Hygiene and environmental health advances最新文献

{"title":"Access to hygiene facilities and experiences of hygiene-related disease: A pilot study of unsheltered individuals in Tucson, Arizona","authors":"Bianca Nava ,&nbsp;Amanda M. Wilson","doi":"10.1016/j.heha.2024.100100","DOIUrl":"10.1016/j.heha.2024.100100","url":null,"abstract":"<div><p>Unsheltered individuals have limited access to restroom facilities. With this, many unsheltered individuals are forced to urinate, defecate, and engage in other hygiene practices outdoors. They may also lack access to necessary hygiene toiletries or wait to urinate or defecate until they are able to gain access to a facility. These challenges can lead to health issues, like urinary tract infections (UTIs), diarrhea, rashes, etc. The study objective was to understand the relationship between lack of access to basic hygiene facilities and health effects among unsheltered individuals. A verbal survey (English and Spanish) was used to explore the relationship between hygiene and unsheltered status. In Fall 2022, a researcher accompanied the homeless outreach team from El Rio Health, a Federally Qualified Health Center in Tucson, Arizona to verbally consent and recruit participants. Thirty consenting unsheltered adults ranging in ages from 29 to 68 years old participated in the study. Access to water was the greatest reported hygiene barrier, followed by access to soap, concerns for privacy, and concerns for safety. Eleven of thirty participants experienced a UTI at least once since becoming unsheltered and nine of thirty experienced a yeast infection at least once, with female participants having a statistically significant (<em>p</em> &lt; 0.05) higher rate of occurrence than male participants. In addition, 19/30 of participants experienced a rash at least once and 17/30 of participants experienced diarrhea at least once. However, 20/30 of participants did not seek medical care for their health-related issues. Low healthcare utilization when there is a high need for care highlights the importance of community outreach and care for those experiencing homelessness. Next steps include replicating the project on a larger scale to determine generalizability.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"11 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000138/pdfft?md5=7cbe95cd1cd86d51fda5035869986736&pid=1-s2.0-S2773049224000138-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141850596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative multivariate analysis for high-touch surface disinfection using optimized ultraviolet-C LEDs configuration","authors":"Jahanzeb Sheikh ,&nbsp;Tan Tian Swee ,&nbsp;Syafiqah Saidin ,&nbsp;Sameen Ahmed Malik ,&nbsp;José Javier Serrano Olmedo ,&nbsp;Lee Suan Chua ,&nbsp;Matthias Tiong Foh Thye ,&nbsp;Leong Kah Meng ,&nbsp;Ma Kun","doi":"10.1016/j.heha.2024.100101","DOIUrl":"10.1016/j.heha.2024.100101","url":null,"abstract":"<div><p>UV light-emitting diodes (LEDs) have been regarded as feasible alternatives for traditional UV lamps since the early 2000s, owing to their improved safety features, environmental advantages, and efficiency. Because of the inherent challenges associated with lower intensity of LEDs over extended distances, our findings demonstrated the optimized disinfection efficiency using various LED setups. This study evaluated the antimicrobial effectiveness of single, six, and eight-LED configurations against <em>Staphylococcus aureus</em> (<em>S. aureus</em>), specifically emphasizing attaining the utmost disinfection efficiency within an extended range of up to 60 cm. With an 8-LED configuration, the study achieved a substantial reduction of 6.10×10⁴ CFU/mL from an initial level of 5.20×10⁹ CFU/mL, corresponding to 4.9-log₁₀ inactivation, requiring a dose of 264 µJ-cm⁻². 2.9-log₁₀ inactivation was achieved using a 6-LED, yielding lower yet comparable efficiency requiring 192 µJ-cm⁻² of dose. However, with 60 µJ-cm⁻² of dose, a single LED could only reduce the bacterial burden from the initial level to merely 0.2-log₁₀ inactivation, corresponding to 2.9 × 10⁹ CFU/mL, under similar exposure settings. In conclusion, UV-LEDs show promise for disinfection, with LED configuration and distance significantly impacting their efficiency, holding perspective for various applications, particularly within healthcare facilities.