Min Zhang , Dan Cai , Lijuan Zhang , Qian Zhang , Ping Ding , Xiaoxia Chen , Chushan Huang , Guocheng Hu , Tingzhen Li
{"title":"Polybrominated diphenyl ethers in aquatic products of Guangzhou city, South China: Accumulation, distribution and health risk","authors":"Min Zhang , Dan Cai , Lijuan Zhang , Qian Zhang , Ping Ding , Xiaoxia Chen , Chushan Huang , Guocheng Hu , Tingzhen Li","doi":"10.1016/j.heha.2023.100085","DOIUrl":"10.1016/j.heha.2023.100085","url":null,"abstract":"<div><p>Studies have shown that consuming aquatic products is the primary pathway for human uptake of polybrominated diphenyl ethers (PBDEs). This study collected seven types of aquatic products eaten in Guangzhou City. Gas chromatography‒mass spectrometry (GC/MS) was used to investigate eight PBDE congeners to analyze their concentration, distribution, and potential risk. The concentration of PBDEs in aquatic products ranged from 1.92 to 91.11 ng/g lw, with BDE–209, BDE–99, and BDE–154 as the predominant PBDE congeners. Moreover, the concentrations and congener profiles of these contaminants vary in aquatic products. The highest accumulation level was found in shrimp and clams, primarily attributed to dietary habits, metabolic capacity, and accumulation of xenobiotics. According to the dietary questionnaire, the total consumption of aquatic animals was 82.64 g/day, with a significant non-carcinogenic risk to consumers in Guangzhou at higher levels of consumption (HI ≥ 1). Therefore, the maximum allowable daily consumption of grass carp, crucian carp, tilapia, Japanese seaperch, shrimp, clam and crab is 33.33, 55.00, 67.50, 44.44, 41.67, and 51.67 g/day, corresponding to daily intake frequencies of 5, 8, 10, 6, 6, 7, and 5 times/month, respectively. Our results could provide reasonable dietary advice for humans.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100085"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000417/pdfft?md5=e1e8cae69a5cf9d437902d3d6be1d983&pid=1-s2.0-S2773049223000417-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138609411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jin-Long Mai , Wei-Wei Yang , Yuan Zeng , Yu-Feng Guan , She-Jun Chen
{"title":"Volatile organic compounds (VOCs) in residential indoor air during interior finish period: Sources, variations, and health risks","authors":"Jin-Long Mai , Wei-Wei Yang , Yuan Zeng , Yu-Feng Guan , She-Jun Chen","doi":"10.1016/j.heha.2023.100087","DOIUrl":"10.1016/j.heha.2023.100087","url":null,"abstract":"<div><p>Building and furniture materials are significant sources of volatile organic compounds (VOCs) and determine their long-time indoor levels. However, the variations of indoor VOCs and associated health risks of interior finishers during the construction stages are poorly understood. In this study, VOCs in the indoor microenvironments were measured at different interior finishing stages at two renovated residences using thermal desorption and gas chromatography-mass spectrometry. The mean concentrations of the Σ15 VOCs were 118.2 μg/m<sup>3</sup> in Home A and 232.5 μg/m<sup>3</sup> in Home B. The simultaneous outdoor levels were approximately three times lower than indoors. The VOC concentrations were obviously lower than previous measurements in newly renovated residences, reflecting reduced use of these VOCs in interior materials. Temporal variations in the VOC concentrations during the interior finish period were compound- or room-dependent at each residence The remarkable rise in the VOC concentrations was largely affected by furniture installation at both residences. The non-cancer risks of VOC exposure were lower for both interior finishers and occupants. However, the cumulative cancer risks for interior finishers (1.2 × 10<sup>−4</sup>) exceed the acceptable threshold limit. The occupational exposure at the wall painting stage was the highest, and formaldehyde is the most significant contributor to both cancer and noncancer risks. This study also highlights the importance of detecting novel VOCs that may be present in interior finish materials as indicated by the TVOC measurements.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100087"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000430/pdfft?md5=0a90a13d749306b6bad4ff55d9247d1a&pid=1-s2.0-S2773049223000430-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138614024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuxuan Zhao , Jing Wang , Gongshu Liu , Yeganeh Ataei , Carl-Gustaf Bornehag , Wei Liu , Qinghao Zhang , Jianjun Huang , Peizhe Sun , Yuexia Sun
{"title":"The CHECH study: A prospective pregnancy cohort study on CHemical exposure and children's health in Tianjin, China","authors":"Yuxuan Zhao , Jing Wang , Gongshu Liu , Yeganeh Ataei , Carl-Gustaf Bornehag , Wei Liu , Qinghao Zhang , Jianjun Huang , Peizhe Sun , Yuexia Sun","doi":"10.1016/j.heha.2023.100084","DOIUrl":"https://doi.org/10.1016/j.heha.2023.100084","url":null,"abstract":"<div><p>The CHemical Exposure and Children's Health (CHECH) study is an ongoing pregnancy cohort study in Tianjin, China. This paper describes the background, aim and the study design, which can be followed by future researchers to design and conduct similar studies. The abundance and the potential adverse health outcomes of endocrine disrupting chemicals (EDCs) is concerning. More notably, developing fetuses and infants are more vulnerable to EDCs exposure. The CHECH study aims to investigate the importance of early life exposure to multiple EDCs (phthalates and their