Frontiers in pain research (Lausanne, Switzerland)最新文献

{"title":"Machine learning predicting acute pain and opioid dose in radiation treated oropharyngeal cancer patients.","authors":"Vivian Salama, Laia Humbert-Vidan, Brandon Godinich, Kareem A Wahid, Dina M ElHabashy, Mohamed A Naser, Renjie He, Abdallah S R Mohamed, Ariana J Sahli, Katherine A Hutcheson, Gary Brandon Gunn, David I Rosenthal, Clifton D Fuller, Amy C Moreno","doi":"10.3389/fpain.2025.1567632","DOIUrl":"10.3389/fpain.2025.1567632","url":null,"abstract":"<p><strong>Introduction: </strong>Acute pain is common among oral cavity/oropharyngeal cancer (OCC/OPC) patients undergoing radiation therapy (RT). This study aimed to predict acute pain severity and opioid doses during RT using machine learning (ML), facilitating risk-stratification models for clinical trials.</p><p><strong>Methods: </strong>A retrospective study examined 900 OCC/OPC patients treated with RT during 2017-2023. Pain intensity was assessed using NRS (0-none, 10-worst) and total opioid doses were calculated using morphine equivalent daily dose (MEDD) conversion factors. Analgesics efficacy was assessed using combined pain intensity and total MEDD. ML predictive models were developed and validated, including Logistic Regression (LR), Support Vector Machine (SVM), Random Forest (RF), and Gradient Boosting Machine (GBM). Model performance was evaluated using discrimination and calibration metrics, while feature importance was investigated using bootstrapping.</p><p><strong>Results: </strong>For predicting pain intensity, the GBM demonstrated superior discrimination performance (AUROC 0.71, recall 0.39, and <i>F</i>1 score 0.48). For predicting the total MEDD, LR model outperformed other models (AUROC 0.67). For predicting analgesics efficacy, the SVM achieved the highest specificity (0.97), while the RF and GBM models achieved the highest AUROC (0.68). RF model emerged as the best calibrated model with an ECE of 0.02 and 0.05 for pain intensity and MEDD prediction, respectively. Baseline pain scores and vital signs demonstrated the most contributing features.</p><p><strong>Conclusion: </strong>ML models showed promise in predicting end-of-treatment pain intensity, opioid requirements and analgesics efficacy in OCC/OPC patients. Baseline pain score and vital signs are crucial predictors. Their implementation in clinical practice could facilitate early risk stratification and personalized pain management.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1567632"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived injustice and its relation to chronic pain outcome in complex regional pain syndrome and chronic musculoskeletal pain.","authors":"Corinna Baum, Cora Rebhorn, Anne Martinelli, Dorothee Heining, Sabine Weimert, Sandra Bücher, Livia Steenken, Sebastian Steinmetz, Frank Birklein, Violeta Dimova","doi":"10.3389/fpain.2025.1554630","DOIUrl":"https://doi.org/10.3389/fpain.2025.1554630","url":null,"abstract":"<p><strong>Objectives: </strong>Clinical observations indicate that patients with complex regional pain syndrome (CRPS) tend to ruminate about their illness. Perceived injustice is a negative cognitive-emotional appraisal regarding the severity of loss associated with blame, unfairness, and pain. We investigated injustice beliefs in CRPS compared with chronic musculoskeletal pain (CMP), where previous evidence indicates clinical relevance for pain-related outcome in this patients' group. The role of perceived injustice in relation to pain intensity and disability was tested through a mediation model including catastrophizing thoughts of pain.</p><p><strong>Methods: </strong>Patients with CRPS (mean age <i>M</i> = 50.9, <i>SD</i> = 13.8) and CMP (mean age <i>M</i> = 53.9, <i>SD</i> = 8.0 years) were enrolled at two independent specialized outpatient clinics. All patients completed questionnaires on pain intensity, pain disability, and perceived injustice, levels of depression and pain catastrophizing.</p><p><strong>Results: </strong>CRPS patients displayed higher levels of perceived injustice than the CPM patients. Higher pain intensity in both cohorts was indirectly associated with more feelings and beliefs of injustice through a higher tendency to catastrophize about pain and pain-related information. In contrast, only in the CMP group higher pain-related disability was related to higher catastrophizing, which mediated the effect of perceived injustice.</p><p><strong>Conclusions: </strong>Perceived injustice influences especially pain intensity through pain catastrophizing. This interaction appears to be common for both pain syndromes.