Frontiers in pain research (Lausanne, Switzerland)最新文献

{"title":"Preventing opioid prescribing for low back pain using multimodal mechanical stimulation vs. TENS: a randomized-controlled trial.","authors":"Amy L Baxter, Jena L Etnoyer-Slaski, Jessica Allia Rice Williams, Kevin Swartout, Lindsey L Cohen, M Louise Lawson","doi":"10.3389/fpain.2025.1612572","DOIUrl":"10.3389/fpain.2025.1612572","url":null,"abstract":"<p><strong>Background: </strong>Low back pain (LBP) is the most common reason for outpatient opioid prescribing: a quarter of patients receive prescriptions, leading to opioid use disorder (OUD) in 5%. Guideline-recommended multimodal interventions often face implementation barriers, and effective modalities (e.g., electrical stimulation) lack coverage. A multimodal mechanical stimulation (M-Stim) device for LBP has demonstrated safety and efficacy in pain reduction, but its impact on opioid use has not yet been determined.</p><p><strong>Methods: </strong>As part of an NIH-funded double-blind study to reduce pain and opioid use, patients with moderate-to-severe LBP presenting to two suburban chiropractic centers were randomized to receive either the M-Stim device or a transcutaneous electrical nerve stimulation (TENS) unit for 30 min daily, in addition to other therapies. Analgesic use was reported daily for 28 days, with new prescribing followed weekly for 3 months. The primary outcome was prescribing in the opioid-naïve subjects. Secondary endpoints included risk factors for prolonged use in the opioid-naïve subjects, milligram morphine equivalents (MME) for opioid users between the first and last 2 weeks, and prescribing compared with national rates.</p><p><strong>Results: </strong>After informed consent, 159 eligible patients were randomized to M-Stim (87) or TENS (72) (mean age 42.6 years, 54% female, BMI 30.9, NRS 5.5) between 23 June 2022 and 31 December 2023. Zero opioid-naïve M-Stim participants (<i>n</i> = 43) received prescriptions (0% vs. 8.6%, Fisher's exact <i>p</i> = 0.086), and those taking opioids used significantly fewer MME [7.5 (SD 3.54) vs. 498.5 MME (SD 474.9), <i>p</i> < 0.0001] for fewer of reported days [M-Stim 2/47 (4.2%)] compared with TENS [<i>n</i> = 36, 38/102 (37%), RR 0.11 (95% CI 0.28-0.44), <i>p</i> = 0.0018]. M-Stim significantly reduced MME in opioid users [-44.6% (32.33 MME), <i>p</i> = 0.02], use days for those with BMI ≥30 [-3 (99% CI -5.73 to -0.26), <i>p</i> = 0.032], and prescribing compared with national rates [9.8% vs. 25%, -63%, RR 0.32 (95% CI 0.16-0.66), <i>p</i> = 0.002] while TENS did not.</p><p><strong>Conclusions: </strong>Among chiropractic patients with moderate-to-severe LBP, added use of a multimodal M-Stim device in the opioid-naïve subjects significantly reduced factors associated with OUD compared with TENS and reduced use days for those with BMI ≥30. This novel device is a potential alternative to prescribing opioids as first line for LBP management.</p><p><strong>Clinical trial registration: </strong>https://clinicaltrials.gov/study/NCT04491175, identifier NCT04491175.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1612572"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Integrating sensors and artificial intelligence for objective pain detection and quantification: unveiling new possibilities.","authors":"Youngsun Kong, Raul Fernandez Rojas, Hugo F Posada-Quintero","doi":"10.3389/fpain.2025.1654743","DOIUrl":"https://doi.org/10.3389/fpain.2025.1654743","url":null,"abstract":"","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1654743"},"PeriodicalIF":2.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The treatment of chemotherapy-induced peripheral neuropathy: a review of current management options and a potential role for scrambler therapy.","authors":"Hassan Aboumerhi, Henry Vucetic, Andrew Gruenzel, Bahar Moftakhar, Mona Gupta, Santosh K Rao, Michael D Staudt","doi":"10.3389/fpain.2025.1607102","DOIUrl":"10.3389/fpain.2025.1607102","url":null,"abstract":"<p><p>Chemotherapy-induced peripheral neuropathy (CIPN) presents a growing medical and financial burden on patients and the healthcare system alike. This has been treated with conservative and interventional care limited by efficacy, side effects, and lack of coverage. As such, there is an unmet treatment need for effective non-invasive or minimally invasive therapies for the treatment of CIPN. Scrambler therapy (ST) is a peripheral, non-invasive neuromodulation technique, which uses transcutaneous electrical stimulation to modulate pain signals. ST has shown mixed results in clinical trials; while some patients report symptom relief, more robust evidence is required before it can be widely recommended. This review article outlines the burden of CIPN and the current state of treatment, including pharmacological and interventional therapies. The emerging data on ST and its role in treating CIPN is highlighted, including a review of published observational and randomized controlled trials. We also discuss the gaps and challenges ahead in establishing this therapy as a standard of care.