metabolites, bisphenol A and their substitutes, perfluorinated compounds and poly brominated diphenyl ethers) for multiple health outcomes in Chinese children, namely sexual development, neurodevelopment, metabolism and growth, as well as asthma and allergy. A total of 2238 pregnant women were recruited in Tianjin from May 2017 to April 2021 with a response rate of 90 %. Among these women, 2255 children were born with available information, including 47 pairs of twins. Urine samples were collected from pregnant women and children, while air and dust samples were obtained from the home environment during pregnancy and infancy periods. Information on children's health was gathered through physical examinations and questionnaires. The CHECH study, which collected exposure information and health outcomes at multiple time points, will contribute to the understanding of prenatal exposure to EDCs and their impact on children's health, thereby facilitating the development of risk assessments aimed at reducing exposure and associated health risks.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100084"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000405/pdfft?md5=46a5699788d9c492a359cce94921c2e3&pid=1-s2.0-S2773049223000405-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138558634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mengyuan Ren , Mingliang Fang , Jing Liu , Qun Lu , Hongchu Bao , Lili Zhuang , Fangang Meng , Bo Pan , Lailai Yan , Zhiwen Li , Jia Xu , Bin Han , Zhipeng Bai , Chan Tian , Ying Wang , Bin Wang
{"title":"Applying hair exposome for linking environmental exposure to reproductive health: A comprehensive review and research perspective","authors":"Mengyuan Ren , Mingliang Fang , Jing Liu , Qun Lu , Hongchu Bao , Lili Zhuang , Fangang Meng , Bo Pan , Lailai Yan , Zhiwen Li , Jia Xu , Bin Han , Zhipeng Bai , Chan Tian , Ying Wang , Bin Wang","doi":"10.1016/j.heha.2023.100086","DOIUrl":"10.1016/j.heha.2023.100086","url":null,"abstract":"<div><p>Increasing evidences have revealed a close relationship between various environmental exposures and reproductive health. The real-world complex exposure scenario along with intricate interactions effects of these exposures has high demands of exposome-wide association studies for human risk assessment. With the development of exposomic studies, applying hair exposome to link environmental factors and reproductive health outcomes has obvious potential advantages. However, the reliability of utilizing hair to characterize exposome is always of high concern for researchers. In this review, we briefly summarized studies about the effects of environmental exposures on several typical reproductive health outcomes, described state-of-the-art situation of applying hair exposome for reproductive health risk assessment, elucidated the advantages (e.g., containing abundant exposure factors, low expenses for sampling, and tracing exposure history), and proposed the unsolved issues in this area. We also conducted a comprehensive discussion about the reliability of various hair biomarkers and primarily established the biomarker databases. Finally, a standardized framework on using hair exposome for reproductive health study was proposed to provide fundamental approach for future studies. We concluded that it is promising to apply hair exposome to evaluate the effects of the environmental factors on human reproductive health.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100086"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000429/pdfft?md5=ac091d74bccc4a0b12af9120214b4092&pid=1-s2.0-S2773049223000429-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138626926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kathy C. Nguyen , Subramanian Karthikeyan , Ellen J.D. Lye , Huda Masoud , Janine Clarke , Julie L. Yome , Djordje Vladisavljevic , Laurie H.M. Chan , Annie St-Amand
{"title":"Blood lead levels in the general population and vulnerable sub-populations and related risk factors for lead exposure in Canada","authors":"Kathy C. Nguyen , Subramanian Karthikeyan , Ellen J.D. Lye , Huda Masoud , Janine Clarke , Julie L. Yome , Djordje Vladisavljevic , Laurie H.M. Chan , Annie St-Amand","doi":"10.1016/j.heha.2024.100088","DOIUrl":"10.1016/j.heha.2024.100088","url":null,"abstract":"<div><p>Lead is an environmental contaminant that is considered a major public health concern due to its effects on various body systems, such as the neurological, cardiovascular, immune and renal systems. Scientific evidence indicates that health effects occur in people at blood lead levels (BLLs) lower than those previously established as levels of concern; no safe level of lead exposure has been established. Lead has been monitored as part of various national and international biomonitoring programs. The aims of this study were: (1) to examine BLLs in the Canadian general population and vulnerable sub-populations between 2007 and 2013 using data from the Canadian Health Measures Survey (CHMS); and (2) to assess factors that are associated with elevated BLLs in these populations. BLLs in Canadians were in a decreasing trend over the study period. BLLs in Canadians varied by age and sex. Those aged 60 to 79 years had the highest BLLs, while the 12 to 19 years age group had the lowest BLLs. Males exhibited significantly higher BLLs than females. In young children aged 3 to 5 years, 99.9 % had BLLs below 5 µg/dL (blood lead reference level for children). BLLs in pregnant women were lower than those in non-pregnant women in the same age range. Multivariable regression analysis suggested that factors such as immigration status, household income, educational level, age of dwelling, smoking status, second-hand smoke exposure, alcohol consumption, and fish and shellfish consumption, were significantly associated with BLLs. This study presents the first robust analysis of BLLs in the Canadian vulnerable populations and assessment of factors associated with elevated BLLs. This information may be useful to identify population subgroups who are differentially exposed to lead based on various exposure factors and are at risk for lead exposure in Canada.