Frontiers in pain research (Lausanne, Switzerland)最新文献

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Rescue analgesia with a transversus abdominis plane block alleviates moderate-to-severe pain and improves oxygenation after abdominal surgery: a randomized controlled trial. 腹横肌平面阻滞镇痛可减轻腹部手术后的中度至重度疼痛并改善氧合:随机对照试验。
IF 2.5
Frontiers in pain research (Lausanne, Switzerland) Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI: 10.3389/fpain.2024.1454665
Jingxian He, Shuai Qin, Yuwen Wang, Qiuping Ye, Penglei Wang, Ye Zhang, Yun Wu
{"title":"Rescue analgesia with a transversus abdominis plane block alleviates moderate-to-severe pain and improves oxygenation after abdominal surgery: a randomized controlled trial.","authors":"Jingxian He, Shuai Qin, Yuwen Wang, Qiuping Ye, Penglei Wang, Ye Zhang, Yun Wu","doi":"10.3389/fpain.2024.1454665","DOIUrl":"10.3389/fpain.2024.1454665","url":null,"abstract":"<p><strong>Background: </strong>Abdominal surgery is a common surgical procedure that is frequently associated with substantial postoperative pain. However, rescue analgesia using opioids is associated with several adverse effects. The transversus abdominis plane block (TAPB) has been demonstrated to be effective as part of multimodal analgesia. This study aims to evaluate the effects of rescue analgesia using the TAPB following abdominal surgery.</p><p><strong>Methods: </strong>Ninety patients undergoing abdominal surgery and reporting a numeric rating scale (NRS) score of cough pain ≥4 on the first postoperative day were randomized to receive either sufentanil or TAPB for rescue analgesia. Pain scores and arterial oxygen pressure (PaO<sub>2</sub>) were evaluated before and after the administration of rescue analgesia. Sleep quality and gastrointestinal function were assessed postoperatively. The primary outcome was the degree of pain relief on coughing 30 min after the administration of rescue analgesia.</p><p><strong>Results: </strong>Patients of both groups reported a significantly reduced NRS score on coughing 30 min after receiving rescue analgesia (<i>P</i> <sub>paired</sub> < 0.001 for both groups). Notably, the degree of pain relief was significantly higher in the TAPB group than in the sufentanil group [median (interquartile range), -3 (-4 to -2) vs. -2 (-2 to -1), median difference = -1; 95% confidence interval, -2 to -1; <i>P</i> < 0.001]. Moreover, patients in the TAPB group experienced less pain than those in the sufentanil group during the following 24 h. When evaluated, PaO<sub>2</sub> increased significantly after rescue analgesia was administered in the TAPB group (<i>P</i> <sub>paired</sub> < 0.001); however, there were no significant intragroup differences in the sufentanil group (<i>P</i> <sub>paired</sub> = 0.129). Patients receiving the TAPB experienced better quality of sleep than those receiving sufentanil (<i>P</i> = 0.008), while no statistical differences in gastrointestinal function were observed between the two groups.</p><p><strong>Conclusion: </strong>Rescue analgesia with the TAPB on the first postoperative day alleviated pain, enhanced oxygenation, and improved sleep quality in patients undergoing abdominal surgery; however, its effect on gastrointestinal function requires further research.</p><p><strong>Clinical trial registration: </strong>This study was registered in the Chinese Clinical Trial Registry (https://www.chictr.org.cn/showproj.html?proj=170983, ChiCTR2200060285) on 26 May 2022: Patients were recruited during the period between 30 May 2022 and 14 February 2023, and a follow-up of the last enrolled patient was completed on 16 March 2023.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric pain physician workforce: an assessment of supply and demand. 儿科疼痛医生队伍:供需评估。
IF 2.5
Frontiers in pain research (Lausanne, Switzerland) Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI: 10.3389/fpain.2024.1390736
Christopher B Theriault, Tracy Burns, Kenneth Goldschneider, Anjali Koka, Deirdre Logan, Steven J Weisman, Robert T Wilder, R Blake Windsor, William T Zempsky