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1554630"},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The moderating role of extraversion in the relationship between trait mindfulness and pain adaptation.","authors":"Chen Lu, Nele Berner, Lena Hagel, Nils Jannik Heukamp, Vera Moliadze, Frauke Nees","doi":"10.3389/fpain.2025.1534339","DOIUrl":"https://doi.org/10.3389/fpain.2025.1534339","url":null,"abstract":"<p><strong>Introduction: </strong>Pain habituation, the reduction in response to repeated painful stimuli, is a positive adaptation process, while pain sensitization is linked to chronic pain. Traits like mindfulness and extraversion affect pain processing, but their influence on pain adaptation and potential interactions remains underexplored. This study aimed to examine the relationship between trait mindfulness, extraversion, and pain adaptation, assessing their predictive value and any interaction effects.</p><p><strong>Materials and method: </strong>Fifty-two healthy participants, mean age = 23.29 ± 2.052 years, completed questionnaires measuring trait mindfulness and extraversion, followed by an experimental pain stimulation to assess pain adaptation. Correlation analysis and hierarchical regression analysis were used to explore the relationships between traits and pain adaptation, and potential interaction effects.</p><p><strong>Result: </strong>Trait mindfulness positively correlated with extraversion, but neither trait showed a significant correlation with pain adaptation. In addition, neither trait mindfulness nor extraversion significantly predicted pain adaptation. However, a significant interaction was found between the two traits, suggesting that extraversion moderates the relationship between trait mindfulness and pain adaptation.</p><p><strong>Conclusion: </strong>Trait mindfulness and extraversion are interrelated traits whose interaction affects pain habituation and the extent to which individuals with higher levels of trait mindfulness exhibit greater pain adaptation appears to depend on their levels of extraversion. These findings suggest that trait mindfulness and extraversion may act as protective factors in chronic pain development. Mindfulness-based interventions may be particularly effective for individuals with specific personality traits. This can inform further research to explore these implications for pain management.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1534339"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum bone metabolism biomarkers in predicting tumor bone metastasis risk and their association with cancer pain: a retrospective study.","authors":"Sijia Zhang, Kai Huang, Tian Zhou, Yao Wang, Yunqing Xu, Quan Tang, Guangqin Xiao","doi":"10.3389/fpain.2025.1514459","DOIUrl":"https://doi.org/10.3389/fpain.2025.1514459","url":null,"abstract":"<p><strong>Background: </strong>This study aims to develop a novel nomogram predictive model utilizing serum bone metabolism biomarkers to accurately predict and diagnose tumor bone metastasis. The creation of this model holds significant clinical implications, supporting the development of targeted intervention strategies, providing robust laboratory data, and guiding early patient treatment.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted involving 266 patients treated at hospitals from September 2021 to January 2024. Patients were classified into three groups based on disease characteristics: tumor patients without bone metastasis, tumor patients with bone metastasis, and a control group consisting of individuals with neither tumor nor bone metabolism-related conditions. The primary serum bone metabolism biomarkers assessed included the N-terminal mid fragment of osteocalcin (NMID), the total N-terminal propeptide of type I procollagen (TPINP), and the C-terminal telopeptide of type I collagen β-special sequence (β-CTX). Multivariate statistical methods, including logistic regression and Cox regression, were employed for data analysis, while the nomogram model was rigorously evaluated using a variety of tools such as receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>The study found that the levels of NMID, TPINP, and β-CTX were significantly elevated in patients with bone metastasis compared to the other groups. These biomarkers were strongly associated with the incidence of tumor bone metastasis and identified as independent risk factors for this condition. The nomogram model demonstrated exceptional predictive performance, characterized by high area under the AUC values, robust time-dependent ROC curves, accurate calibration curves, and effective decision curve analysis. Notably, a positive correlation was observed between NMID, TPINP, β-CTX, and numeric rating scale (NRS) pain scores, providing valuable biomarkers for evaluating and managing pain associated with tumor bone metastasis.</p><p><strong>Conclusion: </strong>This study successfully established a nomogram predictive model based on serum bone metabolism biomarkers, with NMID, TPINP, and β-CTX emerging as critical indicators. The correlation between these biomarkers and NRS pain scores offers a novel understanding of the pain mechanisms associated with tumor bone metastasis, providing clinicians with essential reference points for diagnostic and therapeutic decision-making, thereby enhancing the practical application of the model in clinical settings.