ,&nbsp;Tara Sabo-Attwood ,&nbsp;Saber M. Hussain ,&nbsp;Chang-Yu Wu","doi":"10.1016/j.heha.2023.100074","DOIUrl":"10.1016/j.heha.2023.100074","url":null,"abstract":"<div><p>CeO₂ and CuO nanoparticles (NPs) are used as additives in petrodiesel to enhance engine performance leading to reduced diesel combustion emissions.   Despite their benefits, the additive application poses human health concerns by releasing inhalable NPs into the ambient air.  In this study, a bioinspired lung cell exposure system, Dosimetric Aerosol <em>in Vitro</em> Inhalation Device (DAVID), was employed for evaluating the toxicity of aerosolized CeO₂ and CuO NPs with a short duration of exposure (≤10 min vs. hours in other systems) and without exerting toxicity from non-NP factors.  Human epithelial A549 lung cells were cultured and maintained within DAVID at the air-liquid interface (ALI), onto which aerosolized NPs were deposited, and experiments in submerged cells were used for comparison.  Exposure of the cells to the CeO₂ NPs did not result in detectable IL-8 release, nor did it produce a significant reduction in cell viability based on lactate dehydrogenase (LDH) assay, with a marginal decrease (10%) at the dose of 388 μg/cm² (273 cm²/cm²).  In contrast, exposure to CuO NPs resulted in a concentration dependent reduction in LDH release based on LDH leakage, with 38% reduction in viability at the highest dose of 52 μg/cm² (28.3 cm²/cm²).  Cells exposed to CuO NPs resulted in a dose dependent cellular membrane toxicity and expressed IL-8 secretion at a global dose five times lower than cells exposed under submerged conditions.  However, when comparing the ALI results at the local cellular dose of CuO NPs to the submerged results, the IL-8 secretion was similar.  In this study, we demonstrated DAVID as a new exposure tool that helps evaluate aerosol toxicity in simulated lung environment. Our results also highlight the necessity in choosing the right assay endpoints for the given exposure scenario, e.g., LDH for ALI and Deep Blue for submerged conditions for cell viability.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"7 ","pages":"Article 100074"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/5c/nihms-1929001.PMC10500621.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10358808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}