Plasma levels of immune system activation markers Neopterin and Kynurenine-to-Tryptophan Ratio, and oral health among community-dwelling adults in Norway: a population-based, cohort study.

IF 1.4 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Acta Odontologica Scandinavica Pub Date : 2025-05-13 DOI:10.2340/aos.v84.43535

Sarala Banjara, Ellen Berggreen, Jannicke Igland, Anne-Kristine Åstrøm, Øivind Midttun, Dagmar Bunæs, Gerhard Sulo

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Abstract

Objective: Periodontitis is a condition characterised by inflammation. Neopterin and kynurenine-to-tryptophan ratio (KTR) are markers of immune system activation in response to inflammation whose elevated levels are linked to higher incidence and poorer prognosis of various systemic diseases. Their potential association with oral health remains underexplored. The aim of this study was to prospectively investigate the associations between these biomarkers and periodontal health status among community-dwelling adults in Hordaland County, Norway.

Materials and methods: Neopterin and KTR were measured in 1,298 participants of the Hordaland Health Study, 1997-1999. Information on oral health indicators was obtained from the 'Hordaland-Oral Health Survey', 2020-2022. Ordinal logistic regression and negative binomial regression were used to explore the association between biomarkers and periodontitis, tooth loss, and current inflammation (extend of sites with pocket depth ≥4mm and bleeding on probing) and odds ratios (OR) and incidence rate ratios (IRR), along with respective 95% confidence intervals (CI) were reported.

Results: No association was found between biomarker levels and periodontitis [neopterin: OR = 0.96, 95% CI: 0.69-1.33 for fourth (Q4) vs. first quartile (Q1); KTR: OR = 0.85, 95% CI: 0.61-1.18 for Q4 vs. Q1], tooth loss [neopterin: IRR = 1.00, 95% CI: 0.94-1.06 for Q4 vs. Q1; KTR: IRR = 0.97, 95% CI: 0.91-1.03 for Q4 vs. Q1) or extend of inflammation [neopterin: OR = 0.87, 95% CI: 0.70-1.09 for Q4 vs. Q1; KTR: OR = 0.98, 95% CI: 0.78-1.23 for Q4 vs. Q1].

Conclusion: Plasma levels of neopterin and KTR were not prospectively associated with periodontal health and number of missing teeth.

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免疫系统激活标志物新蝶呤和犬尿氨酸与色氨酸比的血浆水平与挪威社区居住成年人的口腔健康：一项基于人群的队列研究

目的：牙周炎是一种以炎症为特征的疾病。Neopterin和kynurenine-to-tryptophan比值（KTR）是免疫系统对炎症反应激活的标志，其水平升高与各种全身性疾病的高发病率和较差预后有关。它们与口腔健康的潜在联系仍未得到充分探讨。本研究的目的是前瞻性地调查这些生物标志物与挪威霍达兰县社区居民牙周健康状况之间的关系。材料和方法：对1997-1999年霍德兰健康研究的1,298名参与者的新蝶呤和KTR进行了测量。关于口腔健康指标的信息来自2020-2022年“霍德兰-口腔健康调查”。使用有序逻辑回归和负二项回归来探讨生物标志物与牙周炎、牙齿脱落和当前炎症（牙袋深度≥4mm的部位延伸和探诊时出血）之间的关系，并报告优势比（OR）和发病率比（IRR）以及各自的95%置信区间（CI）。结果：未发现生物标志物水平与牙周炎之间存在关联[新蝶呤：OR = 0.96, 95% CI: 0.69-1.33，第四（Q4） vs第一四分位数（Q1）；KTR: OR = 0.85, 95% CI: 0.61-1.18 [Q4 vs. Q1]，牙齿脱落[neopterin: IRR = 1.00, 95% CI: 0.94-1.06]；KTR: IRR = 0.97, 95% CI: 0.91-1.03, Q4 vs Q1)或炎症扩展[新蝶呤：or = 0.87, 95% CI: 0.70-1.09, Q4 vs Q1；KTR: OR = 0.98, 95% CI: 0.78-1.23 （Q4 vs. Q1）。结论：血浆neopterin和KTR水平与牙周健康和缺牙数无前瞻性关联。

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