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1607102"},"PeriodicalIF":2.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classifying office workers with and without cervicogenic headache or neck and shoulder pain using posture-based deep learning models: a multicenter retrospective study.","authors":"Ui-Jae Hwang, Junghun Han, Oh-Yun Kwon, Yu Seong Chu, Sejung Yang","doi":"10.3389/fpain.2025.1614143","DOIUrl":"10.3389/fpain.2025.1614143","url":null,"abstract":"<p><strong>Objective: </strong>To develop and evaluate deep learning models for classifying office workers with and without cervicogenic headache (CH) and/or neck and shoulder pain (NSP), based on habitual sitting posture images.</p><p><strong>Methods: </strong>This multicenter, retrospective, observational study analyzed 904 digital images of habitual sitting postures of 531 office workers. Three deep learning models (VGG19, ResNet50, and EfficientNet B5) were trained and evaluated to classify the CH, NSP, and combined CH + NSP. Model performance was assessed using 4-fold cross-validation with metrics including area under the curve (AUC), accuracy (ACC), sensitivity (Sen), specificity (Spe), and F1 score. Statistical significance was evaluated using 95% confidence intervals. Class Activation Mapping (CAM) was used to visualize the model focus areas.</p><p><strong>Results: </strong>Among 531 office workers (135 with CH, 365 with NSP, 108 with both conditions and 139 control group), ResNet50 achieved the highest performance for CH classification with an AUC of 0.782 (95% CI: 0.770-0.793) and an accuracy of 0.750 (95% CI: 0.731-0.768). NSP classification showed more modest results, with ResNet50 achieving an accuracy of 0.677 (95% CI: 0.640-0.713). In the combined CH + NSP classification, EfficientNet B5 demonstrated the highest AUC of 0.744 (95% CI: 0.647-0.841). CAM analysis revealed distinct focus areas for each condition: the cervical region for CH, the lower body for NSP, and broader neck and trunk regions for combined CH + NSP.</p><p><strong>Conclusion: </strong>Deep learning models show potential for classifying CH and NSP based on habitual sitting posture images, with varying performances across conditions. The ability of these models to detect subtle postural patterns associated with different musculoskeletal conditions suggests their possible applications for early detection and intervention. However, the complex relationship between static posture and musculoskeletal pain underscores the need for a multimodal assessment approach in clinical practice.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1614143"},"PeriodicalIF":2.5,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a kappa opioid receptor antagonist on delayed postoperative pain recovery in a novel mouse sleep disorder model.","authors":"Hisakatsu Ito, Masaaki Kawakami, Masashi Yoshida, Sadamu Sugimoto, Tomonori Takazawa","doi":"10.3389/fpain.2025.1516935","DOIUrl":"10.3389/fpain.2025.1516935","url":null,"abstract":"<p><strong>Introduction: </strong>Sleep disturbances have been shown to exacerbate pain sensitivity and prolong recovery from pain. However, conventional animal models of sleep disturbance, which involve physical disruptions, such as water or forced movement, might not fully represent modern human sleep disorders.</p><p><strong>Methods: </strong>We utilized a novel sleep disorder model, the perpetual avoidance of water on a wheel (PAWW) model, which induces spontaneous activity, chronic stress, and abnormal sleep-wake cycles in mice. We investigated the effects of a kappa opioid receptor (KOR) antagonist, nor-binaltorphimine (nor-BNI), on pain recovery in a postoperative pain model in mice in a state of disordered sleep. After 1 week of acclimation, the mice were housed in PAWW or regular cages for 2 weeks. Sleep conditions were evaluated using electroencephalogram and electromyogram recordings, and postoperative pain recovery following plantar incision was assessed using von Frey tests. We also examined the effects of nor-BNI on pain recovery.</p><p><strong>Results: </strong>The evaluation showed that PAWW housing significantly increased activity during the light phase, disrupted sleep patterns, and delayed postoperative pain recovery. The administration of nor-BNI alleviated the delayed pain recovery.