Hygiene and environmental health advances最新文献

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Atmospheric halogenated hydrocarbons emitted from a flame retardant production base and the influence on ozone formation potential and health risks 阻燃剂生产基地排放的大气卤代烃及其对臭氧形成潜力和健康风险的影响
Hygiene and environmental health advances Pub Date : 2023-12-01 Epub Date: 2023-07-02 DOI: 10.1016/j.heha.2023.100070
Qinhao Lin , Wei Kang , Shuo Lin , Yingxin Yu , Taicheng An
{"title":"Atmospheric halogenated hydrocarbons emitted from a flame retardant production base and the influence on ozone formation potential and health risks","authors":"Qinhao Lin ,&nbsp;Wei Kang ,&nbsp;Shuo Lin ,&nbsp;Yingxin Yu ,&nbsp;Taicheng An","doi":"10.1016/j.heha.2023.100070","DOIUrl":"10.1016/j.heha.2023.100070","url":null,"abstract":"<div><p>The flame retardant industrial park is a significant source of atmospheric volatile organic compound (VOC) emissions. A flame retardant factory is generally associated with abundant salt pans, which facilitate brine raw materials for flame retardant production. However, the concentrations and compositions of these VOCs from the factories and the surrounding salt pans are still unclear. Therefore, this study characterized the VOCs from various production areas in a flame retardants factory and its surrounding salt pans. We investigated five VOC types: alkanes, aromatic hydrocarbons (AHs), halogenated hydrocarbons (HHs), halogenated aromatic hydrocarbons, and halogenated olefin. AHs (41.0 ± 26.3 µg/m<sup>3</sup>) were the dominant VOC type in the factory, followed by HHs (7.64 ± 6.52 µg/m<sup>3</sup>). As for the surrounding salt pans, HHs (89.6 ± 55.9 µg/m<sup>3</sup>), followed by AHs (20.9 ± 13.8 µg/m<sup>3</sup>). Generally, HHs and AHs were found to be potential cancer risks, especially 1,2-dichlorothane, 1,2-trichlorothane, and benzene. Furthermore, the diffusion of AHs or HHs from the study areas may affect the local residential area and school. AHs were the study region's most significant contributor to ozone formation potential. Consequently, this study provides detailed characteristics of VOCs in flame retardant industrial parks and contributes to developing targeted control strategies.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100070"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44178209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iron- and protein rich diets may boost hemoglobin levels among informal electronic waste recyclers exposed to metals at Agbogbloshie, Ghana 在加纳阿博布罗西,富含铁和蛋白质的饮食可能会提高接触金属的非正式电子废物回收者的血红蛋白水平
Hygiene and environmental health advances Pub Date : 2023-12-01 Epub Date: 2023-07-10 DOI: 10.1016/j.heha.2023.100073
Sylvia A. Takyi , John Arko-Mensah , Niladri Basu , Serwaa Bawuah , Duah Dwomoh , Julius N. Fobil
{"title":"Iron- and protein rich diets may boost hemoglobin levels among informal electronic waste recyclers exposed to metals at Agbogbloshie, Ghana","authors":"Sylvia A. Takyi ,&nbsp;John Arko-Mensah ,&nbsp;Niladri Basu ,&nbsp;Serwaa Bawuah ,&nbsp;Duah Dwomoh ,&nbsp;Julius N. Fobil","doi":"10.1016/j.heha.2023.100073","DOIUrl":"10.1016/j.heha.2023.100073","url":null,"abstract":"<div><p>While human exposure to metals may play a role in the pathogenesis of anemia, consumption of balanced diets may boost blood hemoglobin (Hb) levels in humans. Although informal electronic waste (e-waste) recycling processes have recently drawn attention as an important source of pollution, there is almost no empirical evidence on the relationship between diet, metals exposure and anemia among e-waste recyclers. Therefore, we evaluated possible ameliorating effects of diet on metal exposure related anemia, as measured by Hb levels of e-waste recyclers and a reference population in Ghana.