Acta Odontologica Scandinavica最新文献

{"title":"Impact of molar incisor hypomineralization on oral health-related quality of life, dental fear and anxiety in Swedish children.","authors":"Adnan Hajdarević, Birgitta Jälevik, Emina Čirgić, Agneta Robertson, Nina Sabel","doi":"10.2340/aos.v84.43856","DOIUrl":"10.2340/aos.v84.43856","url":null,"abstract":"<p><strong>Objectives: </strong>The aims this research were to analyze self-reported oral health-related quality of life (OHRQoL) and dental fear and anxiety (DFA) in 11-year-old patients after either restorative treatment or after extraction of first permanent molars (FPM) affected by severe molar incisor hypomineralization (MIH). The research question focused on whether these treatments lead to different outcomes of DFA and OHRQoL over time.</p><p><strong>Materials and methods: </strong>GuREx-MIH, a multicenter trial, was conducted involving 83 children aged 6-9 years who were diagnosed with severe MIH in FPMs. Patients were randomly assigned to receive either restorative treatment with resin composite or extraction. Patient comfort was assessed through OHRQoL and DFA, using the Swedish version of the Child Perceptions Questionnaire (CPQ11-14) and the Children's Fear Survey Schedule-Dental Subscale (CFSS-DS), which were administered before treatment (T0) and at follow-up when patients were 11 years old (T1). Descriptive statistical analyses were conducted and comparisons between the restorative and extraction groups were performed using T-tests.</p><p><strong>Results: </strong>A total of 79 patients completed the study, with 43 allocated to restorative treatment and 36 to extraction. At follow-up, the mean OHRQoL score was 8.9 (standard deviation [SD] 7.3) for patients in the restorative group and 9.6 (SD 6.7) for those in the extraction group (p: 0.337, T-test). The mean DFA score was 21.5 (SD 5.5) for the restorative group and 23.1 (SD 6.8) for the extraction group (p: 0.130, T-test).</p><p><strong>Conclusions: </strong>Restorative treatment and extraction of FPMs affected by MIH lead to similar impact on DFA and OHRQoL at 11 years of age.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"363-370"},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of diode laser for pulpotomy in primary teeth: a meta-analysis of randomised controlled trials.","authors":"Yue Gao, Mina Hu, Jian Xu","doi":"10.2340/aos.v84.43804","DOIUrl":"10.2340/aos.v84.43804","url":null,"abstract":"<p><strong>Objective: </strong>To systematically evaluate the efficacy of diode laser for pulpotomy in primary teeth using meta-analysis.  Methods: Electronic databases (PubMed, Web of Science, Cochrane Library, and Embase) were systematically searched to include randomised controlled trials (RCTs) evaluating the efficacy of diode laser pulpotomy in primary teeth, with the control group receiving conventional treatment without diode laser. This meta-analysis was based on a systematic literature search. Meta-analyses were conducted based on different follow-up times and control groups to assess the clinical and radiographic success rates of diode laser pulpotomy.  Results: A total of 17 RCTs met the inclusion criteria, involving 1,018 primary teeth. Meta-analysis results based on different follow-up times (≤ 3 months, 6 months, 9 months, ≥12 months) showed similar clinical success rates (total: relative risk [RR], 1.01; 95% confidence interval [CI], 0.99-1.03; I2 = 0%) and radiographic success rates (total: RR, 0.99; 95% CI, 0.97-1.02; I2 = 0%) between diode laser pulpotomy and conventional treatment. Meta-analysis based on different control groups (formocresol-zinc oxide eugenol [FC-ZOE], ferric sulfate-zinc oxide eugenol [FS-ZOE], mineral trioxide aggregate-zinc oxide eugenol [MTA-ZOE], simvastatin gel-resin modified glass ionomer cement [SG-REGIC]) showed similar clinical success rates between diode laser pulpotomy and FC-ZOE (RR: 1.00; 95% CI: 0.98-1.02), MTA-ZOE (RR: 1.01; 95% CI: 0.94-1.09), and SG-REGIC (RR: 0.99; 95% CI: 0.83-1.17), but it was more likely to achieve clinical success compared to FS-ZOE (RR: 1.04; 95% CI: 1.01-1.07). In addition, diode laser pulpotomy showed similar radiographic success rates with different control groups.  Conclusion: Diode laser can be considered as an alternative treatment method to current conventional pulpotomy. However, further high-quality trials are needed to confirm the accuracy and reliability of these findings.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"332-340"},"PeriodicalIF":1.