Acta Odontologica Scandinavica最新文献

{"title":"A comparison and evaluation of the use of three orthodontic indices in assessing the treatment outcome.","authors":"Rayed Aldausari, Maryam Al-Zayer, Marie Pegelow","doi":"10.2340/aos.v85.46998","DOIUrl":"10.2340/aos.v85.46998","url":null,"abstract":"<p><strong>Objective: </strong>To assess the differences in treatment outcome evaluation using the Dental Health Component (DHC) and Aesthetic Component (AC) of the Index of Orthodontic Treatment Need (IOTN), the Index of Complexity, Outcome and Need (ICON), and the Peer Assessment Rating (PAR), and to examine scoring agreement between orthodontic residents and undergraduate students.</p><p><strong>Material and methods: </strong>A total of 87 study casts were assessed using the IOTN, ICON, and PAR indices to evaluate treatment outcome, with intra- and inter-examiner reliability examined.</p><p><strong>Results: </strong>High to very high correlation was observed among AC, ICON, and PAR at T1 (p < 0.0001), while at T2, a high correlation was found between ICON and AC (p < 0.0001). Low correlations were found between DHC and both PAR and ICON. A negligible correlation was found between AC and DHC at T2. IOTN components showed good reproducibility at T1, whereas DHC, ICON, and PAR demonstrated moderate reliability at T2. Among orthodontic residents, ICON showed moderate (T1) and good (T2) reliability. PAR showed excellent reliability at T1. Among all examiners, all indices had moderate reliability at T1, and both ICON and PAR had poor reliability at T2.</p><p><strong>Conclusions: </strong>ICON was the most reliable index among orthodontic residents and required less scoring time than PAR, although IOTN remained the quickest to apply.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"85 ","pages":"732-738"},"PeriodicalIF":1.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of caries data in the Swedish Quality Register (SKaPa) in a cohort of 19-year-olds in Region Värmland, Sweden.","authors":"Tita Kirkinen, Gunilla Klingberg, Erik Hesselbom, Aron Naimi-Akbar","doi":"10.2340/aos.v85.46895","DOIUrl":"10.2340/aos.v85.46895","url":null,"abstract":"<p><strong>Objective: </strong>The Swedish Quality Register for Caries and Periodontal Disease (SKaPa) is a national registry providing oral health data for children and adolescents. Since no validation has been performed on adolescents with permanent dentitions, the aim of this study was to evaluate SKaPa data for dental caries in 19-year-olds.</p><p><strong>Material and methods: </strong>This diagnostic accuracy study included a random sample of 19-year-olds (N = 250) examined in 2014 in the Public Dental Service, Region Värmland. Clinical records served as the reference standard and SKaPa variables as the index test. Number of decayed and filled teeth (DFT), number of decayed, missing, and filled teeth (DMFT), missing teeth due to caries (MTC), missing teeth due to any reason (MTA), number of decayed teeth (DT), and number of filled teeth (FT) were evaluated. Agreement was evaluated using exact agreement, Cohen's kappa, and intraclass correlation coefficients.</p><p><strong>Results: </strong>Data showed high agreement for DFT, DMFT, MTA, DT, and FT (kappa between 0.82 and 0.90; ICC 0.93-0.96). SKaPa underestimated caries by 6-7%. Among 155 participants with DFT/DMFT ≥1, only three had MTC, limiting evaluation.</p><p><strong>Conclusions: </strong>SKaPa caries data demonstrate high accuracy. However, as MTC could not be evaluated, DMFT should be used with caution in research at this point. Researchers should instead use DFT but be observant of the risk of an underdiagnosis of dental caries in SKaPa for 19-year-olds.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"85 ","pages":"725-731"},"PeriodicalIF":1.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication-related osteonecrosis of the jaw in cancer and osteoporosis patients: a retrospective seven-year single-center Norwegian cohort study of clinical profiles and documented soft tissue healing.","authors":"Safiyye Süslü, Håvard J Haugen, Tormod B Krüger, Janne Elin Reseland, Bente Brokstad Herlofson","doi":"10.2340/aos.v85.46983","DOIUrl":"10.2340/aos.v85.46983","url":null,"abstract":"<p><strong>Objective: </strong>To compare systemic profiles, oral findings, and documented soft tissue healing between cancer and osteoporosis patients with medication-related osteonecrosis of the jaw (MRONJ).</p><p><strong>Material and methods: </strong>This retrospective single-center cohort included 105 cases treated in 2013-2019 (56 cancer; 49 osteoporosis). Healing at last follow-up was analyzed using adjusted logistic regression and Firth sensitivity analysis.