</p><p>This repeated measure study used data collected from e-waste recyclers (<em>n</em>=142) and a reference population (<em>n</em>=65) between March 2017 and October 2018. Stored whole blood samples were analyzed for the following metals; Cd, Pb, Rb, Tb, Tl, and Eu. Next, Hb levels were analysed using the URIT-810® semiautomatic biochemistry analyzer. Furthermore, a 48-hour dietary recall questionnaire was administered to assess dietary intake parameters such as protein, folate, carbohydrates, Fe, Ca, Mg, Se, Zn, and Cu. Ordinary regression models were used to estimate joint effects of metals and nutrients on Hb levels.</p><p>At baseline, the mean Hb was lower among recyclers (12.99 ± 3.17 g/dL) than the reference group (13.02±2.37 g/dL). Blood Pb, Cd, Rb, Eu and Tb were associated with significant decreases in Hb levels of e-waste recyclers. Dietary intake of proteins and Fe was associated with concomitant increase in Hb levels of both groups as well as when analysis was restricted to recyclers. Despite the high exposure of e-waste recyclers to a myriad of metals, consumption of Fe-rich diets appears to ameliorate anemia and improved Hb levels (β=0.229; 95% CI: 0.013, 0.445; <em>p</em>=0.04). Therefore, the consumption of Fe and protein-rich foods may boost blood Hb levels in e-waste recyclers, even though exposure to high levels of metals is a predictor of anemia among this worker-group.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100073"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44741288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening for elevated blood lead levels using single hair strands: Accounting for external contamination 使用单根头发筛选血铅水平升高:考虑外部污染
Hygiene and environmental health advances Pub Date : 2023-12-01 Epub Date: 2023-09-04 DOI: 10.1016/j.heha.2023.100081
Jennie R. Christensen , Geriene O. LaBine , Joyce McBeth
{"title":"Screening for elevated blood lead levels using single hair strands: Accounting for external contamination","authors":"Jennie R. Christensen ,&nbsp;Geriene O. LaBine ,&nbsp;Joyce McBeth","doi":"10.1016/j.heha.2023.100081","DOIUrl":"10.1016/j.heha.2023.100081","url":null,"abstract":"<div><p>Hair has long been explored as a potential biomarker of lead exposure since lead is readily adsorbed into hair's keratinous matrix; however, the utility of hair as a biomarker for lead exposure is hampered by its susceptibility to external contamination: lead particles attach to the exposed hair surface, confounding estimates of endogenous concentrations. This study describes the development of a hair screening tool, in which the confounding influence of external contamination are mitigated by focusing on the unexposed hair root, to predict elevated blood lead levels (BLLs). This tool requires a single strand of scalp hair, which is analyzed using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Forty-four (44) workers with high potential for lead exposure, and 63 reference individuals (with no known lead exposure) volunteered for the study. Hair lead level (HLL) thresholds were developed using methods from clinical assessment to screen exceedances of BLL thresholds at 10 and 15 µg/dL. Hair from both groups showed significantly lower lead concentrations in below-scalp portions compared to above the scalp (above-scalp was 11.2 times higher in workers, and 3.7 times higher in reference group). Hair lead concentrations below the scalp in workers significantly predicted BLLs. HLL thresholds for screening BLLs were 0.60 mg/kg and 0.75 mg/kg for BLLs of 10 µg/dL and 15 µg/dL, respectively. These HLL thresholds yielded high sensitivity (&gt;85%), and slightly lower specificity (67% and 33%, for BLL thresholds of 10 µg/dL and 15 µg/dL, respectively). This study provides reference HLLs in non-contaminated portions of hair (&lt;0.097 mg/kg), shows the significance of external contamination on exposed portions of hair even in a reference population, and assesses the effectiveness of below-scalp hair as a biomarker of elevated lead exposure. This hair screening tool effectively predicted BLL exceedances and could be considered as a non-invasive alternative to blood sampling.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48693017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A comparison study of environmental health related issues and policies between private and public U.S. schools using multi-level data 使用多层次数据对美国私立和公立学校环境健康相关问题和政策的比较研究