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100088"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000011/pdfft?md5=ca6f5b9ed2a6d123df5ddc569e174d5a&pid=1-s2.0-S2773049224000011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139684797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melissa L. Vermette , Mason R. Hicks , Keyvan Khoroush , Mark Y. Teo , Byron D. Gates
{"title":"Wipe sampling of antineoplastic drugs from workplace surfaces: A review of analytical methods and recommendations","authors":"Melissa L. Vermette , Mason R. Hicks , Keyvan Khoroush , Mark Y. Teo , Byron D. Gates","doi":"10.1016/j.heha.2024.100089","DOIUrl":"https://doi.org/10.1016/j.heha.2024.100089","url":null,"abstract":"<div><p>Antineoplastic drugs (ADs) are primarily used to manage cancer and are becoming more prevalent as cancer cases increase globally. A primary route of exposure for workers administering these hazardous drugs is <em>via</em> dermal absorption from contact with contaminated surfaces. To assess the risk in a workplace, wipe sampling is used to inspect and assess suspect workplace surfaces (i.e., as a form of worker exposure and environmental monitoring). Despite widespread use of ADs, there are no standards or proficiency testing programs (at this time) for surface wipe sampling protocols specifically for residues that contain ADs. Current literature provides many different analytical methods developed by research groups for detecting one or more ADs in residue found in the workplace. These studies contain significant variability in the techniques and materials used and, therefore, also vary in their outcomes. This review highlights the variability observed in the results obtained from current methods and points to opportunities that might assist in addressing these inconsistencies towards preparing standard methodologies for wipe sampling of ADs. This review also discusses critical factors to consider when optimizing the steps performed for surface wipe sampling. The inter-dependent steps discussed in this review for surface wipe sampling are: (i) adsorption of analyte onto a wipe; (ii) desorption of the analyte from the wipe; and (iii) detection of the sampled analyte. The first two steps require optimization of both chemical and physical factors to create a successful sampling method. The detection step has largely been optimized due in part to the sensitivity of analytical instrumentation, but there remain opportunities to develop more effective methodologies for timely feedback and an increased sensitivity to platinum-based ADs. This review also provides additional recommendations to improve reporting of results from the wipe sampling of ADs and highlights the need for additional research on the occupational and surface exposure limits for ADs.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100089"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000023/pdfft?md5=04c1448545d432d4e198c003ded2eb39&pid=1-s2.0-S2773049224000023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139743771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Savabieasfahani , F.Basher Ahamadani , Ban Talib Fadhel
{"title":"Congenital anomalies in Baghdad children born near US military burn-pits: A case-control study showing tungsten and chromium association with increased odds of disease","authors":"M. Savabieasfahani , F.Basher Ahamadani , Ban Talib Fadhel","doi":"10.1016/j.heha.2024.100090","DOIUrl":"https://doi.org/10.1016/j.heha.2024.100090","url":null,"abstract":"<div><p>Increases in congenital anomalies were reported from Iraq post-2003. We investigated associations of residential proximity to two US military bases – Camp Victory and Base Falcon – and metal levels in hair samples of children with congenital anomalies (22 cases and 9 controls). We developed mixed effects logistic regression models with village as the random effect, congenital anomalies as the outcome and distance to the closest US base and hair metal levels (one at a time) as the exposure, controlling for child's age, sex, and paternal education. We explored the mediation of the association between proximity to the base and congenital anomalies by hair metal levels. Children with higher tungsten (W) in hair had marginally higher odds of congenital anomalies (OR=1.32, 95 %CI = (1.01,2.02), <em>P</em>=.10). One µg/kg increase in W was associated with 41 % higher odds of a congenital abnormality (95 %CI=(1.08,2.33), <em>P</em>=.04). But proximity to military bases didn't have any effect on congenital anomalies. Higher hair chromium (Cr) marginally increased the odds of congenital anomalies (OR=1.02, 95 %CI=(1.00,.05), <em>P</em>=.09). Children with one µg/kg higher concentration of Cr in hair had 3 % higher odds of having congenital anomalies (95 %CI=(1.01,1.07), <em>P</em>=.04). Analyses were conducted by Inductively Coupled Plasma Mass Spectrometry.