</p><p><strong>Results: </strong>Of 102 cases with known final status, 68 had documented healing. Osteoporosis cases were older, predominantly female, and had longer antiresorptive exposure than cancer cases (76.7 ± 11.1 vs. 70.0 ± 8.5 years; 102.5 ± 77.8 vs. 34.6 ± 28.5 months; both p < 0.001). Stage II predominated and Stage 0 was uncommon (3/105, 2.9%). Previous tooth extraction at the MRONJ lesion site was more frequent in osteoporosis (95.9% vs. 71.4%; p < 0.001). Surgical treatment was associated with higher healing odds (adjusted odds ratio [OR]: 11.12, 95% confidence interval [CI]: 4.12 to 33.35; p < 0.001), whereas cancer indication was associated with lower odds (adjusted OR: 0.23, 95% CI: 0.07 to 0.68; p = 0.011).</p><p><strong>Conclusions: </strong>Systemic profiles differed; oral patterns were similar. Non-random treatment and missing healing dates limit interpretation. Previous tooth extraction was the most frequent antecedent event; its indication and timing were unverified.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"85 ","pages":"713-724"},"PeriodicalIF":1.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between socioeconomic status and dental caries in adolescents - a systematic review of cohort studies.","authors":"Marit Slåttelid Skeie, Kristin Solveig Klock, Göran Dahllöf, Hedda Høvik, Ida Sofie Karlsen Sletten, Tone Natland Fagerhaug, Abhijit Sen","doi":"10.2340/aos.v85.46953","DOIUrl":"10.2340/aos.v85.46953","url":null,"abstract":"<p><strong>Introduction: </strong>Early adolescence is a critical period for caries initiation, underlining the need for updated knowledge on effective caries indicators. This systematic review of cohort studies aimed to assess the association between socioeconomic status (SES), involving a wide range of indicators, and dental caries in adolescents aged 12-19.</p><p><strong>Materials and methods: </strong>Four databases (MEDLINE, Embase, Cochrane Library, and Web of Science) were systematically searched for relevant publications from January 1, 2000, through December 5, 2025. SES and SES proxy indicators were parental education, income, and occupation, and adolescents' school type, their social capital, and immigrant background. Composite SES indicators combined the aforementioned variables. The risk of bias was evaluated using a modified Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>Studies (n = 21) from 11 countries across five continents were included, covering approximately 66,000 adolescents. An inverse relationship was documented between caries and mothers' education (six of seven studies), fathers' education (three of four studies), and parental income (three of six studies). School type (three studies), social capital (two studies), immigrant background (four studies), and composite SES indicators (five of six studies) were also linked to caries. However, the effect measures and definitions of exposures and outcomes were not consistent.</p><p><strong>Conclusions: </strong>An inverse association was observed between maternal education and caries, while corresponding associations with fathers' education and parental income were weaker and less consistent. This type of association was also observed for adolescents' school types, their social capital, and composite SES indicators. Immigrant background served as a caries predictor. However, the substantial heterogeneity in the included studies did not allow for meta-analyses and limited definite conclusions. The findings underscore the need to develop and validate robust composite SES measures applicable across diverse global contexts.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"85 ","pages":"693-712"},"PeriodicalIF":1.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13651455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal analysis of dental healthcare costs among adolescents living in Amsterdam.","authors":"Tessa S Van Ligten, Catherine M C Volgenant, Egija Zaura, Denise Duijster","doi":"10.2340/aos.v85.46952","DOIUrl":"10.2340/aos.v85.46952","url":null,"abstract":"<p><strong>Objectives: </strong>The aim was to analyze patterns of oral healthcare consumption from 2009 to 2016 of adolescents living in Amsterdam. It was assessed whether visiting a dentist earlier in childhood and regular dental attendance between ages 10 and 16 were associated with oral healthcare consumption at age 17. Dental costs (in euros) were used as a proxy for oral healthcare consumption since data on dental performance codes, number of visits, or clinical data were not available in this study.