Hygiene and environmental health advances Pub Date : 2023-12-01 Epub Date: 2023-09-04 DOI: 10.1016/j.heha.2023.100079
Yi Lu , Christine Bozlak , Erin Bell , Haider A. Khwaja , Shao Lin
{"title":"A comparison study of environmental health related issues and policies between private and public U.S. schools using multi-level data","authors":"Yi Lu ,&nbsp;Christine Bozlak ,&nbsp;Erin Bell ,&nbsp;Haider A. Khwaja ,&nbsp;Shao Lin","doi":"10.1016/j.heha.2023.100079","DOIUrl":"10.1016/j.heha.2023.100079","url":null,"abstract":"<div><h3>Objective</h3><p>Little is known about school environmental health (EH) problems in private schools. This study identified and compared the school EH related issues and policies between private and public schools in the U.S.</p></div><div><h3>Methods</h3><p>School EH information was collected from school administrators on two levels – in New York State (NYS) and nationwide. In NYS, questionnaires were developed and distributed to administrators from both public and private schools via conferences (2015–2016). Nationwide survey data were obtained from the 2014 School Health Policies and Practices Study. We compared the perceived school environment as well as policies related to identification and training on EH issues between private and public schools both in NYS and nationwide.</p></div><div><h3>Results</h3><p>In NYS, both private and public schools reported limited use of proactive approaches in identifying EH issues. Compared to public schools, more private school respondents reported poorer perceived indoor air quality (IAQ) (30% vs. 0%), along with less routine training and lower use of policies that help improve air quality in school. Nationwide, fewer private schools implemented indoor air quality management programs (18% vs. 58%) and were able to always meet ventilation standards (44% vs. 64%) than public schools. Staff members in private schools received less required training on a wide range of EH issues than staff members in public schools.</p></div><div><h3>Conclusion</h3><p>U.S. private schools reported worse perceived indoor air quality than public schools and a lack of awareness and protective policies. Future environmental research and implementation of policies are needed in private schools.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000351/pdfft?md5=93dabc13a3c9148e6d3737c335a69b98&pid=1-s2.0-S2773049223000351-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42927410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible hazardous components in dental alginates: Physicochemical properties by a mineralogical and spectroscopic investigation 牙藻酸盐中可能的有害成分:通过矿物学和光谱研究的物理化学性质
Hygiene and environmental health advances Pub Date : 2023-12-01 Epub Date: 2023-11-13 DOI: 10.1016/j.heha.2023.100083
Matteo Ardit , Tommaso Baroni , Fabio Capacci , Giulio Arcangeli , Maurizio Romanelli , Alfonso Zoleo , Silvana Capella , Elena Belluso , Pietro Gabellini , Raffaello Cioni , Francesco Di Benedetto
{"title":"Possible hazardous components in dental alginates: Physicochemical properties by a mineralogical and spectroscopic investigation","authors":"Matteo Ardit ,&nbsp;Tommaso Baroni ,&nbsp;Fabio Capacci ,&nbsp;Giulio Arcangeli ,&nbsp;Maurizio Romanelli ,&nbsp;Alfonso Zoleo ,&nbsp;Silvana Capella ,&nbsp;Elena Belluso ,&nbsp;Pietro Gabellini ,&nbsp;Raffaello Cioni ,&nbsp;Francesco Di Benedetto","doi":"10.1016/j.heha.2023.100083","DOIUrl":"10.1016/j.heha.2023.100083","url":null,"abstract":"<div><p>Alginates are products used as impression materials in dentistry and prosthetics. They consist of polymers, calcium alginates mixed with diatomite and additives. Recently, the occurrence of severe silicosis associated with exposure to respirable dust of such materials has increased the scientific interest in understanding how these materials may pose a toxicological problem to workers. The primary objective of this study is to improve the understanding of both the existence and the characteristics of the toxicant(s) contained in these materials, with the goal of better defining the risk assessment for this occupational setting.