{"title":"Pediatric pain physician workforce: an assessment of supply and demand.","authors":"Christopher B Theriault, Tracy Burns, Kenneth Goldschneider, Anjali Koka, Deirdre Logan, Steven J Weisman, Robert T Wilder, R Blake Windsor, William T Zempsky","doi":"10.3389/fpain.2024.1390736","DOIUrl":"https://doi.org/10.3389/fpain.2024.1390736","url":null,"abstract":"<p><strong>Introduction: </strong>Many youth with pain lack access to pediatric pain expertise. There is a critical shortage of pediatric pain physicians, due partly to a paucity of training programs in Pediatric Pain Medicine. Pain fellowships are Anesthesiology-based and there is no pathway to fellowship training or Pain Medicine board certification for pediatricians. This workforce assessment sought to examine the current state of Pediatric Pain Medicine in the United States and future interest in pursuing Pain Medicine among pediatricians.</p><p><strong>Methods: </strong>A multidisciplinary working group of Pain Medicine clinicians designed three surveys to examine pediatric comprehensive pain programs in the US, practice patterns of pediatricians and their motivations and opinions regarding Pain Medicine board certification, and current residents' exposure to and interest in Pediatric Pain Medicine.</p><p><strong>Results: </strong>Wait times for initial evaluations are two months or longer for two-thirds of responding centers, and barriers to increase staff size and resources were reported, including an inadequate number of trained or available physicians. Pediatricians expressed interest in earning board certification in Pain Medicine, given the opportunity. Additionally, there is interest among pediatric residents in pursuing Pediatric Pain Medicine, and qualitative data highlight information residents perceived needing in order to pursue a career in the field.</p><p><strong>Discussion: </strong>Results demonstrate the need for increased training opportunities in pediatric pain medicine. A formal pathway to Pain Medicine for Pediatricians should be developed to increase the potential workforce and to address the lack of trained pediatric pain specialists, thereby improving access to care for youth with pain.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating pain in non-verbal critical care patients: a narrative review of the critical care pain observation tool and Its clinical applications. 评估非语言危重症患者的疼痛:危重症疼痛观察工具及其临床应用的叙述性回顾。
IF 2.5
Frontiers in pain research (Lausanne, Switzerland) Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI: 10.3389/fpain.2024.1481085
Abebe Dilie Afenigus
{"title":"Evaluating pain in non-verbal critical care patients: a narrative review of the critical care pain observation tool and Its clinical applications.","authors":"Abebe Dilie Afenigus","doi":"10.3389/fpain.2024.1481085","DOIUrl":"https://doi.org/10.3389/fpain.2024.1481085","url":null,"abstract":"<p><strong>Background: </strong>Assessing pain in critically ill patients who cannot communicate verbally poses significant challenges. Traditional self-report measures are ineffective for these patients, making the need for reliable observational tools crucial.</p><p><strong>Objective: </strong>To evaluate the effectiveness, reliability, and clinical applicability of the Critical Care Pain Observation Tool (CPOT) in various intensive care unit (ICU) settings and to explore potential innovations for improving its use and integration into clinical practice.</p><p><strong>Methods: </strong>A narrative review evaluated the Critical Care Pain Observation Tool (CPOT) for non-communicative ICU patients, comparing it to the Behavioral Pain Scale (BPS) and the FLACC scale. The review assessed CPOT's effectiveness across different ICU settings, identified limitations and challenges, and explored potential enhancements such as electronic scoring, additional physiological indicators, and improved training protocols.</p><p><strong>Results: </strong>The CPOT has been validated as an effective pain assessment tool for non-verbal ICU patients. It evaluates pain through facial expressions, body movements, muscle tension, and ventilator compliance. The CPOT shows superior sensitivity at 76.5% compared to 62.7% for the BPS and offers a more comprehensive assessment of pain indicators like muscle tension and ventilator compliance than the FLACC scale. Despite its strengths, the CPOT has limitations, including inter-rater variability and challenges in certain patient populations. Barriers to implementation include resource constraints and the need for extensive training.