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different oral barrier membranes on the efficacy and safety of guided bone regeneration in patients with dental implants: a systematic review and meta-analysis.","authors":"Haozhou Tang, Yonghui Zhang","doi":"10.2340/aos.v84.43758","DOIUrl":"10.2340/aos.v84.43758","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to systematically evaluate the effects of different oral barrier membranes on bone regeneration, focusing on their clinical efficacy and safety during dental implant procedures.</p><p><strong>Methods: </strong>A comprehensive search was conducted in PubMed, EMBASE, ScienceDirect, Cochrane Library, CNKI, VIP, and CBM databases for case-control and cohort studies published between January 2002 and March 2025. Two independent researchers screened and extracted data, and statistical analysis was performed using RevMan 5.3. The study was registered in PROSPERO (CRD492390).</p><p><strong>Results: </strong>A total of 11 clinical controlled and cohort studies with 1,003 patients were included. The absorbable membrane group demonstrated a significantly higher success rate (p < 0.05), greater bone graft thickness (p < 0.05), and fewer adverse reactions (p < 0.05). Meta-analysis showed no significant difference in osseointegration, total mineralised tissue, and non-mineralised tissue (p > 0.05).</p><p><strong>Conclusion: </strong>Absorbable oral barrier membranes exhibit superior safety and efficacy profiles, making them a preferred choice for guided bone regeneration. However, further studies with higher methodological quality and longer follow-up durations are required.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"318-331"},"PeriodicalIF":1.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewer's dilemma when facing a 'voluminous' manuscript.","authors":"Shigeki Matsubara","doi":"10.2340/aos.v84.43808","DOIUrl":"10.2340/aos.v84.43808","url":null,"abstract":"<p><p>N/A.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"341-342"},"PeriodicalIF":1.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Danish endodontic practice-based research network: follow-up data.","authors":"Lise-Lotte Kirkevang, Lotte Hein Sørensen","doi":"10.2340/aos.v84.43857","DOIUrl":"10.2340/aos.v84.43857","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this prospective, clinical study was to follow-up root canal treatments performed by dentists in the practice-based endodontic research network setting, to assess treatment outcome and factors related to treatment outcome.</p><p><strong>Material and methods: </strong>Baseline information from 536 teeth was included, follow-up information on 269 teeth (50%) was available. Treatments were performed by 12 dentists during 2017-2018. Follow-up period varied from 3.5 months to 3 years. Treatment outcome was assessed in periapical radiographs using the Periapical Index (PAI). Cases were classified as referred or not. Pre-, intra-, and post-operative variables were recorded by the dentists during treatment and analysed at follow-up in relation to treatment outcome.</p><p><strong>Results: </strong>Periapical status improved or remained healthy in 174 (66%) teeth. If PAI at baseline was 3, 4, or 5, the outcome was affected negatively (p = 0.049). The length and seal of the root filling was assessed adequate in 75% and 63% of the teeth, respectively. Adequate seal (p = 0.02) and length (p = 0.03) resulted in improved treatment outcome.</p><p><strong>Conclusions: </strong>When initial periapical status and/or quality of the root filling was good, there was a higher chance of a successful treatment outcome.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"343-348"},"PeriodicalIF":1.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between odontogenic and sinus pathologies - a low-dose CBCT study.","authors":"Veli-Pekka Riekki, Mika T Nevalainen, Marianne Haapea, Annina Sipola, Soili Kallio-Pulkkinen, Michaela K Bode","doi":"10.2340/aos.v84.43779","DOIUrl":"10.2340/aos.v84.43779","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate maxillary sinus and odontogenic findings in low-dose CBCT, and to test if associations exist between these findings.  Methods: From 263 consecutive CBCT scans, 212 were included. Evaluated odontogenic parameters were periapical lesions (PAI), marginal periodontal bone loss (PBL), root contact to the maxillary sinus, the presence of crowns, implants, defective restorations and extensive caries. Maxillary sinus findings were categorized as mucosal thickening (MT; generalized and localized), mucosal retention cysts, and opacification/fluid level. Crosstabulations and generalized estimating equations were used as statistical tests. Prevalence and bias adjusted kappas were calculated for inter- and intra-observer agreement.