</p><p>Two commercial dental alginates were subjected to a mineralogical, microchemical and spectroscopic investigation. The results indicate the presence of a significant amount of diatomite, clearly identified by micromorphology and formed mainly by cristobalite. The respirable fraction of the dust represents at least 30  % of the total number of particles, and this fraction contains a relevant amount of crystalline silica particles. Conversely, the investigated alginate materials do not exhibit the presence of radical species.</p><p>The results obtained confirm that the cristobalite detected originates from the high-temperature transformation of amorphous silica during the calcination process of diatomite, prior to mixing with the other components. The same process also produces wollastonite (CaSiO<sub>3</sub>), which, like cristobalite, is a crystalline phase known for its toxicological effects. The present findings call for a rethinking of dental alginates with regard to the definition of their health risks for technical operators.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100083"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000399/pdfft?md5=50894293228e154b1fe3583c48795e26&pid=1-s2.0-S2773049223000399-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135714983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Water quality in rural Greenland - acceptability and safety 格陵兰农村的水质——可接受性和安全性
Hygiene and environmental health advances Pub Date : 2023-09-01 DOI: 10.1016/j.heha.2023.100065
Judith Y A Maréchal, L. Hansen, P. Jensen
{"title":"Water quality in rural Greenland - acceptability and safety","authors":"Judith Y A Maréchal, L. Hansen, P. Jensen","doi":"10.1016/j.heha.2023.100065","DOIUrl":"https://doi.org/10.1016/j.heha.2023.100065","url":null,"abstract":"","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54448291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Persistence of MRSA and ESBL-producing E. coli and K. oxytoca in river water 耐甲氧西林金黄色葡萄球菌和产esbl的大肠杆菌和脱氧梭菌在河水中的持久性
Hygiene and environmental health advances Pub Date : 2023-09-01 Epub Date: 2023-07-04 DOI: 10.1016/j.heha.2023.100072
Sarah M. Essert , Nicole Zacharias , Tabea Precht , Debbie Pankratz , Karolin Funken , Nico T. Mutters , Thomas Kistemann , Christiane Schreiber
{"title":"Persistence of MRSA and ESBL-producing E. coli and K. oxytoca in river water","authors":"Sarah M. Essert ,&nbsp;Nicole Zacharias ,&nbsp;Tabea Precht ,&nbsp;Debbie Pankratz ,&nbsp;Karolin Funken ,&nbsp;Nico T. Mutters ,&nbsp;Thomas Kistemann ,&nbsp;Christiane Schreiber","doi":"10.1016/j.heha.2023.100072","DOIUrl":"10.1016/j.heha.2023.100072","url":null,"abstract":"<div><p>Due to climate change precipitation patterns are changing in terms of frequency and quantity in Germany. As a result, prolonged dry weather can lead to extremely low flow rates in river systems with large portions of treated wastewater. However, storm events and heavy rainfall events are increasing too, which may lead to higher frequencies of combined sewer overflows. Increased microbial pollution (e.g. coliform bacteria, clostridia, faecal streptococci) of waterbodies after heavy precipitation events was demonstrated in several studies. Pathogenic multi-resistant bacteria enter waterbodies via sewer systems. The persistence potential of such pathogens in aquatic environments is mainly still unknown. This study investigated the growth behaviour of Gram-negative extended spectrum beta-Lactamase-producing <em>Klebsiella oxytoca</em> and <em>Escherichia coli</em> and Gram-positive methicillin-resistant <em>Staphylococcus aureus</em> in river water. The concentrations of these antibiotic-resistant bacteria were monitored in batch experiments using river water differently impacted by wastewater. <em>Staphylococcus aureu</em>s persisted for at least 