</p><p><strong>Conclusion: </strong>The Critical Care Pain Observation Tool (CPOT) is a highly effective instrument for assessing pain in non-verbal ICU patients, demonstrating superior accuracy and reliability compared to other tools like the Behavioral Pain Scale (BPS) and FLACC scale. Its detailed approach, covering facial expressions, body movements, muscle tension, and ventilator compliance, offers a detailed measure of pain. However, challenges such as inter-rater variability and limitations in specific patient populations highlight the need for ongoing refinement and research.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing analgesia in acute renal colic pain: a randomized controlled trial of gabapentin adjunct to ketorolac-based regimen. 增强急性肾绞痛的镇痛效果:加巴喷丁辅助酮咯酸疗法的随机对照试验。
IF 2.5
Frontiers in pain research (Lausanne, Switzerland) Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI: 10.3389/fpain.2024.1427711
Parisa Kianpour, Parmis Valavioun, Pooya Payandemehr, Arash Safaei, Yasaman Borhani, Hooshyar Honarmand, Mojtaba Mojtahedzadeh, Kamal Basiri, Elahe Karimpour-Razkenari, Farhad Najmeddin
{"title":"Enhancing analgesia in acute renal colic pain: a randomized controlled trial of gabapentin adjunct to ketorolac-based regimen.","authors":"Parisa Kianpour, Parmis Valavioun, Pooya Payandemehr, Arash Safaei, Yasaman Borhani, Hooshyar Honarmand, Mojtaba Mojtahedzadeh, Kamal Basiri, Elahe Karimpour-Razkenari, Farhad Najmeddin","doi":"10.3389/fpain.2024.1427711","DOIUrl":"10.3389/fpain.2024.1427711","url":null,"abstract":"<p><strong>Background: </strong>Renal colic is characterized by severe pain that is highly disabling. Gabapentin, an antiepileptic medication, is often recommended as a first-line therapy for neuropathic pain. However, its effectiveness in managing somatic pain, which is defined as the result of activity by pain receptors in the deep tissues, such as renal colic pain, is not as well-established.</p><p><strong>Method: </strong>A phase 3 randomized clinical trial was conducted to evaluate the adjuvant analgesic effects of gabapentin on acute renal colic pain. Eligible patients participated in the study via random allocation to the control or gabapentin groups using the block randomization method. All patients received a shared regimen of ketorolac and rescue morphine as the conventional analgesic treatment for renal colic pain. Gabapentin was added as an adjuvant analgesic for the gabapentin group.</p><p><strong>Result: </strong>A total of 63 individuals with an average age of 41.35 ± 13.08, were enrolled and completed the study. At the time of admission, there were no significant differences between the baseline characteristics of two groups, with exception of weight. The gabapentin group showed a significantly higher percentage of patients with pain severity of less than 5 after 60 and 90 min, as well as a significantly lower percentage of morphine rescue requirement and total morphine intake (mg) and mg/kg.</p><p><strong>Conclusion: </strong>In cases of acute renal colic, gabapentin significantly decreases both the amount of morphine required and the degree of pain, indicating that it may be a useful adjutant to standard analgesic regimens. Treatment regimens that include gabapentin may help individuals manage their pain and become less reliant on opioids.</p><p><strong>Clinical trial registration: </strong>https://irct.behdasht.gov.ir/trial/56066, identifier: IRCT20200322046833N2.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-opioid psychiatric medications for chronic pain: systematic review and meta-analysis. 治疗慢性疼痛的非阿片类精神药物:系统回顾和荟萃分析。
IF 2.5
Frontiers in pain research (Lausanne, Switzerland) Pub Date : 2024-10-10 eCollection Date: 2024-01-01 DOI: 10.3389/fpain.2024.1398442
Shahana Ayub, Anil Krishna Bachu, Lakshit Jain, Shanli Parnia, Siddhi Bhivandkar, Rizwan Ahmed, Jasleen Kaur, Surya Karlapati, Sakshi Prasad, Hansini Kochhar, Oghenetega Esther Ayisire, Saloni Mitra, Bikona Ghosh, Sushma Srinivas, Sahar Ashraf, Bhavani Nagendra Papudesi, Palash Kumar Malo, Shoib Sheikh, Michael Hsu, Domenico De Berardis, Saeed Ahmed