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1514459"},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous electrical nerve stimulation as an adjuvant treatment for thoracolumbar acute hyperesthesia in chondrodystrophic dogs: a prospective blinded controlled clinical study.","authors":"Débora Gouveia, Ana Cardoso, Carla Carvalho, Marina Moisés, André Coelho, Maria Manuel Balça, Rui Alvites, Ana Colette Maurício, António Ferreira, Ângela Martins","doi":"10.3389/fpain.2025.1496607","DOIUrl":"10.3389/fpain.2025.1496607","url":null,"abstract":"<p><strong>Introduction: </strong>Acute paraspinal hyperesthesia in dogs can result in a combination of nociceptive and neuropathic pain, often requiring pharmacological intervention. However, non-pharmacologic approaches, such as two-channel transcutaneous electrical nerve stimulation (TENS), may also be beneficial. Evidence from human medicine suggests that conventional TENS reduces pain scores and potentially decreases the need for analgesic medication. This study aimed to evaluate the efficacy of TENS as an adjunctive treatment for thoracolumbar paraspinal hyperesthesia in dogs.</p><p><strong>Methods: </strong>This prospective, blinded, controlled cohort study was conducted in a clinical setting. Dogs diagnosed with paraspinal hyperesthesia, classified as grade 4 or 5 on the modified Frankel scale (MFS) and with a dynamic interactive visual analog scale (DIVAS) score ≥14, were included. The subjects were randomized into two groups: the study group (SG), which received standard pharmacological protocol (PSP) plus TENS, and the control group (CG), which received PSP only. Observers blinded to treatment allocation scored video recordings of the dogs. Assessments were performed every 24 hours from T0 (admission) to T8, with evaluations in SG occurring 5 minutes before each TENS session.</p><p><strong>Results: </strong>A total of 818 dogs were enrolled, with 605 (74%) in the SG and 213 (26%) in the CG. In the first 48 hours, SG demonstrated a faster reduction in muscle tone compared to CG. While all dogs transitioned from a hyperesthetic to a non-painful state, SG showed a significantly faster recovery from T2 (48 h) to T4. A significant difference was observed between groups in DIVAS scores (<i>p</i> < 0.001). Additionally, SG had a shorter mean hospital stay (2.14 days) compared to CG, which required twice as long (<i>p</i> < 0.001).</p><p><strong>Discussion: </strong>These findings suggest that TENS may be an effective adjunctive therapy for managing acute thoracolumbar hyperesthesia in dogs, promoting early recovery by reducing pain, medication dependency, and hospitalization duration. However, the study's reliance on subjective assessments presents a limitation, potentially introducing bias. Further research with objective outcome measures is necessary to validate these findings and optimize the integration of TENS in veterinary pain management protocols.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1496607"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The acceptability, feasibility, and usability of a virtual reality pain education and rehabilitation program for Veterans: a mixed-methods study.","authors":"Amelia K Mardon, Dianne Wilson, Hayley B Leake, Daniel Harvie, Andre Andrade, K Jane Chalmers, Aaron Bowes, G Lorimer Moseley","doi":"10.3389/fpain.2025.1535915","DOIUrl":"10.3389/fpain.2025.1535915","url":null,"abstract":"<p><strong>Introduction: </strong>Persistent pain is a leading cause of medical discharges for Veterans. Pain science education (PSE) aims to better people's understanding about pain and is effective at reducing pain and depressive symptoms in Veterans. Preliminary evidence suggests virtual reality (VR)-delivered PSE has clinical benefits for people with persistent pain. This study investigated the acceptability, feasibility, and usability for VR-PSE for Veterans with persistent pain.</p><p><strong>Methods: </strong>Veterans (<i>n</i> = 7) and healthcare professionals (HCPs) experienced in treating Veterans (<i>n</i> = 5) participated in workshops that involved working through the VR-PSE program, online questionnaires, and a focus group. Quantitative data were analysed by descriptive statistics. Qualitative data were analysed using a framework analysis according to the Theoretical Framework of Acceptability (TFA). A mixed-methods analysis combined the quantitative and qualitative data via triangulation, with the findings presented according to the TFA domains.</p><p><strong>Results: </strong>The VR-PSE program was considered easy to use, engaging, and adaptable for different functional capabilities. Appropriate screening for contraindications prior to using the VR-PSE program was considered important by HCPs. Both Veterans and HCPs emphasized the need for a trusting client-clinician relationship to improve the acceptability of the VR-PSE program.</p><p><strong>Discussion: </strong>Overall, the VR-PSE program was found to be acceptable, feasible, and usable and may be a useful tool to incorporate into the clinical management of Veterans with persistent pain. Further research is needed to investigate the efficacy of VR-PSE programs on clinical outcomes for Veterans with persistent pain.