3 days at incubation temperatures of 8 and 18 °C. The persistence of <em>K</em>. <em>oxytoca</em> and <em>E</em>. <em>coli</em> was shown for at least 37 days at both temperatures. In the river water at 8 °C, bacteria concentrations decreased slower, suggesting diminished persistence of ARB (antibiotic-resistant bacteria) with increasing temperatures. Initial concentrations of ARB and other pathogens in river water corresponded to the impact of wastewater. However, significant effects on the persistence itself by wastewater impact could not be shown for the bacteria species tested. Further studies should pursue our approaches concerning the persistence of pathogenic ARB in freshwater to assess the health risk for humans and animals.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"7 ","pages":"Article 100072"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46580793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fate of enteric bacteria and viruses in silt loam soil amended with biofertilizers made from human feces and urine for crop production 用人类粪便和尿液制成的生物肥料改良粉壤土中肠道细菌和病毒的命运
Hygiene and environmental health advances Pub Date : 2023-09-01 Epub Date: 2023-06-10 DOI: 10.1016/j.heha.2023.100067
Priscila Carlon , Fernanda Daniela Gonçalves Ferreira , Cacea Furlan Maggi Carloto , Gislaine Fongaro , Maria Elisa Magri
{"title":"Fate of enteric bacteria and viruses in silt loam soil amended with biofertilizers made from human feces and urine for crop production","authors":"Priscila Carlon ,&nbsp;Fernanda Daniela Gonçalves Ferreira ,&nbsp;Cacea Furlan Maggi Carloto ,&nbsp;Gislaine Fongaro ,&nbsp;Maria Elisa Magri","doi":"10.1016/j.heha.2023.100067","DOIUrl":"10.1016/j.heha.2023.100067","url":null,"abstract":"<div><p>Human excreta can be used as biofertilizers due to their nutrient and organic matter content. Nevertheless, the behavior of microorganisms should be investigated, as enteric pathogens can accumulate in the soil. Therefore, we evaluated the survival and transport of two enteric bacteria (<em>E. coli</em> and <em>Salmonella enterica</em>) and two enteric virus surrogates (MS2 and ΦX-174 bacteriophages) when applied as contaminants of four biofertilizers on <em>Lactuca sativa</em> production. The study was carried out in lysimeters outdoors with repacked silt loam soil, using a randomized block design (RBD) with six treatments and three replicates. Biofertilizers were urea-treated feces, feces composted with organic waste, stored liquid urine, and struvite and were inoculated at 10<sup>6</sup>–10<sup>7</sup> cfu/pfu g<sup>−1</sup> of <em>E. coli</em> and bacteriophages strains and 10<sup>7</sup>–10<sup>9</sup> of <em>S. enterica</em>. Soil amended with composted feces exhibited the lowest decimal reductions (T<sub>90</sub>) for the microorganisms evaluated, with 10.2 days for <em>E. coli</em>, 11.9 days for <em>S. enterica</em>, 22.2 days for MS2, and 3.7 days for ΦX-174. Urea-treated feces temporarily hindered the growth and survival of <em>E. coli</em> and <em>S. enterica</em> in the soil. However, both bacteria were present after one month, while MS2 showed a stable concentration with this biofertilizer. <em>E. coli</em> presented a stable behavior when applied with urine, whereas MS2 was stable with urea-treated feces, urine, and struvite. ΦX-174 and <em>S. enterica</em> were not considered good representatives of most resistant enteric pathogens’ behavior in the soil during food production since they were not detected in leachate and showed a rapid die-off in soil. <em>E. coli</em> leached faster and in higher concentrations than MS2, which presented higher concentrations in deeper soil layers, from 10 to 20 cm. Therefore, using urine, struvite, and urea-treated faces implied a higher chance of infection, as a decimal reduction time was not observed during the 36 days of the experiment. As a result, in short-term cultures, it is recommended that additional hygiene barriers are taken to avoid infection since <em>E. coli</em> and MS2 were still detected at the end of the experiment. An interval of 90 days between fertilizing and harvesting is recommended to prevent pathogen infection. These results are the basis for a quantitative risk assessment of human excreta-based biofertilizers for food production.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"7 ","pages":"Article 100067"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46750308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxicity assessment of CeO₂ and CuO nanoparticles at the air-liquid interface using bioinspired condensational particle growth 采用仿生缩聚颗粒生长法评价氧化铈和氧化铜纳米颗粒在气液界面的毒性