{"title":"Non-opioid psychiatric medications for chronic pain: systematic review and meta-analysis.","authors":"Shahana Ayub, Anil Krishna Bachu, Lakshit Jain, Shanli Parnia, Siddhi Bhivandkar, Rizwan Ahmed, Jasleen Kaur, Surya Karlapati, Sakshi Prasad, Hansini Kochhar, Oghenetega Esther Ayisire, Saloni Mitra, Bikona Ghosh, Sushma Srinivas, Sahar Ashraf, Bhavani Nagendra Papudesi, Palash Kumar Malo, Shoib Sheikh, Michael Hsu, Domenico De Berardis, Saeed Ahmed","doi":"10.3389/fpain.2024.1398442","DOIUrl":"https://doi.org/10.3389/fpain.2024.1398442","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The escalating number of deaths related to opioid usage has intensified the pursuit of non-opioid alternatives for managing chronic pain. It's often observed that psychiatric comorbidities coexist in patients suffering from chronic pain. There are a variety of psychotropic medications that have demonstrated effectiveness in treating both psychiatric symptoms and pain. This systematic review and meta-analysis aim to assess the effectiveness of various psychiatric drugs in managing specific types of chronic pain, including fibromyalgia, neuropathic pain, and chronic low back pain.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A comprehensive search of five major databases was conducted through February 2023 to identify randomized controlled trials (RCTs) that met our inclusion criteria, focusing on outpatients Over 18 years of age with chronic pain. The study assessed the effectiveness of duloxetine, mirogabalin, pregabalin, gabapentin, and tricyclic antidepressants (TCAs), including serotonin-norepinephrine reuptake inhibitors (SNRIs), across various chronic pain conditions such as fibromyalgia, neuropathic pain, and chronic low back pain. The primary outcome measures included pain reduction, improvement in function, and quality of life. Of the 29 RCTs in the systematic review, 20 studies qualified for the meta-analysis. The analysis was stratified by pain type and treatment duration (short-term ≤14 weeks vs. long-term &gt;14 weeks), using Hedge's g standardized mean differences and a random-effects model, along with sensitivity and subgroup analyses.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The overall short-term intervention effect across all studies was significant (SMD -1.45, 95% CI -2.15 to -0.75, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), with considerable heterogeneity (I&lt;sup&gt;2&lt;/sup&gt; = 99%). For fibromyalgia, both duloxetine and mirogabalin demonstrated substantial efficacy with SMDs of -2.42 (95% CI -3.67 to -1.18, &lt;i&gt;p&lt;/i&gt; &lt; 0.0001) and -2.10 (95% CI -3.28 to -0.92, &lt;i&gt;p&lt;/i&gt; = 0.0005), respectively. Conversely, treatments for neuropathic pain and chronic low back pain, including those with amitriptyline and desipramine, did not show significant benefits. The effectiveness of gabapentin could not be conclusively determined due to limited representation in the data. Additionally, no consistent long-term benefits were observed for any of the medications.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;While the results of this study underscore the importance of exploring non-opioid alternatives for chronic pain management, particularly in light of the opioid crisis, it is crucial to interpret the findings carefully. Our analysis suggests that certain psychiatric medications, such Duloxetine and mirogabalin demonstrated significant short-term efficacy in fibromyalgia patients. However, their effectiveness in treating neuropathic pain and chronic low back pain was not statistically significant. Additionally, the effectiveness of gabapentin and other medications, such as pr","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11499177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report: Reduction in post-amputation phantom limb pain intensity accompanying the onset of phantom limb telescoping. 病例报告:伴随幻肢伸缩的截肢后幻肢疼痛强度降低。
IF 2.5
Frontiers in pain research (Lausanne, Switzerland) Pub Date : 2024-10-09 eCollection Date: 2024-01-01 DOI: 10.3389/fpain.2024.1409352
Andrea Aternali, Heather Lumsden-Ruegg, Lora Appel, Sander L Hitzig, Amanda L Mayo, Joel Katz