</p><p><strong>Methods: </strong>The study population consisted of all 12-year-old adolescents living in Amsterdam in 2012. Retrospective, longitudinal data on dental costs and sociodemographics were obtained via Statistics Netherlands. Explanatory variables were whether dental costs were incurred at age 9 (in 2009; yes/no and amount) and whether consecutive dental costs were incurred from the age of 10 to 16 (between 2010 and 2015; yes/no). The outcome was dental costs at age 17 (in 2016; yes/no and amount).</p><p><strong>Results: </strong>Dental costs at age 17 were available for 6,871 children. Dental costs at age 9 and consecutive dental costs were significantly associated with having dental costs at age 17. The amount of dental costs at age 9 was significantly and positively associated with higher dental costs at age 17. No association was found between consecutive dental costs during childhood and the amount of dental costs at age 17.</p><p><strong>Conclusions: </strong>A large volume of oral healthcare consumption earlier in childhood was associated with high dental costs for 17-year-olds. Adolescents who regularly visited a dentist during childhood continued to do so at age 17. However, regular dental attendance was not associated with lower dental costs at age 17.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"85 ","pages":"683-692"},"PeriodicalIF":1.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13651456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial activity of chlorhexidine alone and in combination with metronidazole, Punica granatum, and Curcuma longa against Porphyromonas gingivalis: an in vitro study.","authors":"Nujud Alamry, Shatha S ALHarthi, Shorouq Subhi ALHarthi, Najla Naif Al-Dabbagh, Manal Matouq Shalabi, Shahad Ali Alsaqami, Afrah E Mohammed, Kawther Aabed","doi":"10.2340/aos.v85.46854","DOIUrl":"10.2340/aos.v85.46854","url":null,"abstract":"<p><strong>Background: </strong>The aim was to evaluate the antibacterial activity of 0.2% chlorhexidine (CHX) alone and in combination with metronidazole, Punica granatum extract, and Curcuma longa extract against Porphyromonas gingivalis.</p><p><strong>Materials and methods: </strong>An in vitro experimental study was performed using P. gingivalis strain ATCC 33277. Bacteria were cultured under anaerobic conditions. Ten experimental groups were evaluated: 0.2% CHX, 0.5% metronidazole, 100% P. granatum extract, 0.1 and 1.0% C. longa extracts, their respective combinations with 0.2% CHX, and distilled water. Antibacterial activity was assessed using an agar-well diffusion assay, and the diameter of the bacterial growth inhibition zone was measured in millimeters. Statistical significance was established at P < 0.05.</p><p><strong>Results: </strong>The combination of 0.2% CHX and 0.5% metronidazole demonstrated the greatest antibacterial activity, producing the largest inhibition zone (21.67 ± 1.60 mm). This value was significantly greater than those observed for CHX alone (16.44 ± 1.09 mm, P < 0.01), P. granatum combined with CHX (18.11 ± 0.11 mm, P < 0.01), 0.1% C. longa combined with CHX (18.89 ± 0.40 mm, P < 0.01), and 1.0% C. longa combined with CHX (18.40 ± 0.62 mm, P < 0.01). Among the individual agents, 100% P. granatum extract demonstrated the greatest antibacterial activity (20.67 ± 0.00 mm), whereas metronidazole alone, both C. longa extracts, and the negative control produced no measurable inhibition zones.</p><p><strong>Conclusions: </strong>The combination of CHX and metronidazole exhibits the strongest antibacterial activity, whereas P. granatum extracts demonstrate substantial antibacterial activity against P. gingivalis.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"85 ","pages":"678-682"},"PeriodicalIF":1.7,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency dental visits and no-shows among children and adolescents in public oral health service in Finland: a retrospective evaluation.","authors":"Shweta Goswami, Jussi Furuholm, Minna Kaila, Battsetseg Tseveenjav","doi":"10.2340/aos.v85.46926","DOIUrl":"10.2340/aos.v85.46926","url":null,"abstract":"<p><strong>Objective: </strong>To find out the occurrence of emergency visits and compare the co-existence of emergency visits and dental no-shows among children and adolescents in public oral health services in Helsinki, Finland.</p><p><strong>Methods: </strong>This was a register-based retrospective follow-up study. The data were collected from electronic health information register systems, Effica and Lifecare, of under-18-year-olds who attended public oral health care provided by the City of Helsinki during 2006-2020. The information collected for this study was patients' age, sex, actualised, missing and emergency dental visits, as well as all actualised visits' oral examination details and preventive, restorative and orthodontic treatment procedures (n = 200,790). Regression models were used to assess odds ratios (OR) and Rate ratios (RR).