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"11 ","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277304922400014X/pdfft?md5=4ada6873c8640341da8ccf8af922dfad&pid=1-s2.0-S277304922400014X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between prolonged dual use of cigarettes and E-cigarettes and psychosocial factors among U.S. Smokers: Secondary data analysis from the 2013 to 2019 PATH study","authors":"Rui Chen ,&nbsp;Angela Aherrera ,&nbsp;Miranda R. Jones ,&nbsp;Elizabeth A. Stuart ,&nbsp;Meghan F. Davis ,&nbsp;Ana M. Rule","doi":"10.1016/j.heha.2024.100103","DOIUrl":"10.1016/j.heha.2024.100103","url":null,"abstract":"<div><h3>Objective</h3><p>Dual use of combustible cigarettes and e-cigarettes is common among U.S. tobacco users, yet misperceptions about the harm of dual use persist, often oversimplifying its multifaceted exposure and health impacts. To address this gap, we evaluated the association of prolonged dual use (consecutive use for more than 1 year) with psychosocial factors, including perceptions of absolute and relative harm of e-cigarettes, social norms, and intentions to quit smoking, among U.S. adult smokers over time.</p></div><div><h3>Methods</h3><p>Using the data from Waves 1 to 5 (2013–2019) from the Population Assessment of Tobacco and Health (PATH) Study, we characterized dual use and prolonged dual use by sociodemographics and psychosocial factors among U.S. adult smokers. We examined the association between dual use, including prolonged dual use, and psychosocial factors over time using logistic regression.</p></div><div><h3>Results</h3><p>Dual use of smokers decreased from 19.8 % in 2013 to 16.4 % in 2019, and prolonged dual use among dual users decreased from 40.0 % in 2013 to 27.4 % in 2019. Prolonged dual users, independent of frequency of use, presented significantly higher cigarette dependence than temporary dual users. The perception of absolute e-cigarette harm (perceiving e-cigarettes as very or extremely harmful) was negatively associated with prolonged dual use. No significant association was found between prolonged dual use and perception of relative e-cigarette harm (perceiving e-cigarettes are less harmful that cigarettes) as well with intentions to quit smoking and beliefs that most people disapprove of e-cigarette use.</p></div><div><h3>Conclusion</h3><p>: Increased perceptions of absolute harm of e-cigarettes, rather than relative harm, appear to decrease prolonged dual use. Public health strategies should consider further emphasis in educating users of the absolute harm, as opposed to endorsing e-cigarette use as a harm reduction alternative, in their tobacco cessation efforts to further discourage dual use.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"11 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000163/pdfft?md5=12e5d20389317eb976e7821e55a0355f&pid=1-s2.0-S2773049224000163-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and age characteristics of thunderstorm asthma emergency department visits","authors":"M. Luke Smith ,&nbsp;Richard F. MacLehose ,&nbsp;Chris H. Wendt ,&nbsp;Jesse D. Berman","doi":"10.1016/j.heha.2024.100099","DOIUrl":"10.1016/j.heha.2024.100099","url":null,"abstract":"<div><p>Severe asthma has been shown to occur in the combined presence of high pollen and thunderstorm conditions, also known as ‘thunderstorm asthma.’ First studied as severe epidemic events, recent longitudinal work studied less dramatic but more frequent occurrences. We explore thunderstorm asthma-related emergency department visits in the Minneapolis-St. Paul metropolitan area and evaluated risk differences by sex and age. We define a thunderstorm asthma exposure event as the daily occurrence of 2 or more lightning strikes during high pollen periods, and use daily counts of asthma-related emergency department visits to estimate relative and absolute risk of severe asthma during thunderstorm asthma events for the full population and for sex and age subgroups. The overall population had a 1.06 (95 % CI: 1.02, 1.09) times higher risk of asthma-related ED visits during thunderstorm asthma events compared to days without thunderstorm asthma events. Children under 18 show no higher risk (RR 1.02; 95 % CI: 0.97 1.08), but adults 18–44 years (RR 1.08; 95 % CI: 1.02, 1.13) and 45 and up (RR 1.08; 95 % CI 1.02, 1.15) show higher relative risk. Absolute risk measures show similar patterns to the age and sex results, but age-sex subgroups show more variation in absolute vs relative risk. Our results support an association between ED visits and thunderstorm asthma and provide evidence of varying risks by sex across the life course. These differences in risk have implications for clinical treatment of this allergic type of asthma and for future research into this poorly recognized environmental exposure.