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"9 ","pages":"Article 100090"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000035/pdfft?md5=c04a701ff6d76ddc9009ace6400e739b&pid=1-s2.0-S2773049224000035-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139700287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum regarding missing declaration of competing interest statements and ethical statements in previously published articles","authors":"","doi":"10.1016/j.heha.2023.100082","DOIUrl":"https://doi.org/10.1016/j.heha.2023.100082","url":null,"abstract":"","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100082"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049223000387/pdfft?md5=d23238212462f43f62f029ebe4c53afe&pid=1-s2.0-S2773049223000387-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92108562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kuan-Che Feng , Haijiao Liu , Anish Ghai , Juyi Li , Huiting Luo , Won-Il Lee , Steffen Mueller , Jerome Cymerman , Marcia Simon , Miriam Rafailovich
{"title":"The influence of environmental conditions and hypochlorous acid (HOCl) fogging on the infectivity of H1N1 influenza virus","authors":"Kuan-Che Feng , Haijiao Liu , Anish Ghai , Juyi Li , Huiting Luo , Won-Il Lee , Steffen Mueller , Jerome Cymerman , Marcia Simon , Miriam Rafailovich","doi":"10.1016/j.heha.2023.100077","DOIUrl":"https://doi.org/10.1016/j.heha.2023.100077","url":null,"abstract":"<div><p>The influence of different environmental factors on the infectivity of H1N1 influenza virus was measured. We found less than 1-log reduction when viruses were exposed to NaCl solutions up to 5 M or solutions with pH = 4 through 11 for one hour. The infectivity of the virus was sensitive to the solution temperature. A log reduction ranging from 2 to more than 6 was observed starting at 50 °C and spanning just 3 or 5 for 10- or 30 min exposures, respectively. Drying the virus in media on aluminum or polymer coupons for 48 h resulted in a log reduction of 4 when kept at room temperature, but less than one when kept at 4 °C or -20 °C. Log reduction greater than 6 occurred at room temperature after 3 days, but only 1-log reduction occurred at 4 and -20 °C after 6 days. Drying on different coinage achieved similar results, except for pennies, where more than 6-log reduction was observed after 24 h. HOCl was used to fog the aluminum and polymer surfaces, placed vertically, for 5 and 7.5 min to achieve a log reduction of 4 and for 6.5 respectively. Storage of opened solution containers for 9 months at ambient resulted in a decrease in chlorine concentration from 550 ppm to 240 ppm. Fogging with the old solution was still able to achieve a log reduction of 6.5 after 7.5 min fogging. The study indicates that exposure to common environmental conditions such as a wide pH range, high salinity, and low temperatures has only a minor effect on infectivity. which can persist for more than 5 days when dried on commonly encountered surfaces, allowing accumulation of infectious viral titre. Fogging with HOCl is an effective method of delivering disinfectants to large areas, achieving complete reduction of the viral titer on both horizontal and vertical surfaces.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100077"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49891248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Agribusiness in Brazil and its dependence on the use of pesticides","authors":"Shaiane Carla Gaboardi , Luciano Zanetti Pessôa Candiotto , Carolina Panis","doi":"10.1016/j.heha.2023.100080","DOIUrl":"10.1016/j.heha.2023.100080","url":null,"abstract":"<div><p>By virtue of its availability of arable land, tropical climate, and abundance of water resources, Brazil is one of the largest agricultural and livestock producers in the world, with agribusiness geared towards global trade. Consequently, the country appears on the international scene as one of the main consumers of pesticides. This article presents the current panorama of pesticide use in Brazil and highlights the tendency of government permissiveness and support in this sector, through the increase in the number of registrations granted annually and strategies to modify the current legislation. The methodological procedures were: discussion about causes and consequences of pesticide use, considering economic interests, social and environmental impacts; collection and analysis of data made available by official Brazilian agencies on the pesticides marketing and main cultivated products; study of Bill 6,299/2002; and positioning of public institutions linked to work, health and the environment, through the technical notes issued by them. Conceptually, we found our arguments on Political Ecology and Geography ideas to demonstrate that the exacerbated use of pesticides in Brazil is a great environmental and social injustice, contaminating natural resources and the Brazilian population that handles or consumes food and water with high levels of residues. The data reveal that the productive specialization has led to a progressive increase in the use of pesticides in Brazil, and the government has been extremely permissive of, and even conniving with, the interests of companies linked to agribusiness, making the process of evaluating and releasing pesticide products even less rigid.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"8 ","pages":"Article 100080"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44312400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}