</p><p><strong>Results: </strong>The overall occurrence of emergency dental visits was 29.2%. It was 21.9% among individuals who had no dental no-shows and 43.7% among those who had at least one or more no-shows. No-shows were linked to 24% higher odds of emergency visits in the fully adjusted model (OR = 1.24, 95% confidence interval [CI]: 1.21-1.27, p < 0.001). The finding remained significant, with nearly a fivefold increase in odds among individuals receiving both orthodontic and restorative treatment (G4) (OR = 4.79, 95% CI: 4.62-4.96, p < 0.001) than among those receiving check-ups and preventive visits (G1) in the fully adjusted model. Temporal analysis showed that 44.5% of individuals had a no-show preceding their first emergency visit, while 55.5% had an emergency visit prior to their first no-show.</p><p><strong>Conclusions: </strong>Dental no-shows and emergency dental visits were linked, and their temporal pattern was bidirectional.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"85 ","pages":"669-677"},"PeriodicalIF":1.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149035858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and predictors of root resorption after delayed replantation of permanent teeth.","authors":"Yingrui Zhou, Hongwei Ma, Yan Zhang, Haoliang Guo, Ran Ma","doi":"10.2340/aos.v85.46816","DOIUrl":"10.2340/aos.v85.46816","url":null,"abstract":"<p><p>Root resorption is a common but unpredictable complication after delayed replantation of avulsed permanent teeth. Evidence from real-world settings regarding its long-term incidence and associated clinical factors remains limited. This study aimed to determine the incidence of root resorption and identify clinical factors associated with its occurrence following delayed replantation of permanent teeth in a real-world tertiary care setting. This retrospective cohort study analyzed patients aged 7-30 years who underwent delayed replantation (> 60 min extra-alveolar time) between 2019 and 2022 at a tertiary dental trauma center, with ≥ 12 months of follow-up. Clinical and radiographic data were reviewed, and root resorption was classified according to predefined radiographic and clinical criteria. Multivariable logistic regression was used to identify factors associated with the occurrence of root resorption, while Kaplan-Meier survival analysis and Cox proportional hazards regression were performed to evaluate the time to first root resorption event. Competing-risk analysis was conducted, considering tooth extraction as a competing event. Among 120 eligible patients (mean age 14 ± 5 years), root resorption occurred in 72 teeth (60.0%), including inflammatory (41.7%) and replacement (58.3%) types based on radiographic and clinical classification. Among all delayed replanted teeth, the estimated tooth survival and functional retention rates at 24 months were 78.3% and 68.3%, respectively. Teeth with root resorption showed longer extra-alveolar times, more frequent dry storage, and delayed or absent root canal treatment (all P < 0.01). Multivariable logistic regression identified prolonged extra-alveolar time (> 2 h), dry storage, absence of root canal treatment, and delayed endodontic intervention (> 14 days) as factors associated with a higher occurrence of root resorption. Multivariable logistic regression identified prolonged extra-alveolar time (> 2 h), dry storage, absence of root canal treatment, and delayed endodontic intervention (> 14 days) as factors independently associated with a higher occurrence of root resorption. Root resorption occurred in 60% of delayed replanted teeth in this cohort. Prolonged extra-alveolar time, dry storage, and delayed or absent endodontic treatment were independently associated with a higher occurrence of root resorption. These findings highlight the importance of timely management and appropriate endodontic intervention after delayed replantation; however, the retrospective single-center design limits causal interpretation, and further prospective studies are needed to validate these associations.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"85 ","pages":"654-668"},"PeriodicalIF":1.7,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-1246 regulates odontogenic differentiation of human dental pulp stem cells in an inflammatory microenvironment by targeting AXIN2: an in vitro study.","authors":"Shunying Wu, Yueyan Wang, Jiayi Yang","doi":"10.2340/aos.v85.46788","DOIUrl":"https://doi.org/10.2340/aos.v85.46788","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the modulatory function of microRNA-1246 (miR-1246) in the odontogenic differentiation of human dental pulp stem cells (hDPSCs) under inflammatory conditions in vitro and to elucidate its underlying molecular mechanism.