Frontiers in pain research (Lausanne, Switzerland)最新文献

{"title":"Classifying office workers with and without cervicogenic headache or neck and shoulder pain using posture-based deep learning models: a multicenter retrospective study.","authors":"Ui-Jae Hwang, Junghun Han, Oh-Yun Kwon, Yu Seong Chu, Sejung Yang","doi":"10.3389/fpain.2025.1614143","DOIUrl":"10.3389/fpain.2025.1614143","url":null,"abstract":"<p><strong>Objective: </strong>To develop and evaluate deep learning models for classifying office workers with and without cervicogenic headache (CH) and/or neck and shoulder pain (NSP), based on habitual sitting posture images.</p><p><strong>Methods: </strong>This multicenter, retrospective, observational study analyzed 904 digital images of habitual sitting postures of 531 office workers. Three deep learning models (VGG19, ResNet50, and EfficientNet B5) were trained and evaluated to classify the CH, NSP, and combined CH + NSP. Model performance was assessed using 4-fold cross-validation with metrics including area under the curve (AUC), accuracy (ACC), sensitivity (Sen), specificity (Spe), and F1 score. Statistical significance was evaluated using 95% confidence intervals. Class Activation Mapping (CAM) was used to visualize the model focus areas.</p><p><strong>Results: </strong>Among 531 office workers (135 with CH, 365 with NSP, 108 with both conditions and 139 control group), ResNet50 achieved the highest performance for CH classification with an AUC of 0.782 (95% CI: 0.770-0.793) and an accuracy of 0.750 (95% CI: 0.731-0.768). NSP classification showed more modest results, with ResNet50 achieving an accuracy of 0.677 (95% CI: 0.640-0.713). In the combined CH + NSP classification, EfficientNet B5 demonstrated the highest AUC of 0.744 (95% CI: 0.647-0.841). CAM analysis revealed distinct focus areas for each condition: the cervical region for CH, the lower body for NSP, and broader neck and trunk regions for combined CH + NSP.</p><p><strong>Conclusion: </strong>Deep learning models show potential for classifying CH and NSP based on habitual sitting posture images, with varying performances across conditions. The ability of these models to detect subtle postural patterns associated with different musculoskeletal conditions suggests their possible applications for early detection and intervention. However, the complex relationship between static posture and musculoskeletal pain underscores the need for a multimodal assessment approach in clinical practice.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1614143"},"PeriodicalIF":2.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a kappa opioid receptor antagonist on delayed postoperative pain recovery in a novel mouse sleep disorder model.","authors":"Hisakatsu Ito, Masaaki Kawakami, Masashi Yoshida, Sadamu Sugimoto, Tomonori Takazawa","doi":"10.3389/fpain.2025.1516935","DOIUrl":"10.3389/fpain.2025.1516935","url":null,"abstract":"<p><strong>Introduction: </strong>Sleep disturbances have been shown to exacerbate pain sensitivity and prolong recovery from pain. However, conventional animal models of sleep disturbance, which involve physical disruptions, such as water or forced movement, might not fully represent modern human sleep disorders.</p><p><strong>Methods: </strong>We utilized a novel sleep disorder model, the perpetual avoidance of water on a wheel (PAWW) model, which induces spontaneous activity, chronic stress, and abnormal sleep-wake cycles in mice. We investigated the effects of a kappa opioid receptor (KOR) antagonist, nor-binaltorphimine (nor-BNI), on pain recovery in a postoperative pain model in mice in a state of disordered sleep. After 1 week of acclimation, the mice were housed in PAWW or regular cages for 2 weeks. Sleep conditions were evaluated using electroencephalogram and electromyogram recordings, and postoperative pain recovery following plantar incision was assessed using von Frey tests. We also examined the effects of nor-BNI on pain recovery.</p><p><strong>Results: </strong>The evaluation showed that PAWW housing significantly increased activity during the light phase, disrupted sleep patterns, and delayed postoperative pain recovery. The administration of nor-BNI alleviated the delayed pain recovery.</p><p><strong>Discussion: </strong>These findings suggest that sleep disorders, such as those modeled by PAWW, could delay postoperative pain recovery, and that KOR antagonists might provide therapeutic benefits in the management of delayed recovery of postoperative pain induced by sleep disorders.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1516935"},"PeriodicalIF":2.