Hygiene and environmental health advances Pub Date : 2023-09-01 Epub Date: 2023-08-06 DOI: 10.1016/j.heha.2023.100074
Trevor B. Tilly , Ryan X. Ward , Alyssa F. Morea , M. Tyler Nelson , Sarah E. Robinson , Arantzazu Eiguren-Fernandez , Gregory S. Lewis , John A. Lednicky , Tara Sabo-Attwood , Saber M. Hussain , Chang-Yu Wu
{"title":"Toxicity assessment of CeO₂ and CuO nanoparticles at the air-liquid interface using bioinspired condensational particle growth","authors":"Trevor B. Tilly ,&nbsp;Ryan X. Ward ,&nbsp;Alyssa F. Morea ,&nbsp;M. Tyler Nelson ,&nbsp;Sarah E. Robinson ,&nbsp;Arantzazu Eiguren-Fernandez ,&nbsp;Gregory S. Lewis ,&nbsp;John A. Lednicky ,&nbsp;Tara Sabo-Attwood ,&nbsp;Saber M. Hussain ,&nbsp;Chang-Yu Wu","doi":"10.1016/j.heha.2023.100074","DOIUrl":"10.1016/j.heha.2023.100074","url":null,"abstract":"<div><p>CeO<sub>2</sub> and CuO nanoparticles (NPs) are used as additives in petrodiesel to enhance engine performance leading to reduced diesel combustion emissions.   Despite their benefits, the additive application poses human health concerns by releasing inhalable NPs into the ambient air.  In this study, a bioinspired lung cell exposure system, Dosimetric Aerosol <em>in Vitro</em> Inhalation Device (DAVID), was employed for evaluating the toxicity of aerosolized CeO<sub>2</sub> and CuO NPs with a short duration of exposure (≤10 min vs. hours in other systems) and without exerting toxicity from non-NP factors.  Human epithelial A549 lung cells were cultured and maintained within DAVID at the air-liquid interface (ALI), onto which aerosolized NPs were deposited, and experiments in submerged cells were used for comparison.  Exposure of the cells to the CeO<sub>2</sub> NPs did not result in detectable IL-8 release, nor did it produce a significant reduction in cell viability based on lactate dehydrogenase (LDH) assay, with a marginal decrease (10%) at the dose of 388 μg/cm<sup>2</sup> (273 cm<sup>2</sup>/cm<sup>2</sup>).  In contrast, exposure to CuO NPs resulted in a concentration dependent reduction in LDH release based on LDH leakage, with 38% reduction in viability at the highest dose of 52 μg/cm<sup>2</sup> (28.3 cm<sup>2</sup>/cm<sup>2</sup>).  Cells exposed to CuO NPs resulted in a dose dependent cellular membrane toxicity and expressed IL-8 secretion at a global dose five times lower than cells exposed under submerged conditions.  However, when comparing the ALI results at the local cellular dose of CuO NPs to the submerged results, the IL-8 secretion was similar.  In this study, we demonstrated DAVID as a new exposure tool that helps evaluate aerosol toxicity in simulated lung environment. Our results also highlight the necessity in choosing the right assay endpoints for the given exposure scenario, e.g., LDH for ALI and Deep Blue for submerged conditions for cell viability.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"7 ","pages":"Article 100074"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/5c/nihms-1929001.PMC10500621.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10358808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dengue outbreak following unprecedented flooding in Pakistan 巴基斯坦发生史无前例的洪水后爆发登革热
Hygiene and environmental health advances Pub Date : 2023-09-01 Epub Date: 2023-08-06 DOI: 10.1016/j.heha.2023.100076
Omer A. Shaikh , Mirza T. Baig , Sara Tahir , Ad-Duhaa E. Parekh , Abdulqadir J. Nashwan
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