</p><p><strong>Methods: </strong>An inflammatory state was replicated in vitro by treating hDPSCs with lipopolysaccharide (LPS). miR-1246 expression was modulated via transfection with its mimics or inhibitors. Cell proliferation, movement, and apoptosis were assessed. Odontogenic differentiation capacity was assessed via alkaline phosphatase (ALP) activity, Alizarin Red S (ARS) staining, and transcript levels by quantitative real-time quantitative real-time polymerase chain reaction (qRT-PCR), along with Western blotting. To validate the direct interaction between miR-1246 and AXIN2, a dual-luciferase reporter assay was employed. All experiments were performed in three independent biological replicates.</p><p><strong>Results: </strong>miR-1246 overexpression significantly reduced inflammatory cytokine levels (IL-1β, P < 0.05; IL-6, P < 0.05; TNF-α, P < 0.001) and partially restored hDPSC proliferation (P < 0.01), migration (P < 0.001), and survival (reduced apoptosis rate, P < 0.001). It also significantly increased ALP activity (P < 0.001), mineralized nodule formation (P < 0.001), and the expression of odontogenic markers (NRP1, DSPP, DMP1). Mechanistically, miR-1246 directly targeted AXIN2, preventing AXIN2-mediated β-catenin degradation and promoting the Wnt/β-catenin pathway, elevating downstream factors such as Cyclin D1 and c-Myc. AXIN2 knockdown reproduced the differentiation-promoting effects of miR-1246, whereas AXIN2 overexpression diminished them.</p><p><strong>Conclusion: </strong>miR-1246 promotes the odontogenic differentiation of hDPSCs and partially counteracts the detrimental effects of inflammation in vitro by directly targeting and inhibiting AXIN2 expression, thereby stimulating the Wnt/β-catenin signaling cascade.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"85 ","pages":"635-653"},"PeriodicalIF":1.7,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiographic assessment and orthodontic intervention effects on orthodontically induced root resorption: a systematic review and meta-analysis of clinical trials.","authors":"Khalid Ayidh Alqahtani, Hamod Alqahtani, Abdullah Saad Alqahtani, Mahmud Uz Zaman, Wajdi A Mohammed Bin, Saleh Alhindi, Nasser Raqe Alqhtani","doi":"10.2340/aos.v85.46818","DOIUrl":"10.2340/aos.v85.46818","url":null,"abstract":"<p><p>The relative contribution of radiographic methods and characteristics of the orthodontic intervention to orthodontically induced root resorption (OIRR) remains unknown. The aims of this systematic review and meta-analysis were to (1) estimate the pooled OIRR effect across orthodontic intervention versus comparator contrasts, (2) compare pooled estimates by radiographic method (2D [two-dimensional] vs. 3D/CBCT [three-dimensional/cone-beam computed tomography]), and (3) explore whether force mechanics (intrusive versus nonintrusive) modified OIRR magnitude. Seven randomized controlled trials and one prospective study (January 2010-October 2025) were included. Only OIRR was the outcome, reported as correlation coefficients (r). The primary analysis combined within-study intervention-versus-comparator estimates. Subgroup analysis of 2D versus 3D/CBCT imaging was prespecified, whereas post-hoc analysis of intrusive versus nonintrusive mechanics was performed. The pooled analysis for the primary outcome showed a small, nonsignificant OIRR effect (r = 0.07; 95% confidence interval [CI]: -0.12 to 0.27; p = 0.372) with high heterogeneity (I2 = 84.0%). Radiographic method did not change the pooled estimates significantly (p = 0.331). Force-mechanics analysis showed that intrusive mechanics was related to significantly higher root resorption than nonintrusive mechanics (r = 0.40; 95% CI = 0.15 to 0.65 versus r = -0.03; 95% CI = -0.16 to 0.10; p < 0.001). This accounted for 87.1% of the between-study variance. The average orthodontic intervention effect on OIRR was small and not significant; however, the OIRR magnitude was strongly affected by force mechanics, particularly by intrusive forces. There was no significant difference in pooled estimates by radiographic method; however, 3D/CBCT provides superior volumetric quantification and should be used judiciously according ALARA (as low as reasonably achievable) principles.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"85 ","pages":"623-634"},"PeriodicalIF":1.7,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13587028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}