</p><p><strong>Results: </strong>The only dental finding statistically associated with sinus pathology when compared to healthy sinuses was root contact, which increased the risk for generalized MT (OR = 1.47, p = 0.015), mucosal retention cysts (OR = 2.60, p < 0.001) and opacification/fluid (OR = 1.76, p = 0.018). All parameters showed almost perfect or substantial intra- and interobserver reliability, except for PBL, where the former was moderate and the latter fair.</p><p><strong>Conclusion: </strong>Root contact was the only dental finding significantly associated with sinus pathology. Thus, there may be fewer associations between radiological dental findings and sinus pathology than previously thought. With the exception of PBL, all parameters demonstrated at least substantial intra- and interobserver reliability, indicating that the assessment is reliable overall.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"310-317"},"PeriodicalIF":1.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence of mutations in tumour suppressor genes among oral cancer in Naswar, smokeless tobacco users.","authors":"Fatima Iqbal, Sajjad Ahmad, Hoor Maryam, Humaira Amin","doi":"10.2340/aos.v84.43778","DOIUrl":"10.2340/aos.v84.43778","url":null,"abstract":"<p><strong>Objective: </strong>Smokeless tobacco has been linked to the genetic modification of oral squamous cell carcinoma (OSCC). Our study aims to further investigate the disease among Naswar users at the genomic level to understand genetic diversity and discover new targeted therapy.</p><p><strong>Methods: </strong>A multi-centre descriptive cross sectional research was designed comprising a total of 80 cases of OSCC who were habitual users of Naswar. Out of the 80 cases, whole exome sequencing (WES) was applied to 7 formalin fixed paraffin embedded (FFPE) tissues of OSCC. We further investigated immunohistochemical expression of mutant TP53 and CDKN2A protein in tissues of 80 OSCC samples. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS) version 19.</p><p><strong>Results: </strong>Among the total 2,216 somatic variants identified in tumour suppressor genes (TSGs), we compared the high frequency mutation genes reported in OSCC in Catalogue of Somatic Mutations in Cancer (COSMIC) database with research samples, and found that TP53 (85.7%), NOTCH1 (85.7%), and FAT1 (85.7%) showed higher rate of mutation. Among single nucleotide variants, higher prevalence of C/T and G/A base change was noted. Interestingly, a distinct panel of 12 genes was detected to be mutated in 100% samples which was not previously reported compared to Single Nucleotide Polymorphism Database (dbSNP). PTPRT mutation (rs2867655) was present in seven samples and IGF2R (rs629849) was seen in two samples. A statistically significant relation was observed between mutant TP53 protein expression and duration of Naswar use and clinical stages while difference in CDKN2A protein expression was found to be statistically significant with respect to stage only.</p><p><strong>Conclusions: </strong>Our study presented preliminary data of genetic aberrations in patients exposed to known risk factor (Naswar). These findings can enhance the understanding of genetic aetiology and serve as basis for innovative targets of therapy.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"299-309"},"PeriodicalIF":1.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-reported oral health outcomes after switching to a novel nicotine pouch technology: a pilot study.","authors":"Giusy Rita Maria La Rosa, Karl Fagerström, Sebastiano Antonio Pacino, Jan Kowalski, Renata Górska, Stefan Gospodaru, Gheorghe Bordeniuc, Valeriu Fala, Amaliya Amaliya, Iain Chapple, Riccardo Polosa","doi":"10.2340/aos.v84.43805","DOIUrl":"10.2340/aos.v84.43805","url":null,"abstract":"<p><strong>Objective: </strong>Nicotine pouch use has been linked to oral health concerns, including oral lesions and gingival irritation. This pilot study examines self-reported oral health outcomes following the use of a novel nicotine pouch (Stingfree Strong Blue Mint), with an impermeable barrier on the interior side designed to reduce mucosal irritation.</p><p><strong>Materials and methods: </strong>A total of 23 Swedish dentists who were current snus or nicotine pouch users participated in a 5-week observational study. Baseline and follow-up assessments included self-reported oral health status and photographic documentation of mucosal conditions, reviewed by an independent blinded dental expert. Primary outcomes included changes in self-reported snus lesions, gingival recession, gingival irritation, and gingivitis.  Results: The prevalence of self-reported snus lesions decreased from 95.7% (n = 22) to 69.6% (n = 16). Median Axell-scale lesion severity declined from 2 (interquartile range [IQR]: 1-3) to 1 (IQR: 0-2) (z = 3.756, p = 0.0002). Moderate-to-severe lesions (Axell score ≥ 3) dropped from 39.1% (n = 9) to 0% (n = 0). Self-reported gingivitis cases (n = 3) were eliminated, and gingival irritation decreased by 90.0%.