{"title":"Case Report: Reduction in post-amputation phantom limb pain intensity accompanying the onset of phantom limb telescoping.","authors":"Andrea Aternali, Heather Lumsden-Ruegg, Lora Appel, Sander L Hitzig, Amanda L Mayo, Joel Katz","doi":"10.3389/fpain.2024.1409352","DOIUrl":"https://doi.org/10.3389/fpain.2024.1409352","url":null,"abstract":"<p><strong>Introduction: </strong>Individuals with limb loss frequently report post-amputation phenomena, including nonpainful phantom sensations, phantom limb pain (PLP), and residual limb pain (RLP). Although post-amputation pain is common, not all patients benefit from widely accepted treatments. A greater understanding of phantom limb \"telescoping\", the experience of one's phantom hand or foot gradually approaching the residual limb, may assist in developing more effective interventions for reducing post-amputation pain. This case report explores the relationships between PLP, RLP, telescoping, and psychosocial experience in one person with a lower limb amputation. The aim of this case is to illustrate one possible relationship between telescoping and PLP as the mechanisms linking the two remain equivocal.</p><p><strong>Methods: </strong>The participant is a 35-year-old male who underwent a transfemoral amputation due to a traumatic injury to his right leg approximately 4 years prior. He responded to questionnaires evaluating demographic and health-related information (e.g., age, sex, marital status, reason for amputation), pain and psychological variables via the Brief Pain Inventory (BPI-SF), ID Pain Questionnaire (IDPQ), Pain Catastrophizing Scale (PSC-4), Patient Health Questionnaire-4 (PHQ-4), Life Orientation Test-Revised (LOT-R), Connor-Davidson Resilience Scale (CD-RISC2), and Chronic Pain Acceptance Questionnaire (CPAQ-8) and telescoping, measured by a newly developed app. The participant completed a semi-structured interview that was designed to ascertain patterns in the overlapping experience of phantom limb telescoping and post-amputation pain.</p><p><strong>Results: </strong>The participant rated his average PLP as 10 on a Numeric Rating Scale (NRS) from 0 (\"no pain\") to 10 (\"worst pain imaginable\") shortly after amputation. Approximately 12 months later, the participant noticed a shortening of his phantom limb, with a concurrent decrease in PLP. At present, his average NRS pain intensity is a 5/10. The participant described how the daily, debilitating PLP intensity diminished to weekly, manageable pain over time. Most notably, his responses on questionnaires were consistent with neuropathic PLP, mild to moderate levels of pain interference, a high level of catastrophic thinking about pain, low optimism, and mild symptoms of anxiety and depression.</p><p><strong>Discussion: </strong>In this report, telescoping appeared to be preceded by an initial reduction in PLP intensity but these findings are based on a single case report and must be replicated with a large sample size before we have a clearer idea of the relationship between telescoping and PLP. This study provides insight into factors that may maintain PLP, generating targets for further investigation.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacology of spinal interventions: review of agents used in spine pain procedures. 脊柱介入的药理学:脊柱疼痛手术所用药物综述。
IF 2.5
Frontiers in pain research (Lausanne, Switzerland) Pub Date : 2024-10-09 eCollection Date: 2024-01-01 DOI: 10.3389/fpain.2024.1408905
Ericson John V Torralba, Robert F Short, Jeffrey B Travers, John M Mathis
{"title":"Pharmacology of spinal interventions: review of agents used in spine pain procedures.","authors":"Ericson John V Torralba, Robert F Short, Jeffrey B Travers, John M Mathis","doi":"10.3389/fpain.2024.1408905","DOIUrl":"https://doi.org/10.3389/fpain.2024.1408905","url":null,"abstract":"<p><p>Spine procedures are commonly performed to diagnose and treat various spinal conditions, ranging from degenerative disc disease to vertebral fractures. These procedures often involve the use of pharmaceutical agents to enhance the efficacy of the intervention and improve patient outcomes. This review provides an overview of the pharmaceuticals commonly utilized in spine procedures, including corticosteroids, anesthetics, antibiotics, radiographic contrast, neurolytic agents, and materials used in kyphoplasty and vertebroplasty. This review summarizes the utilization of these pharmaceutical agents in spine procedures in an effort to optimize patient outcomes. Understanding the pharmacological properties and appropriate uses of these pharmaceuticals is essential for interventionalist and healthcare providers involved in the care of patients undergoing spinal interventions.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The perpetual evidence-practice gap: addressing ongoing barriers to chronic pain management in primary care in three steps. 证据与实践之间的永久鸿沟:分三步走解决基层医疗中慢性疼痛管理的持续障碍。