</p><p>Plain Language Summary: Recent research has highlighted the existence of Thunderstorm asthma events, a phenomenon in which pollen grains rupture in the conditions that occur with a thunderstorm, releasing sub-pollen particles that are capable of triggering severe asthma in susceptible populations. Where severe asthma is a disease that usually impacts children, we find in this study that asthma ED visits associated with thunderstorm asthma events more frequently impact adults, particularly males 18–44 and females 45 and up.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"11 ","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000126/pdfft?md5=2069b0fa0173b6a2621c5feba8aca92e&pid=1-s2.0-S2773049224000126-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of endocrine disrupting chemicals with renal function in older individuals","authors":"Jiaoyang Chen ,&nbsp;Yue Wang ,&nbsp;Zhixin Zhao ,&nbsp;Ye Deng ,&nbsp;Tianyun Wang ,&nbsp;Yuting Xiang ,&nbsp;Yuting Wang ,&nbsp;Jiamei Chen ,&nbsp;Miao He","doi":"10.1016/j.heha.2024.100098","DOIUrl":"10.1016/j.heha.2024.100098","url":null,"abstract":"<div><h3>Background</h3><p>Since the twentieth century, endocrine-disrupting substances (EDCs) such as phthalates and organophosphates have been utilised in various goods. The long-term usage of these products may have negative effects on people's health. Most EDCs are metabolized through kidneys, but there are few research investigating renal damage from exposure to EDCs in the elderly. This study aims to examine the effects of EDCs exposure on renal function in the elderly population.</p></div><div><h3>Methods</h3><p>In this cross-sectional study, a total of 200 elder from a community in northeast China were enrolled. All subjects were investigated by questionnaire, physical examination, and biological sample collection. Estimated glomerular filtration rate (eGFR) was used to classify renal function group. Lasso regression was used to screen out the EDCs related to renal function. After covariate adjustment, binary logistic regression was used to analyze the relationship between decreased renal function and EDCs. Weighted quantile sum (WQS) regression was used to assess the association of combined-EDCs with decreased renal function, subgroup analyses were performed to identify potentially sensitive populations to the effects of EDCs on decreased renal function.</p></div><div><h3>Results</h3><p>Binary logistic regression showed that 3,5-di-tert-butyl-4-hydroxybenzoic acid (BHT-COOH), Mono(3-carboxypropyl) phthalate (MCPP), and Methyl paraben (MeP) were negatively associated with decreased renal function, with odds ratio (OR) and 95% confidence intervals of 0.591 (0.366, 0.954), 0.990 (0.981, 0.999) and 0.997 (0.995, 0.999), respectively. WQS regression found DPP (Weights = 22.5%) to have the greatest effect on decreased renal function in the elderly. Moreover, significant potential interactions were observed among MEHP&amp;MOcP with hypertension on decreased renal function (<em>P</em>_interaction = 0.014), as well as BPS and MEHP&amp;MocP with Overweight/obesity on decreased renal function (<em>P</em>_interaction = 0.032, 0.024).</p></div><div><h3>Conclusions</h3><p>BHT-COOH, MCPP, and MeP were negatively associated with decreased renal function in the elderly. Elders with hypertension and who are overweight /obesity may be more sensitive to EDCs.