</p><p><strong>Conclusions: </strong>Preliminary findings suggest that the use of the Stingfree Strong Blue Mint nicotine pouch may reduce mucosal irritation. While promising, these findings warrant validation through large randomised controlled trials to establish long-term effectiveness and safety.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"292-298"},"PeriodicalIF":1.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective study analysing outcomes of the coronectomy procedure at a university dental teaching clinic in Norway.","authors":"Umar Sharif, Stein Atle Lie, Cecilie Gudveig Gjerde","doi":"10.2340/aos.v84.43759","DOIUrl":"10.2340/aos.v84.43759","url":null,"abstract":"<p><p>Mandibular third molars (3M) are often associated with pathologies necessitating their surgical removal. Removal of 3M can cause injury to the inferior alveolar nerve (IAN). In coronectomy, a surgical option for 3M that present a significant risk of injury to the IAN, only the crown is removed, and the root/roots are left in situ, and may move after surgery. Methodology: A retrospective review was done to analyse the outcomes of coronectomy procedures performed at the Clinic of Oral and Maxillofacial Surgery, Institute of Clinical Odontology (IKO), University of Bergen (UiB) between 2014 and 2020. During this period, a total of 63 coronectomy procedures were performed. All 63 patients were contacted after approval from the regional ethical committee, and a total of 44 patients consented to participate in the study. Radiographic analysis was done based on panoramic radiographs (OPG), and patient records were analysed to assess which demographic and local factors were associated with root migration along with the number of post-operative complications. Results: Root migration was not associated with gender, root anatomy, or pattern of tooth impaction. Root migration was observed significantly more often in the younger age group, that is, ≤25 years. There were four reported cases of post-operative complications; two of those cases resolved with systemic antibiotics, while surgical intervention was necessary in the other two cases to remove the remaining roots. There were no reported cases of transient or permanent neurosensory disturbances.  Conclusion: Coronectomy is a viable technique to avoid nerve injury with 3M removal.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"284-291"},"PeriodicalIF":1.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of fixed appliance treatment on root resorption in root canal-treated teeth: a systematic review and meta-analysis.","authors":"Yongfang Feng, Rong Wang, Yumin Zhou, Shengnan Zhan","doi":"10.2340/aos.v84.43642","DOIUrl":"10.2340/aos.v84.43642","url":null,"abstract":"<p><strong>Objective: </strong>The relationship between orthodontic treatment and root resorption in endodontically treated teeth remains controversial. This systematic review and meta-analysis aimed to evaluate the effects of fixed appliance treatment on root resorption in root canal-treated teeth compared to vital teeth.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across multiple databases including PubMed, Embase, Cochrane Library, Web of Science, Sinomed, CNKI, and Wanfang. Studies comparing root resorption between root canal-treated teeth and vital teeth during orthodontic treatment were included. The methodological quality was assessed using the Cochrane risk of bias tool. Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated using random-effects models.</p><p><strong>Results: </strong>Ten studies involving 266 patients met the inclusion criteria. The overall effect showed no significant difference in root resorption between root canal-treated teeth and vital teeth (SMD = -0.08, 95% CI: -0.24 to 0.08, I² = 7.0%). Subgroup analyses revealed no significant differences based on measurement methods, extraction versus non-extraction treatment, or tooth position. However, extraction cases demonstrated a numerical trend toward greater root resorption in root canal-treated teeth (SMD = -0.70, 95% CI: -1.50 to 0.11, I² = 67.1%, p = 0.048), while the non-extraction group showed no meaningful differences (SMD = -0.07, 95% CI: -0.42 to 0.28, I² = 49.2%, p = 0.096).</p><p><strong>Conclusions: </strong>This meta-analysis suggests that root canal-treated teeth do not show significantly different root resorption patterns compared to vital teeth during orthodontic treatment. However, extraction cases may require careful monitoring due to a tendency toward increased root resorption.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"84 ","pages":"275-283"},"PeriodicalIF":1.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}