</p><p><strong>Discussion: </strong>These findings suggest that sleep disorders, such as those modeled by PAWW, could delay postoperative pain recovery, and that KOR antagonists might provide therapeutic benefits in the management of delayed recovery of postoperative pain induced by sleep disorders.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1516935"},"PeriodicalIF":2.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota-mediated pain sensitization: mechanisms and therapeutic implications.","authors":"Minghe Zhao, Ling Zhang, Zhihui Liu","doi":"10.3389/fpain.2025.1626515","DOIUrl":"10.3389/fpain.2025.1626515","url":null,"abstract":"<p><p>Emerging evidence has illuminated the pivotal role of gut microbiota in modulating pain sensitivity through bidirectional gut-brain interactions. Current research demonstrates that gut microbial communities significantly influence pain perception by regulating both central and peripheral sensitization mechanisms across various pain modalities. This review synthesizes current knowledge on the mechanisms underlying gut microbiota-mediated pain sensitization, encompassing: (1) cross-talk within the microbiome-gut-brain axis, (2) regulatory effects of microbial metabolites on central and peripheral sensitization pathways, and (3) bioactive compounds derived from gut microbiota that participate in pain modulation. Furthermore, we systematically evaluate the therapeutic potential of microbiota-targeted interventions including probiotic supplementation, fecal microbiota transplantation, and dietary modifications in pain management. To advance this promising field, future investigations should prioritize three key directions: establishing causal relationships through rigorous verification, accelerating clinical translation of preclinical findings, and developing personalized microbial-based therapeutic strategies.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1626515"},"PeriodicalIF":2.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and user experience of augmented reality psychoeducation and mindfulness body scan for chronic low back pain.","authors":"Robin Conen, Nikolai Hepke, Jörg Lohscheller, Steffen Mueller, Ana N Tibubos","doi":"10.3389/fpain.2025.1600637","DOIUrl":"10.3389/fpain.2025.1600637","url":null,"abstract":"<p><strong>Background: </strong>Chronic low back pain (CLBP) is prevalent and a multimodal therapy is indicated, including psychological treatment. Effective conventional treatments involve psychoeducation and mindfulness-based body scans, while virtual reality offers superior but temporary pain relief. Augmented Reality (AR), which combines conventional and virtual methods, is a novel therapeutic strategy.</p><p><strong>Methods: </strong>We investigated the viability and acceptability of an AR intervention for CLBP by incorporating psychoeducation and mindfulness-based body scan techniques. 40 participants in two studies with a one-arm design underwent an educational AR intervention (Study I, <i>n</i> ₁ = 18) and an enhanced version with an additional body scan (Study II, <i>n</i> ₂ = 22). The studies focused on evaluating technical feasibility and multiple facets of user experience.</p><p><strong>Results: </strong>The results demonstrated high feasibility with low dropout rates (Study I: 10%, Study II: 0%). User experience ratings ranged from \"Above Average\" to \"Excellent,\" with the advanced intervention receiving higher ratings. While Study I showed no significant changes in affect pre- vs. post-intervention, Study II exhibited a significant reduction in negative affect and improved valence. Qualitative analysis provided insights into technical requirements and user perceptions.</p><p><strong>Discussion: </strong>The AR prototype emerges as a promising psychoeducational tool for CLBP, aligning with current treatment guidelines and providing a basis for future controlled clinical trials. Limitations include the absence of a high-pain intervention group, as Study I reported a pain intensity of <i>M</i> = 1.05 and Study II reported <i>M</i> = 1.77 (Range: 0-10). Further research such as clinical trials with control groups is required to validate the efficacy of the piloted approach. The AR-based psychoeducation and mindfulness body scan intervention for CLBP demonstrated technical feasibility and a good user experience.</p><p><strong>Clinical trial registration: </strong>Open Science Framework.io; https://doi.org/10.17605/OSF.IO/DSW5X and https://doi.org/10.17605/OSF.IO/XVJBZ.