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"11 ","pages":"Article 100098"},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000114/pdfft?md5=081838dccf4e3b0f93d1a1e22127a1ae&pid=1-s2.0-S2773049224000114-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141637343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the association between PM2.5 concentration and hospital admissions for pediatric asthma in Ho Chi Minh City, Viet Nam","authors":"Tinh Huu Ho ,&nbsp;Chinh Van Dang ,&nbsp;Thao Thi Bich Pham ,&nbsp;Hien Thi Thu Ngo ,&nbsp;Supat Wangwongwatana","doi":"10.1016/j.heha.2024.100097","DOIUrl":"https://doi.org/10.1016/j.heha.2024.100097","url":null,"abstract":"<div><p>Despite the growing concern over the impact of ambient fine particulate matter (PM_2.5) on respiratory health, studies on the association between PM_2.5 and childhood asthma in Vietnam have remained relatively sparse.</p><p>The study aimed to evaluate the short-term effects of PM_2.5 on asthma hospital admissions in Ho Chi Minh City (HCMC), the most populous city in Vietnam. The PM_2.5 database from 2016 to 2019 was collected at two fixed monitoring stations. The health database was collected from all three children's hospitals. A time-series regression analysis was conducted to examine the associations between the daily PM_2.5 concentration and hospitalizations for asthma.</p><p>A total of 11,223 records of children under five years old hospitalized for asthma were collected, of which 64 % were male and 70 % were aged 2 to under five years old. The daily mean PM_2.5 concentration over the study period was 28.2 μg/m³. Each 10 μg/m³ increase in PM_2.5 at lag₂, lag_3, and lag₀₄, we found that the excess risk of total asthma hospital admission was 2.71 %, 2.63 %, and 3.9 %, respectively. According to the subgroup analysis, female gender and children aged from two to under five years had more significant effects.</p><p>PM_2.5 poses a risk to children's health; therefore, the local authority should prioritize improving the air quality.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"11 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000102/pdfft?md5=487e0ffd0276fd44abd429d71af22baa&pid=1-s2.0-S2773049224000102-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141593235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In the wake of a surge in naegleria fowleri infections: Overcoming challenges and implementing protective measures in Pakistan","authors":"Juvairia Yousuf,&nbsp;Laiba Afaq,&nbsp;Uzma Aslam,&nbsp;Nabahat Shafi,&nbsp;Zainab Syyeda Rahmat","doi":"10.1016/j.heha.2024.100095","DOIUrl":"https://doi.org/10.1016/j.heha.2024.100095","url":null,"abstract":"","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"10 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000084/pdfft?md5=7f3e86ea42590709e3aef105dfa2b95c&pid=1-s2.0-S2773049224000084-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140950313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between metal exposure and body mass index of preschool children of Shaanxi, China","authors":"Yan Zhao ,&nbsp;Zhaoyang Li ,&nbsp;Xinyue Wen ,&nbsp;Hongqiu Li ,&nbsp;Huifang He ,&nbsp;Jing Han","doi":"10.1016/j.heha.2024.100094","DOIUrl":"10.1016/j.heha.2024.100094","url":null,"abstract":"<div><p>There are few studies on the association between polymetallic exposure and obesity in preschool children, and the conclusions are inconsistent. The study aimed to explore the association between urine metals and body mass index (BMI). For 342 preschool children in the industrial park of Shaanxi, China, uniformly trained investigators collected basic information of preschoolers and measured height and weight. Morning urine were collected, and BMI were calculated. We measured concentrations of 22 urine metals by quadrupole inductively coupled plasma-mass spectrometry (ICP-MS).</p><p>The least absolute shrinkage and selective operator (LASSO) regression model was used to screen urine metals larger impact on BMI. In the polymetallic exposure model, generalized linear regression was used to explore the relationship between the selected urine metals and BMI. The overall relationship between urine metals and BMI was analyzed using restricted cubic spline (RCS). The interaction method was used to explore the influence of metal-metal interaction on BMI. After adjustment for covariates, ln-transformed urinary copper (Cu) levels and urinary molybdenum (Mo) levels were negatively associated with BMI, (Cu, β=−1.219, 95% CI: −2.047, −0.391, <em>P</em>&lt;0.05; Mo, β=−0.797, 95% CI: −1.508, −0.087, <em>P</em>&lt;0.05). Polymetallic model showed similar results. Both ln-transformed urinary Cu levels and urinary Mo levels were negatively correlated with BMI (Cu: β=−1.556, 95% CI: −2.488, −0.624, <em>P</em>&lt;0.05; Mo: β=−0.915, 95% CI: −1.817, −0.013, <em>P</em>&lt;0.05). The results of RCS visually demonstrate that Cu and BMI are non-linearly correlated (<em>P</em> _total &lt; 0.001, <em>P</em> _nonliearity = 0.005), Mo and BMI are linearly correlated (<em>P</em> _total &lt; 0.05, <em>P</em> _nonliearity = 0.099) Urinary Cu was negatively correlated with BMI nonlinearly in preschool children, and there was a borderline interaction between urinary Mo and Cu levels.