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota-mediated pain sensitization: mechanisms and therapeutic implications.","authors":"Minghe Zhao, Ling Zhang, Zhihui Liu","doi":"10.3389/fpain.2025.1626515","DOIUrl":"10.3389/fpain.2025.1626515","url":null,"abstract":"<p><p>Emerging evidence has illuminated the pivotal role of gut microbiota in modulating pain sensitivity through bidirectional gut-brain interactions. Current research demonstrates that gut microbial communities significantly influence pain perception by regulating both central and peripheral sensitization mechanisms across various pain modalities. This review synthesizes current knowledge on the mechanisms underlying gut microbiota-mediated pain sensitization, encompassing: (1) cross-talk within the microbiome-gut-brain axis, (2) regulatory effects of microbial metabolites on central and peripheral sensitization pathways, and (3) bioactive compounds derived from gut microbiota that participate in pain modulation. Furthermore, we systematically evaluate the therapeutic potential of microbiota-targeted interventions including probiotic supplementation, fecal microbiota transplantation, and dietary modifications in pain management. To advance this promising field, future investigations should prioritize three key directions: establishing causal relationships through rigorous verification, accelerating clinical translation of preclinical findings, and developing personalized microbial-based therapeutic strategies.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1626515"},"PeriodicalIF":2.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and user experience of augmented reality psychoeducation and mindfulness body scan for chronic low back pain.","authors":"Robin Conen, Nikolai Hepke, Jörg Lohscheller, Steffen Mueller, Ana N Tibubos","doi":"10.3389/fpain.2025.1600637","DOIUrl":"10.3389/fpain.2025.1600637","url":null,"abstract":"<p><strong>Background: </strong>Chronic low back pain (CLBP) is prevalent and a multimodal therapy is indicated, including psychological treatment. Effective conventional treatments involve psychoeducation and mindfulness-based body scans, while virtual reality offers superior but temporary pain relief. Augmented Reality (AR), which combines conventional and virtual methods, is a novel therapeutic strategy.</p><p><strong>Methods: </strong>We investigated the viability and acceptability of an AR intervention for CLBP by incorporating psychoeducation and mindfulness-based body scan techniques. 40 participants in two studies with a one-arm design underwent an educational AR intervention (Study I, <i>n</i> ₁ = 18) and an enhanced version with an additional body scan (Study II, <i>n</i> ₂ = 22). The studies focused on evaluating technical feasibility and multiple facets of user experience.</p><p><strong>Results: </strong>The results demonstrated high feasibility with low dropout rates (Study I: 10%, Study II: 0%). User experience ratings ranged from \"Above Average\" to \"Excellent,\" with the advanced intervention receiving higher ratings. While Study I showed no significant changes in affect pre- vs. post-intervention, Study II exhibited a significant reduction in negative affect and improved valence. Qualitative analysis provided insights into technical requirements and user perceptions.</p><p><strong>Discussion: </strong>The AR prototype emerges as a promising psychoeducational tool for CLBP, aligning with current treatment guidelines and providing a basis for future controlled clinical trials. Limitations include the absence of a high-pain intervention group, as Study I reported a pain intensity of <i>M</i> = 1.05 and Study II reported <i>M</i> = 1.77 (Range: 0-10). Further research such as clinical trials with control groups is required to validate the efficacy of the piloted approach. The AR-based psychoeducation and mindfulness body scan intervention for CLBP demonstrated technical feasibility and a good user experience.</p><p><strong>Clinical trial registration: </strong>Open Science Framework.io; https://doi.org/10.17605/OSF.IO/DSW5X and https://doi.org/10.17605/OSF.IO/XVJBZ.