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1600637"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights and progress on postoperative analgesia of radical gastrectomy for gastric cancer: a comprehensive review.","authors":"Linghui Li, Yuanyuan Zhao, Huan Chen, Jianqin Zhao, Mengjun Dai, Qi Wang, Jie Lv, Wei Wang","doi":"10.3389/fpain.2025.1601220","DOIUrl":"10.3389/fpain.2025.1601220","url":null,"abstract":"<p><p>Gastric cancer is a common and highly lethal malignancy of the digestive system, with surgical resection as the primary treatment approach. However, postoperative analgesia management remains a major clinical challenge. Postoperative pain not only affects recovery speed but may also lead to complications, thereby influencing prognosis. Recent research on postoperative pain following gastric cancer surgery has expanded, exploring various analgesic methods, including pharmacological therapy, neuraxial blocks, and non-pharmacological approaches, with growing emphasis on individualized analgesia protocols. Despite the proposal of multiple analgesic techniques, current research indicates that their effectiveness and safety are still inadequately assessed in clinical applications. This review aims to discuss the physiological mechanisms of postoperative pain following gastric cancer surgery, modern analgesic strategies, and related research, to provide a theoretical basis and clinical guidance for improving postoperative quality of life.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1601220"},"PeriodicalIF":2.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional evidence from a case report supports a novel hypothesis on the association between complex regional pain syndrome and lymphedema.","authors":"M Mark Melin, John C Rasmussen, Melissa B Aldrich, Ron J Karni, Caroline E Fife, Kristen A Eckert","doi":"10.3389/fpain.2025.1540930","DOIUrl":"10.3389/fpain.2025.1540930","url":null,"abstract":"<p><p>A previous report of 4 heterogeneous cases demonstrated that automated manual lymphatic drainage therapy (AMLDT), administered by a novel, pneumatic mat of 16 pressurized air channels that inflate and deflate sequentially to mimic the stretch and release action of manual lymphatic drainage therapy (MLD), altered lymphatic contractility and relieved pain. Near-infrared fluorescence imaging (NIRF-LI) was used 1 h before AMLDT, during 1 h of AMDLT, and 30-60 min after treatment to obtain images that could be used to determine lymphatic contractility, as measured by pulsing frequency over a given timeframe. Herein, a case of type 2 complex regional pain syndrome (CRPS, with nerve dysfunction confirmed) and lymphedema following a complex fracture on the lower leg is reported in further detail, with a discussion explaining the association between autonomic and lymphatic dysfunction and their combined contribution to the development of chronic pain. More specifically, this case provides clinical evidence of the association between autonomic nervous system dysfunction, lymphatic dysfunction, and CRPS. We believe that the regulation of lymphatic flow is a potential therapeutic pathway to alleviate the symptoms of CRPS. Further research on the association between autonomic and lymphatic dysfunction and pain is warranted, particularly in patients with CRPS and symptoms of edema following leg fractures.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1540930"},"PeriodicalIF":2.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive transcranial magnetic stimulation at low frequency for the treatment of fibromyalgia. Results from the first treatment cohort at the brainwave clinic.","authors":"Elliot Nation, Anushka Irani, Stephanie Barrett","doi":"10.3389/fpain.2025.1558175","DOIUrl":"10.3389/fpain.2025.1558175","url":null,"abstract":"<p><strong>Objective: </strong>To assess the clinical effectiveness of low-frequency repetitive transcranial magnetic stimulation (rTMS) in treating fibromyalgia (FM) in a real-world setting.</p><p><strong>Methods: </strong>Eighteen adults diagnosed with FM received 20 sessions of low-frequency rTMS over the right dorsolateral prefrontal cortex (DLPFC). Pain and symptom burden were assessed using the Numerical Rating Scale (NRS), Fibromyalgia Impact Questionnaire (FIQ), Sheehan Disability Scale (SDS), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Outcomes were compared using paired <i>t</i>-tests.</p><p><strong>Results: </strong>Statistically significant improvements were observed in NRS, FIQ, BDI, and BAI. A non-significant trend towards reduced disability (SDS) was observed. No serious adverse effects were reported.</p><p><strong>Conclusion: </strong>Low-frequency rTMS over the DLPFC shows promise as a safe and effective treatment for FM, improving pain, mood, and impact of FM symptoms, with a trend towards improving disability. Further research with larger cohorts is needed.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":"6 ","pages":"1558175"},"PeriodicalIF":2.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}