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1535915"},"PeriodicalIF":2.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptomatic joint hypermobility is not a barrier to attendance, graduation, or satisfaction for adults participating in a multidisciplinary pain rehabilitation program.","authors":"Lindsay G Flegge, Emma Estrella, Elizabeth K Harris, Adam T Hirsh, Michael A Bushey","doi":"10.3389/fpain.2025.1472160","DOIUrl":"10.3389/fpain.2025.1472160","url":null,"abstract":"<p><strong>Introduction: </strong>Symptomatic joint hypermobility, as found in conditions like hypermobile Ehlers-Danlos syndrome (hEDS), presents unique challenges in pain management due to associated symptoms such as chronic pain, joint instability, and dysautonomia. Despite the high prevalence of hypermobility and associated healthcare costs, there is a lack of research on effective treatments for these patients, particularly in the context of multidisciplinary pain rehabilitation programs.</p><p><strong>Objective: </strong>This study aims to compare the baseline characteristics, attendance, graduation rates, and patient satisfaction of hypermobile and non-hypermobile adult outpatients participating in a multidisciplinary pain rehabilitation program (PRP).</p><p><strong>Methods: </strong>This retrospective cohort study analyzed clinical data from 335 patients at the Indiana University Health Pain Navigation Service between January 1, 2023, and December 31, 2023. Baseline characteristics were assessed using patient-reported outcome measures, and attendance and graduation rates were tracked. Hypermobile and non-hypermobile groups were compared with independent samples t-tests and chi-squared tests. A multiple linear regression model was used to assess the impact of hypermobility diagnosis on PRP attendance, with pertinent demographic and baseline clinical scores entered as covariates.</p><p><strong>Results: </strong>Hypermobile patients differed significantly from non-hypermobile patients in demographics, including age, gender, race, education, and employment status. Despite these differences, hypermobile patients did not differ from non-hypermobile patients in PRP attendance or graduation rates. Baseline pain, depression, and pain catastrophizing scores were lower in the hypermobile group. Exit surveys indicated similar levels of overall satisfaction with the program, though hypermobile patients were less likely to report that their needs were fully met than were non-hypermobile patients.</p><p><strong>Discussion: </strong>Despite the potential for joint hypermobility to pose a barrier to participation in multidisciplinary pain rehabilitation programs, we found no evidence that patients with a hypermobile diagnosis had less participation in an intensive outpatient pain rehabilitation program. After accounting for group differences in key demographic and clinical variables, there were no significant differences in PRP attendance between hypermobile and non-hypermobile patients. Our results are encouraging regarding the potential for multidisciplinary pain rehabilitation programs to serve the needs of these patients.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1472160"},"PeriodicalIF":2.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond <i>p</i>-values: a cross-sectional umbrella review of chemotherapy-induced peripheral neuropathy treatments.","authors":"Alice L Ye, Salahadin Abdi","doi":"10.3389/fpain.2025.1564662","DOIUrl":"10.3389/fpain.2025.1564662","url":null,"abstract":"<p><strong>Introduction: </strong>Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of neurotoxic chemotherapy agents, significantly impacting the daily lives of many cancer survivors. Despite thousands of articles published on CIPN, we remain no closer to a successful treatment regimen for the condition. In recent years, several new clinical trials and systematic reviews have been published, many exploring nonpharmaceutical interventions, prompting the need for a comprehensive synthesis of this emerging evidence.</p><p><strong>Methods: </strong>We conducted an umbrella review to identify and appraise the 19 systematic reviews (SRs) published in 2023 that examined randomized controlled trials (RCTs) for established CIPN treatment. We focused our analysis on the three most researched treatment options: oral drugs, exercise, and acupuncture. RCTs not previously synthesized together were reviewed, and effect size analyses were performed to allow readers to interpret the existing literature beyond binary <i>p</i>-values.</p><p><strong>Results: </strong>Our analysis of RCTs revealed the following key findings. For cancer survivors with CIPN after completing chemotherapy, serotonin-norepinephrine reuptake inhibitors (SNRIs) as well as acupuncture provided at least short-term relief for pain and sensory symptoms. For patients with CIPN who were actively undergoing chemotherapy, home-based balance and strength training exercises appeared to alleviate symptoms. Effect size analyses highlighted variability in treatment responses, underscoring the limitations of relying solely on <i>p</i>-values to assess intervention efficacy.