IF 2.5
Frontiers in pain research (Lausanne, Switzerland) Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI: 10.3389/fpain.2024.1376462
Laura Ellen Ashcraft, Megan E Hamm, Serwaa S Omowale, Valerie Hruschak, Elizabeth Miller, Shaun M Eack, Jessica S Merlin
{"title":"The perpetual evidence-practice gap: addressing ongoing barriers to chronic pain management in primary care in three steps.","authors":"Laura Ellen Ashcraft, Megan E Hamm, Serwaa S Omowale, Valerie Hruschak, Elizabeth Miller, Shaun M Eack, Jessica S Merlin","doi":"10.3389/fpain.2024.1376462","DOIUrl":"https://doi.org/10.3389/fpain.2024.1376462","url":null,"abstract":"<p><strong>Background: </strong>Most management of chronic pain, a serious illness affecting the physical and psychological wellbeing of millions, occurs in primary care settings. Primary care practitioners (PCPs) attempt to provide evidence-based practices to treat chronic pain. However, there continues to be a gap between the care people receive and the evidence. The objectives for this study were to (1) explore determinants of evidence-based chronic pain management and (2) develop a novel approach to using implementation science to address the evidence-practice gap.</p><p><strong>Method: </strong>A convenience sample of twenty-one Pennsylvania PCPs participated in one-time semi-structured telephone interviews. Interviews were transcribed verbatim and both deductive and inductive approaches were used during analysis. We used the Consolidated Framework for Implementation Research (CFIR) and the Expert Recommendations for Implementing Change (ERIC) to inform our analysis and findings.</p><p><strong>Results: </strong>We identified determinants of evidence-based chronic pain management across the CFIR domains of Intervention Characteristics, Characteristics of Individuals, and the Outer Setting and reported implementation strategies. Based on identified themes, we developed a three-step process to support the ongoing and pragmatic implementation of evidence-based chronic pain management in primary care settings.</p><p><strong>Conclusions: </strong>Previous efforts exist to integrate implementation science into chronic pain management; yet a gap persists. Implementation approaches should prioritize the needs of people living with chronic pain and their families. Further, future approaches or strategies used should build on the current three-step model to include the fourth step of tailoring existing implementation strategies to the specific needs of chronic pain in the clinical context.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond pain privacy and pain meters: a new vision for pain biomarkers. 超越疼痛隐私和疼痛测量仪:疼痛生物标志物的新愿景。
IF 2.5
Frontiers in pain research (Lausanne, Switzerland) Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI: 10.3389/fpain.2024.1397645
Charles Djordjevic, Carl Y Saab
{"title":"Beyond pain privacy and pain meters: a new vision for pain biomarkers.","authors":"Charles Djordjevic, Carl Y Saab","doi":"10.3389/fpain.2024.1397645","DOIUrl":"https://doi.org/10.3389/fpain.2024.1397645","url":null,"abstract":"<p><p>To an individual, pain is unambiguously real. To a caregiver, assessing pain in others is a challenging process shrouded in doubt. To explain this challenge, many assume that pain \"belongs\" exclusively to the bearer of that experience and accept the dogma that pain is private. However, privacy also entails that it is <i>not</i> possible to identify, share, or communicate that experience with others. Obviously, this is not true and the consequences of pain privacy would be devastating for healthcare. Pain is indeed unique and subjective, but not necessarily private. Pain is in fact readily communicable, though perhaps not as effectively and reliably as caregivers would like. On the other hand, healthcare systems mandate objective metrics in pain diagnosis. Smiley face caricatures are a staple of clinical practice and a universal standard for reporting pain levels. These conditions create a double paradox: Assess a private experience that is inaccessible, <i>and</i> use numerical scales to measure subjective attributes. Navigating this stressful environment, medical professionals