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1600637"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights and progress on postoperative analgesia of radical gastrectomy for gastric cancer: a comprehensive review.","authors":"Linghui Li, Yuanyuan Zhao, Huan Chen, Jianqin Zhao, Mengjun Dai, Qi Wang, Jie Lv, Wei Wang","doi":"10.3389/fpain.2025.1601220","DOIUrl":"10.3389/fpain.2025.1601220","url":null,"abstract":"<p><p>Gastric cancer is a common and highly lethal malignancy of the digestive system, with surgical resection as the primary treatment approach. However, postoperative analgesia management remains a major clinical challenge. Postoperative pain not only affects recovery speed but may also lead to complications, thereby influencing prognosis. Recent research on postoperative pain following gastric cancer surgery has expanded, exploring various analgesic methods, including pharmacological therapy, neuraxial blocks, and non-pharmacological approaches, with growing emphasis on individualized analgesia protocols. Despite the proposal of multiple analgesic techniques, current research indicates that their effectiveness and safety are still inadequately assessed in clinical applications. This review aims to discuss the physiological mechanisms of postoperative pain following gastric cancer surgery, modern analgesic strategies, and related research, to provide a theoretical basis and clinical guidance for improving postoperative quality of life.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1601220"},"PeriodicalIF":2.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional evidence from a case report supports a novel hypothesis on the association between complex regional pain syndrome and lymphedema.","authors":"M Mark Melin, John C Rasmussen, Melissa B Aldrich, Ron J Karni, Caroline E Fife, Kristen A Eckert","doi":"10.3389/fpain.2025.1540930","DOIUrl":"10.3389/fpain.2025.1540930","url":null,"abstract":"<p><p>A previous report of 4 heterogeneous cases demonstrated that automated manual lymphatic drainage therapy (AMLDT), administered by a novel, pneumatic mat of 16 pressurized air channels that inflate and deflate sequentially to mimic the stretch and release action of manual lymphatic drainage therapy (MLD), altered lymphatic contractility and relieved pain. Near-infrared fluorescence imaging (NIRF-LI) was used 1 h before AMLDT, during 1 h of AMDLT, and 30-60 min after treatment to obtain images that could be used to determine lymphatic contractility, as measured by pulsing frequency over a given timeframe. Herein, a case of type 2 complex regional pain syndrome (CRPS, with nerve dysfunction confirmed) and lymphedema following a complex fracture on the lower leg is reported in further detail, with a discussion explaining the association between autonomic and lymphatic dysfunction and their combined contribution to the development of chronic pain. More specifically, this case provides clinical evidence of the association between autonomic nervous system dysfunction, lymphatic dysfunction, and CRPS. We believe that the regulation of lymphatic flow is a potential therapeutic pathway to alleviate the symptoms of CRPS. Further research on the association between autonomic and lymphatic dysfunction and pain is warranted, particularly in patients with CRPS and symptoms of edema following leg fractures.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1540930"},"PeriodicalIF":2.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive transcranial magnetic stimulation at low frequency for the treatment of fibromyalgia. Results from the first treatment cohort at the brainwave clinic.","authors":"Elliot Nation, Anushka Irani, Stephanie Barrett","doi":"10.3389/fpain.2025.1558175","DOIUrl":"10.3389/fpain.2025.1558175","url":null,"abstract":"<p><strong>Objective: </strong>To assess the clinical effectiveness of low-frequency repetitive transcranial magnetic stimulation (rTMS) in treating fibromyalgia (FM) in a real-world setting.</p><p><strong>Methods: </strong>Eighteen adults diagnosed with FM received 20 sessions of low-frequency rTMS over the right dorsolateral prefrontal cortex (DLPFC). Pain and symptom burden were assessed using the Numerical Rating Scale (NRS), Fibromyalgia Impact Questionnaire (FIQ), Sheehan Disability Scale (SDS), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Outcomes were compared using paired <i>t</i>-tests.</p><p><strong>Results: </strong>Statistically significant improvements were observed in NRS, FIQ, BDI, and BAI. A non-significant trend towards reduced disability (SDS) was observed. No serious adverse effects were reported.</p><p><strong>Conclusion: </strong>Low-frequency rTMS over the DLPFC shows promise as a safe and effective treatment for FM, improving pain, mood, and impact of FM symptoms, with a trend towards improving disability. Further research with larger cohorts is needed.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1558175"},"PeriodicalIF":2.