</p><p><strong>Discussion: </strong>Through an umbrella review approach, we demonstrate that SRs are often less systematic than expected. None of the 19 SRs captured all relevant RCTs within their search timeframe. However, by cross-referencing SRs, we identified 41 RCTs across 42 publications, illustrating the feasibility of an umbrella review approach to uncover relevant trials. Furthermore, many SRs exhibited methodological concerns that limit the interpretability of their findings. Finally, we discuss multiple opportunities for refining methods and reporting in future CIPN treatment trials.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024508283, PROSPERO (42024508283).</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1564662"},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mobile phone dependence and musculoskeletal pain prevalence in adolescents: a cross-sectional study.","authors":"David Mauricio Parra-Fernandez, Margareth Lorena Alfonso-Mora, María Alejandra Sánchez-Vera, Paola Sarmiento-Gonzalez, Andrea Milena García Becerra, Miriam Guerra-Balic","doi":"10.3389/fpain.2025.1489293","DOIUrl":"10.3389/fpain.2025.1489293","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between adolescents' mobile phone dependence (MPD) and musculoskeletal pain.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 622 adolescents aged 10-18 in Tabio, Colombia. Participants completed an online survey that included the MPD and the Nordic Musculoskeletal Questionnaire, which assessed musculoskeletal pain symptoms.</p><p><strong>Results: </strong>56.3% (<i>n</i> = 350) participants reported experiencing musculoskeletal pain, with the upper back being the most affected area (30.4%, <i>n</i> = 193). Adolescents reporting pain had significantly higher MPD scores compared to those without pain (mean 29 vs. 24, <i>p</i> < 0.001). Additionally, females exhibited higher MPD scores than males (mean 29 vs. 25, <i>p</i> < 0.001) and had a higher prevalence of pain (32% vs. 24%). Furthermore, older adolescents in the 11th grade had higher MPD scores than younger adolescents in the 5th grade (mean 31 vs. 21, <i>p</i> < 0.019). Logistic regression analysis indicated that specific MPD dimensions, namely \"abuse\" and \"difficulty regulating use,\" were significantly associated with general pain and neck pain, but no association was observed with upper back pain. Furthermore, female sex was linked to both neck and upper back pain.</p><p><strong>Conclusion: </strong>This study found that the MPD dimensions of \"abuse\" and \"difficulty regulating use\" were significantly associated with neck pain, regardless of the adolescents' sex.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1489293"},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferential C-nociceptor stimulation facilitates peripheral axon reflex flare, but not secondary mechanical hyperalgesia.","authors":"Luana Daneffel, Roman Rukwied, Martin Schmelz, Wilhelm Ruppen, Tobias Schneider","doi":"10.3389/fpain.2025.1556429","DOIUrl":"10.3389/fpain.2025.1556429","url":null,"abstract":"<p><p>\"Silent\" C-nociceptors are crucial for inducing the axon reflex erythema in humans and may also contribute to spinal sensitization such as secondary hyperalgesia. Electrical slow depolarizing stimulation paradigms activate unmyelinated C-fibers [25 ms half-sine (HS) profile] whereas A-fibers are stimulated by 500 µs rectangular (R) pulses. We therefore expect to provoke larger areas of axon-reflex flare (silent nociceptor activation) and secondary hyperalgesia to HS stimuli. We compared axon-reflex erythema and secondary mechanical hyperalgesia areas induced by intracutaneous electrical HS and R stimuli using stimulation intensities that induced pain ratings of 3 and 6 on a numeric rating scale (NRS 0-10) in 24 healthy volunteers. Slowly depolarizing C-fiber stimulation was linked to lower current intensities required to induce pain (NRS 6: HS 3.6 vs. R 9.2 mA, <i>p</i> = 0.001) and resulted in larger axon reflex erythema for high stimulus intensities (AUC_Flare: NRS 6, 320.7 vs. 234.1 cm²⋅min, <i>p</i> = 0.015; NRS 3, 79.1 vs. 51.0 cm²⋅min; <i>p</i> = 0.114). Preferential C-fiber stimulation indicated a correlation of axon-reflex erythema with the areas of secondary mechanical hyperalgesia (NRS 6: <i>r</i> = 0.21, <i>p</i> = 0.036; NRS 3: <i>r</i> = 0.48, <i>p</i> = 0.0016). In contrast, the mean area of secondary mechanical hyperalgesia did not differ between HS and R [AUC_Hyper: NRS 6, 1,555 (HS) vs. 1,585 cm²⋅min (R), <i>p</i> = 0.893; NRS 3, 590 (HS) vs. 449 cm²⋅min (R), <i>p</i> = 0.212] albeit it developed faster during HS. Our data confirm that silent nociceptors provoke the axon reflex erythema, but their role in secondary hyperalgesia appears to be less crucial. <b>Clinical trial number:</b> NCT0544026.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1556429"},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}