</p><p>Further researches are needed to validate these associations and reveal underlying mechanisms</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"10 ","pages":"Article 100094"},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000072/pdfft?md5=d82dff54982235e51c7423cc0d6bc773&pid=1-s2.0-S2773049224000072-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141048416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salmonella Typhimurium outbreak caused by contaminated chocolate highlights the importance of food hygiene and a socially responsible food chain","authors":"Hannu Korkeala ,&nbsp;Tarja Koskela ,&nbsp;Katri Jalava","doi":"10.1016/j.heha.2024.100096","DOIUrl":"https://doi.org/10.1016/j.heha.2024.100096","url":null,"abstract":"<div><p>Recent global salmonella outbreak was linked to chocolate products but potential role of cocoa beans has been neglected. Chocolate related salmonella outbreaks have occurred mostly during low cocoa price levels. Food business operators should ensure hygiene at all production stages. These outbreaks highlight corporate social responsibility while demonstrating the need of multi-professional approaches.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"10 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000096/pdfft?md5=e8ae9bc974fc0de81c6175b100e0fae3&pid=1-s2.0-S2773049224000096-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140952408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coal-fired PM2.5 induces endothelial cell injury and the expression of atherosclerosis-related adhesion molecules: Involvement of the p38 and JNK signaling pathways","authors":"Yanping Zhang ,&nbsp;Hanyun Zheng ,&nbsp;Siqi Wang ,&nbsp;Xuetao Wei ,&nbsp;Qin Li ,&nbsp;Feifei Wang","doi":"10.1016/j.heha.2024.100093","DOIUrl":"10.1016/j.heha.2024.100093","url":null,"abstract":"<div><p>It has been reported that PM_2.5 causes endothelial cell injury and promotes atherosclerosis. However, the exact mechanism through which coal-fired PM_2.5 induces endothelial cell injury, and the involvement of the p38 and JNK signaling pathways in this process remain unclear. In this study, EA.hy926 cells were exposed to coal-fired PM_2.5 at concentrations of 25, 50, and 100 μg/mL, and the toxic effects were observed. The phosphorylation of the JNK and p38 signaling pathways was investigated through western blot analysis. Additionally, the expression of adhesion molecules (ICAM-1 and E-selectin) was assessed using ELISA and flow cytometry. Changes in cellular toxicity and adhesion molecules were evaluated after pretreatment with the p38 inhibitor SB203580 (10 μM) and the JNK inhibitor SP600125 (25 μM). We observed that exposure to coal-fired PM_2.5 led to a decrease in cell survival rate and proliferation while promoting apoptosis. Exposure to coal-fired PM_2.5 promoted the expression of ICAM-1 and E-selectin, as well as the phosphorylation of p38 and JNK in EA.hy926 cells. After using p38 and JNK inhibitors, there was an observed increase in cell survival rate and proliferation, accompanied by a decrease in apoptosis. The levels of ICAM-1 and E-selectin showed no significant changes with the addition of p38 and JNK inhibitors. Our results indicated that coal-fired PM_2.5 caused cellular toxicity and increased the levels of ICAM-1 and E-selectin. The p38 and JNK signaling pathways might play a role in the reduction of cell viability, while the regulation of ICAM-1 and E-selectin might not be influenced by these pathways.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"10 ","pages":"Article 100093"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000060/pdfft?md5=c729f6fa76ea09161f111e6d024e74cd&pid=1-s2.0-S2773049224000060-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140761194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}