experience intellectual dissonance, patients are frustrated, and value-based care is undermined. Offering a way out, first, we refute the privacy and objectification of pain citing philosophical, behavioral, and neuroscientific arguments. We discuss Wittgensteinian views against privacy, explore the clear evolutionary advantage of communicating pain to others, and identify neural circuits in the mammalian brain that contribute to empathy. Second, we highlight the subjectivity of pain, embracing the complexity and uniqueness of an individual's pain. We also provide compelling evidence for brain mechanisms that actively shape the pain experience according to predictive coding principles. Third, we offer a vision for the development of biomarker technologies that assess pain fairly without engendering bias against the patient's narrative. Our recommendations are based on the overwhelming appreciation that \"medicine by emoji\" is inadequate for capturing the multidimensional nature of pain. Our view is that the most promising candidates for pain biomarkers consist of self-reports as ground truth <i>augmented</i> by physiological signatures of biological relevance to pain. Integration of subjective and objective multimodal features will be key for the development of comprehensive pain assessment models.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing chronic low back pain management: an initial neuroimaging study of a mobile interoceptive attention training. 加强慢性腰背痛管理:移动互感注意力训练的初步神经影像学研究。
IF 2.5
Frontiers in pain research (Lausanne, Switzerland) Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI: 10.3389/fpain.2024.1408027
Irina A Strigo, Sergio Garcia Guerra, Salvatore Torrisi, Emily Murphy, Tiffany Toor, Veronica Goldman, Benedict J Alter, An Thanh Vu, Rich Hecht, Jeff Lotz, Alan N Simmons, Wolf E Mehling
{"title":"Enhancing chronic low back pain management: an initial neuroimaging study of a mobile interoceptive attention training.","authors":"Irina A Strigo, Sergio Garcia Guerra, Salvatore Torrisi, Emily Murphy, Tiffany Toor, Veronica Goldman, Benedict J Alter, An Thanh Vu, Rich Hecht, Jeff Lotz, Alan N Simmons, Wolf E Mehling","doi":"10.3389/fpain.2024.1408027","DOIUrl":"https://doi.org/10.3389/fpain.2024.1408027","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic low back pain (cLBP) poses significant challenges, often addressed through avoidance or distraction. Emerging evidence suggests that mind-body interventions, like our novel Mind Your Pain (MyP) smartphone mobile application, may offer relief. We conducted a single-arm, mixed-methods neuroimaging study to assess the degree to which treatment response to our 8-week intervention, as measured by the reduction in the Pain, Enjoyment of Life and General Activity Scale (PEG), was associated with enhanced pain-related insula activation over time.</p><p><strong>Methods: </strong>Twenty-nine individuals with cLBP completed patient-reported assessments, qualitative sensory testing (QST) measures, and neuroimaging pre- and post-MyP. Functional MRI data during experimental heat pain on the left forearm were collected and analyzed, comparing responders (≥50% reduction in PEG scores) and non-responders.</p><p><strong>Results: </strong>MyP led to significant decreases in PEG scores overall. Furthermore, MyP responders exhibited increased pain-related activation in key brain regions, including the contralateral posterior insula, bilateral ventral anterior insula, ventral anterior cingulate, dorsolateral prefrontal cortex, and nucleus accumbens. Although baseline behavioral and sensory measures did not differ between the two responder groups, baseline neural differences related to the impact of the endogenous back pain were observed.</p><p><strong>Discussion: </strong>MyP appears to modify pain response and underlying neural circuitry, suggesting neural changes in interoception may serve as biomarkers for mind-body interventions in cLBP. This study highlights the potential of MyP as a novel approach for cLBP management, warranting further investigation.</p>","PeriodicalId":73097,"journal":{"name":"Frontiers in pain research (Lausanne, Switzerland)","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11471628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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