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rotating-pulling-poking manipulation effectively alleviates pain symptoms of lateral ankle sprain: an animal experimental study.","authors":"Haibao Wen, Jinghua Gao, Fudong Shi, Jin Li, Minrui Fu, Minshan Feng, Luguang Li, Chunyu Gao, Jianguo Li","doi":"10.3389/fpain.2025.1532867","DOIUrl":"10.3389/fpain.2025.1532867","url":null,"abstract":"<p><p>This study aimed to explore the analgesic mechanism of the Rotating - Pulling - Poking Manipulation in treating acute lateral ankle sprain (ALAS). Thirty rats were randomly divided into 5 groups in the first experiment to determine the dose - effect relationship by detecting ankle pain thresholds at different time points. The results showed that the 5-min manipulation group had the best analgesic effect, with the bipedal weight - bearing difference decreasing over time and pain relief time shortened. In the second experiment, 30 rats were divided into 3 groups. After manipulation, samples from PAG and RVM were tested. The results indicated that compared with the model group, the 5-min manipulation group had increased MOR expression in PAG and 5 - HT concentration in cerebrospinal fluid, decreased expressions of BDNF, p - TrkB/TrkB in PAG and NR2A in RVM, and reduced contents of IL - 6, IL - 1β, TNF - α in ankle soft tissues. In conclusion, the Rotating - Pulling - Poking Manipulation can relieve pain by exciting the descending inhibitory system mediated by opioid receptors in the brain center, weakening the descending facilitation system mediated by the BDNF/TrkB/NR2A signaling pathway, and reducing the inflammatory response.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1532867"},"PeriodicalIF":2.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and refinement of the sore throat pain model as an assay for measuring therapeutic effects on acute pain.","authors":"Bernard P Schachtel, Adrian Shephard","doi":"10.3389/fpain.2025.1576168","DOIUrl":"10.3389/fpain.2025.1576168","url":null,"abstract":"<p><p>The physical and subjective status of patients with acute throat pain has been developed and refined over the past 40 years as an acute pain model to measure changes in patient-reported symptoms attributed to active pharmacologic intervention when patients with painful pharyngitis are evaluated under randomized, double-blind, placebo-controlled conditions. Acute, painful pharyngitis is a familiar experience for the majority of adults and children (\"a sore throat\" is the most common example of the aches and pains of the common cold). As such, the condition has served as a general acute pain model to demonstrate the acute effects of non-prescription-strength analgesic agents (for mild-to-moderate pain) and prescription-strength analgesics (for moderate-to-severe pain). Here we discuss the methodologic features of this clinical pharmacology assay as it was refined from its original examinations of classic, orally administered, acute analgesics (aspirin, acetaminophen, aspirin with caffeine, ibuprofen) to its more recent evaluations of celecoxib, valdecoxib, topical benzydamine, and topical flurbiprofen.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1576168"},"PeriodicalIF":2.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruptions in cortical circuit connectivity distinguish widespread hyperalgesia from localized pain.","authors":"George Kenefati, Mika M Rockholt, Katherine Eisert, Qiaosheng Zhang, Deborah Ok, Christopher G Gharibo, Lucia Daiana Voiculescu, Lisa V Doan, Zhe Sage Chen, Jing Wang","doi":"10.3389/fpain.2025.1548500","DOIUrl":"10.3389/fpain.2025.1548500","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to investigate the interregional functional connectivity in chronic back pain patients with widespread hyperalgesia, patients with localized back pain, and pain-free controls using stimulus-evoked high-density EEG recordings.</p><p><strong>Methods: </strong>We conducted high-density EEG recordings to compare the functional connectivity and betweenness centrality between these groups.</p><p><strong>Results: </strong>Compared with controls, chronic pain patients showed altered functional connectivity between regions that process cognitive information and regions that process sensory or affective information. Widespread hyperalgesia, however, is further differentiated from localized pain by decreased inter-hemispheric connectivity of sensory and affective areas and increased intra-hemispheric connectivity between sensory and cognitive cortices. Graph-theoretic analysis showed that whereas chronic pain is associated with decreased centrality of prefrontal, orbitofrontal, and cingulate areas, widespread hyperalgesia is distinguished by increased centrality of prefrontal and insular areas.</p><p><strong>Discussion: </strong>Together, our results show that although widespread hyperalgesia shares certain features with localized pain, it is further characterized by distinct cortical mechanisms.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1548500"},"PeriodicalIF":2.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}